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Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0370","doi-asserted-by":"crossref","first-page":"35952","DOI":"10.1039\/C6RA01868H","article-title":"Two new mixed copper(ii)-dipeptide complexes of N,N-donor heterocycle ligands: studies on their non-covalent DNA binding, chemical nuclease, antioxidant and anticancer activities","volume":"6","author":"Gan","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0375","doi-asserted-by":"crossref","first-page":"11849","DOI":"10.1039\/C6DT01496H","article-title":"Synthesis, structure, magnetic and biological activity studies of bis-hydrazone derived Cu(ii) and Co(ii) coordination compounds","volume":"45","author":"Golla","year":"2016","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0380","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1039\/C5RA20607C","article-title":"Mixed-ligand copper(ii)-phenolate complexes: structure and studies on DNA\/protein binding profiles, DNA cleavage, molecular docking and cytotoxicity","volume":"6","author":"Kathiresan","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0385","doi-asserted-by":"crossref","first-page":"9073","DOI":"10.1039\/C6DT00461J","article-title":"Mixed-ligand copper(ii) Schiff base complexes: the role of the co-ligand in DNA binding, DNA cleavage, protein binding and cytotoxicity","volume":"45","author":"Lian","year":"2016","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0390","doi-asserted-by":"crossref","first-page":"8468","DOI":"10.1039\/c3dt32659d","article-title":"Nuclease and anti-proliferative activities of copper(ii) complexes of N3O tripodal ligands involving a sterically hindered phenolate","volume":"42","author":"Berthet","year":"2013","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0395","first-page":"1745","article-title":"DNA and nuclear aggregates of polyamines","volume":"1823","author":"Iacomino","year":"2012","journal-title":"BBA-Mol. Cell. Res."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0400","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nrc1454","article-title":"Polyamines and cancer: old molecules, new understanding","volume":"4","author":"Gerner","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0405","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1158\/1541-7786.81.2.2","article-title":"Regulation of polyamine analogue cytotoxicity by c-Jun in human MDA-MB-435 cancer cells","volume":"2","author":"Huang","year":"2004","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0410","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1021\/bm800412r","article-title":"DNA interaction with antitumor polyamine analogues: a comparison with biogenic polyamines","volume":"9","author":"N'soukpo\u00e9-Kossi","year":"2008","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0415","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1021\/jp910411c","article-title":"Solvent effects on the kinetics of the interaction of 1-pyrenecarboxaldehyde with calf thymus DNA","volume":"114","author":"Secco","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0420","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1002\/anie.201509593","article-title":"Electrocatalytic O2 reduction at a bio-inspired mononuclear copper phenolato complex immobilized on a carbon nanotube electrode","volume":"55","author":"Gentil","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0425","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1002\/chem.200400099","article-title":"Galactose oxidase models: solution chemistry, and phenoxyl radical generation mediated by the copper status","volume":"10","author":"Michel","year":"2004","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0430","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.1021\/jm701207m","article-title":"Amine\u2212guanidine switch: a promising approach to improve DNA binding and antiproliferative activities","volume":"50","author":"Ohara","year":"2007","journal-title":"J. Med. Chem."},{"year":"2009","series-title":"Gaussian 09, Revision D.01","author":"Frisch","key":"10.1016\/j.jinorgbio.2017.11.006_bb0435"},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0440","doi-asserted-by":"crossref","first-page":"8822","DOI":"10.1103\/PhysRevB.33.8822","article-title":"Density-functional approximation for the correlation energy of the inhomogeneous electron gas","volume":"33","author":"Perdew","year":"1986","journal-title":"Phys. Rev. B"},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0445","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","article-title":"Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density","volume":"37","author":"Lee","year":"1988","journal-title":"Phys. Rev. B: Condens. Matter Mater. Phys."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0450","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1063\/1.464913","article-title":"Density-functional thermochemistry. III. The role of exact exchange","volume":"98","author":"Becke","year":"1993","journal-title":"J. Chem. Phys."},{"year":"1995","series-title":"Recent Advances in Density Functional Methods","author":"Casida","key":"10.1016\/j.jinorgbio.2017.11.006_bb0455"},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0460","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1021\/cr9904009","article-title":"Quantum mechanical continuum solvation models","volume":"105","author":"Tomasi","year":"2005","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0465","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0021-9258(19)41891-7","article-title":"Ethidium binding affinity of circular lambda deoxyribonucleic acid determined fluorometrically","volume":"250","author":"Hinton","year":"1975","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0470","unstructured":"Despite that 1 could be isolated as single crystals for structural characterization (see ref. 84) it was not possible to crystallize the complexes 2\u20134, presumably because of the large flexibility of the putrescine arm. It must however be emphasized that the geometry observed in 1, i.e. square pyramidal copper ion with an equatorial phenolate and an exogenous ligand (chloride) that completes the coordination sphere, provides a good model for the coordination polyhedron in the other ligands."