{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T17:35:16Z","timestamp":1788716116926,"version":"build-2803163510"},"reference-count":126,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jinorgbio.2021.111691","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T11:23:09Z","timestamp":1639048989000},"page":"111691","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Zinc ionophores: chemistry and biological applications"],"prefix":"10.1016","volume":"228","author":[{"given":"Simone","family":"Scavo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-4790","authenticated-orcid":false,"given":"Valentina","family":"Oliveri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2021.111691_bb0005","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1039\/b004816j","article-title":"The bioinorganic chemistry of zinc: synthetic analoguesof zinc enzymes that feature tripodal ligands","author":"Parkin","year":"2000","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0010","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1021\/acs.biochem.6b00216","article-title":"Labile Low-Molecular-Mass Metal Complexes in Mitochondria: Trials and Tribulations of a Burgeoning Field","volume":"55","author":"Lindahl","year":"2016","journal-title":"Biochemistry."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0015","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/0955-2863(93)90052-X","article-title":"Physiological roles of zinc in the plasma membrane of mammalian cells","volume":"4","author":"Bettger","year":"1993","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0020","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1126\/science.1060331","article-title":"Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis","volume":"292","author":"Outten","year":"2001","journal-title":"Science (80-. )"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0025","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/jn\/130.5.1437S","article-title":"Function and mechanism of zinc metalloenzymes","volume":"130","author":"McCall","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.abb.2016.04.010","article-title":"The biological inorganic chemistry of zinc ions","volume":"611","author":"Kr\u0119\u017cel","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0035","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1021\/cr800556u","article-title":"Coordination dynamics of zinc in proteins","volume":"109","author":"Maret","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0040","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00775-011-0797-4","article-title":"Zinc homeostasis and signaling in health and diseases","volume":"16","author":"Fukada","year":"2011","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0045","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s12576-017-0521-4","article-title":"Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis","volume":"67","author":"Hara","year":"2017","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0050","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9365747","article-title":"Function, structure, and transport aspects of ZIP and ZnT Zinc transporters in immune cells","volume":"2018","author":"Bin","year":"2018","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0055","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s10534-011-9451-4","article-title":"Transition metal homeostasis: From yeast to human disease","volume":"24","author":"Bleackley","year":"2011","journal-title":"BioMetals."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0060","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.bbamcr.2006.03.005","article-title":"Zinc transporters and the cellular trafficking of zinc","volume":"1763","author":"Eide","year":"2006","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0065","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0005-2736(03)00048-8","article-title":"The LZT proteins; The LIV-1 subfamily of zinc transporters","volume":"1611","author":"Taylor","year":"2003","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0070","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3945\/an.112.003210","article-title":"Discovery of human zinc deficiency: Its impact on human health and disease","volume":"4","author":"Prasad","year":"2013","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0075","first-page":"1","article-title":"The emerging role of zinc transporters in cellular homeostasis and cancer","volume":"2","author":"Bafaro","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0080","first-page":"389","article-title":"Zinc and human disease","volume":"13","author":"Maret","year":"2013","journal-title":"Met. Ions Life Sci."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0085","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s12640-009-9085-2","article-title":"Endogenous zinc mediates apoptotic programmed cell death in the developing brain","volume":"17","author":"Cho","year":"2010","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0090","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/03602532.2012.725414","article-title":"Metallothioneins and zinc in cancer diagnosis and therapy","volume":"44","author":"Krizkova","year":"2012","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0095","doi-asserted-by":"crossref","first-page":"19439","DOI":"10.1074\/jbc.C000165200","article-title":"Evidence that the \u03b2-amyloid plaques of Alzheimer\u2019s disease represent the redox-silencing and entombment of A\u03b2 by zinc","volume":"275","author":"Cuajungco","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0100","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1002\/1097-0142(19810401)47:7<1845::AID-CNCR2820470721>3.0.CO;2-B","article-title":"Serum zinc levels in lung cancer patients","volume":"47","author":"Issell","year":"1981","journal-title":"Cancer."