{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:31:08Z","timestamp":1770906668184,"version":"3.50.1"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.jinorgbio.2019.110988","type":"journal-article","created":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T21:18:45Z","timestamp":1578259125000},"page":"110988","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Unprecedented formation of palladium(II)-pyrazole based thiourea from chromone thiosemicarbazone and [PdCl2(PPh3)2]: Interaction with biomolecules and apoptosis through mitochondrial signaling pathway"],"prefix":"10.1016","volume":"205","author":[{"given":"Jebiti","family":"Haribabu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandrasekar","family":"Balachandran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoharan Muthu","family":"Tamizh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuvaraj","family":"Arun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nattamai S.P.","family":"Bhuvanesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramasamy","family":"Karvembu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2019.110988_bb0005","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/222385a0","article-title":"Platinum compounds: a new class of potent antitumour agents","volume":"222","author":"Rosenberg","year":"1969","journal-title":"Nature"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0010","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1021\/acs.chemrev.5b00597","article-title":"The next generation of platinum drugs: targeted Pt(II) agents, nanoparticle delivery, and Pt(IV) prodrugs","volume":"116","author":"Johnstone","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0015","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1021\/cr4004314","article-title":"Synthetic methods for the preparation of platinum anticancer complexes","volume":"114","author":"Wilson","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0020","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1039\/C7DT04615D","article-title":"Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes","volume":"47","author":"Cullinane","year":"2018","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0025","series-title":"Cisplatin, Chemistry and Biochemistry of a Leading Anticancer Drug","author":"Rosenberg","year":"1999"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0030","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/0022-1902(79)80496-0","article-title":"The synthesis and screening for anti-bacterial, cancer, -fungicidal and -viral activities of some complexes of palladium and nickel","volume":"41","author":"Graham","year":"1979","journal-title":"J. Inorg. Nucl. Chem."},{"issue":"3","key":"10.1016\/j.jinorgbio.2019.110988_bb0035","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1021\/acs.inorgchem.7b02732","article-title":"Palladium complexes of N,N\u2032-bis(2-aminoethyl)oxamide (H2L): structural (PdIIL, PdII2L2, and PdIVLCl2), electrochemical, dynamic 1H NMR and cytotoxicity studies","volume":"57","author":"Gavrish","year":"2018","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0040","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1039\/C4CS00063C","article-title":"Anticancer palladium complexes: a focus on PdX2L2, palladacycles and related complexes","volume":"43","author":"Kapdi","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0045","doi-asserted-by":"crossref","first-page":"12496","DOI":"10.1039\/C9DT02663K","article-title":"Para metallation of 3-acetyl-chromen-2-one Schiff bases in tetranuclear palladacycles: focus on their biomolecular interaction and in vitrocytotoxicity","volume":"48","author":"Kalaiarasi","year":"2019","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0050","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1039\/b514859f","article-title":"Design of targeting ligands in medicinal inorganic chemistry","volume":"35","author":"Storr","year":"2006","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0055","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1128\/jb.59.5.667-674.1950","article-title":"The chemotherapy of experimental tuberculosis. I. In vitro activity of thiosemicarbazides, thiosemicarbazones, and related compounds","volume":"50","author":"Donovick","year":"1950","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0060","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF01062223","article-title":"Antifungal and antitumor activity of heterocyclic thiosemicarbazones and their metal complexes: current status","volume":"5","author":"Liberta","year":"1992","journal-title":"Biometals"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0065","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.poly.2017.06.044","article-title":"Copper, nickel and zinc complexes of 3-acetyl coumarin thiosemicarbazone: synthesis, characterization and in vitro evaluation of cytotoxicity and DNA\/protein binding properties","volume":"135","author":"Anees Rahman","year":"2017","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0070","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0166-3542(86)90002-1","article-title":"Thiosemicarbazones of 