{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:56:26Z","timestamp":1790603786381,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272392"],"award-info":[{"award-number":["82272392"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["U25A20132"],"award-info":[{"award-number":["U25A20132"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jinf.2026.106813","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:30:24Z","timestamp":1784179824000},"page":"106813","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic characterisation of ST11-KL19 carbapenem-resistant Klebsiella pneumoniae carrying dual carbapenemases and hypervirulence-associated markers"],"prefix":"10.1016","volume":"93","author":[{"given":"Zelin","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2174-7985","authenticated-orcid":false,"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jinf.2026.106813_bib1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S1473-3099(21)00399-6","article-title":"Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study","volume":"22","author":"Wang","year":"2022","journal-title":"Lancet Infect Dis"},{"issue":"_2","key":"10.1016\/j.jinf.2026.106813_bib2","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1093\/cid\/ciy642","article-title":"In-hospital Medical Costs of Infections Caused by Carbapenem-resistant Klebsiella pneumoniae","volume":"67","author":"Huang","year":"2018","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2026.106813_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101083","article-title":"Expansion and transmission dynamics of high risk carbapenem-resistant Klebsiella pneumoniae subclones in China: an epidemiological, spatial, genomic analysis","volume":"74","author":"Wang","year":"2024","journal-title":"Drug Resist Updat"},{"issue":"23","key":"10.1016\/j.jinf.2026.106813_bib4","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1016\/j.scib.2023.10.038","article-title":"Chasing the landscape for intrahospital transmission and evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae","volume":"68","author":"Liu","year":"2023","journal-title":"Sci Bull"},{"key":"10.1016\/j.jinf.2026.106813_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2024.127839","article-title":"Hypervirulent and carbapenem-resistant Klebsiella pneumoniae: a global public health threat","volume":"288","author":"Lei","year":"2024","journal-title":"Microbiol Res"},{"issue":"3","key":"10.1016\/j.jinf.2026.106813_bib6","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41564-024-01612-1","article-title":"Carbapenem-resistant Klebsiella pneumoniae capsular types, antibiotic resistance and virulence factors in China: a longitudinal, multi-centre study","volume":"9","author":"Hu","year":"2024","journal-title":"Nat Microbiol"},{"issue":"2","key":"10.1016\/j.jinf.2026.106813_bib7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3201\/eid2602.190594","article-title":"Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China","volume":"26","author":"Zhou","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jinf.2026.106813_bib8","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1038\/s41467-025-60765-7","article-title":"Tracking international and regional dissemination of the KPC\/NDM co-producing Klebsiella pneumoniae","author":"Zhang","year":"2025","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.jinf.2026.106813_bib9","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s40265-018-0902-x","article-title":"Ceftazidime-Avibactam: a review in the treatment of serious gram-negative bacterial infections","volume":"78","author":"Shirley","year":"2018","journal-title":"Drugs"},{"issue":"1","key":"10.1016\/j.jinf.2026.106813_bib10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s43856-025-00748-3","article-title":"Increasing polymyxin resistance in clinical carbapenem-resistant Klebsiella pneumoniae strains in China between 2000 and 2023","volume":"5","author":"Xie","year":"2025","journal-title":"Commun Med"},{"issue":"1","key":"10.1016\/j.jinf.2026.106813_bib11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41426-018-0129-7","article-title":"Evolution of tigecycline- and colistin-resistant CRKP (carbapenem-resistant Klebsiella pneumoniae) in vivo and its persistence in the GI tract","volume":"7","author":"Zhang","year":"2018","journal-title":"Emerg Microbes Infect"},{"issue":"5","key":"10.1016\/j.jinf.2026.106813_bib12","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/cmb.2012.0021","article-title":"SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing","volume":"19","author":"Bankevich","year":"2012","journal-title":"J Comput Biol"},{"issue":"6","key":"10.1016\/j.jinf.2026.106813_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005595","article-title":"Unicycler: resolving bacterial genome assemblies from short and long sequencing reads","volume":"13","author":"Wick","year":"2017","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.jinf.2026.106813_bib14","doi-asserted-by":"crossref","first-page":"D206","DOI":"10.1093\/nar\/gkt1226","article-title":"The SEED and the Rapid Annotation of microbial genomes using Subsystems Technology (RAST)","volume":"42","author":"Overbeek","year":"2014","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"10.1016\/j.jinf.2026.106813_bib15","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1101\/gr.186072.114","article-title":"CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes","volume":"25","author":"Parks","year":"2015","journal-title":"Genome Res"},{"issue":"1","key":"10.1016\/j.jinf.2026.106813_bib16","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1038\/s41467-021-24448-3","article-title":"A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex","volume":"12","author":"Lam","year":"2021","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.jinf.2026.106813_bib17","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1093\/jac\/dkaa345","article-title":"ResFinder 4.0 for predictions of phenotypes from genotypes","volume":"75","author":"Bortolaia","year":"2020","journal-title":"J