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1479-5876-8-118","article-title":"Zinc in innate and adaptive tumor immunity","volume":"8","author":"John","year":"2010","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-015-0486-y","article-title":"Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer","volume":"15","author":"Chandler","year":"2016","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0115","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrurol.2013.43","article-title":"Zinc and zinc transporters in prostate carcinogenesis","volume":"10","author":"Kolenko","year":"2013","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0120","author":"Fashner"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0125","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1542\/peds.109.5.898","article-title":"Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children","volume":"109","author":"Strand","year":"2002","journal-title":"Pediatrics."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0130","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1053\/j.gastro.2006.02.062","article-title":"Zinc in the Treatment of Acute Diarrhea: Current Status and Assessment","volume":"130","author":"Hoque","year":"2006","journal-title":"Gastroenterology."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0135","series-title":"Wilson Dis.","first-page":"203","article-title":"Zinc therapy of wilson disease","author":"Houwen","year":"2019"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0140","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.ica.2003.09.014","article-title":"Zn-polyphenol chelation: Complexes with quercetin, (+)-catechin, and derivatives: I optical and NMR studies","volume":"357","author":"Le Nest","year":"2004","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0145","series-title":"Rationale for the Mechanism of Zinc Interaction in the Immune System, in: Nutr","first-page":"501","author":"Dardenne","year":"2020"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0150","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.3390\/nu9121286","article-title":"Zinc as a gatekeeper of immune function","volume":"9","author":"Wessels","year":"2017","journal-title":"Nutrients."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0155","doi-asserted-by":"crossref","first-page":"213474","DOI":"10.1016\/j.ccr.2020.213474","article-title":"Biomedical applications of copper ionophores","volume":"422","author":"Oliveri","year":"2020","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0160","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1039\/c2dt12188c","article-title":"Chelation therapy in Wilson\u2019s disease: From d-penicillamine to the design of selective bioinspired intracellular Cu(i) chelators","volume":"41","author":"Delangle","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0165","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ccr.2011.06.013","article-title":"Chelating agents for human diseases related to aluminium overload","volume":"256","author":"Crisponi","year":"2012","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0170","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.2174\/0929867321666140601161939","article-title":"Copper Chelators: Chemical Properties and Bio-medical Applications","volume":"21","author":"Tegoni","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0175","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0009-2797(99)00166-0","article-title":"Apoptosis induced by chelation of intracellular zinc is associated with depletion of cellular reduced glutathione level in rat hepatocytes","volume":"125","author":"Nakatani","year":"2000","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0180","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1039\/C9CS00373H","article-title":"Transition metal chelators, pro-chelators, and ionophores as small molecule cancer chemotherapeutic agents","volume":"49","author":"Steinbrueck","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0185","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: A free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0190","doi-asserted-by":"crossref","first-page":"9.12.1","DOI":"10.1002\/0471141755.ph0912s49","article-title":"Overview on the rule of five","volume":"49","author":"Pollastri","year":"2010","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0195","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.2174\/138955712802762095","article-title":"Metal-dithiocarbamate complexes: chemistry and biological activity","volume":"12","author":"Hogarth","year":"2012","journal-title":"Mini-Reviews Med. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0200","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1046\/j.1471-4159.1999.721586.x","article-title":"Pyrrolidine Dithiocarbamate Induces Bovine Cerebral Endothelial Cell Death by Increasing the Intracellular Zinc Level","volume":"72","author":"Kim","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0205","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0014-5793(99)00390-7","article-title":"Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-\u03baB activation","volume":"449","author":"Kim","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0210","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.1021\/acs.jmedchem.6b00238","article-title":"Zinc(II)-Thiosemicarbazone Complexes Are Localized to the Lysosomal Compartment Where They Transmetallate with Copper Ions to Induce Cytotoxicity","volume":"59","author":"Stacy","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0215","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/ejic.201601120","article-title":"Structures of the Copper and Zinc Complexes of PBT2, a Chelating Agent Evaluated as Potential Drug for Neurodegenerative Diseases","volume":"2017","author":"Nguyen","year":"2017","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0220","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ejmech.2016.05.007","article-title":"8-Hydroxyquinolines