2-acetylpyridine, 2-acetylquinoline, 1-acetylisoquinoline, and related compounds as inhibitors of herpes simplex virus in vitro and in a cutaneous herpes guinea pig model","volume":"6","author":"Shipman","year":"1986","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0075","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1128\/jb.61.2.127-134.1951","article-title":"Studies on chemotherapy of vaccinia virus: I. An experimental design for testing antiviral agents","volume":"61","author":"Brownlee","year":"1951","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0080","doi-asserted-by":"crossref","first-page":"11638","DOI":"10.1002\/slct.201702390","article-title":"Ru(II)-p-cymene thiosemicarbazone complexes as inhibitors of amyloid \u03b2 (a\u03b2) peptide aggregation and a\u03b2-induced cytotoxicity","volume":"2","author":"Haribabu","year":"2017","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0085","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1021\/acs.jmedchem.8b01031","volume":"62","author":"Ohui","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0090","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1021\/acs.jmedchem.5b01399","article-title":"Novel mechanism of cytotoxicity for the selective selenosemicarbazone, 2-acetylpyridine 4,4-dimethyl-3-selenosemicarbazone (Ap44mSe): lysosomal membrane permeabilization","volume":"59","author":"Al-Eisawi","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0095","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.1021\/bi00825a005","article-title":"Inhibition of ribonucleoside diphosphate reductase by 1-formylisoquinoline thiosemicarbazone and related compounds","volume":"9","author":"Sartorelli","year":"1970","journal-title":"Biochem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0100","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1126\/science.6306767","article-title":"Ribonucleotide reductase\u2014a radical enzyme","volume":"221","author":"Reichard","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0105","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.1021\/acs.jmedchem.6b00238","article-title":"Zinc(II) thiosemicarbazone complexes are localized to the lysosomal compartment where they transmetallate with copper ions to induce cytotoxicity","volume":"59","author":"Stacy","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0110","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1021\/jo0480545","article-title":"Synthesis of 5-substituted-1H-indol-2-yl-1H-quinolin-2-ones: a novel class of KDR kinase inhibitors","volume":"70","author":"Kuethe","year":"2005","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0115","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.ejmech.2007.02.012","article-title":"Synthesis, characterization and antiamoebic activity of new indole-3-carboxaldehyde thiosemicarbazones and their Pd(II) complexes","volume":"42","author":"Husain","year":"2007","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0120","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1021\/cr020033s","article-title":"The combinatorial synthesis of bicyclic privileged structures or privileged substructures","volume":"103","author":"Horton","year":"2003","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0125","doi-asserted-by":"crossref","first-page":"5879","DOI":"10.1021\/acs.jmedchem.6b00527","article-title":"Discovery of new chemical entities for old targets: insights on the lead optimization of chromone-based monoamine oxidase B (MAO-B) inhibitors","volume":"59","author":"Reis","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0130","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0162-3109(00)00242-3","article-title":"Inhibition of L-leucine methyl ester mediated killing of THP-1, a human monocytic cell line, by a new anti-inflammatory drug, T614","volume":"49","author":"Sawada","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0135","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1016\/j.bmcl.2005.03.082","article-title":"Identification of antitumor activity of pyrazole oxime ethers","volume":"15","author":"Park","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0140","first-page":"1167","article-title":"Synthesis of triazenopyrazole derivatives as potential inhibitors of HIV-1","volume":"130","author":"Janus","year":"1999","journal-title":"Monatsh. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0145","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1023\/A:1010494525001","article-title":"Synthesis and antimicrobial activity of the products of interaction of 3-aroyl-2,4-dihydro-1H-pyrrolobenzoxazine-1,2,4-triones with urea and thiourea","volume":"35","author":"Pimerova","year":"2001","journal-title":"Pharm. Chem. J."