{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:58:46Z","timestamp":1793998726904,"version":"4.8.0"},"reference-count":130,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.jinorgbio.2021.111454","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T20:06:42Z","timestamp":1617048402000},"page":"111454","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Design and application of nanoparticles as vaccine adjuvants against human corona virus infection"],"prefix":"10.1016","volume":"219","author":[{"given":"Lichun","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2021.111454_bb0005","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","article-title":"Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding","volume":"395","author":"Lu","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0010","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3390\/v12020244","article-title":"Systematic comparison of two animal-to-human transmitted human coronaviruses: SARS-CoV-2 and SARS-CoV","volume":"12","author":"Xu","year":"2020","journal-title":"Viruses-Basel"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0015","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s11427-020-1637-5","article-title":"Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission","volume":"63","author":"Xu","year":"2020","journal-title":"Sci. China-Life Sci."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0020","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jpha.2020.03.001","article-title":"Molecular immune pathogenesis and diagnosis of COVID-19","volume":"10","author":"Li","year":"2020","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0025","article-title":"SARS-CoV-2 infectivity and neurological targets in the brain","author":"Lukiw","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0030","article-title":"Caution: The clinical characteristics of COVID-19 patients at admission are changing","author":"Chen","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0035","doi-asserted-by":"crossref","first-page":"7039","DOI":"10.1128\/JVI.03273-12","article-title":"A case for the ancient origin of coronaviruses","volume":"87","author":"Wertheim","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0040","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrmicro775","article-title":"SARS--beginning to understand a new virus","volume":"1","author":"Stadler","year":"2003","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0045","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1146\/annurev-micro-020518-115759","article-title":"Human coronavirus: host-pathogen interaction","volume":"73","author":"Fung","year":"2019","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0050","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.arcmed.2020.03.004","article-title":"Can bioactive lipids inactivate coronavirus (COVID-19)?","volume":"51","author":"Das","year":"2020","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0055","first-page":"1501","article-title":"New insights from chemical biology: molecular basis of transmission, diagnosis, and therapy of SARS-CoV-2","volume":"2","author":"Zhao","year":"2020","journal-title":"J. Chin. Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0060","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1126\/science.abc6952","article-title":"A neutralizing human antibody binds to the N-terminal domain of the spike protein of SARS-CoV-2","volume":"369","author":"Chi","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0065","first-page":"734","article-title":"Generation of a broadly useful model for COVID-19 pathogenesis","volume":"182","author":"Sun","year":"2020","journal-title":"Vaccination, and Treatment, Cell"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0070","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tips.2020.05.005","article-title":"In vitro and animal models for SARS-CoV-2 research","volume":"41","author":"Takayama","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0075","doi-asserted-by":"crossref","first-page":"104792","DOI":"10.1016\/j.antiviral.2020.104792","article-title":"Coronavirus membrane fusion mechanism offers as a potential target for antiviral development","volume":"178","author":"Tang","year":"2020","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0080","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41586-020-2332-7","article-title":"Proteomics of SARS-CoV-2-infected host cells reveals therapy targets","volume":"583","author":"Bojkova","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0085","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00912-2020","article-title":"Understanding the renin-angiotensin-aldosterone-SARS-CoV axis: a comprehensive review","volume":"56","author":"Ingraham","year":"2020","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0090","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1152\/physiolgenomics.00087.2020","article-title":"SARS-CoV-2, ACE2 expression, and systemic organ invasion","volume":"53","author":"Ashraf","year":"2021","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0095","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1038\/nm1210","article-title":"Targeting the innate immune response with improved vaccine adjuvants","volume":"11","author":"Pashine","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0100","doi-asserted-by":"crossref","first-page":"12370","DOI":"10.1021\/acsnano.0c06109","article-title":"Engineering antiviral