{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:42:01Z","timestamp":1789872121708,"version":"4.0.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.jinorgbio.2020.111077","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T12:06:53Z","timestamp":1584965213000},"page":"111077","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Synthesis, characterization, DNA binding and cytotoxicity studies of two novel Cu(II)-2-(2\u2032-pyridyl) quinoxaline complexes"],"prefix":"10.1016","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0778-9684","authenticated-orcid":false,"given":"Eutuxia","family":"Lioli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Psycharis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine P.","family":"Raptopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni K.","family":"Efthimiadou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana A.","family":"Mitsopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2020.111077_bb0005","doi-asserted-by":"crossref","first-page":"7064","DOI":"10.1002\/chem.201000148","article-title":"Advances in platinum chemotherapeutics","volume":"16","author":"Harper","year":"2010","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/157489206775246458","article-title":"Platinum complexes as anticancer agents","volume":"1","author":"Kostova","year":"2006","journal-title":"Recent Pat. Anticancer Drug Discov."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0015","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1039\/b904071d","article-title":"Recent developments in ruthenium anticancer drugs","volume":"1","author":"Levina","year":"2009","journal-title":"J. Metallomics"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0020","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1002\/ejic.200600723","article-title":"Classical and non-classical ruthenium-based anticancer drugs: towards targeted chemotherapy","volume":"2006","author":"Han Ang","year":"2006","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0025","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jinorgbio.2007.07.002","article-title":"Synthesis, characterization, DFT studies and DNA binding of mixed platinum (II) complexes containing quinoxaline and 1, 2-dithiolate ligands","volume":"102","author":"Mitsopoulou","year":"2008","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0030","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1039\/c2dt11759b","article-title":"DNA binding and antiproliferative activity toward human carcinoma cells of copper (II) and zinc (II) complexes of a 2, 5-diphenyl [1, 3, 4] oxadiazole derivative","volume":"41","author":"Terenzi","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0035","doi-asserted-by":"crossref","first-page":"11560","DOI":"10.1021\/bi9909389","article-title":"Raman spectroscopic study on the copper (II) binding mode of prion octapeptide and its pH dependence","volume":"38","author":"Miura","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0040","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s00775-012-0940-x","article-title":"1, 10-Phenanthroline promotes copper complexes into tumor cells and induces apoptosis by inhibiting the proteasome activity","volume":"17","author":"Zhang","year":"2012","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0045","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.1021\/jm400965m","article-title":"Novel mixed-ligand copper (I) complexes: role of diimine ligands on cytotoxicity and genotoxicity","volume":"56","author":"Gandin","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0050","doi-asserted-by":"crossref","first-page":"13409","DOI":"10.1039\/C7DT02763J","article-title":"Selective formation of discrete versus polymeric copper organophosphates: DNA cleavage and cytotoxic activity","volume":"46","author":"Bhat","year":"2017","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0055","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.saa.2009.10.018","article-title":"Synthesis, spectral, crystallography and thermal investigations of novel Schiff base complexes of manganese (III) derived from heterocyclic \u03b2-diketone with aromatic and aliphatic diamine","volume":"75","author":"Surati","year":"2010","journal-title":"Spectrochimica Acta Part A, Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0060","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.poly.2010.11.016","article-title":"Preparation and structural characterization of nickel(II), cobalt(II), zinc(II) and tin(IV) complexes of the isatin Schiff bases of S-methyl and S-benzyldithiocarbazates","volume":"30","author":"Akbar","year":"2011","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2006.02.031","article-title":"Synchronous fluorescence, UV\u2013visible spectrophotometric, and voltammetric studies of the competitive interaction of bis(1,10-phenanthroline)copper(II) complex and neutral red with DNA","volume":"352","author":"Ni","year":"2006","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0070","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.jinorgbio.2004.09.014","article-title":"A novel cytotoxic ternary copper(II) complex of 1,10-phenanthroline and l-threonine with DNA nuclease activity","volume":"98","author":"Zhang","year":"2004","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0075","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1021\/cr400135x","article-title":"Advances in copper complexes as anticancer agents","volume":"114","author":"Santini","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0080","first-page":"386","article-title":"Exploring potential of quinoxaline moiety","volume":"3","author":"Patidar","year":"2011","journal-title":"Int. J. Pharmtech Res."