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0475","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1002\/chem.200304880","article-title":"Galactose oxidase models: tuning the properties of CuII\u2013phenoxyl radicals","volume":"9","author":"Philibert","year":"2003","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0480","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1039\/b605852c","article-title":"Galactose Oxidase models: 19F NMR as a powerful tool to study the solution chemistry of tripodal ligands in the presence of copper(ii)","author":"Michel","year":"2006","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0485","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1002\/ejic.200600286","article-title":"Galactose oxidase models: creation and modification of proton transfer coupled to copper(II) coordination processes in pro-phenoxyl ligands","volume":"2006","author":"Michel","year":"2006","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0490","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1039\/B813036A","article-title":"Galactose oxidase models: insights from 19F NMR spectroscopy","author":"Michel","year":"2009","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0495","unstructured":"The relative affinity of the copper ion for the ligands was tentatively assessed by a competition experiment with nitrilotriacetic acid (NTA). At one molar equivalent of NTA added the intensity of the CT transition remains >90% of the initial one, disclosing a much higher affinity of the tripodal ligands for the copper ion. For higher NTA concentration a rapid precipitation of the tripodal ligand is observed, precluding any accurate determination of the binding constant."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0500","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1039\/DT9840001349","article-title":"Synthesis, structure, and spectroscopic properties of copper(II) compounds containing nitrogen-sulphur donor ligands; the crystal and molecular structure of aqua[1,7-bis(N-methylbenzimidazol-2[prime or minute]-yl)-2,6-dithiaheptane]copper(II) perchlorate","author":"Addison","year":"1984","journal-title":"J. Chem. Soc. Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0505","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1002\/ejic.200601091","article-title":"Ten years of a biomimetic approach to the copper(II) radical site of galactose oxidase","author":"Thomas","year":"2007","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0510","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1039\/j29680000973","article-title":"Anodic oxidation of amines. Part I. Cyclic voltammetry of aliphatic amines at a stationary glassy-carbon electrode","author":"Masui","year":"1968","journal-title":"J. Chem. Soc. B: Phys. Org."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0515","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.3390\/molecules19032829","article-title":"Chiroptical properties and the racemization of pyrene and tetrathiafulvalene-substituted allene: substitution and solvent effects on racemization in tetrathiafulvalenylallene","volume":"19","author":"Hasegawa","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0520","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0022-2836(74)90031-X","article-title":"Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice","volume":"86","author":"McGhee","year":"1974","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0525","doi-asserted-by":"crossref","first-page":"42041","DOI":"10.1074\/jbc.M406053200","article-title":"Structural analysis of DNA interactions with biogenic polyamines and cobalt(III)hexamine studied by Fourier transform infrared and capillary electrophoresis","volume":"279","author":"Ouameur","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0530","unstructured":"The fluorescence of EtBr is not altered by the addition of the complexes in the absence of DNA."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0535","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070510","article-title":"Binding of the biogenic polyamines to deoxyribonucleic acids of varying base composition: base specificity and the associated energetics of the interaction","volume":"8","author":"Kabir","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0540","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/259333a0","article-title":"Compact form of DNA induced by spermidine","volume":"259","author":"Gosule","year":"1976","journal-title":"Nature"},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0545","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0006-3495(96)79232-9","article-title":"DNA mesophases induced by spermidine: structural properties and biological implications","volume":"71","author":"Pelta","year":"1996","journal-title":"Biophys. J."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0550","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/(SICI)1097-0282(1997)44:3<269::AID-BIP6>3.0.CO;2-T","article-title":"DNA condensation by multivalent cations","volume":"44","author":"Bloomfield","year":"1997","journal-title":"Biopolymers"},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0555","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1529\/biophysj.104.052100","article-title":"Contribution of hydrophobicity to thermodynamics of ligand-DNA binding and DNA collapse","volume":"88","author":"Patel","year":"2005","journal-title":"Biophys. J."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0560","unstructured":"In order to ensure that the reaction was complete within 1 hour we investigated the kinetics of the DNA cleavage in the presence of ascorbate (see ESI) for four representative complexes. The reaction was found to be extremely rapid, since it is complete within 2 minutes for both 1 and 2."},{"key":"10.1016\/j.jinorgbio.2017.11.006_bb0565","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0006-3495(01)76027-4","article-title":"Fourier transform Raman study of the structural specificities on the interaction between DNA and biogenic polyamines","volume":"80","author":"Ruiz-Chica","year":"2001","journal-title":"Biophys. J."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013417305950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013417305950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:02:04Z","timestamp":1750982524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013417305950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":113,"alternative-id":["S0162013417305950"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2017.11.006","relation":{},"ISSN":["0162-0134"],"issn-type":[{"type":"print","value":"0162-0134"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Copper(II) complexes of N3O tripodal ligands appended with pyrene and polyamine groups: Anti-proliferative and nuclease activities","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2017.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}