{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:00:03Z","timestamp":1790856003891,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jinorgbio.2022.111772","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T10:54:08Z","timestamp":1645786448000},"page":"111772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["DNA, a target of mixed chelate copper(II) compounds (Casiopeinas\u00ae) studied by electrophoresis, UV\u2013vis and circular dichroism techniques."],"prefix":"10.1016","volume":"231","author":[{"given":"Yeshenia","family":"Figueroa-DePaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Resendiz-Acevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Graciela","family":"D\u00e1vila-Manzanilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Garc\u00eda-Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Ortiz-Frade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Serment-Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Ruiz-Azuara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2022.111772_bb0005","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2174\/0929867003375317","article-title":"Molecular modeling and computer aided drug design. Examples of their applications in medicinal chemistry","volume":"7","author":"Ooms","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0010","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/minf.200900081","article-title":"Structure-based approaches to target fishing and ligand profiling","volume":"29","author":"Rognan","year":"2010","journal-title":"Mol. Inform."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0015","first-page":"180","article-title":"Avances en el dise\u00f1o de f\u00e1rmacos asistido por computadora","volume":"26","author":"Medina-Franco","year":"2015","journal-title":"Educ. Quim."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0020","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0305-7372(03)00116-6","article-title":"Gonz\u00e1lez Bar\u00f3n, classification of anticancer drugs - a new system based on therapeutic targets","volume":"29","author":"Espinosa","year":"2003","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-411636-8.00001-8","article-title":"Drug-DNA intercalation: from discovery to the molecular mechanism","author":"Mukherjee","year":"2013","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0030","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1021\/ed083p728","article-title":"Products of chemistry the discovery and development of cisplatin","volume":"83","author":"Alderden","year":"2006","journal-title":"J. Chem. Educ."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0035","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0009-2797(80)90122-2","article-title":"Kinetic analysis of the in vitro binding of radioactive cis- and trans-dichlorodiammineplatinum(II) to DNA","volume":"30","author":"Johnson","year":"1980","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0040","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1021\/cr980421n","article-title":"Structure, recognition, and processing of cisplatin-DNA adducts","volume":"99","author":"Jamieson","year":"1999","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0045","doi-asserted-by":"crossref","DOI":"10.1039\/C8CS00157J","article-title":"Molecular methods for assessment of non-covalent metallodrug\u2013DNA interactions","author":"Kellett","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0050","first-page":"809","article-title":"Transition metal complexes as drugs and chemotherapeutic agents","volume":"11","author":"Farrell","year":"1989","journal-title":"Met. Complex. Drugs Chemother. Agents"},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0055","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1155\/MBD.2001.19","article-title":"Knigth\u2019s move in the periodic table, from copper to platinum, novel antitumor mixed chelate copper compounds, casiopeinas, evaluated by an in vitro human and murine cancer cell line panel","volume":"8","author":"Gracia-Mora","year":"2001","journal-title":"Metal-Based Drugs"},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0060","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1021\/cr400135x","article-title":"Advances in copper complexes as anticancer agents","volume":"114","author":"Santini","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0065","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1593\/neo.04607","article-title":"Cas Ilgly induces apoptosis in glioma C6 cells in vitro and in vivo through caspase-dependent and caspase-independent mechanisms","volume":"7","author":"Trejo-Sol\u00eds","year":"2005","journal-title":"Neoplasia."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0070","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10534-007-9089-4","article-title":"Casiopeina III-ia induces apoptosis in HCT-15 cells in vitro through caspase-dependent mechanisms and has antitumor effect in vivo","volume":"21","author":"Carvallo-Chaigneau","year":"2008","journal-title":"BioMetals."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0075","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1107\/S0108270192000556","article-title":"Mixed chelate complexes. II. Structures of L-alaninato(aqua)(4,7-diphenyl-1,10-phenanthroline)copper(II) nitrite monohydrate and aqua(4,7-dimethyl-1,10-phenanthroline)(glycinato)(nitrato)copper(II) monohydrate","volume":"49","author":"Solans","year":"1993","journal-title":"Acta Crystallogr. Sect. C Cryst. Struct. Commun."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0080","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1107\/S0108270187095507","article-title":"Structure of (1,10-Phenanthroline)(salicylaldehydato)copper(lI) nitrate","volume":"2","author":"Solans","year":"1987","journal-title":"Acta Crystallogr. Sect. C Cryst. Struct. Commun."