vaccines","volume":"14","author":"Zhou","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0105","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.biologicals.2010.06.002","article-title":"Mode of action of adjuvants: implications for vaccine safety and design","volume":"38","author":"Mastelic","year":"2010","journal-title":"Biologicals"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0110","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.it.2009.12.009","article-title":"The immunobiology of aluminium adjuvants: how do they really work?","volume":"31","author":"Exley","year":"2010","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0115","first-page":"1459394","article-title":"Adjuvants: classification, modus operandi, and licensing","volume":"2016","author":"Apostolico Jde","year":"2016","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0120","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1016\/j.vaccine.2019.04.055","article-title":"Vaccine adjuvants: understanding the structure and mechanism of adjuvanticity","volume":"37","author":"Shi","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0125","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nri2510","article-title":"Towards an understanding of the adjuvant action of aluminium","volume":"9","author":"Marrack","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0130","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1002\/eji.1830260915","article-title":"In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to Freund's complete adjuvant, but continues to induce T helper 2 cytokine production","volume":"26","author":"Brewer","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0135","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0008-8749(89)90011-7","article-title":"Different T helper cell subsets elicited in mice utilizing two different adjuvant vehicles: the role of endogenous interleukin 1 in proliferative responses","volume":"121","author":"Grun","year":"1989","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0140","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/eji.201747150","article-title":"The vaccine adjuvant alum promotes IL-10 production that suppresses Th1 responses","volume":"48","author":"Oleszycka","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0145","first-page":"143","article-title":"Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminium hydroxide: effect on antigen uptake and antigen presentation","volume":"61","author":"Mannhalter","year":"1985","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0150","doi-asserted-by":"crossref","first-page":"2004210","DOI":"10.1002\/adma.202004210","article-title":"Particulate alum via Pickering emulsion for an enhanced COVID-19 vaccine adjuvant","volume":"32","author":"Peng","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0155","doi-asserted-by":"crossref","first-page":"22893","DOI":"10.1021\/acsami.7b03965","article-title":"Aluminum (oxy)hydroxide Nanosticks synthesized in Bicontinuous reverse microemulsion have potent vaccine adjuvant activity","volume":"9","author":"Li","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0160","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/S0140-6736(13)61049-1","article-title":"Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial","volume":"381","author":"Zhu","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0165","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0140-6736(17)33106-9","article-title":"Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials","volume":"391","author":"Modjarrad","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0170","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1093\/intimm\/dxh143","article-title":"A subcutaneously injected UV-inactivated SARS coronavirus vaccine elicits systemic humoral immunity in mice","volume":"16","author":"Takasuka","year":"2004","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/2965cfae-b77d-4014-8b7b-236e01a35492","article-title":"Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus","volume":"7","author":"Tseng","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0180","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1586\/14760584.2014.912134","article-title":"Current advancements and potential strategies in the development of MERS-CoV vaccines","volume":"13","author":"Zhang","year":"2014","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0185","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1586\/erv.12.126","article-title":"Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome","volume":"11","author":"Jiang","year":"2012","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112602","article-title":"Tailoring subunit vaccine immunity with adjuvant combinations and delivery routes using the Middle East respiratory coronavirus (MERS-CoV) receptor-binding domain as an antigen","volume":"9","author":"Lan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0195","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.cell.2020.06.008","article-title":"Development of an inactivated vaccine candidate, BBIBP-CorV, with potent protection against SARS-CoV-2","volume":"182","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0200","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1039\/C6CC02595A","article-title":"Alumina-encapsulated vaccine formulation with improved thermostability and immunogenicity","volume":"52","author":"Zhou","year":"2012","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0205","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jconrel.2013.10.032","article-title":"Aluminum