in medicinal chemistry: A structural perspective","volume":"120","author":"Oliveri","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0225","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.canlet.2008.06.011","article-title":"Zinc-binding compounds induce cancer cell death via distinct modes of action","volume":"271","author":"Ding","year":"2008","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0230","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jinorgbio.2010.08.014","article-title":"Hydroxyquinoline based binders: Promising ligands for chelatotherapy?","volume":"105","author":"Budimir","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0235","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jinorgbio.2013.09.016","article-title":"Complex forming competition and in-vitro toxicity studies on the applicability of di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone (Dp44mT) as a metal chelator","volume":"130","author":"Ga\u00e1l","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0240","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0304-4203(85)90017-9","article-title":"Determination of the Zinc Complexing Capacity in Seawater by Cathodic Stripping Voltammetry of Zinc - APDC Complex Ions","volume":"16","author":"Van den Berg","year":"1985","journal-title":"Mar. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0245","first-page":"500","article-title":"The influence of chemical constitution on antibacterial activity. VIII. 2-Mercaptopyridine-N-oxide, and some general observations on metalbinding agents","volume":"37","author":"Albert","year":"1956","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0250","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1080\/00958972.2019.1638510","article-title":"Synthesis, characterization and antioxidant activity of EGCG complexes with copper and zinc ions","volume":"72","author":"Alhafez","year":"2019","journal-title":"J. Coord. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0255","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/hlca.19770600115","article-title":"Pyridinderivate als Komplexbildner. XI. Die Thermodynamik der Metallkomplexbildung mit Bis-, Tris- und Tetrakis[(2-pyridyl)methyl]-aminen","volume":"60","author":"Anderegg","year":"1977","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0260","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jinorgbio.2007.10.030","article-title":"Zinc binding ligands and cellular zinc trafficking: Apo-metallothionein, glutathione, TPEN, proteomic zinc, and Zn-Sp1","volume":"102","author":"Rana","year":"2008","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0265","series-title":"An Acrodermatitis Enteropathica-Associated Zn Transporter, ZIP4","author":"Bin","year":"2017"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0270","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/09546630600791434","article-title":"Zinc in skin pathology and care","volume":"17","author":"Nitzan","year":"2006","journal-title":"J. Dermatolog. Treat."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0275","series-title":"JIMD Rep","article-title":"A zinc sulphate-resistant acrodermatitis enteropathica patient with a novel mutation in SLC39A4 gene","author":"Kilic","year":"2012"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2006.01.006","article-title":"Zinc requirements and the risks and benefits of zinc supplementation","author":"Maret","year":"2006","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/0006-291X(79)91825-4","article-title":"The possible role of Diodoquin as a zinc ionophore in the treatment of acrodermatitis enteropathica","author":"Aggett","year":"1979","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0072543","article-title":"Clioquinol Synergistically Augments Rescue by Zinc Supplementation in a Mouse Model of Acrodermatitis Enteropathica","volume":"8","author":"Geiser","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0295","doi-asserted-by":"crossref","DOI":"10.3390\/nu11010206","article-title":"Zn-DTSM, a zinc ionophore with therapeutic potential for acrodermatitis enteropathica?","volume":"11","author":"Bray","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0300","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s12275-009-0049-2","article-title":"Potentiation of bacterial killing activity of zinc chloride by pyrrolidine dithiocarbamate","volume":"48","author":"Choi","year":"2010","journal-title":"J. Microbiol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0305","doi-asserted-by":"crossref","DOI":"10.1590\/1678-7757-2017-0161","article-title":"Two mechanisms of oral malodor inhibition by zinc ions","volume":"26","author":"Suzuki","year":"2018","journal-title":"J. Appl. Oral Sci."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0310","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1128\/AAC.00129-14","article-title":"Inhibition of aminoglycoside 6\u2032-N-acetyltransferase type Ib by zinc: Reversal of amikacin resistance in Acinetobacter baumannii and Escherichia coli by a zinc ionophore","volume":"58","author":"Lin","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0315","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1128\/AAC.01106-15","article-title":"Inhibition of aminoglycoside 6\u2032-N-acetyltransferase type Ib-mediated amikacin resistance in Klebsiella pneumoniae by zinc and copper pyrithione","volume":"59","author":"Chiem","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0320","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3389\/fcimb.2018.00410","article-title":"Zinc Blockade of SOS Response Inhibits Horizontal Transfer of Antibiotic Resistance Genes in Enteric Bacteria","volume":"8","author":"Crane","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0325","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ijantimicag.2017.08.002","article-title":"Inhibition of aminoglycoside 6\u2032-N-acetyltransferase type Ib-mediated amikacin resistance by zinc complexed with clioquinol, an ionophore active against tumors and neurodegenerative diseases","volume":"51","author":"Chiem","year":"2018","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0330","first-page":"1","article-title":"Restoration of susceptibility to amikacin by 8-hydroxyquinoline analogs complexed to zinc","author":"Magall\u00f3n","year":"2019","journal-title":"BioRxiv."