{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:38:36Z","timestamp":1790127516986,"version":"4.0.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"BMBF Bonn","doi-asserted-by":"publisher","award":["EULACH16\/T020108"],"award-info":[{"award-number":["EULACH16\/T020108"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 35\/1314-1 FUGG"],"award-info":[{"award-number":["INST 35\/1314-1 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HL 53941"],"award-info":[{"award-number":["U01 HL 53941"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007161","name":"Boston University","doi-asserted-by":"publisher","award":["HHSN268201500001I"],"award-info":[{"award-number":["HHSN268201500001I"]}],"id":[{"id":"10.13039\/100007161","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007161","name":"Boston University","doi-asserted-by":"publisher","award":["N01-HC-25195"],"award-info":[{"award-number":["N01-HC-25195"]}],"id":[{"id":"10.13039\/100007161","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007161","name":"Boston University","doi-asserted-by":"publisher","award":["75N92019D00031"],"award-info":[{"award-number":["75N92019D00031"]}],"id":[{"id":"10.13039\/100007161","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005366","name":"Universitetet i Oslo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020560","name":"South East Regional Health Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020560","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003542","name":"Ministerium f\u00fcr Wissenschaft, Forschung und Kunst Baden-W\u00fcrttemberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100026701","name":"Lane Arts Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100026701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jinf.2025.106613","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T06:55:19Z","timestamp":1757660119000},"page":"106613","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Small-RNA sequencing identifies serum microRNAs associated with abnormal electrocardiography findings in patients with Chagas disease"],"prefix":"10.1016","volume":"91","author":[{"given":"Michael","family":"Mueller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Blandino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4430-296X","authenticated-orcid":false,"given":"Dominique","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Zulantay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Apt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5229-3007","authenticated-orcid":false,"given":"Nelson M.","family":"Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Llancaqueo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lineth","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Nicastri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Giancola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4545-8034","authenticated-orcid":false,"given":"Andrea","family":"Angheben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Gabrielli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine B.","family":"Rounge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"Langseth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Waldenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Salinas-Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justo","family":"Lorenzo Bermejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jinf.2025.106613_bib1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jacc.2013.05.046","article-title":"Chagas disease: an overview of clinical and epidemiological aspects","volume":"62","author":"Nunes","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.jinf.2025.106613_bib2","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1086\/605091","article-title":"An estimate of the burden of Chagas disease in the United States","volume":"49","author":"Bern","year":"2009","journal-title":"Clin Infect Dis"},{"issue":"9723","key":"10.1016\/j.jinf.2025.106613_bib3","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(10)60061-X","article-title":"Chagas disease","volume":"375","author":"Rassi","year":"2010","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jinf.2025.106613_bib4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.repc.2019.12.006","article-title":"Chagas cardiomyopathy and heart failure: from epidemiology to treatment","volume":"39","author":"Santos","year":"2020","journal-title":"Rev Port Cardiol"},{"issue":"1","key":"10.1016\/j.jinf.2025.106613_bib5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10741-010-9211-5","article-title":"Chronic Chagas\u2019 heart disease: a disease on its way to becoming a worldwide health problem: epidemiology, etiopathology, treatment, pathogenesis and laboratory medicine","volume":"17","author":"Mu\u00f1oz-Saravia","year":"2012","journal-title":"Heart Fail Rev"},{"issue":"5","key":"10.1016\/j.jinf.2025.106613_bib6","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1056\/NEJMra1410150","article-title":"Chagas' disease","volume":"373","author":"Bern","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jinf.2025.106613_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112020","article-title":"Advances in the treatment of Chagas disease: promising new drugs, plants and targets","volume":"142","author":"Garc\u00eda-Huertas","year":"2021","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"10.1016\/j.jinf.2025.106613_bib8","doi-asserted-by":"crossref","first-page":"e1186","DOI":"10.1093\/cid\/ciac579","article-title":"A phase 2, randomized, multicenter, placebo-controlled, proof-of-concept trial of oral fexinidazole in adults with chronic indeterminate Chagas disease","volume":"76","author":"Torrico","year":"2023","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.jinf.2025.106613_bib9","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s13063-020-4226-2","article-title":"Efficacy