hydroxide nanoparticles show a stronger vaccine adjuvant activity than traditional aluminum hydroxide microparticles","volume":"173","author":"Li","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0210","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1016\/j.vaccine.2016.04.081","article-title":"Towards understanding the mechanism underlying the strong adjuvant activity of aluminum salt nanoparticles","volume":"34","author":"Ruwona","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0215","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tox.2016.11.018","article-title":"Non-linear dose-response of aluminium hydroxide adjuvant particles: selective low dose neurotoxicity","volume":"375","author":"Crepeaux","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0220","doi-asserted-by":"crossref","first-page":"126444","DOI":"10.1016\/j.jtemb.2019.126444","article-title":"Acute exposure and chronic retention of aluminum in three vaccine schedules and effects of genetic and environmental variation","volume":"58","author":"McFarland","year":"2020","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0225","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1080\/14760584.2017.1355733","article-title":"Calcium phosphate nanoparticles as a new generation vaccine adjuvant","volume":"16","author":"Lin","year":"2017","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0230","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1016\/j.vaccine.2019.05.074","article-title":"Antibody-mediated protection against MERS-CoV in the murine model","volume":"37","author":"New","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0235","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2147\/IJN.S152141","article-title":"Double-stranded phosphodiester cytosine-guanine oligodeoxynucleotide complexed with calcium phosphate as a potent vaccine adjuvant for activating cellular and Th1-type humoral immunities","volume":"13","author":"Hanagata","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0240","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1016\/j.vaccine.2017.07.016","article-title":"Calcium phosphate nanoparticle (CaPNP) for dose-sparing of inactivated whole virus pandemic influenza a (H1N1) 2009 vaccine in mice","volume":"35","author":"Morcl","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0245","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/vaccines8010110","article-title":"Effective activation of human antigen-presenting cells and cytotoxic CD8+ T cells by a calcium phosphate-based nanoparticle vaccine delivery system","volume":"8","author":"Scheffel","year":"2020","journal-title":"Vaccines"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0250","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.actbio.2020.04.021","article-title":"Genetic immunization against hepatitis B virus with calcium phosphate nanoparticles in vitro and in vivo","volume":"110","author":"Rojas-Sanchez","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0255","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jcis.2016.03.007","article-title":"Gene delivery using calcium phosphate nanoparticles: optimization of the transfection process and the effects of citrate and poly(l-lysine) as additives","volume":"471","author":"Khan","year":"2016","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0260","doi-asserted-by":"crossref","first-page":"88","DOI":"10.7774\/cevr.2015.4.1.88","article-title":"Systemic antibody response to nano-size calcium phospate biocompatible adjuvant adsorbed HEV-71 killed vaccine","volume":"4","author":"Saeed","year":"2015","journal-title":"Clin. Exp. Vaccine Res."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0265","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1039\/C6SC03631G","article-title":"Immunological properties of gold nanoparticles","volume":"8","author":"Dykman","year":"2017","journal-title":"Chem. Sci."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0270","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jconrel.2017.04.024","article-title":"Effects of gold nanoparticle-based vaccine size on lymph node delivery and cytotoxic T-lymphocyte responses","volume":"256","author":"Kang","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0275","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.actbio.2018.08.011","article-title":"Size-dependent neutralizing activity of gold nanoparticle-based subunit vaccine against dengue virus","volume":"78","author":"Quach","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0280","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1021\/nn3057005","article-title":"Gold nanoparticles as a vaccine platform: influence of size and shape on immunological responses in vitro and in vivo","volume":"7","author":"Niikura","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0285","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1021\/nl300027p","article-title":"Surface-engineered gold nanorods: promising DNA vaccine adjuvant for HIV-1 treatment","volume":"12","author":"Xu","year":"2012","journal-title":"Nano Lett."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0290","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/1348-0421.12754","article-title":"Gold nanoparticle-adjuvanted S protein induces a strong antigen-specific IgG response against severe acute respiratory syndrome-related coronavirus infection, but fails to induce protective antibodies and limit eosinophilic infiltration in lungs","volume":"64","author":"Sekimukai","year":"2020","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0295","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s12195-017-0505-8","article-title":"Adjuvant-loaded spiky gold nanoparticles for activation of innate immune cells","volume":"10","author":"Nam","year":"2017","journal-title":"Cell. Mol. Bioeng."