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0085","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jorganchem.2005.07.023","article-title":"An experimental and DFT computational study of a novel zerovalent tetracarbonyl tungsten complex of 2-(20-pyridyl)quinoxaline","volume":"691","author":"Veroni","year":"2006","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0090","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/973742","article-title":"Synthesis, characterization, DNA binding, and photocleavage activity of oxorhenium (V) complexes with-diimine and quinoxaline ligands","volume":"2010","author":"Mitsopoulou","year":"2010","journal-title":"Bioinorg. Chem. Appl."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0095","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1039\/b208769c","article-title":"Synthesis and characterization of a novel complex: Mo(CO)4[2-(2\u2032pyridyl)quinoxaline]. An insight based on experimental and theoretical data","author":"Veroni","year":"2003","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0100","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1016\/j.jorganchem.2008.04.035","article-title":"Synthesis, spectroscopic properties and crystal structure of mononuclear tricarbonylrhenium (I) chloride complexes carrying 6-functionalised quinoxalines","volume":"693","author":"Veroni","year":"2008","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0105","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1016\/j.jorganchem.2006.09.060","article-title":"Isolation, X-ray structure and properties of an unusual pentacarbonyl (2,2\u2032-pyridyl-quinoxaline) tungsten complex","volume":"691","author":"Veroni","year":"2006","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0110","series-title":"Pentacarbonyl [2-(2\u2032-Pyridyl)quinoxaline-\u03baN4]tungsten: A Combined Study of Its Conformational and Electronic Structure Based on Experimental and DFT-TDDFT Data","first-page":"120","volume":"vol. 2007","author":"Makedonas","year":"2007"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0115","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0020-1693(00)90718-7","article-title":"1:1 metal complexes of 2-(2\u2032-pyridyl)quinoxaline, a ligand unexpectedly formed by the reaction between 2-acetylpyridine and 1,2-phenylenediamine","volume":"207","author":"Kasselouri","year":"1993","journal-title":"Inorganica Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0120","series-title":"CrystalClear","author":"Rigaku","year":"2005"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0125","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1107\/S0108767307043930","article-title":"A short history of SHELX","volume":"64","author":"Sheldrick","year":"2008","journal-title":"Acta Crystallogr. Sect. A: Found. Crystallogr."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0130","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053273314026370","article-title":"SHELXT\u2013integrated space-group and crystal-structure determination","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst. A."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0135","series-title":"Crystal Impact-GbR","first-page":"53227","article-title":"Diamond-crystal and molecular structure visualization","volume":"vol. 102","author":"Brandenburg","year":"2006"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0140","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1021\/ja01640a067","article-title":"A further examination of the molecular weight and size of desoxypentose nucleic acid","volume":"76","author":"Reichmann","year":"1954","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jinorgbio.2014.02.003","article-title":"Re (I) tricarbonyl complex of 1, 10-phenanthroline-5, 6-dione: DNA binding, cytotoxicity, anti-inflammatory and anti-coagulant effects towards platelet activating factor","volume":"135","author":"Kaplanis","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0150","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3109\/10409238209108704","article-title":"Spectroscopic analysis of drug-nucleic acid interaction","volume":"12","author":"Dougherty","year":"1982","journal-title":"Crit. Rev. Biochem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0155","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/bip.1969.360080105","article-title":"Viscosity and sedimentation study of sonicated DNA\u2013proflavine complexes","volume":"8","author":"Cohen","year":"1969","journal-title":"Biopolymers"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0160","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0022-0728(03)00192-X","article-title":"Cyclic voltammetry and scanning electrochemical microscopy of ferrocenemethanol at monolayer and bilayer-modified gold electrodes","volume":"547","author":"Cannes","year":"2003","journal-title":"J. Electroanal. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2013.03.013","article-title":"Drug\u2013DNA interactions and their study by UV\u2013Visible, fluorescence spectroscopies and cyclic voltametry","volume":"124","author":"Sirajuddin","year":"2013","journal-title":"J. Photoch. Photobio. B."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0170","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ica.2016.01.012","article-title":"Palladium(II) and plastinum(II) complexes of derivatives of 2-(4\u2032 aminophen-yl)benzothiazole as potential anticancer agents","volume":"444","author":"Mavroidi","year":"2016","journal-title":"Inorganica Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0175","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jinorgbio.2006.11.007","article-title":"DNA interaction of new copper(II) complexes with sulfonamides as ligands","volume":"101","author":"Mac\u0131as","year":"2007","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0180","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0185","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/j.bmcl.2011.01.061","article-title":"Synthesis, characterization and anti-tumor activity of moxifloxacin\u2013copper complexes against breast cancer cell lines","volume":"21","author":"Patitungkho","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0190","doi-asserted-by":"crossref","first-page":"11153","DOI":"10.3390\/molecules180911153","article-title":"Metal complexes of quinolone antibiotics and their applications: an update","volume":"18","author":"Uivarosi","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0195","doi-asserted-by":"crossref","DOI":"10.2174\/1875038901003010027","article-title":"Application of electrochemical methods for analysis of fluoroquinolones antibacterial agents and fluoroquinolones-DNA interactions","volume":"3","author":"Radi","year":"2010","journal-title":"Open Chem. Biomed. Meth. J."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0200","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jinorgbio.2006.07.019","article-title":"Structure and biological properties of the copper(II) complex with the quinolone antibacterial drug N-propyl-norfloxacin and 2,20-bipyridine","volume":"101","author":"Efthimiadou","year":"2007","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0205","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.jinorgbio.2007.12.011","article-title":"Copper(II) complexes with sparfloxacin and nitrogen-donor heterocyclic ligands: structure\u2013activity relationship","volume":"102","author":"Efthimiadou","year":"2008","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0210","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1021\/jm7013259","article-title":"Novel copper (II) complex of N-propyl-norfloxacin and 1, 10-phenanthroline with enhanced antileukemic and DNA nuclease activities","volume":"51","author":"Katsarou","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0215","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/215392","article-title":"Evaluation of DNA binding, cleavage, and cytotoxic activity of Cu(II), Co(II),and Ni(II) sciff base complexes od 1-phenylndoline-2,3-dione with isonicotinohydrazide","volume":"2014","author":"Gomathi","year":"2014","journal-title":"Bioinorg. Chem. Appl."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0220","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1039\/C4DT02733G","article-title":"Binding of copper(II) polypyridyl complexes to DNA and consequences for DNA-based asymmetric catalysis","volume":"44","author":"Draksharapu","year":"2015","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0225","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0277-5387(98)00304-0","article-title":"Mixed ligand Ru(II) complexes with 2,2\u2032-bipyridine and 2-(2\u2032-pyridyl)quinoxaline","volume":"18","author":"Garoufis","year":"1998","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0230","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/2164232X.2014.887448","article-title":"Synthesis and characterization of mononuclear copper (II) complex of tetradentate N2S2 donor set and the study of DNA and bovine serum albumin binding","volume":"1","author":"Sarkar","year":"2014","journal-title":"Complex Metals"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0235","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/BF00812317","article-title":"Ligand-structure effect on electrochemical reduction of copper (II) complexes","volume":"123","author":"Labuda","year":"1992","journal-title":"Monatsh. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0240","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1039\/DT9840001349","article-title":"Synthesis, structure, and spectroscopic properties of copper (II) compounds containing nitrogen\u2013sulphur donor ligands; the crystal and molecular structure of aqua [1, 7-bis (N-methylbenzimidazol-2\u2032-yl)-2, 6-dithiaheptane] copper (II) perchlorate","author":"Addison","year":"1984","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0245","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1021\/ar00172a005","article-title":"Encoding and decoding hydrogen-bond patterns of organic compounds","volume":"23","author":"Etter","year":"1990","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0250","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.inoche.2012.03.030","article-title":"An unusual axial\u2013axial combination of alternating cyclic rings in the chair conformations of hexameric water and chlorine-water clusters","volume":"20","author":"Naiya","year":"2012","journal-title":"Inorg. Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0255","doi-asserted-by":"crossref","first-page":"16065","DOI":"10.1039\/C7DT03062B","article-title":"Catalytic fixation of atmospheric carbon dioxide by copper (II) complexes of bidentate ligands","volume":"46","author":"Muthuramalingam","year":"2017","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0260","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.saa.2014.11.085","article-title":"Synthesis, DNA interactions and antibacterial PDT of Cu (II) complexes of phenanthroline based photosensitizers via singlet oxygen generation","volume":"138","author":"Sudhamani","year":"2015","journal-title":"Spectrochim. Acta A"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0265","doi-asserted-by":"crossref","first-page":"11988","DOI":"10.1039\/C4DT01348D","article-title":"Ferrocenyl-L-amino acid copper(II) complexes showing remarkable photo-induced anticancer activity in visible light","volume":"43","author":"Goswami","year":"2014","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0270","doi-asserted-by":"crossref","first-page":"6596","DOI":"10.2174\/1381612822666160831114622","article-title":"Methods for elucidation of DNA-anticancer drug interactions and their applications in the development of new drugs","volume":"22","author":"Misiak","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0275","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1021\/ic801144x","article-title":"Induction of cell death by ternary copper (II) complexes of l-tyrosine and diimines: role of coligands on DNA binding and cleavage and anticancer activity","volume":"48","author":"Ramakrishnan","year":"2009","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0280","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/0968-0896(95)00053-J","article-title":"Criteria for the mode of binding of DNA binding agents","volume":"3","author":"Suh","year":"1995","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0285","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/j.ica.2007.10.006","article-title":"Characterization and DNA interaction of the Pt (II)(pq)(bdt) complex: a theoretical and experimental research","volume":"361","author":"Mitsopoulou","year":"2008","journal-title":"Inorganica Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0290","doi-asserted-by":"crossref","first-page":"7528","DOI":"10.1021\/ja00258a046","article-title":"Voltammetric studies of the interaction of tris (1, 10-phenanthroline) cobalt (III) with DNA","volume":"109","author":"Carter","year":"1987","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0295","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jinorgbio.2017.07.008","article-title":"Aryl-1H-imidazole [4, 5f][1, 10] phenanthroline Cu (II) complexes: electrochemical and DNA interaction studies","volume":"175","author":"Rajebhosale","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0300","doi-asserted-by":"crossref","first-page":"10765","DOI":"10.1039\/b912711a","article-title":"Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors","author":"S\u00e1nchez-Cano","year":"2009","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0305","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/bip.1973.360120109","article-title":"Different conformations of double-stranded nucleic acid in solution as revealed by circular dichroism","volume":"12","author":"Ivanov","year":"1973","journal-title":"Biopolymers"},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0310","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jinorgbio.2010.01.011","article-title":"Synthesis and characterization of the ligand based on benzoxazole and its transition metal complexes: DNA-binding and antitumor activity","volume":"104","author":"Jiang","year":"2010","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0315","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/j.jinorgbio.2005.08.011","article-title":"Oxidative DNA cleavage mediated by a new copper (II) terpyridine complex: crystal structure and DNA binding studies","volume":"99","author":"Uma","year":"2005","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2020.111077_bb0320","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1038\/nprot.2007.475","article-title":"Circular dichroism to determine binding mode and affinity of ligand\u2013DNA interactions","volume":"2","author":"Garbett","year":"2007","journal-title":"Nat. Protoc."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013420301057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013420301057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:57:25Z","timestamp":1758985045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013420301057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":64,"alternative-id":["S0162013420301057"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2020.111077","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis, characterization, DNA binding and cytotoxicity studies of two novel Cu(II)-2-(2\u2032-pyridyl) quinoxaline complexes","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2020.111077","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111077"}}