{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:55:42Z","timestamp":1785214542257,"version":"3.55.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21877018"],"award-info":[{"award-number":["21877018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jinorgbio.2021.111706","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T11:13:20Z","timestamp":1641381200000},"page":"111706","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Iridium(III) complexes entrapped in liposomes trigger mitochondria-mediated apoptosis and GSDME-mediated pyroptosis"],"prefix":"10.1016","volume":"228","author":[{"given":"Huiwen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanling","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2021.111706_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116401","article-title":"Cyclodextrin as a magic switch in covalent and non-covalent anticancer drug release systems","volume":"242","author":"Tian","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0010","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bcp.2018.02.023","article-title":"Lanatoside C inhibits cell proliferation and induces apoptosis through attenuating Wnt\/\u03b2-catenin\/c-Myc signaling pathway in human gastric cancer cell","volume":"150","author":"Hu","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0015","first-page":"1764","article-title":"Bioactive iridium and rhodium complexes as therapeutic agents, Coordin","volume":"257","author":"Leung","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0020","doi-asserted-by":"crossref","first-page":"23482","DOI":"10.1039\/C9NR07015J","article-title":"Novel synthesis of platinum complexes and their intracellular delivery to tumor cells by means of magnetic nanoparticles","volume":"11","author":"Quarta","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0025","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1021\/jm901556u","article-title":"Cytotoxicity, hydrophobicity, uptake, and distribution of osmium(II) anticancer complexes in ovarian cancer cells","volume":"53","author":"van Rijt","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0030","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1021\/acs.inorgchem.7b02747","article-title":"Photoactivated in vitro anticancer activity of rhenium(I) tricarbonyl complexes bearing water-soluble phosphines","volume":"57","author":"Marker","year":"2018","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0035","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s12039-018-1492-6","article-title":"Cyclometallated imidazo-phenanthroline iridium complexes and their anticancer activity","volume":"130","author":"Garg","year":"2018","journal-title":"J. Chem. Sci."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0040","first-page":"2589","article-title":"Novel iridium (III)-derived organometallic compound for the inhibition of human platelet activation","volume":"41","author":"Shyu","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0045","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jinorgbio.2017.04.028","article-title":"Design, synthesis and evaluation of anticancer activity of ruthenium (II) polypyridyl complexes","volume":"173","author":"Tang","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0050","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jinorgbio.2016.01.003","article-title":"Synthesis, characterization, in vitro cytotoxicity and anticancer effects of ruthenium(II) complexes on BEL-7402 cells","volume":"157","author":"Zang","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0055","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1039\/C9QI01492F","article-title":"Novel cyclometalated iridium(iii) phosphine-imine (P^N) complexes: highly efficient anticancer and anti-lung metastasis agents in vivo","volume":"7","author":"Xu","year":"2020","journal-title":"Inorg. Chem. Front."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0060","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.dyepig.2018.10.019","article-title":"Bichromophoric anticancer drug: targeting lysosome with rhodamine modified cyclometalated iridium(III) complexes","volume":"162","author":"Ma","year":"2019","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2021.111465","article-title":"Evaluation of anticancer effects in vitro of new iridium(III) complexes targeting the mitochondria","volume":"221","author":"Hao","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2021.111580","article-title":"DNA-binding and evaluation of anticancer activity in vitro and in vivo of iridium(III) polypyridyl complexes","volume":"224","author":"Zhang","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105290","article-title":"Anticancer effect evaluation in vitro and in vivo of iridium(III) polypyridyl complexes targeting DNA and mitochondria","volume":"115","author":"Zhang","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0080","first-page":"1993","article-title":"Highly fluorescent and biocompatible iridium nanoclusters for cellular imaging","volume":"24","author":"Vankayala","year":"2013","journal-title":"J. Mater. Sci: Mater. M."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0085","doi-asserted-by":"crossref","first-page":"8094","DOI":"10.1002\/anie.201503067","article-title":"Tracking cancer metastasis in vivo by using an iridium-based hypoxia-activated optical oxygen nanosensor","volume":"54","author":"Zheng","year":"2015","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0090","doi-asserted-by":"crossref","first-page":"26830","DOI":"10.1021\/acsami.8b10842","article-title":"Reaching biocompatibility with nanoclays: eliminating the cytotoxicity of Ir(III) complexes","volume":"32","author":"Gr\u00fcner","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0095","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ejmech.2019.06.009","article-title":"Studies of anticancer activity in vitro and in vivo of iridium(III) polypyridyl complexes-loaded liposomes as drug delivery system","volume":"178","author":"Zhang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0100","article-title":"Improving plasma stability and antitumor effect of gemcitabine via PEGylated liposome prepared by active drug loading","volume":"57","author":"Ding","year":"2020","journal-title":"J. Drug Deliv. Sci. Tec."