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0150","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1021\/jm00380a020","article-title":"3, 4-Diphenyl-1H-pyrazole-1-propanamine antidepressants","volume":"28","author":"Bailey","year":"1985","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0155","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1021\/acs.inorgchem.8b02390","article-title":"Synthesis of camphor-derived bis (pyrazolylpyridine) rhodium(III) complexes: structure\u2013reactivity relationships and biological activity","volume":"58","author":"Petrovic","year":"2019","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0160","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1021\/acs.organomet.8b00702","article-title":"Coordination behavior of N, N\u2032, N \u2033-trisubstituted guanidine ligands in their Ru\u2013arene complexes: synthetic, DNA\/protein binding, and cytotoxic studies","volume":"38","author":"Jeyalakshmi","year":"2019","journal-title":"Organometallics"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0165","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1039\/C8NJ04246B","article-title":"Highly active copper(I) complexes of aroylthiourea ligands against cancer cells-synthetic and biological studies","volume":"43","author":"Jeyalakshmi","year":"2019","journal-title":"New J. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0170","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jinorgbio.2018.02.014","article-title":"Nickel(II) bis(isatin thiosemicarbazone) complexes induced apoptosis through mitochondrial signaling pathway and G0\/G1 cell cycle arrest in IM-9 cells","volume":"182","author":"Balachandran","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0175","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ejmech.2019.06.061","article-title":"Novel tetranuclear ruthenium(II) arene complexes showing potent cytotoxic and antimetastatic activity as well as low toxicity in vivo","volume":"179","author":"Mohamed Subarkhan","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molstruc.2017.05.013","article-title":"Synthesis, structural characterisation and biological evolution of chromanones","volume":"1145","author":"Bheemarasetti","year":"2017","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0185","doi-asserted-by":"crossref","first-page":"6520","DOI":"10.1002\/anie.200902618","article-title":"A base-promoted tandem reaction of 3-(1-alkynyl) chromones with 1, 3-dicarbonyl compounds: an efficient approach to functional xanthones","volume":"48","author":"Zhao","year":"2009","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0190","doi-asserted-by":"crossref","first-page":"11611","DOI":"10.1016\/j.tet.2008.10.023","article-title":"Successive Michael reactions on chromone derivatives with dimethyl 1,3-acetonedicarboxylate: one-pot synthesis of functionalized benzophenones, benzo[c]chromones and hydroxybenzoylfuroates","volume":"64","author":"Terzidis","year":"2008","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0195","doi-asserted-by":"crossref","first-page":"10818","DOI":"10.1039\/C7NJ03743K","article-title":"Synthesis, structures and mechanistic pathways of anticancer activity of palladium(II) complexes with indole-3-carbaldehyde thiosemicarbazones","volume":"42","author":"Haribabu","year":"2018","journal-title":"New J. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0200","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.poly.2004.02.004","article-title":"Structural and spectral studies of nickel(II) complexes of di-2-pyridyl ketone N4,N4-(butane-1,4-diyl) thiosemicarbazone","volume":"23","author":"Philip","year":"2004","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0205","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1039\/c0ob01000f","article-title":"Synthesis of novel functional polycyclic chromones through Michael addition and double cyclizations","volume":"9","author":"Liu","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0210","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1007\/s11172-008-0291-5","article-title":"Reaction of 3-(polyfluoroacyl) chromones with hydrazines: new regioselective synthesis of RF-containing pyrazoles","volume":"57","author":"Sosnovskikh","year":"2008","journal-title":"Russ. Chem. Bull. Int. Ed."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0215","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0277-5387(02)01330-X","article-title":"Structural and spectral characterization of transition metal complexes of 2-pyridineformamide N(4)-dimethylthiosemicarbazone","volume":"22","author":"Fostiak","year":"2003","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0220","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1039\/C6NJ03516G","article-title":"New binuclear Ni(II) metallates containing ONS chelators: synthesis, characterisation, DNA binding, DNA cleavage, protein binding, antioxidant activity, antimicrobial and in vitro cytotoxicity","volume":"41","author":"Kalaiarasi","year":"2017","journal-title":"New J. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0225","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1002\/ejic.201000317","article-title":"Synthesis, structure and in vitro biological screening of palladium(II) complexes of functionalised salicylaldimine thiosemicarbazones as antimalarial and anticancer agents","author":"Chellan","year":"2010","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0230","doi-asserted-by":"crossref","first-page":"12538","DOI":"10.1039\/c2dt31199b","article-title":"New palladium and platinum complexes with bioactive 3,5-diacetyl-1,2,4-triazol bis(4-cyclohexyl thiosemicarbazone) ligand: chemistry, antiproliferative activity and preliminary toxicity studies","volume":"41","author":"Matesanz","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0235","doi-asserted-by":"crossref","first-page":"59428","DOI":"10.1039\/C5RA10973F","article-title":"Palladium(II) complexes containing ONO tridentate hydrazone for Suzuki-Miyaura coupling of aryl chlorides in aqueous-organic media","volume":"5","author":"Arumugam","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0240","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1039\/C7RA12104K","article-title":"An investigation on 3-acetyl-7-methoxy-coumarin Schiff bases and their Ru(II) metallates with potent antiproliferative activity and enhanced LDH and NO release","volume":"8","author":"Kalaiarasi","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0245","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jinorgbio.2019.02.012","article-title":"Half-sandwich Ru(\u03b76-p-cymene) complexes featuring pyrazole appended ligands: synthesis, DNA binding and in vitro cytotoxicity","volume":"194","author":"Huang","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0250","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ica.2017.12.040","article-title":"Synthesis, DNA and BSA binding of Pd(II) and Pt(II) complexes featuring tetrazolylacetic acids and their esters","volume":"473","author":"Protas","year":"2018","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0255","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.ica.2004.01.031","article-title":"Synthesis, crystal structure and photo-induced DNA cleavage activity of ternary copper(II)-thiosemicarbazone complexes having heterocyclic bases","volume":"357","author":"Thomas","year":"2004","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0260","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.jinorgbio.2011.07.018","article-title":"DNA as molecular target of analogous palladium and platinum anti-Trypanosoma cruzi compounds: a comparative study","volume":"105","author":"Vieites","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0265","doi-asserted-by":"crossref","first-page":"96946","DOI":"10.1039\/C6RA22480F","article-title":"Synthetic investigation on chirally pure Mannich derivatives of pseudophenylpropanolamine and their anticancer properties against HepG-2 cells with inhibition of JAK2\/STAT3","volume":"6","author":"Balachandran","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0270","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/284555a0","article-title":"Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation","volume":"284","author":"Wyllie","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0275","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1039\/C3DT51922H","article-title":"Remarkable anticancer activity of ferrocenyl-terpyridine platinum(II) complexes in visible light with low dark toxicity","volume":"43","author":"Mitra","year":"2014","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0280","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/onc.2015.287","article-title":"Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer","volume":"35","author":"Merino","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0285","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1182\/blood.V91.9.3379","article-title":"Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses","volume":"91","author":"Kitada","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0290","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0295","doi-asserted-by":"crossref","first-page":"8786","DOI":"10.1038\/sj.onc.1206039","article-title":"Chemotherapy: targeting the mitochondrial cell death pathway","volume":"21","author":"Debatin","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0300","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1021\/ml300065z","article-title":"Synthesis and antitumor activity of ellagic acid peracetate","volume":"3","author":"Ren","year":"2012","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.jinorgbio.2019.110988_bb0305","doi-asserted-by":"crossref","first-page":"4532","DOI":"10.1021\/jm500458c","article-title":"Arene\u2013ruthenium(II) acylpyrazolonato complexes: apoptosis-promoting effects on human cancer cells","volume":"57","author":"Pettinari","year":"2014","journal-title":"J. Med. Chem."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013419306713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013419306713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:57:29Z","timestamp":1758985049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013419306713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":61,"alternative-id":["S0162013419306713"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2019.110988","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unprecedented formation of palladium(II)-pyrazole based thiourea from chromone thiosemicarbazone and [PdCl2(PPh3)2]: Interaction with biomolecules and apoptosis through mitochondrial signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2019.110988","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110988"}}