and safety assessment of different dosage of benznidazol for the treatment of Chagas disease in chronic phase in adults (MULTIBENZ study): study protocol for a multicenter randomized Phase II non-inferiority clinical trial","volume":"21","author":"Molina-Morant","year":"2020","journal-title":"Trials"},{"key":"10.1016\/j.jinf.2025.106613_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ijpddr.2019.11.004","article-title":"Current trends in the pharmacological management of Chagas disease","volume":"12","author":"Ribeiro","year":"2020","journal-title":"Int J Parasitol Drugs Drug Resist"},{"issue":"2","key":"10.1016\/j.jinf.2025.106613_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0012849","article-title":"Redefining the treatment of Chagas disease: a review of recent clinical and pharmacological data for a novel formulation of nifurtimox","volume":"19","author":"Altcheh","year":"2025","journal-title":"PLoS Negl Trop Dis"},{"issue":"10115","key":"10.1016\/j.jinf.2025.106613_bib12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0140-6736(17)31612-4","article-title":"Chagas disease","volume":"391","author":"Perez-Molina","year":"2018","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.jinf.2025.106613_bib13","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1590\/S0074-02762009000400002","article-title":"Present situation and new strategies for Chagas disease chemotherapy: a proposal","volume":"104","author":"Coura","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.jinf.2025.106613_bib14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijid.2018.05.019","article-title":"Course of serological tests in treated subjects with chronic Trypanosoma cruzi infection: a systematic review and meta-analysis of individual participant data","volume":"73","author":"Sguassero","year":"2018","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jinf.2025.106613_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.765879","article-title":"Immunomodulation for the treatment of chronic Chagas disease cardiomyopathy: a new approach to an old enemy","volume":"11","author":"Santos","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"issue":"9039","key":"10.1016\/j.jinf.2025.106613_bib16","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S0140-6736(96)04128-1","article-title":"Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection","volume":"348","author":"de Andrade","year":"1996","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.jinf.2025.106613_bib17","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1093\/cid\/ciw477","article-title":"Safety profile of nifurtimox for treatment of Chagas disease in the United States","volume":"63","author":"Forsyth","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.jinf.2025.106613_bib18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1590\/S0036-46652002000100006","article-title":"Long term evaluation of etiological treatment of chagas disease with benznidazole","volume":"44","author":"Cancado","year":"2002","journal-title":"Rev Inst Med Trop Sao Paulo"},{"issue":"14","key":"10.1016\/j.jinf.2025.106613_bib19","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1056\/NEJMoa1507574","article-title":"Randomized trial of benznidazole for chronic Chagas' cardiomyopathy","volume":"373","author":"Morillo","year":"2015","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.jinf.2025.106613_bib20","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00948-19","article-title":"MicroRNA-155 deficiency exacerbates Trypanosoma cruzi infection","volume":"88","author":"Jha","year":"2020","journal-title":"Infect Immun"},{"key":"10.1016\/j.jinf.2025.106613_bib21","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3389\/fmicb.2018.00269","article-title":"Circulating plasma microRNA-208a as potential biomarker of chronic indeterminate phase of Chagas disease","volume":"9","author":"Linhares-Lacerda","year":"2018","journal-title":"Front Microbiol"},{"issue":"12","key":"10.1016\/j.jinf.2025.106613_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008889","article-title":"miRNAs may play a major role in the control of gene expression in key pathobiological processes in Chagas disease cardiomyopathy","volume":"14","author":"Laugier","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"issue":"8","key":"10.1016\/j.jinf.2025.106613_bib23","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1039\/C4OB02104E","article-title":"A review: microRNA detection methods","volume":"13","author":"Tian","year":"2015","journal-title":"Org Biomol Chem"},{"issue":"2","key":"10.1016\/j.jinf.2025.106613_bib24","doi-asserted-by":"crossref","first-page":"0011865","DOI":"10.1371\/journal.pntd.0011865","article-title":"Unraveling the role of miRNAs as biomarkers in Chagas cardiomyopathy: insights into molecular pathophysiology","volume":"18","author":"Ribeiro","year":"2024","journal-title":"Plos Negl Trop Dis"},{"issue":"2","key":"10.1016\/j.jinf.2025.106613_bib25","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3390\/cells9020276","article-title":"miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis","volume":"9","author":"Condrat","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jinf.2025.106613_bib26","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/1476-4598-9-306","article-title":"Serum microRNAs as non-invasive biomarkers for cancer","volume":"9","author":"Brase","year":"2010","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jinf.2025.106613_bib27","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1755-8794-6-16","article-title":"Serum microRNAs profile from genome-wide serves as a fingerprint for diagnosis of acute myocardial infarction and angina pectoris","volume":"6","author":"Li","year":"2013","journal-title":"BMC