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0335","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02391-18","article-title":"Chemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance","volume":"9","author":"Bohlmann","year":"2018","journal-title":"MBio"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mSphere.00157-20","article-title":"Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2","volume":"5","author":"Harbison-Price","year":"2020","journal-title":"MSphere."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0345","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1021\/acsinfecdis.9b00307","article-title":"Neisseria gonorrhoeae Becomes Susceptible to Polymyxin B and Colistin in the Presence of PBT2","volume":"6","author":"Jen","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0350","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1021\/acsinfecdis.0c00887","article-title":"Disruption of Metallostasis in the Anaerobic Human Pathogen Fusobacterium nucleatum by the Zinc Ionophore PBT2","volume":"7","author":"Van Zuylen","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0355","doi-asserted-by":"crossref","first-page":"127110","DOI":"10.1016\/j.bmcl.2020.127110","article-title":"Substituted sulfonamide bioisosteres of 8-hydroxyquinoline as zinc-dependent antibacterial compounds","volume":"30","author":"McGowan","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0360","doi-asserted-by":"crossref","first-page":"115837","DOI":"10.1016\/j.bmc.2020.115837","article-title":"C-2 derivatized 8-sulfonamidoquinolines as antibacterial compounds","volume":"29","author":"Davison","year":"2021","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1001176","article-title":"Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture","volume":"6","author":"te Velthuis","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0370","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/advances\/nmz013","article-title":"The Role of Zinc in Antiviral Immunity","volume":"10","author":"Read","year":"2019","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0375","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0166-3542(02)00109-2","article-title":"Effect of antioxidants on apoptosis induced by influenza virus infection: Inhibition of viral gene replication and transcription with pyrrolidine dithiocarbamate","volume":"56","author":"Uchide","year":"2002","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0380","doi-asserted-by":"crossref","first-page":"6004","DOI":"10.1128\/JVI.76.12.6004-6015.2002","article-title":"Antiviral Effects of Pyrrolidine Dithiocarbamate on Human Rhinoviruses","volume":"76","author":"Gaudernak","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0385","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1099\/vir.0.82634-0","article-title":"PDTC inhibits picornavirus polyprotein processing and RNA replication by transporting zinc ions into cells","volume":"88","author":"Lanke","year":"2007","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0390","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1128\/JVI.01543-08","article-title":"Antiviral Activity of the Zinc Ionophores Pyrithione and Hinokitiol against Picornavirus Infections","volume":"83","author":"Krenn","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0395","doi-asserted-by":"crossref","first-page":"8675","DOI":"10.1128\/JVI.00869-13","article-title":"Pyrrolidine Dithiocarbamate Inhibits Herpes Simplex Virus 1 and 2 Replication, and Its Activity May Be Mediated through Dysregulation of the Ubiquitin-Proteasome System","volume":"87","author":"Qiu","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0400","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.antiviral.2013.07.001","article-title":"Zinc ionophores pyrithione inhibits herpes simplex virus replication through interfering with proteasome function and NF-\u03baB activation","volume":"100","author":"Qiu","year":"2013","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0405","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1111\/bcp.14826","article-title":"Zinc supplementation as an adjunct therapy for COVID-19: Challenges and opportunities","volume":"87","author":"Chinni","year":"2021","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0410","first-page":"129801","article-title":"Can food and food supplements be deployed in the fight against the COVID 19 pandemic?","volume":"2021","author":"Celik","year":"1865","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0415","series-title":"Zinc ( II )\u2014 The Overlooked \u00c9 minence Grise of Chloroquine \u2019 s Fight against COVID-19\u00a0?","first-page":"1","author":"Hecel","year":"2020"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0420","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1007\/s12011-020-02194-9","article-title":"Can Zn Be a Critical Element in COVID-19 Treatment?","volume":"199","author":"Rahman","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0425","first-page":"17","article-title":"Zinc and respiratory tract infections: Perspectives for CoviD\u201919 (Review)","volume":"46","author":"Skalny","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0430","doi-asserted-by":"crossref","first-page":"10083","DOI":"10.1039\/D1CC03563K","article-title":"Zinc 2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro","volume":"57","author":"Love Panchariya","year":"2021","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0435","doi-asserted-by":"crossref","first-page":"10349","DOI":"10.1021\/bi0504761","article-title":"Papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV): Expression, purification, characterization, and inhibition","volume":"44","author":"Han","year":"2005","journal-title":"Biochemistry."