{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T02:48:11Z","timestamp":1789267691565,"version":"build-2803163510"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006048","name":"Universidad de la Rep\u00fablica Uruguay","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["305190\/2017-2"],"award-info":[{"award-number":["305190\/2017-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006049","name":"Comisi\u00f3n Sectorial de Investigaci\u00f3n Cient\u00edfica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/24669-8"],"award-info":[{"award-number":["2017\/24669-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/50366-7"],"award-info":[{"award-number":["2015\/50366-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["050\/2013"],"award-info":[{"award-number":["050\/2013"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.jinorgbio.2019.110930","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T12:18:36Z","timestamp":1574079516000},"page":"110930","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Synthesis and structural characterization of a series of ternary copper(II)-L-dipeptide-neocuproine complexes. Study of their cytotoxicity against cancer cells including MDA-MB-231, triple negative breast cancer cells"],"prefix":"10.1016","volume":"203","author":[{"given":"Natalia","family":"Alvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Vi\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celisnolia M.","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F.S.","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alzir A.","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Ellena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J.","family":"Costa-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianella","family":"Facchin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2019.110930_bb0005","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1021\/cr400135x","article-title":"Advances in copper complexes as anticancer agents","volume":"114","author":"Santini","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0010","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ica.2017.08.043","article-title":"Copper complexes as artificial DNA metallonucleases: from Sigman\u2019s reagent to next generation anti-cancer agent?","volume":"472","author":"McGivern","year":"2017","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0015","first-page":"18","article-title":"A therapeutic journey of mixed ligand complexes containing 1,10-phenanthroline derivatives: a review","volume":"16","author":"Mahalakshmi","year":"2016","journal-title":"chemistry"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0020","series-title":"Biomedical Applications of Metals","first-page":"213","article-title":"Mechanism of action of anticancer metallodrugs","author":"Mej\u00eda","year":"2018"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0025","series-title":"Metal-Based Anticancer Agents","first-page":"91","article-title":"Recent advances in anticancer copper compounds","author":"Kellett","year":"2019"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0030","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1039\/C8DT00794B","article-title":"Hypotoxic copper complexes with potent anti-metastatic and anti-angiogenic activities against cancer cells","volume":"47","author":"Shi","year":"2018","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0035","doi-asserted-by":"crossref","first-page":"16446","DOI":"10.1039\/C7DT03242K","article-title":"Synthesis, characterization, and anticancer activity of two mixed ligand copper (II) complexes by regulating the VEGF\/VEGFR2 signaling pathway","volume":"46","author":"Qin","year":"2017","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0040","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/ange.201710910","article-title":"A copper (II) phenanthroline metallopeptide that targets and disrupts mitochondrial function in breast cancer stem cells","volume":"130","author":"Laws","year":"2018","journal-title":"Angew. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0045","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1002\/cbic.201800358","article-title":"The next generation of anticancer metallopharmaceuticals: cancer stem cell-active inorganics","volume":"19","author":"Laws","year":"2018","journal-title":"ChemBioChem"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0050","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.tiv.2011.05.008","article-title":"Genotoxicity of the copper antineoplastic coordination complexes casiopeinas\u00ae","volume":"25","author":"Serment-Guerrero","year":"2011","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0055","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ejmech.2017.01.045","article-title":"Synergistic effects between a copper-based metal Casiope\u00edna III-Ia and cisplatin","volume":"129","author":"Davila-Manzanilla","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0060","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jinorgbio.2016.11.007","article-title":"Genotoxic assessment of the copper chelated compounds Casiopeinas: clues about their mechanisms of action","volume":"166","author":"Serment-Guerrero","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0065","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jinorgbio.2019.03.012","article-title":"Antigiardiasic activity of Cu(II) coordination compounds: redox imbalance and membrane damage after a short exposure time","volume":"195","author":"Rufino-Gonz\u00e1lez","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0070","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1582-4934.2011.01292.x","article-title":"A