Med Genom"},{"key":"10.1016\/j.jinf.2025.106613_bib28","article-title":"Comparison of the clinical value of miRNAs and conventional biomarkers in AMI: a systematic review","volume":"12","author":"Wang","year":"2021","journal-title":"Front Genet"},{"issue":"1","key":"10.1016\/j.jinf.2025.106613_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40659-021-00345-3","article-title":"Circulating miR-146a as a possible candidate biomarker in the indeterminate phase of Chagas disease","volume":"54","author":"Ballinas-Verdugo","year":"2021","journal-title":"Biol Res"},{"issue":"16","key":"10.1016\/j.jinf.2025.106613_bib30","first-page":"20","article-title":"Circulating miRNAs as potential biomarkers associated with cardiac remodeling and fibrosis in Chagas disease cardiomyopathy","author":"Nonaka","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.jinf.2025.106613_bib31","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ijcard.2014.05.019","article-title":"MicroRNAs miR-1, miR-133a, miR-133b, miR-208a and miR-208b are dysregulated in chronic Chagas disease cardiomyopathy","volume":"175","author":"Ferreira","year":"2014","journal-title":"Int J Cardiol"},{"issue":"9","key":"10.1016\/j.jinf.2025.106613_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004572","article-title":"Admixture in Latin America: geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals","volume":"10","author":"Ruiz-Linares","year":"2014","journal-title":"PLoS Genet"},{"issue":"2","key":"10.1016\/j.jinf.2025.106613_bib33","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/15476286.2017.1403003","article-title":"A comprehensive profile of circulating RNAs in human serum","volume":"15","author":"Umu","year":"2018","journal-title":"RNA Biol"},{"key":"10.1016\/j.jinf.2025.106613_bib34","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s13104-016-1900-2","article-title":"AdapterRemoval v2: rapid adapter trimming, identification, and read merging","volume":"9","author":"Schubert","year":"2016","journal-title":"BMC Res Notes"},{"issue":"4","key":"10.1016\/j.jinf.2025.106613_bib35","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"issue":"2","key":"10.1016\/j.jinf.2025.106613_bib36","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"issue":"9","key":"10.1016\/j.jinf.2025.106613_bib37","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1101\/gr.135350.111","article-title":"GENCODE: the reference human genome annotation for The ENCODE Project","volume":"22","author":"Harrow","year":"2012","journal-title":"Genome Res"},{"issue":"7845","key":"10.1016\/j.jinf.2025.106613_bib38","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41586-021-03205-y","article-title":"Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program","volume":"590","author":"Taliun","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jinf.2025.106613_bib39","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1749-6632.1963.tb13299.x","article-title":"An approach to longitudinal studies in a community: the Framingham Study","volume":"107","author":"Dawber","year":"1963","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"10.1016\/j.jinf.2025.106613_bib40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/oxfordjournals.aje.a112813","article-title":"An investigation of coronary heart disease in families. The Framingham offspring study","volume":"110","author":"Kannel","year":"1979","journal-title":"Am J Epidemiol"},{"issue":"11","key":"10.1016\/j.jinf.2025.106613_bib41","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/aje\/kwm021","article-title":"The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination","volume":"165","author":"Splansky","year":"2007","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jinf.2025.106613_bib42","article-title":"Diverse human extracellular RNAs are widely detected in human plasma","volume":"7","author":"Freedman","year":"2016","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.jinf.2025.106613_bib43","first-page":"1077","article-title":"The Sleep Heart Health Study: design, rationale, and methods","volume":"20","author":"Quan","year":"1997","journal-title":"Sleep"},{"key":"10.1016\/j.jinf.2025.106613_bib44","series-title":"R: A Language and Environment for Statistical Computing","author":"Team. RC","year":"2013"},{"key":"10.1016\/j.jinf.2025.106613_bib45","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"issue":"4","key":"10.1016\/j.jinf.2025.106613_bib46","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.pcad.2009.11.008","article-title":"Chagas cardiomyopathy\u2014where do we stand after a hundred years?","volume":"52","author":"Biolo","year":"2010","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.jinf.2025.106613_bib47","unstructured":"Maechler MRP, Croux C, Todorov V, Ruckstuhl A, Salibian-Barrera M, Verbeke T, et al. robustbase: Basic Robust Statistics. R package version 0.95\u20130. \u3008http:\/\/robustbase.r-forge.r-project.org\/\u3009."