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0105","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbrc.2020.09.014","article-title":"Liposome-encapsulated peptide PDBSN ameliorates high-fat-dietinduced obesity and improves metabolism homeostasis","volume":"533","author":"Shen","year":"2020","journal-title":"Biochem. Bioph. Res. Co."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0110","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.3390\/nano9111575","article-title":"Tumor targeting by monoclonal antibody functionalized magnetic nanoparticles","volume":"9","author":"Oltolina","year":"2019","journal-title":"Nanomaterials (Basel)"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0115","doi-asserted-by":"crossref","first-page":"36219","DOI":"10.1039\/D0RA07325C","article-title":"Grafting of anti-nucleolin aptamer into preformed and remotely loaded liposomes through aptamer-cholesterol post-insertion","volume":"10","author":"Nsairat","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0120","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.tibtech.2014.06.010","article-title":"Mechanisms of cooperation in cancer nanomedicine: towards systems nanotechnology","volume":"32","author":"Hauert","year":"2014","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0125","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1021\/acs.nanolett.7b00132","article-title":"A liposome encapsulated ruthenium polypyridine complex as a theranostic platform for triple-negative breast cancer","volume":"17","author":"Shen","year":"2017","journal-title":"Nano Lett."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0130","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1021\/acsnano.0c02197","article-title":"Supramolecular aggregation-induced emission nanodots with programmed tumor microenvironment responsiveness for image-guided orthotopic pancreatic cancer therapy","volume":"14","author":"Chen","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0135","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1021\/acs.jmedchem.6b01846","article-title":"Design, synthesis, and biological evaluation of mitochondria-targeted flavone-naphthalimide-polyamine conjugates with antimetastatic activity","volume":"60","author":"Dai","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0140","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1158\/0008-5472.CAN-15-2534","article-title":"Mitochondria-targeted analogues of metformin exhibit enhanced antiproliferative and radiosensitizing effects in pancreatic cancer cells","volume":"13","author":"Cheng","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0145","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0005-2728(98)00110-8","article-title":"Mitochondria as regulators of apoptosis: doubt no more","volume":"1366","author":"Susin","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0150","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41420-020-00349-0","article-title":"The caspase-3\/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer","volume":"6","author":"Jiang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0155","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1246\/bcsj.65.1006","article-title":"Synthesis and properties of diamino-substituted dipyrido [3,2-a: 2\u2032,3\u2032-c]phenazine","volume":"65","author":"Yamada","year":"1998","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0160","doi-asserted-by":"crossref","first-page":"6647","DOI":"10.1021\/ja00334a031","article-title":"Photophysical effects of metal-carbon bonds in ortho-metalated complexes of Ir(III) and Rh(III)","volume":"106","author":"Sprouse","year":"1985","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0165","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1016\/j.bmc.2004.06.038","article-title":"Synthesis, acute toxicities, and antitumor effects of novel 9-substituted \u03b2-carboline derivatives","volume":"12","author":"Cao","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0170","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00217-007-0706-9","article-title":"Preparation of salidroside nano-liposomes by ethanol injection method and in vitro release study","volume":"227","author":"Fan","year":"2008","journal-title":"Eur. Food Res. Technol."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2019.09.018","article-title":"Recent advances on thermosensitive and pH-sensitive liposomes employed in controlled release","volume":"315","author":"Aghdam","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0180","doi-asserted-by":"crossref","first-page":"12649","DOI":"10.1016\/j.molliq.2020.112649","article-title":"PEGylated liposomes as an emerging therapeutic platform for oral nanomedicine in cancer therapy: in vitro and in vivo assessment","volume":"303","author":"Singh","year":"2020","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0185","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.2147\/IJN.S170035","article-title":"Iridium (III) complex-loaded liposomes as a drug delivery system for lung cancer through mitochondrial dysfunction","volume":"13","author":"Liao","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0190","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1208\/s12249-010-9487-8","article-title":"Optimization of PEGylation conditions for BSA nanoparticles using response surface methodology","volume":"11","author":"Kouchakzadeh","year":"2010","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0195","series-title":"Modern Pharmacology","first-page":"21","author":"Craig","year":"1990"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0200","first-page":"25","article-title":"The pKa distribution of drugs: application to drug discovery, Perspect","volume":"1","author":"Manallack","year":"2007","journal-title":"Med. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2020.111014","article-title":"Liposomes encapsulated iridium(III) polypyridyl complexes enhance anticancer activity in vitro and in vivo","volume":"205","author":"Bai","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0215","doi-asserted-by":"crossref","first-page":"11712","DOI":"10.1021\/acsomega.9b01022","article-title":"Design, synthesis, DNA\/HSA binding, and cytotoxic activity of half-sandwich Ru(II)-arene complexes containing triarylamine-thiosemicarbazone hybrids","volume":"4","author":"Muralisankar","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2019.110909","article-title":"Identification of two mitochondrial-targeting cyclometalated iridium(III) complexes as potent anti-glioma stem cells agents","volume":"203","author":"Peng","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0225","doi-asserted-by":"crossref","first-page":"9934","DOI":"10.1039\/C8DT01858H","article-title":"Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium","volume":"47","author":"Konkankit","year":"2018","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2020.105732","article-title":"ROS enhances the cytotoxicity of cisplatin by inducing apoptosis and autophagy in tongue squamous cell carcinoma cells","volume":"122","author":"Xue","year":"2020","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0235","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/725370","article-title":"Inflammation, iron, energy failure, and oxidative stress in the pathogenesis of multiple sclerosis","volume":"2015","author":"Haider","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0240","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3390\/ijms19010217","article-title":"Endothelial Ca2+ signaling and the resistance to anticancer treatments: partners in crime","volume":"19","author":"Moccia","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0245","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0300-9084(02)01375-5","article-title":"The permeability transition pore complex: another view","volume":"84","author":"Halestrap","year":"2002","journal-title":"Biochimie."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0250","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/j.2040-4603.2017.tb00748.x","article-title":"Calcium transport and signaling in mitochondria","volume":"7","author":"Sagua","year":"2017","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0255","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0260","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.inoche.2018.06.011","article-title":"A phosphorescent cyclometalated iridium(III) complex as mitochondriatargeted theranostic anticancer agent","volume":"94","author":"Xiao","year":"2018","journal-title":"Inorg. Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0265","article-title":"Cytochrome c light-up graphene oxide nanosensor for the targeted self-monitoring of mitochondria-mediated tumor cell death","volume":"173","author":"Han","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0270","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/CAD.0000000000000340","article-title":"Role of p38 MAPK activation and mitochondrial cytochrome-c release in allicin-induced apoptosis in SK-N-SH cells","volume":"27","author":"Zhuang","year":"2016","journal-title":"Anti-Cancer Drugs"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0275","article-title":"Antiproliferative and antiinflammatory coxib-combretastatin hybrids suppress cell cycle progression and induce apoptosis of MCF7 breast cancer cells","volume":"30","author":"Ngo","year":"2020","journal-title":"Mol. Divers."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0280","doi-asserted-by":"crossref","first-page":"15240","DOI":"10.1021\/acsomega.9b01863","article-title":"Theranostic lysosomal targeting anticancer and antimetastatic agents: half-sandwich iridium(III) rhodamine complexes","volume":"4","author":"Ma","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0285","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.apsb.2020.06.015","article-title":"Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis","volume":"10","author":"Zhang","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0290","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1080\/15384101.2020.1743911","article-title":"Metformin activates AMPK\/SIRT1\/NF-\u03baB pathway and induces mitochondrial dysfunction to drive caspase3\/GSDME-mediated cancer cell pyroptosis","volume":"19","author":"Zheng","year":"2020","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112446","article-title":"Single and dual target inhibitors based on Bcl-2: promising anti-tumor agents for cancer therapy","volume":"201","author":"Liu","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0300","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/S0028-3908(02)00032-1","article-title":"CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat","volume":"42","author":"Krupinski","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0305","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41419-019-1441-4","article-title":"Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells","volume":"10","author":"Yu","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0310","doi-asserted-by":"crossref","first-page":"14128","DOI":"10.1038\/ncomms14128","article-title":"Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic\/pyroptotic cell death","volume":"8","author":"Rogers","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jinorgbio.2021.111706_bb0315","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a Gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013421003536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013421003536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:05:57Z","timestamp":1758985557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013421003536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":63,"alternative-id":["S0162013421003536"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2021.111706","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iridium(III) complexes entrapped in liposomes trigger mitochondria-mediated apoptosis and GSDME-mediated pyroptosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2021.111706","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111706"}}