novel copper complex induces paraptosis in colon cancer cells via the activation of ER stress signalling","volume":"16","author":"Gandin","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13698-1","article-title":"Therapeutic potential of the phosphino Cu(I) complex (HydroCuP) in the treatment of solid tumors","volume":"7","author":"Gandin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0080","doi-asserted-by":"crossref","first-page":"6235","DOI":"10.1021\/ja109413c","article-title":"Copper binding agents acting as copper ionophores lead to caspase inhibition and paraptotic cell death in human cancer cells","volume":"133","author":"Tardito","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0085","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.microc.2016.12.007","article-title":"Comparative in vitro investigation of anticancer copper chelating agents","volume":"136","author":"Ga\u00e1l","year":"2018","journal-title":"Microchem. J."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0090","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jinorgbio.2018.10.003","article-title":"Anticancer copper complex with nucleus, mitochondrion and cyclooxygenase-2 as multiple targets","volume":"190","author":"Shi","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0095","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.1021\/acs.jmedchem.5b00651","article-title":"Antiangiogenic activity of mononuclear copper (II) polypyridyl complexes for the treatment of cancers","volume":"58","author":"Nagababu","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0100","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00280-006-0364-9","article-title":"Induction of oxidative damage by copper-based antineoplastic drugs (Casiope\u00ednas)","volume":"60","author":"Alem\u00f3n-Medina","year":"2007","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0105","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1021\/acs.chemrev.8b00209","article-title":"Stimuli-responsive therapeutic metallodrugs","volume":"119","author":"Wang","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0110","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1021\/acs.chemrev.8b00396","article-title":"Metal drugs and the anticancer immune response","volume":"119","author":"Englinger","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0115","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1515\/znb-2000-1209","article-title":"Structural and spectroscopic characterization of two new Cu(II)-dipeptide complexes","volume":"55","author":"Facchin","year":"2000","journal-title":"Z. Naturforsch. B"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0120","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0162-0134(02)00367-7","article-title":"Synthesis and characterization of three new Cu(II)-dipeptide complexes","volume":"89","author":"Facchin","year":"2002","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0125","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0020-1693(03)00295-0","article-title":"Cu (II) complexation with His\u2013Gly and His\u2013Ala. X-ray structure of [Cu (his\u2013gly)2(H2O)2]\u00b76H2O","volume":"355","author":"Facchin","year":"2003","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0130","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1021\/ic051957b","article-title":"Weak exchange interaction supported by a biologically relevant long chemical bridge in a Cu-peptide model compound","volume":"45","author":"Vieira","year":"2006","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0135","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1016\/j.poly.2006.03.012","article-title":"Structural characterization of a series of new Cu-dipeptide complexes in solid state and in solution","volume":"25","author":"Facchin","year":"2006","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0140","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.molstruc.2006.03.058","article-title":"Magnetic properties of copper (II) complexes containing peptides. Crystal structure of [Cu (phe-leu)]","volume":"797","author":"Sanchiz","year":"2006","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0145","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.poly.2009.04.029","article-title":"Interaction of Cu-dipeptide complexes with calf thymus DNA and antiproliferative activity of [Cu (ala-phe)] in osteosarcoma-derived cells","volume":"28","author":"Facchin","year":"2009","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0150","series-title":"Proceedings - 12th International Symposium of Metal Ions in Biology and Medicine","first-page":"1","article-title":"Towards the development of new copper compounds for the treatment of cancer: study of the cytotoxic activity of Cu(L-dipeptide)(1,10-phenanthroline) complexes","author":"Iglesias","year":"2013"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0155","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jinorgbio.2014.06.007","article-title":"Synthesis, structural characterization and cytotoxic activity of ternary copper (II)\u2013dipeptide\u2013phenanthroline complexes. A step towards the development of new copper compounds for the treatment of cancer","volume":"139","author":"Iglesias","year":"2014","journal-title":"J. Inorg. Biochem."},{"issue":"1","key":"10.1016\/j.jinorgbio.2019.110930_bb0160","first-page":"1","article-title":"Structural characterization and cytotoxic activity of heteroleptic copper (II) complexes with L-dipeptides and 5-NO2-phenanthroline. Crystal structure of [Cu(Phe-Ala)(5-NO2-Phen)]\u00b74H2O","volume":"1","author":"Iglesias","year":"2015","journal-title":"Struct. Chem. Crystallogr. Commun."