Antimicrob Chemother"},{"issue":"2","key":"10.1016\/j.jinf.2026.106813_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01601-17","article-title":"Genomic insights into colistin-resistant from a Tunisian Teaching Hospital","volume":"62","author":"Jaidane","year":"2018","journal-title":"Antimicrob Agents Ch"},{"issue":"8","key":"10.1016\/j.jinf.2026.106813_bib19","article-title":"MOB-suite: software tools for clustering, reconstruction and typing of plasmids from draft assemblies","volume":"4","author":"Robertson","year":"2018","journal-title":"Microb Genom"},{"key":"10.1016\/j.jinf.2026.106813_bib20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/1471-2164-12-402","article-title":"BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons","volume":"12","author":"Alikhan","year":"2011","journal-title":"Bmc Genom"},{"issue":"7","key":"10.1016\/j.jinf.2026.106813_bib21","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/molbev\/msp077","article-title":"FastTree: computing large minimum evolution trees with profiles instead of a distance matrix","volume":"26","author":"Price","year":"2009","journal-title":"Mol Biol Evol"},{"issue":"22","key":"10.1016\/j.jinf.2026.106813_bib22","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1093\/bioinformatics\/btv421","article-title":"Roary: rapid large-scale prokaryote pan genome analysis","volume":"31","author":"Page","year":"2015","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.jinf.2026.106813_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gku1196","article-title":"Rapid phylogenetic analysis of large samples of recombinant bacterial whole genome sequences using Gubbins","volume":"43","author":"Croucher","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"10.1016\/j.jinf.2026.106813_bib24","doi-asserted-by":"crossref","first-page":"W293","DOI":"10.1093\/nar\/gkab301","article-title":"Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation","volume":"49","author":"Letunic","year":"2021","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.jinf.2026.106813_bib25","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s13059-016-1108-8","article-title":"Rapid scoring of genes in microbial pan-genome-wide association studies with Scoary","volume":"17","author":"Brynildsrud","year":"2016","journal-title":"Genome Biol"},{"key":"10.1016\/j.jinf.2026.106813_bib26","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/1471-2148-7-214","article-title":"BEAST: Bayesian evolutionary analysis by sampling trees","volume":"7","author":"Drummond","year":"2007","journal-title":"BMC Evol Biol"},{"issue":"8","key":"10.1016\/j.jinf.2026.106813_bib27","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00391-17","article-title":"Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates","volume":"61","author":"Chiu","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jinf.2026.106813_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2025.128386","article-title":"mgrB inactivation confers enhanced pathogenicity and immune evasion over mcr-1 expression in colistin-resistant Klebsiella pneumoniae","volume":"303","author":"Ling","year":"2026","journal-title":"Microbiol Res"},{"issue":"11","key":"10.1016\/j.jinf.2026.106813_bib29","doi-asserted-by":"crossref","first-page":"1452 e1","DOI":"10.1016\/j.cmi.2023.07.030","article-title":"Emergence of high-level tigecycline resistance due to the amplification of a tet(A) gene variant in clinical carbapenem-resistant Klebsiella pneumoniae","volume":"29","author":"Yu","year":"2023","journal-title":"Clin Microbiol Infect"},{"issue":"11","key":"10.1016\/j.jinf.2026.106813_bib30","doi-asserted-by":"crossref","first-page":"e846","DOI":"10.1016\/S2666-5247(22)00221-X","article-title":"Distribution and spread of the mobilised RND efflux pump gene cluster tmexCD-toprJ in clinical Gram-negative bacteria: a molecular epidemiological study","volume":"3","author":"Dong","year":"2022","journal-title":"Lancet Microbe"},{"issue":"1","key":"10.1016\/j.jinf.2026.106813_bib31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13073-021-00936-5","article-title":"Mobilization of the nonconjugative virulence plasmid from hypervirulent Klebsiella pneumoniae","volume":"13","author":"Xu","year":"2021","journal-title":"Genome Med"},{"issue":"1","key":"10.1016\/j.jinf.2026.106813_bib32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41467-023-44351-3","article-title":"Increase in antioxidant capacity associated with the successful subclone of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11-KL64","volume":"15","author":"Wang","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jinf.2026.106813_bib33","article-title":"Type IV Secretion Systems: reconciling diversity through a unified nomenclature","volume":"50","author":"Christie","year":"2025","journal-title":"Fems Microbiol Rev"},{"key":"10.1016\/j.jinf.2026.106813_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138980","article-title":"Chiral naproxen enhances horizontal transfer of antibiotic resistance genes in biofilms: Molecular docking reveals stereoselective mechanisms","volume":"495","author":"Li","year":"2025","journal-title":"J Hazard Mater"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445326001398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445326001398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:11:02Z","timestamp":1790601062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445326001398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0163445326001398"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2026.106813","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic characterisation of ST11-KL19 carbapenem-resistant Klebsiella pneumoniae carrying dual carbapenemases and hypervirulence-associated markers","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2026.106813","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd on behalf of British Infection Association.","name":"copyright","label":"Copyright"}],"article-number":"106813"}}