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Res."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0335","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.poly.2004.02.018","article-title":"Synthesis, characterization and bio-activity of metal complexes of bidentate N-S isomeric Schiff bases derived from S\u2011methyldithiocarbazate (SMDTC) and the X-ray structure of the bis[S\u2011methyl\u2011\u03b2\u2011N\u2011(2\u2011furyl\u2011methylketone) dithiocarbazato]cadmium(II) complex","volume":"23","author":"Chew","year":"2004","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0340","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1016\/S0277-5387(01)00817-8","article-title":"Synthesis and characterization of Zn(II) and Cd(II) complexes of S\u2011benzyl\u2011\u03b2\u2011N\u2011(2\u2011pyridyl)methylenedithiocarbazate (HNNS): bioactivity of the HNNS Schiff base and its Zn(II), Cu(II) and Cd(II) complexes and the X-ray structure of the [Zn(NNS)2] complex","volume":"20","author":"Tarafder","year":"2001","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0345","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1016\/S0277-5387(02)01188-9","article-title":"Coordination chemistry and bioactivity of Ni2+, Cu2+, Cd2+ and Zn2+ complexes containing bidentate Schiff bases derived from S\u2011benzyldithiocarbazate and the X-ray crystal structure of bis[S\u2011benzyl\u2011\u03b2\u2011N\u2011(5\u2011methyl\u20112\u2011furylmethylene)dithiocarbazato]cadmium(II)","volume":"21","author":"Tarafder","year":"2002","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0350","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ica.2014.01.001","volume":"413","author":"Khoo","year":"2014","journal-title":"Inorg. 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Rev. Cancer"},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0425","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.drudis.2014.05.002","article-title":"Chemical approaches to targeting drug resistance in cancer stem cells","volume":"19","author":"Sotiropoulou","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0430","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrc3793","article-title":"Mechanisms of disseminated cancer cell dormancy: an awakening field","volume":"14","author":"Sosa","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0435","doi-asserted-by":"crossref","first-page":"12396","DOI":"10.1073\/pnas.1106613108","article-title":"Controversies in clinical cancer dormancy","volume":"108","author":"Uhr","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0440","doi-asserted-by":"crossref","first-page":"E4214","DOI":"10.1073\/pnas.1414389111","article-title":"Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process","volume":"111","author":"Galvao","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0445","doi-asserted-by":"crossref","DOI":"10.1038\/srep19103","article-title":"3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained","volume":"6","author":"Zanoni","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0450","series-title":"CrysAlisPro Software System","author":"Agilent Technologies UK Ltd","year":"2014"},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0455","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053273314026370","article-title":"SHELXT \u2013 integrated space-group and crystal-structure determination","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr. A Found. Adv."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0460","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","article-title":"Crystal structure refinement with SHELXL","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr. 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Crystallogr."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0480","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1107\/S2052520616003954","article-title":"The Cambridge structural database","volume":"72","author":"Groom","year":"2016","journal-title":"Acta Crystallogr. 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Rev."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0520","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1039\/b003010o","article-title":"A critical account on \u03c0\u2013\u03c0 stacking in metal complexes with aromatic nitrogen-containing ligands","author":"Janiak","year":"2000","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0525","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1039\/c3ce00051f","article-title":"The \u201csceptical chymist\u201d: intermolecular doubts and paradoxes","volume":"15","author":"Gavezzotti","year":"2013","journal-title":"CrystEngComm"},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0530","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1039\/C4CC09074H","article-title":"Energy frameworks: insights into interaction anisotropy and the mechanical properties of molecular crystals","volume":"51","author":"Turner","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0535","first-page":"1","article-title":"Structural diversity of isothiocyanato Cd(II) and Zn(II) Girard's T hydrazone complexes in solution and solid state: effect of H-bonding on coordination number and supramolecular assembly of Cd(II) complex in solid state","author":"\u010cobelji\u0107","year":"2018","journal-title":"Struct. Chem."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0540","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1016\/j.poly.2007.03.023","article-title":"Synthesis and characterization of novel Cd(II), Zn(II) and Ni(II) complexes with 2\u2011quinolinecarboxaldehyde selenosemicarbazone. 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Efforts to unravel the factors that determine structure\/nuclearity of the products","volume":"98","author":"Saxena","year":"2015","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0555","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1021\/om100106e","article-title":"NMR chemical shifts of trace impurities: common laboratory solvents, organics, and gases in deuterated solvents relevant to the organometallic chemist","volume":"29","author":"Fulmer","year":"2010","journal-title":"Organometallics"},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0560","series-title":"Encycl. Inorg. Bioinorg. 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Rev."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0575","doi-asserted-by":"crossref","first-page":"11898","DOI":"10.1021\/ic301799p","article-title":"Characterization of DMSO coordination to palladium(II) in solution and insights into the aerobic oxidation catalyst, Pd(DMSO)2 (TFA)2","volume":"51","author":"Diao","year":"2012","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0580","doi-asserted-by":"crossref","first-page":"95191","DOI":"10.1039\/C5RA19849F","article-title":"Zn(II) complex with 2\u2011quinolinecarboxaldehyde selenosemicarbazone: synthesis, structure, interaction studies with DNA\/HSA, molecular docking and caspase-8 and -9 independent apoptose induction","author":"Filipovi\u0107","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0585","doi-asserted-by":"crossref","DOI":"10.1039\/C6RA23940D","article-title":"Quinoline based mono- and bis-(thio)carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models","volume":"6","author":"Bo\u017ei\u0107","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0590","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1039\/C6MD00199H","article-title":"Pro-apoptotic and pro-differentiation induction by 8\u2011quinolinecarboxaldehyde selenosemicarbazone and its Co(III) complex in human cancer cell lines","volume":"7","author":"Filipovi\u0107","year":"2016","journal-title":"Med. Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0595","doi-asserted-by":"crossref","first-page":"108726","DOI":"10.1039\/C6RA24604D","article-title":"Ni(II) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines","volume":"6","author":"Filipovi\u0107","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0600","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081162","article-title":"Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions","volume":"8","author":"Marullo","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0605","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/cancers3011351","article-title":"Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects","volume":"3","author":"Florea","year":"2011","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jinorgbio.2018.10.002_bb0610","doi-asserted-by":"crossref","first-page":"583","DOI":"10.18388\/abp.2002_3768","article-title":"Recognition and repair of DNA-cisplatin adducts","volume":"49","author":"Wo\u017aniak","year":"2002","journal-title":"Acta Biochim. 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