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0165","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jinorgbio.2016.06.005","article-title":"Experimental and theoretical studies of copper complexes with isomeric dipeptides as novel candidates against breast cancer","volume":"162","author":"Facchin","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0170","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ica.2017.06.050","article-title":"Synthesis, structural characterization and cytotoxic activity against tumor cells of heteroleptic copper (I) complexes with aromatic diimines and phosphines","volume":"466","author":"Alvarez","year":"2017","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0175","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/ic50158a014","article-title":"Crystal structure of a mixed-ligand complex of copper (II), 1, 10-phenanthroline, and glycylglycine dianion: glycylglycinato (1, 10-phenanthroline) copper (II) trihydrate","volume":"15","author":"Lim","year":"1976","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0180","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1021\/ic00074a047","article-title":"Ternary metal (II) complexes with tyrosine-containing dipeptides. Structures of copper (II) and palladium (II) complexes involving L-tyrosylglycine and stabilization of copper (II) complexes due to intramolecular aromatic ring stacking","volume":"32","author":"Sugimori","year":"1993","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0185","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0020-1693(00)85383-9","article-title":"Synthesis, characterization and superoxide dismutase activity of some ternary copper (II) dipeptide-2,2\u2032-bipyridine, 1,10-phenanthroline and 2,9-dimethyl-1,10-phenanthroline complexes","volume":"179","author":"Bhirud","year":"1991","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0190","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0020-1693(00)86492-0","article-title":"Preparation and spectral studies of some ternary 2,2\u2032-bipyridine and 1,10-phenanthroline copper (II) dipeptide complexes","volume":"78","author":"Deshpande","year":"1983","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0195","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0162-0134(03)00121-1","article-title":"Synthesis, structure and nuclease properties of several ternary copper (II) peptide complexes with 1, 10-phenanthroline","volume":"95","author":"Garc\u00eda-Raso","year":"2003","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0200","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jmr.2005.08.013","article-title":"EasySpin, a comprehensive software package for spectral simulation and analysis in EPR","volume":"178","author":"Stoll","year":"2006","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0205","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1107\/S0108767307043930","article-title":"A short history of SHELX","volume":"64","author":"Sheldrick","year":"2008","journal-title":"Acta Crystallogr. Sect. A"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0210","first-page":"435","article-title":"SIR92 - a program for automatic solution of crystal structures by direct methods","volume":"27","author":"Altomare","year":"1994","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0215","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","article-title":"Crystal structure refinement with SHELXL","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr. C"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0220","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1107\/S0021889811043202","article-title":"ShelXle: a Qt graphical user interface for SHELXL","volume":"44","author":"Hubschle","year":"2011","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0225","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1107\/S002188980600731X","article-title":"Mercury: visualization and analysis of crystal structures","volume":"39","author":"Macrae","year":"2006","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0230","series-title":"CrystalExplorer, CrystalExplorer (Version 3.1)","author":"Wolff","year":"2012"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0235","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1039\/C7FD00072C","article-title":"Intermolecular interactions in molecular crystals: what\u2019s in a name?","volume":"203","author":"Edwards","year":"2017","journal-title":"Faraday Discuss."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0240","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1039\/B818330A","article-title":"Hirshfeld surface analysis","volume":"11","author":"Spackman","year":"2009","journal-title":"CrystEngComm"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0245","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1039\/b704980c","article-title":"Towards quantitative analysis of intermolecular interactions with Hirshfeld surfaces","author":"McKinnon","year":"2007","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0250","first-page":"62","article-title":"Validity of nucleic acid purities monitored by 260nm\/280nm absorbance ratios","volume":"18","author":"Glasel","year":"1995","journal-title":"Biotechniques"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0255","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1021\/ja01176a030","article-title":"A spectrophotometric investigation of the interaction of iodine with aromatic hydrocarbons","volume":"71","author":"Benesi","year":"1949","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0260","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/bip.360100304","article-title":"Kinetic