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0300","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1039\/C6NH00087H","article-title":"Assembly of hepatitis E vaccine by \u2018in situ\u2019 growth of gold clusters as nano-adjuvants: an efficient way to enhance the immune responses of vaccination","volume":"1","author":"Wang","year":"2016","journal-title":"Nanoscale Horiz."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0305","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1021\/ac503887c","article-title":"Label-free au cluster used for in vivo 2D and 3D computed tomography of murine kidneys","volume":"87","author":"Wang","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0310","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1021\/ac504639u","article-title":"Facile approach to observe and quantify the \u03b1IIb\u03b23 integrin on a single-cell","volume":"87","author":"Zhai","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0315","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1021\/acs.analchem.0c04662","article-title":"3D imaging and quantification of the integrin at a single-cell base on a multisignal nanoprobe and synchrotron radiation soft X-ray tomography microscopy","volume":"93","author":"Zhang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0320","doi-asserted-by":"crossref","first-page":"1604139","DOI":"10.1002\/adfm.201604139","article-title":"Electrically oscillating plasmonic nanoparticles for enhanced DNA vaccination against hepatitis C virus","volume":"27","author":"Draz","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0325","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1073\/pnas.1911734116","article-title":"Unexpected intracellular biodegradation and recrystallization of gold nanoparticles","volume":"117","author":"Balfourier","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0330","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1021\/acs.nanolett.6b04130","article-title":"Extra-large pore mesoporous silica nanoparticles for directing in vivo M2 macrophage polarization by delivering IL-4","volume":"17","author":"Kwon","year":"2017","journal-title":"Nano Lett."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0335","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nbt.3071","article-title":"Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy","volume":"33","author":"Kim","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0340","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.biomaterials.2013.09.060","article-title":"The enhanced immune response of hepatitis B virus DNA vaccine using SiO2@LDH nanoparticles as an adjuvant","volume":"35","author":"Wang","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0345","article-title":"pH-responsive nano-vaccines as antigen and adjuvant carrier that improve vaccine immunogenicity","author":"Freeman","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0350","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.ijbiomac.2020.02.287","article-title":"Alginate-coated chitosan nanoparticles act as effective adjuvant for hepatitis a vaccine in mice","volume":"152","author":"AbdelAllah","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0355","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1021\/mp200553x","article-title":"Dendritic cell targeted chitosan nanoparticles for nasal DNA immunization against SARS CoV nucleocapsid protein","volume":"9","author":"Raghuwanshi","year":"2012","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0360","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1016\/j.bmc.2019.05.033","article-title":"Self-assembly of trimethyl chitosan and poly(anionic amino acid)-peptide antigen conjugate to produce a potent self-adjuvanting nanovaccine delivery system","volume":"27","author":"Nevagi","year":"2019","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0365","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1021\/acs.nanolett.8b00478","article-title":"Potency of a scalable nanoparticulate subunit vaccine","volume":"18","author":"Qiao","year":"2018","journal-title":"Nano Lett."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0370","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1007\/s00705-018-3837-3","article-title":"Inactivated enterovirus 71 with poly-gamma-glutamic acid\/chitosan nano particles (PC NPs) induces high cellular and humoral immune responses in BALB\/c mice","volume":"163","author":"Pathinayake","year":"2018","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0375","first-page":"208","article-title":"Improvement efficacy of influenza Nanovaccine in combination with Hemokinin-1 molecular adjuvant","volume":"10","author":"Dehghan","year":"2018","journal-title":"Avicenna J. Med. Biotechnol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0380","first-page":"149","article-title":"Development of a novel adjuvanted nasal vaccine: C48\/80 associated with chitosan nanoparticles as a path to enhance mucosal immunity","volume":"93","author":"Bento","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0385","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3390\/pharmaceutics11020072","article-title":"Chitosan