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0085","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jinorgbio.2013.05.001","article-title":"Copper(II) mixed chelate compounds induce apoptosis through reactive oxygen species in neuroblastoma cell line CHP-212","volume":"126","author":"Guti\u00e9rrez","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0090","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.taap.2005.06.023","article-title":"Cardiotoxicity of copper-based antineoplastic drugs casiopeinas is related to inhibition of energy metabolism","volume":"212","author":"Hern\u00e1ndez-Esquivel","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0095","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1016\/S0006-2952(03)00212-0","article-title":"Toxic effects of copper-based antineoplastic drugs (Casiopeinas\u00ae) on mitochondrial functions","volume":"65","author":"Mar\u00edn-Hern\u00e1ndez","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0100","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.tox.2009.12.010","article-title":"Manley, Casiope\u00edna IIgly-induced oxidative stress and mitochondrial dysfunction in human lung cancer A549 and H157 cells","author":"Remy Kachadourian","year":"2010","journal-title":"Toxicology."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0105","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jinorgbio.2016.11.007","article-title":"Genotoxic assessment of the copper chelated compounds Casiopeinas: clues about their mechanisms of action","volume":"166","author":"Serment-Guerrero","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0110","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s12011-014-0098-1","article-title":"Analysis of the DNA interaction of copper compounds belonging to the Casiopeinas Antitumoral series","volume":"161","author":"Becco","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0115","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.poly.2015.10.034","article-title":"DNA-binding mode of antitumoral copper compounds (Casiopeinas\u00ae) and analysis of its biological meaning","volume":"102","author":"Bravo-G\u00f3mez","year":"2015","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0120","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cbi.2006.12.002","article-title":"Mixed chelate copper complex, Casiopeina IIgly \u00ae, binds and degrades nucleic acids: a mechanism of cytotoxicity","volume":"165","author":"Rivero-M\u00fcller","year":"2007","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0125","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jinorgbio.2008.10.006","article-title":"Antiproliferative activity and QSAR study of copper(II) mixed chelate [Cu(N-N)(acetylacetonato)]NO3 and [Cu(N-N)(glycinato)]NO3 complexes, (Casiope\u00ednas\u00ae)","volume":"103","author":"Bravo-G\u00f3mez","year":"2009","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0130","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jinorgbio.2012.01.010","article-title":"New achievements on biological aspects of copper complexes Casiope\u00ednas\u00ae: interaction with DNA and proteins and anti-Trypanosoma cruzi activity","volume":"109","author":"Becco","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0135","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.tiv.2011.05.008","article-title":"Genotoxicity of the copper antineoplastic coordination complexes casiopeinas\u00ae","volume":"25","author":"Serment-Guerrero","year":"2011","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0887-2333(99)00082-X","article-title":"Induction of apoptosis by a novel copper- based anticancer compound, Casiopeina II, in L1210 murine leukaemia and CH1 human ovarian carcinoma cells","volume":"14","author":"Kass","year":"2000","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0145","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1093\/nar\/gkv467","article-title":"Intercalation processes of copper complexes in DNA","volume":"43","author":"Galindo-Murillo","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.jinorgbio.2022.111772_bb0150","first-page":"245","article-title":"Metal-based drug-DNA interactions","volume":"57","author":"Garc\u00eda-Ramos","year":"2013","journal-title":"J. Mex. Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0155","doi-asserted-by":"crossref","first-page":"14510","DOI":"10.1039\/c1cp20183b","article-title":"\u03c0-Stacking between Casiopeinas\u00ae and DNA bases","volume":"13","author":"Galindo-Murillo","year":"2011","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0160","series-title":"07\/628,843: RE 35,458","author":"Ruiz-Azuara","year":"1997"},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0165","series-title":"07\/628,628: 5,576,326","author":"Ruiz-Azuara","year":"1996"},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0170","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.micron.2010.05.001","article-title":"The interactions of cisplatin and DNA studied by atomic force microscopy","volume":"41","author":"Liu","year":"2010","journal-title":"Micron"},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0175","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.bbrc.2015.01.050","article-title":"Structural changes of linear DNA molecules induced by cisplatin","volume":"457","author":"Liu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0180","doi-asserted-by":"crossref","first-page":"12926","DOI":"10.1002\/chem.201202050","article-title":"DNA metalating-intercalating hybrid agents for the treatment of chemoresistant cancers","volume":"18","author":"Suryadi","year":"2012","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2013.03.013","article-title":"Drug-DNA interactions and their study by UV-visible, fluorescence spectroscopies and cyclic voltametry","volume":"124","author":"Sirajuddin","year":"2013","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0190","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0005-2787(75)90098-2","article-title":"Binding of ethidium bromide to ribosomal RNA. Absorption, fluorescence, circular and electric dichroism study","volume":"407","author":"Gatti","year":"1975","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0195","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1021\/bc980008m","article-title":"Sequence-specific DNA minor groove binders. Design and synthesis of netropsin and distamycin analogues","volume":"9","author":"Bailly","year":"1998","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0200","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.abb.2015.03.024","article-title":"Studying non-covalent drug-DNA