and hydrodynamic studies of the complex of proflavine with poly A\u00b7poly U","volume":"10","author":"Schmechel","year":"1971","journal-title":"Biopolymers"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0265","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1021\/bi00394a013","article-title":"Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNA","volume":"26","author":"Wolfe","year":"1987","journal-title":"Biochemistry"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0270","series-title":"Drug-DNA Interaction Protocols","first-page":"195","article-title":"Optical absorbance and fluorescence techniques for measuring DNA\u2013drug interactions","author":"Jenkins","year":"1997"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2013.03.013","article-title":"Drug\u2013DNA interactions and their study by UV\u2013visible, fluorescence spectroscopies and cyclic voltametry","volume":"124","author":"Sirajuddin","year":"2013","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0280","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1107\/S2052520616003954","article-title":"The Cambridge structural database","volume":"72","author":"Groom","year":"2016","journal-title":"Acta Crystallogr. B"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0285","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jinorgbio.2014.07.021","article-title":"Mixed ligand copper(II) complexes of 2,9-dimethyl-1,10-phenanthroline: tridentate 3N primary ligands determine DNA binding and cleavage and cytotoxicity","volume":"140","author":"Ganeshpandian","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0290","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1021\/acs.inorgchem.8b00225","article-title":"Electronic and structural effects of inner sphere coordination of chloride to a homoleptic copper(II) diimine complex","volume":"57","author":"Leandri","year":"2018","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0295","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1039\/c0ce00019a","article-title":"When five are six: the myth of five-coordinate copper(II) in supramolecular chemistry","volume":"12","author":"Constable","year":"2010","journal-title":"CrystEngComm"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0300","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.ejmech.2010.11.041","article-title":"Anomalous behavior of pentacoordinate copper complexes of dimethylphenanthroline and derivatives of terpyridine ligands: studies on DNA binding, cleavage and apoptotic activity","volume":"46","author":"Rajalakshmi","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0305","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.ica.2005.09.062","article-title":"Axial versus equatorial coordination of thioether sulfur: mixed ligand copper(II) complexes of 2-pyridyl-N-(2\u2032-methylthiophenyl)-methyleneimine with bidentate diimine ligands","volume":"359","author":"Balamurugan","year":"2006","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0310","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1021\/ic9511175","article-title":"Nitric oxide reduction of the copper(II) complex Cu(dmp)22+ (dmp = 2,9-dimethyl-1,10-phenanthroline)","volume":"35","author":"Tran","year":"1996","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0315","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1021\/ic9713137","article-title":"Investigation of the nitric oxide reduction of the bis(2,9-dimethyl-1,10-phenanthroline) complex of copper(II) and the structure of [Cu(dmp)2(H2O)](CF3SO3)2","volume":"37","author":"Tran","year":"1998","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0320","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1039\/B415057K","author":"Itoh","year":"2005","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0325","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jinorgbio.2003.11.008","article-title":"Metal-assisted light-induced DNA cleavage activity of 2-(methylthio)phenylsalicylaldimine Schiff base copper(II) complexes having planar heterocyclic bases","volume":"98","author":"Reddy","year":"2004","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.poly.2016.11.013","article-title":"Structure and antioxidant superoxide dismutase activity of copper(II) hydrazone complexes","volume":"122","author":"Singh","year":"2017","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0335","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1021\/ic50184a007","article-title":"Crystal and molecular structure of (2,9-dimethyl-1,10-phenanthroline)(glycylglycinato)copper(II) pentahydrate","volume":"17","author":"Simmons","year":"1978","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0340","series-title":"Qu\u00edmica de coordinaci\u00f3n","author":"Gispert","year":"2000"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0345","series-title":"Infrared and Raman Spectra of Inorganic and Coordination Compounds, Applications in Coordination, Organometallic, and Bioinorganic Chemistry","author":"Nakamoto","year":"2009"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0350","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.molstruc.2005.12.016","article-title":"Spectroscopic and theoretical studies on copper (II) complex of maleonitriledithiolate and 5-nitro-1, 10-phenanthroline","volume":"789","author":"Yuan","year":"2006","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0355","series-title":"Advanced Inorganic Chemistry","author":"Cotton","year":"1999"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0360","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0020-1650(74)80002-4","article-title":"Copper (II) chromosomes and the rule of average environment","volume":"10","author":"Billo","year":"1974","journal-title":"Inorg. Nucl. Chem. Lett."