},{"issue":"10","key":"10.1016\/j.jinf.2025.106613_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206239","article-title":"miRWalk: an online resource for prediction of microRNA binding sites","volume":"13","author":"Sticht","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jinf.2025.106613_bib49","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"issue":"W1","key":"10.1016\/j.jinf.2025.106613_bib50","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.jinf.2025.106613_bib51","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/nar\/gkg115","article-title":"PANTHER: a browsable database of gene products organized by biological function, using curated protein family and subfamily classification","volume":"31","author":"Thomas","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jinf.2025.106613_bib52","doi-asserted-by":"crossref","first-page":"D377","DOI":"10.1093\/nar\/gks1118","article-title":"PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees","volume":"41","author":"Mi","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"10.1016\/j.jinf.2025.106613_bib53","doi-asserted-by":"crossref","first-page":"D956","DOI":"10.1093\/nar\/gkz711","article-title":"ncRNA-eQTL: a database to systematically evaluate the effects of SNPs on non-coding RNA expression across cancer types","volume":"48","author":"Li","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jinf.2025.106613_bib54","series-title":"Modern applied statistics with S-PLUS","author":"Venables","year":"2002"},{"key":"10.1016\/j.jinf.2025.106613_bib55","unstructured":"clickR: Semi-Automatic Preprocessing of Messy Data with Change Tracking for Dataset Cleaning. Version R Package Version 0.8.0; 2021. Available online: \u3008https:\/\/CRAN.R-project.org\/package=clickR\u3009."},{"key":"10.1016\/j.jinf.2025.106613_bib56","unstructured":"Mazerolle AICcmodavg: Model Selection and Multimodel Inference Based on (Q)AIC(c). Version R Package Version 2.3-1; 2020. Available online: \u3008https:\/\/cran.r-project.org\/package=AICcmodavg\u3009."},{"issue":"3","key":"10.1016\/j.jinf.2025.106613_bib57","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.4049\/jimmunol.1100033","article-title":"Importance of the CCR5-CCL5 axis for mucosal Trypanosoma cruzi protection and B cell activation","volume":"187","author":"Sullivan","year":"2011","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.jinf.2025.106613_bib58","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbadis.2017.10.006","article-title":"Endogenous osteopontin induces myocardial CCL5 and MMP-2 activation that contributes to inflammation and cardiac remodeling in a mouse model of chronic Chagas heart disease","volume":"1864","author":"Caballero","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jinf.2025.106613_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2020.01.003","article-title":"Peripheral microRNA panels to guide the diagnosis of familial cardiomyopathy","volume":"218","author":"Belmonte","year":"2020","journal-title":"Transl Res"},{"issue":"1","key":"10.1016\/j.jinf.2025.106613_bib60","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s10020-023-00619-4","article-title":"Inhibition of miR-101-3p prevents human aortic valve interstitial cell calcification through regulation of CDH11\/SOX9 expression","volume":"29","author":"Chen","year":"2023","journal-title":"Mol Med"},{"issue":"2","key":"10.1016\/j.jinf.2025.106613_bib61","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/abbs\/gmz154","article-title":"miR-101-3p induces vascular endothelial cell dysfunction by targeting tet methylcytosine dioxygenase 2","volume":"52","author":"Chen","year":"2020","journal-title":"Acta Biochim Biophys Sin"},{"issue":"4","key":"10.1016\/j.jinf.2025.106613_bib62","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1002\/ehf2.13371","article-title":"Identification of novel circulating microRNAs in advanced heart failure by next-generation sequencing","volume":"8","author":"Galluzzo","year":"2021","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jinf.2025.106613_bib63","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3389\/fimmu.2018.00615","article-title":"Genetic polymorphism at CCL5 is associated with protection in Chagas' heart disease: antagonistic participation of CCR1(+) and CCR5(+) cells in chronic chagasic cardiomyopathy","volume":"9","author":"Batista","year":"2018","journal-title":"Front Immunol"},{"issue":"7","key":"10.1016\/j.jinf.2025.106613_bib64","first-page":"1436","article-title":"Association of CCL5 rs2107538, and CCL2 rs3760396 gene polymorphisms with the risk of cardiovascular disease","volume":"50","author":"Mohtavinejad","year":"2021","journal-title":"Iran J Public Health"},{"issue":"12","key":"10.1016\/j.jinf.2025.106613_bib65","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1161\/CIR.0000000000000599","article-title":"Chagas cardiomyopathy: an update of current clinical knowledge and management: a scientific statement from the American Heart Association","volume":"138","author":"Nunes","year":"2018","journal-title":"Circulation"},{"issue":"623","key":"10.1016\/j.jinf.2025.106613_bib66","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1136\/pgmj.53.623.527","article-title":"Diagnosis of Chagas' cardiomyopathy. Non-invasive techniques","volume":"53","author":"Puigb\u00f3","year":"1977","journal-title":"Post Med J"},{"issue":"12","key":"10.1016\/j.jinf.2025.106613_bib67","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1517\/14728222.2013.837886","article-title":"Targeting CCL5 in inflammation","volume":"17","author":"Marques","year":"2013","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.jinf.2025.106613_bib68","series-title":"Chagas Disease","article-title":"Diagnosis of Chagas Disease: Are Clinical Definitions of Heart Involvement Accurate Enough?","author":"Silvestre de Sousa","year":"2020"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445325002130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445325002130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:15:33Z","timestamp":1780388133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445325002130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0163445325002130"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2025.106613","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small-RNA sequencing identifies serum microRNAs associated with abnormal electrocardiography findings in patients with Chagas disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2025.106613","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd on behalf of The British Infection Association.","name":"copyright","label":"Copyright"}],"article-number":"106613"}}