plus compound 48\/80: formulation and preliminary evaluation as a hepatitis B vaccine adjuvant","volume":"11","author":"Bento","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0390","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/bioengineering5020037","article-title":"Anti-RSV peptide-loaded liposomes for the inhibition of respiratory syncytial virus","volume":"5","author":"Joshi","year":"2018","journal-title":"Bioengineering-Basel"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0395","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41541-017-0043-3","article-title":"Humoral and cell-mediated immune responses to H5N1 plant-made virus-like particle vaccine are differentially impacted by alum and GLA-SE adjuvants in a Phase 2 clinical trial","volume":"3","author":"Pillet","year":"2018","journal-title":"npj Vaccines"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0400","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.vaccine.2019.02.048","article-title":"Efficient induction of cell-mediated immunity to varicella-zoster virus glycoprotein E co-lyophilized with a cationic liposome-based adjuvant in mice","volume":"37","author":"Wui","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0405","doi-asserted-by":"crossref","first-page":"16527","DOI":"10.1038\/s41598-018-34853-2","article-title":"Enhancing humoral responses against HIV envelope trimers via nanoparticle delivery with stabilized synthetic liposomes","volume":"8","author":"Tokatlian","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0410","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00443-17","article-title":"Covalent linkage of HIV-1 trimers to synthetic liposomes elicits improved B cell and antibody responses","volume":"91","author":"Bale","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0415","doi-asserted-by":"crossref","first-page":"1700645","DOI":"10.1002\/biot.201700645","article-title":"Monophosphoryl lipid A-adjuvanted virosomes with Ni-chelating lipids for attachment of conserved viral proteins as cross-protective influenza vaccine","volume":"13","author":"Dong","year":"2018","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0420","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4049\/jimmunol.1600173","article-title":"Roles of aluminum hydroxide and monophosphoryl lipid a adjuvants in overcoming CD4+ T cell deficiency to induce isotype-switched IgG antibody responses and protection by T-dependent influenza vaccine","volume":"198","author":"Ko","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0425","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1586\/14760584.2.2.197","article-title":"MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile","volume":"2","author":"Podda","year":"2003","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0430","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/cmi.2015.03","article-title":"Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus","volume":"13","author":"Zhang","year":"2016","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0435","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1016\/j.vaccine.2014.04.016","article-title":"Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice","volume":"32","author":"Coleman","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0440","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1128\/JVI.02980-14","article-title":"Severe acute respiratory syndrome-associated coronavirus vaccines formulated with Delta inulin adjuvants provide enhanced protection while ameliorating lung eosinophilic immunopathology","volume":"89","author":"Honda-Okubo","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0445","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1002\/adma.201300583","article-title":"Morphologically virus-like fullerenol nanoparticles act as the dual-functional nanoadjuvant for HIV-1 vaccine","volume":"25","author":"Xu","year":"2013","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0450","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.msec.2018.12.088","article-title":"The adjuvant effect of C60(OH)22 nanoparticles promoting both humoral and cellular immune responses to HCV recombinant proteins","volume":"97","author":"Liu","year":"2019","journal-title":"Mater. Sci. Eng. C-Mater. Biol. Appl."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0455","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1128\/CVI.00778-14","article-title":"H9N2 influenza whole inactivated virus combined with polyethyleneimine strongly enhances mucosal and systemic immunity after intranasal immunization in mice","volume":"22","author":"Qin","year":"2015","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0460","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3390\/pharmaceutics11090464","article-title":"Comprehensive analysis of the safety profile of a single-stranded RNA nano-structure adjuvant","volume":"11","author":"Park","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0465","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1208\/s12248-018-0233-6","article-title":"Vaccine adjuvant incorporation strategy dictates peptide amphiphile micelle Immunostimulatory capacity","volume":"20","author":"Zhang","year":"2018","journal-title":"AAPS J."