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2020.104742","article-title":"The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade","volume":"176","author":"Coutard","year":"2020","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0445","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/jmv.26523","article-title":"Potential interventions for SARS-CoV-2 infections: Zinc showing promise","volume":"93","author":"Brewer","year":"2021","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0450","doi-asserted-by":"crossref","first-page":"110333","DOI":"10.1016\/j.mehy.2020.110333","article-title":"A possible application of hinokitiol as a natural zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and viral infections","volume":"145","author":"Hoang","year":"2020","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0455","first-page":"192","article-title":"Improving the efficacy of chloroquine and hydroxychloroquine against SARS-CoV-2 may require zinc additives-A better synergy for future COVID-19 clinical trials","volume":"28","author":"Shittu","year":"2020","journal-title":"Infez. Med."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0460","doi-asserted-by":"crossref","first-page":"105938","DOI":"10.1016\/j.ijantimicag.2020.105938","article-title":"New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?","volume":"55","author":"Devaux","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0465","doi-asserted-by":"crossref","first-page":"105949","DOI":"10.1016\/j.ijantimicag.2020.105949","article-title":"Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial","volume":"56","author":"Gautret","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0470","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1111\/bph.15199","article-title":"Targeting zinc metalloenzymes in coronavirus disease 2019","volume":"177","author":"Doboszewska","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0475","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1099\/jmm.0.001250","article-title":"Zinc sulfate in combination with a zinc ionophore may improve outcomes in hospitalized COVID-19 patients","volume":"69","author":"Carlucci","year":"2020","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0480","doi-asserted-by":"crossref","first-page":"109815","DOI":"10.1016\/j.mehy.2020.109815","article-title":"Does zinc supplementation enhance the clinical efficacy of chloroquine\/hydroxychloroquine to win todays battle against COVID-19?","volume":"142","author":"Derwand","year":"2020","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0485","doi-asserted-by":"crossref","first-page":"110273","DOI":"10.1016\/j.mehy.2020.110273","article-title":"Biophysical mechanism for zinc as an anticancer agent","volume":"144","author":"John Gagliardi","year":"2020","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0490","first-page":"824","article-title":"Anti-tumour activity of zinc ionophore pyrithione in human ovarian cancer cells through inhibition of proliferation and migration and promotion of lysosome-mitochondrial apoptosis, Artif. Cells, Nanomedicine","volume":"48","author":"Chen","year":"2020","journal-title":"Biotechnol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0495","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1111\/php.12794","article-title":"A Topical Zinc Ionophore Blocks Tumorigenic Progression in UV-exposed SKH-1 High-risk Mouse Skin","volume":"93","author":"Justiniano","year":"2017","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0500","doi-asserted-by":"crossref","first-page":"12598","DOI":"10.1039\/C6CC06467A","article-title":"Embedding magnetic nanoparticles into coordination polymers to mimic zinc ion transporters for targeted tumor therapy","volume":"52","author":"Ju","year":"2016","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0505","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.bbamcr.2011.09.013","article-title":"Zinc pyrithione induces ERK- and PKC-dependent necrosis distinct from TPEN-induced apoptosis in prostate cancer cells","volume":"1823","author":"Carraway","year":"2012","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0510","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.1158\/0008-5472.CAN-08-0601","article-title":"Synthesis and anticancer properties of water-soluble zinc ionophores","volume":"68","author":"Magda","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0515","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1097\/JTO.0b013e3182208fac","article-title":"The zinc ionophore PCI-5002 radiosensitizes non-small cell lung cancer cells by enhancing autophagic cell death","volume":"6","author":"Kim","year":"2011","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0520","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s13566-013-0111-x","article-title":"Concurrent whole brain radiotherapy and short-course chloroquine in patients with brain metastases: A pilot trial","volume":"2","author":"Eldredge","year":"2013","journal-title":"J. Radiat. Oncol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0525","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.4161\/auto.24921","article-title":"Dual inhibition of autophagy and the AKT pathway in prostate cancer","volume":"9","author":"Lamoureux","year":"2013","journal-title":"Autophagy."