{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:23:40Z","timestamp":1785813820533,"version":"3.56.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007112","name":"University of Cape Town","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007112","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011512","name":"National Research Foundation","doi-asserted-by":"publisher","award":["111707"],"award-info":[{"award-number":["111707"]}],"id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jinorgbio.2020.111328","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:55:01Z","timestamp":1607475301000},"page":"111328","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Diversification of quinoline-triazole scaffolds with CORMs: Synthesis, in vitro and in silico biological evaluation against Plasmodium falciparum"],"prefix":"10.1016","volume":"215","author":[{"given":"Fatima-Zahra","family":"Ishmail","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana R.","family":"Melis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mziyanda","family":"Mbaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory S.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2020.111328_bb0005","series-title":"World malaria report 2018","author":"World health organisation","year":"2018"},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0010","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1111\/febs.14127","volume":"284","author":"Thu","year":"2017","journal-title":"FEBS J."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0015","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ejmech.2017.07.061","volume":"139","author":"Hu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0020","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.3390\/molecules22122268","volume":"22","author":"Nqoro","year":"2017","journal-title":"Molecules."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0025","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1039\/C4MD00091A","volume":"5","author":"Wang","year":"2014","journal-title":"Medchemcomm."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0030","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1007\/s00044-013-0748-4","volume":"23","author":"N\u2019Da","year":"2014","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0035","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1747-0285.2011.01115.x","volume":"78","author":"Manohar","year":"2011","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0040","doi-asserted-by":"crossref","first-page":"8243","DOI":"10.1016\/j.bmc.2010.10.009","volume":"18","author":"Guantai","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0045","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ejmech.2013.01.032","volume":"62","author":"Raj","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0050","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.cell.2011.03.049","volume":"145","author":"Ferreira","year":"2011","journal-title":"Cell."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0055","first-page":"1","volume":"20","author":"Chiang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0060","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nm1586","volume":"13","author":"Pamplona","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0065","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S1474-4422(05)70247-7","volume":"4","author":"Idro","year":"2005","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0070","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1021\/acs.inorgchem.6b02623","volume":"56","author":"Chakraborty","year":"2017","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0075","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1002\/anie.201006598","volume":"50","author":"Romanski","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0080","doi-asserted-by":"crossref","first-page":"7313","DOI":"10.1021\/ic100458j","author":"Zobi","year":"2010","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0085","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1096\/fj.04-2169fje","volume":"19","author":"Motterlini","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0090","doi-asserted-by":"crossref","first-page":"15061","DOI":"10.1002\/chem.201403305","volume":"20","author":"Ward","year":"2014","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0095","first-page":"1","volume":"00","author":"Vitor","year":"2019","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0100","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1107\/S2053229617004429","volume":"73","author":"Stenger-Smith","year":"2017","journal-title":"Acta Crystallogr. Sect. C Struct. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0105","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1128\/AAC.05571-11","volume":"56","author":"Pena","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0110","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1039\/C2CY20532G","volume":"3","author":"Zhang","year":"2013","journal-title":"Catal. Sci. Technol."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0115","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ejmech.2017.12.051","volume":"145","author":"Brand\u00e3o","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0120","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ejmech.2012.01.039","volume":"49","author":"Kristina Starcevic","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0125","doi-asserted-by":"crossref","first-page":"8756","DOI":"10.1021\/jo301265t","volume":"77","author":"Creary","year":"2012","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0130","doi-asserted-by":"crossref","first-page":"11254","DOI":"10.1039\/c3cc46558f","volume":"49","author":"Carrington","year":"2013","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0135","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ica.2011.10.047","volume":"380","author":"Berends","year":"2012","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0140","doi-asserted-by":"crossref","first-page":"8664","DOI":"10.1039\/c4dt00254g","volume":"43","author":"Pai","year":"2014","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0145","doi-asserted-by":"crossref","first-page":"11066","DOI":"10.1021\/acs.inorgchem.9b01581","volume":"58","author":"Jiang","year":"2019","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0150","doi-asserted-by":"crossref","first-page":"8355","DOI":"10.1021\/bi00193a024","volume":"33","author":"Balasubramanian","year":"1994","journal-title":"Biochemistry."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0155","doi-asserted-by":"crossref","first-page":"6801","DOI":"10.1039\/C5DT04849D","volume":"45","author":"Wright","year":"2016","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0160","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1039\/c0dt01809k","volume":"40","author":"Atkin","year":"2011","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0165","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1002\/ejic.201100545","volume":"2011","author":"Br\u00fcckmann","year":"2011","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0170","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ica.2011.02.068","volume":"374","author":"Schatzschneider","year":"2011","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0175","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ica.2011.10.047","volume":"380","author":"Berends","year":"2012","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0180","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1016\/j.bmc.2015.06.044","volume":"23","author":"Taleli","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0185","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1021\/jm701478a","volume":"51","author":"Natarajan","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0190","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0169-4758(96)40001-1","volume":"12","author":"Sullivan","year":"1996","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0195","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1016\/j.bbagen.2014.02.009","volume":"1840","author":"Coronado","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0200","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.1039\/c2dt12247b","volume":"41","author":"Biot","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0205","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0006-2952(97)00510-8","volume":"55","author":"Dorn","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0210","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1016\/j.ejmech.2010.04.011","volume":"45","author":"Kaur","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0215","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1128\/AAC.00121-11","volume":"55","author":"Sandlin","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0220","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ab.2004.11.022","volume":"338","author":"Ncokazi","year":"2005","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0225","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejmech.2019.06.023","volume":"179","author":"Stringer","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0230","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1002\/cbdv.201200033","volume":"9","author":"Bohle","year":"2012","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0235","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ejmech.2018.09.060","volume":"159","author":"L\u2019abbate","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0240","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1039\/C9MD00468H","volume":"11","author":"Veale","year":"2020","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0245","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.4155\/fmc.13.113","volume":"5","author":"Fong","year":"2013","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0250","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1021\/cg025550i","volume":"2","author":"Buller","year":"2002","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0255","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/1062936X.2010.502299","volume":"21","author":"Takahashi","year":"2010","journal-title":"SAR QSAR Environ. Res."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0260","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1002\/pi.4254","volume":"61","author":"Ahamad","year":"2012","journal-title":"Polym. Int."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0265","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1021\/ml400164t","volume":"4","author":"Njogu","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0270","series-title":"How do I dock ligands that contain metals with Glide?","year":"2020"},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0275","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","author":"Friesner","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0280","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1210\/jcem-10-10-1361","volume":"10","author":"Taylor","year":"1950","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0285","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4269\/ajtmh.1993.48.205","volume":"48","author":"Makler","year":"1993","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0290","doi-asserted-by":"crossref","first-page":"9875","DOI":"10.1039\/C7DT01952A","volume":"46","author":"Stringer","year":"2017","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2020.111328_bb0295","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2174\/138620710790980496","volume":"13","author":"Carter","year":"2010","journal-title":"Comb. Chem. High Throughput Screen."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013420303561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013420303561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:00:22Z","timestamp":1758985222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013420303561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":59,"alternative-id":["S0162013420303561"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2020.111328","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diversification of quinoline-triazole scaffolds with CORMs: Synthesis, in vitro and in silico biological evaluation against Plasmodium falciparum","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2020.111328","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111328"}}