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0470","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41541-017-0007-7","article-title":"Alpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells","volume":"2","author":"Lu","year":"2017","journal-title":"npj Vaccines"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0475","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jcis.2018.03.108","article-title":"Hybrids of carbon dots with subunit B of ricin toxin for enhanced immunomodulatory activity","volume":"523","author":"Li","year":"2018","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0480","doi-asserted-by":"crossref","DOI":"10.1038\/s41565-021-00856-w","article-title":"Molybdenum derived from nanomaterials incorporates into molybdenum enzymes and affects their activities in vivo","author":"Cao","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0485","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41565-019-0472-4","article-title":"Long-term pulmonary exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades","volume":"14","author":"Lu","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0490","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1021\/acs.nanolett.8b02638","article-title":"Nanoparticle ligand exchange and its effects at the nanoparticle-cell membrane Interface","volume":"19","author":"Wang","year":"2019","journal-title":"Nano Lett."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0495","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1021\/acs.accounts.9b00126","article-title":"The Nano\u2013bio interactions of nanomedicines: understanding the biochemical driving forces and redox reactions","volume":"52","author":"Wang","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0500","article-title":"The crown and the scepter: roles of the protein corona in nanomedicine","volume":"1805740","author":"Cai","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0505","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1021\/acsnano.6b00745","article-title":"Rapid degradation and high renal clearance of Cu3BiS3 nanodots for efficient cancer diagnosis and photothermal therapy in vivo","volume":"10","author":"Liu","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0510","doi-asserted-by":"crossref","first-page":"8950","DOI":"10.1002\/adma.201603114","article-title":"Gd-hybridized plasmonic au-nanocomposites enhanced tumor-interior drug permeability in multimodal imaging-guided therapy","volume":"28","author":"Wang","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0515","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1107\/S2052252517017912","article-title":"Three-dimensional ultrastructural imaging reveals the nanoscale architecture of mammalian cells","volume":"5","author":"Yao","year":"2018","journal-title":"IUCrJ"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0520","doi-asserted-by":"crossref","first-page":"11488","DOI":"10.1021\/acsnano.9b04970","article-title":"Engineered graphene oxide nanocomposite capable of preventing the evolution of antimicrobial resistance","volume":"13","author":"Zhen","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0525","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1002\/smll.201501245","article-title":"Cysteine-ag cluster hydrogel confirmed by experimental and numerical studies","volume":"11","author":"Cui","year":"2015","journal-title":"Small"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0530","doi-asserted-by":"crossref","first-page":"8680","DOI":"10.1021\/acsnano.9b00114","article-title":"Stability of ligands on nanoparticles regulating the integrity of biological membranes at the nano-lipid Interface","volume":"13","author":"Wang","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0535","doi-asserted-by":"crossref","first-page":"6532","DOI":"10.1021\/acsnano.5b02483","article-title":"Use of synchrotron radiation-analytical techniques to reveal chemical origin of silver-nanoparticle cytotoxicity","volume":"9","author":"Wang","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0540","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1021\/acs.analchem.9b03913","article-title":"Single-particle analysis for structure and Iron chemistry of atmospheric particulate matter","volume":"92","author":"Ding","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0545","doi-asserted-by":"crossref","first-page":"8597","DOI":"10.1128\/JVI.00983-14","article-title":"Effects of toll-like receptor stimulation on eosinophilic infiltration in lungs of BALB\/c mice immunized with UV-inactivated severe acute respiratory syndrome-related coronavirus vaccine","volume":"88","author":"Iwata-Yoshikawa","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0550","doi-asserted-by":"crossref","first-page":"1807616","DOI":"10.1002\/adfm.201807616","article-title":"Viromimetic STING agonist-loaded hollow polymeric nanoparticles for safe and effective vaccination against Middle East respiratory syndrome coronavirus","volume":"29","author":"Lin","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0555","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1038\/s41467-020-17409-9","article-title":"Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice","volume":"11","author":"McKay","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0560","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3390\/pharmaceutics12050441","article-title":"MERS-CoV spike protein vaccine and inactivated influenza vaccine formulated with single strand RNA adjuvant induce T-cell activation through intranasal immunization in mice","volume":"12","author":"Kim","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0565","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3390\/vaccines8020251","article-title":"The potency of an anti-MERS