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0530","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0109180","article-title":"Chloroquine is a zinc ionophore","volume":"9","author":"Xue","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0535","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1158\/0008-5472.CAN-04-3577","article-title":"Anticancer activity of the antibiotic clioquinol","volume":"65","author":"Ding","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0540","doi-asserted-by":"crossref","first-page":"1","DOI":"10.23937\/2378-3419\/3\/1\/1037","article-title":"Zinc ionophore Clioquinol inhibition of hZIP1 deficient Prostate tumor Growth in the Mouse","volume":"3","author":"Franklin","year":"2016","journal-title":"Int J Cancer Clin Res."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0545","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1042\/BJ20081421","article-title":"Clioquinol targets zinc to lysosomes in human cancer cells","volume":"417","author":"Yu","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0550","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.nbd.2011.01.009","article-title":"Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore","volume":"42","author":"Park","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0555","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.ccr.2012.03.042","article-title":"Allele-Specific p53 Mutant Reactivation","volume":"21","author":"Yu","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0560","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.2432","article-title":"Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism","author":"Yu","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0565","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1124\/mol.115.097550err","article-title":"Erratum: Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore (Molecular Pharmacology (2015) 87 (825-831))","volume":"88","author":"Blanden","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0570","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.drudis.2015.07.006","article-title":"Reactivating mutant p53 using small molecules as zinc metallochaperones: Awakening a sleeping giant in cancer","volume":"20","author":"Blanden","year":"2015","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0575","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1021\/bi062106y","article-title":"Zn2+\u2212dependent misfolding of the p53 DNA binding domain","volume":"46","author":"Butler","year":"2007","journal-title":"Biochemistry."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0580","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10060166","article-title":"Zinc metallochaperones as Mutant p53 reactivators: A new paradigm in cancer therapeutics","volume":"10","author":"Kogan","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0585","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.1158\/1078-0432.CCR-18-0822","article-title":"Zinc Metallochaperones Reactivate Mutant p53 Using an ON\/OFF Switch Mechanism: A New Paradigm in Cancer Therapeutics","volume":"24","author":"Yu","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0590","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10534-015-9905-1","article-title":"Improved cytotoxicity of pyridyl-substituted thiosemicarbazones against MCF-7 when used as metal ionophores","volume":"29","author":"Akladios","year":"2016","journal-title":"BioMetals."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0595","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1124\/mol.116.107409","article-title":"Thiosemicarbazones functioning as zinc metallochaperones to reactivate mutant p53","volume":"91","author":"Yu","year":"2017","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0600","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1021\/acs.jmedchem.0c01360","article-title":"Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53","volume":"64","author":"Gilleran","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0605","doi-asserted-by":"crossref","DOI":"10.1021\/acschembio.8b00977","article-title":"A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine A","author":"Vaden","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0610","doi-asserted-by":"crossref","first-page":"8085","DOI":"10.1021\/jf5014633","article-title":"Zinc ionophore activity of quercetin and epigallocatechin-gallate: From hepa 1-6 cells to a liposome model","volume":"62","author":"Dabbagh-Bazarbachi","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0615","first-page":"632","article-title":"Effect of resveratrol and zinc on intracellular zinc status in normal human prostate epithelial cells","volume":"297","author":"Zhang","year":"2009","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0620","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s12011-009-8362-5","article-title":"Mechanism of free Zn(2+) enhancing inhibitory effects of EGCG on the growth of pc-3 cells: Interactions with mitochondria","volume":"131","author":"Yang","year":"2009","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0625","article-title":"Molecular mechanisms of action of epigallocatechin gallate in cancer: Recent trends and advancement","author":"Aggarwal","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.jinorgbio.2021.111691_bb0630","doi-asserted-by":"crossref","first-page":"7369","DOI":"10.1039\/C7RA10997K","article-title":"Epigallocatechin gallate-zinc oxide co-crystalline nanoparticles as an anticancer drug that is non-toxic to normal cells","volume":"8","author":"Samutprasert","year":"2018","journal-title":"RSC Adv."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016201342100338X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016201342100338X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:04:40Z","timestamp":1758985480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016201342100338X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":126,"alternative-id":["S016201342100338X"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2021.111691","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc ionophores: chemistry and biological applications","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2021.111691","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111691"}}