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0365","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1021\/cr00050a003","article-title":"Coordinating properties of the amide bond. Stability and structure of metal ion complexes of peptides and related ligands","volume":"82","author":"Sigel","year":"1982","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0370","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1016\/S0277-5387(99)00279-X","article-title":"Spectrum\u2013structure correlation for visible absorption spectra of copper (II) complexes in aqueous solution","volume":"18","author":"Prenesti","year":"1999","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0375","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.poly.2006.04.026","article-title":"Spectrum\u2013structure correlation for visible absorption spectra of copper (II) complexes showing axial co-ordination in aqueous solution","volume":"25","author":"Prenesti","year":"2006","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0380","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0076-6879(92)11021-A","article-title":"[19] Circular dichroism spectroscopy of DNA","author":"Gray","year":"1992"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0385","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1432-1033.1978.tb12103.x","article-title":"A circular dichroism study of DNA\u00b7platinum complexes","volume":"83","author":"Macquet","year":"1978","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0390","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/jmr.300070211","article-title":"Analysing DNA complexes by circular and linear dichroism","volume":"7","author":"Nord\u00e9n","year":"1994","journal-title":"J. Mol. Recognit."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0395","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/bip.1973.360120109","article-title":"Different conformations of double-stranded nucleic acid in solution as revealed by circular dichroism","volume":"12","author":"Ivanov","year":"1973","journal-title":"Biopolymers"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0400","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1021\/ic9711067","article-title":"Spectral and electrochemical behavior of copper (ii)\u2013phenanthrolines bound to calf thymus DNA. [(5,6-Dimethyl-OP) 2Cu]2+(5, 6-dimethyl-OP = 5, 6-dimethyl-1,10-phenanthroline) induces a conformational transition from B to Z DNA","volume":"37","author":"Mahadevan","year":"1998","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0405","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ica.2018.07.052","article-title":"Development of copper(II)-diimine-iminodiacetate mixed ligand complexes as potential antitumor agents","volume":"483","author":"Alvarez","year":"2018","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0410","first-page":"1","article-title":"Structural characterization and cytotoxic activity of heteroleptic copper (II) complexes with L-dipeptides and 5-NO2-phenanthroline. Crystal structure of [Cu(Phe-Ala)(5-NO2-Phen)]\u00b74H2O","volume":"1","author":"Iglesias","year":"2015","journal-title":"Struct. Chem. Crystallogr. Commun."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0420","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jinorgbio.2006.03.010","article-title":"Synthesis, crystal structure and DNA binding studies of a binuclear copper (II) complex with phenanthroline","volume":"100","author":"Zhang","year":"2006","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0425","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.dyepig.2013.05.028","article-title":"Binding of DNA with Rhodamine B: spectroscopic and molecular modeling studies","volume":"99","author":"Islam","year":"2013","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0430","doi-asserted-by":"crossref","first-page":"15539","DOI":"10.1039\/c2cp42185b","article-title":"Molecular recognition between DNA and a copper-based anticancer complex","volume":"14","author":"Galindo-Murillo","year":"2012","journal-title":"PCCP"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0440","doi-asserted-by":"crossref","first-page":"e0191295","DOI":"10.1371\/journal.pone.0191295","article-title":"Ternary copper (II) complex: NCI60 screening, toxicity studies, and evaluation of efficacy in xenograft models of nasopharyngeal carcinoma","volume":"13","author":"Ahmad","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jinorgbio.2019.110930_bb0445","doi-asserted-by":"crossref","DOI":"10.2217\/nnm-2018-0388","article-title":"Copper complex nanoformulations featuring highly promising therapeutic potential in murine melanoma models","volume":"14","author":"Pinho","year":"2019","journal-title":"Nanomedicine"}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013419305252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013419305252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:01:11Z","timestamp":1758985271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013419305252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":87,"alternative-id":["S0162013419305252"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2019.110930","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and structural characterization of a series of ternary copper(II)-L-dipeptide-neocuproine complexes. Study of their cytotoxicity against cancer cells including MDA-MB-231, triple negative breast cancer cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2019.110930","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110930"}}