coronavirus subunit vaccine depends on a unique combinatorial adjuvant formulation","volume":"8","author":"George","year":"2020","journal-title":"Vaccines"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0570","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41541-018-0089-x","article-title":"Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want","volume":"3","author":"HogenEsch","year":"2018","journal-title":"npj Vaccines"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0575","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1089\/vim.2007.0079","article-title":"Effects of different immunization protocols and adjuvant on antibody responses to inactivated SARS-CoV vaccine","volume":"21","author":"Gai","year":"2008","journal-title":"Viral Immunol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0580","doi-asserted-by":"crossref","first-page":"6678","DOI":"10.1016\/j.vaccine.2008.09.006","article-title":"A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus","volume":"26","author":"Schulze","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0585","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/imm.12462","article-title":"Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus","volume":"145","author":"Guo","year":"2015","journal-title":"Immunology"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0590","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1080\/21645515.2015.1021527","article-title":"Optimization of antigen dose for a receptor-binding domain-based subunit vaccine against MERS coronavirus","volume":"11","author":"Tang","year":"2015","journal-title":"Human Vaccines Immunother."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0595","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1348-0421.2012.00467.x","article-title":"Calreticulin as a hydrophilic chimeric molecular adjuvant enhances IgG responses to the spike protein of severe acute respiratory syndrome coronavirus","volume":"56","author":"Qiu","year":"2012","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0600","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.virol.2005.11.042","article-title":"SARS coronavirus nucleocapsid immunodominant T-cell epitope cluster is common to both exogenous recombinant and endogenous DNA-encoded immunogens","volume":"347","author":"Gupta","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0605","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1089\/vim.2010.0028","article-title":"Immunogenicity and protective efficacy in mice and hamsters of a beta-Propiolactone inactivated whole virus SARS-CoV vaccine","volume":"23","author":"Roberts","year":"2010","journal-title":"Viral Immunol."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0610","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.virol.2005.06.016","article-title":"Long-term protection from SARS coronavirus infection conferred by a single immunization with an attenuated VSV-based vaccine","volume":"340","author":"Kapadia","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0615","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1126\/science.aaz5143","article-title":"Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses","volume":"368","author":"Wu","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0620","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.addr.2016.02.010","article-title":"Role of nanotechnology in HIV\/AIDS vaccine development","volume":"103","author":"Liu","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0625","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.1002\/smll.201401707","article-title":"Functional nanomaterials can optimize the efficacy of vaccines","volume":"10","author":"Liu","year":"2014","journal-title":"Small"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0630","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1126\/science.abc6284","article-title":"DNA vaccine protection against SARS-CoV-2 in rhesus macaques","volume":"369","author":"Yu","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0635","article-title":"Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2","author":"Williamson","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0640","author":"World Health Organization"},{"key":"10.1016\/j.jinorgbio.2021.111454_bb0645","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1126\/science.abb8923","article-title":"Rapid COVID-19 vaccine development","volume":"368","author":"Graham","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jinorgbio.2021.111454_bib646","doi-asserted-by":"crossref","first-page":"101139","DOI":"10.1016\/j.nantod.2021.101139","article-title":"Engineering a self-navigated MnARK nanovaccine for inducing potent protective immunity against novel coronavirus","volume":"38","author":"Wang","year":"2021","journal-title":"Nano Today"}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016201342100101X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016201342100101X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:04:44Z","timestamp":1758985484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016201342100101X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":130,"alternative-id":["S016201342100101X"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2021.111454","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and application of nanoparticles as vaccine adjuvants against human corona virus infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2021.111454","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111454"}}