interactions","volume":"576","author":"Rehman","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0205","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.saa.2012.09.022","article-title":"Determining the mode of interaction of calf thymus DNA with the drug sumatriptan using voltammetric and spectroscopic techniques","volume":"99","author":"Shahabadi","year":"2012","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0210","series-title":"Molecular Cloning. A Laboratory","author":"Maniatis","year":"1989"},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0215","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1093\/nar\/26.6.1473","article-title":"Study of the interaction of DNA with cisplatin and other Pd (II) and Pt (II) complexes by atomic force microscopy","volume":"26","author":"Onoa","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0220","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1002\/elps.1150171003","article-title":"The effect of ethidium bromide on mobility of DNA fragments in agarose gel electrophoresis","volume":"17","author":"Sigmon","year":"1996","journal-title":"Electrophoresis."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0225","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrc1547","article-title":"Bleomycins: towards better therapeutics","volume":"5","author":"Chen","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0230","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1021\/bi9922143","article-title":"Interaction of cisplatin and DNA-targeted 9-aminoacridine platinum complexes with DNA","volume":"39","author":"Temple","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0235","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1021\/ar100140e","article-title":"Metal complexes as DNA intercalators","volume":"44","author":"Liu","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0240","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.saa.2012.01.020","article-title":"New modulated design and synthesis of chiral CuII\/Sn IV bimetallic potential anticancer drug entity: in vitro DNA binding and pBR322 DNA cleavage activity","volume":"90","author":"Tabassum","year":"2012","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0245","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.saa.2012.07.012","article-title":"DNA-binding, spectroscopic and antimicrobial studies of palladium(II) complexes containing 2,2???-bipyridine and 1-phenylpiperazine","volume":"96","author":"Shoukry","year":"2012","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0250","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0022-2836(61)80004-1","article-title":"Structural considerations in the interaction of DNA and acridines","volume":"3","author":"Lerman","year":"1961","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0255","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.saa.2010.11.018","article-title":"Spectroscopic studies on the interaction between Pr(III) complex of an ofloxacin derivative and bovine serum albumin or DNA","volume":"78","author":"Xu","year":"2011","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/S0162-0134(02)00378-1","article-title":"DNA-fiber EPR study of the orientation of Cu(II) complexes of 1,10-phenanthroline and its derivatives bound to DNA: mono(phenanthroline)-copper(II) and its ternary complexes with amino acids","author":"Chikira","year":"2002","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0265","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.jinorgbio.2005.02.020","article-title":"Copper(II) complexes of 1,10-phenanthroline-derived ligands: studies on DNA binding properties and nuclease activity","volume":"99","author":"Hirohama","year":"2005","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0270","doi-asserted-by":"crossref","first-page":"11648","DOI":"10.1021\/acs.jpcb.0c09296","article-title":"Ancillary ligand in ternary CuII complexes guides binding selectivity toward minor-groove DNA","volume":"124","author":"Galindo-Murillo","year":"2020","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0275","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0300-9084(78)80574-4","article-title":"Modifications of the DNA secondary structure upon platinum binding: a proposed model","volume":"60","author":"Macquet","year":"1978","journal-title":"Biochimie."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0280","first-page":"212","article-title":"Chemistry and biology of DNA-binding small molecules","volume":"102","author":"Paul","year":"2012","journal-title":"Curr. Sci."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0285","first-page":"555","article-title":"An overview of the optical and electrochemical methods for detection of DNA \u2013 drug interactions","volume":"61","author":"Aleksic","year":"2014","journal-title":"Acta Chim. Slov."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0290","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1039\/a808479c","article-title":"Extent of intramolecular stacking interactions in the mixed-ligand complexes formed in aqueous solution by copper(II), 2,2\u2032-bipyridine or 1,10-phenanthroline and 2\u2032-deoxyguanosine 5\u2032-monophosphate","author":"L\u00fcth","year":"1999","journal-title":"J. Chem. Soc. Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0295","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1016\/j.poly.2011.07.022","article-title":"A new kind of intermolecular stacking interaction between copper (II) mixed chelate complex (Casiope\u00edna III-ia) and adenine","volume":"30","author":"Garc\u00eda-ramos","year":"2011","journal-title":"Polyhedron."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0300","first-page":"1","article-title":"In vitro DNA-binding, cleavage activity with pBR322, molecular docking and antiproliferative studies of newly synthesized steroidal imidazolidine hybrids","volume":"4","author":"Shabeer","year":"2015","journal-title":"Biomol. Res. Ther."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0305","doi-asserted-by":"crossref","first-page":"10466","DOI":"10.1039\/C6DT01726F","article-title":"Ni(II)\/Cu(II)\/Zn(II) 5,5-diethylbarbiturate complexes with 1,10-phenanthroline and 2,2\u2032-dipyridylamine: synthesis, structures, DNA\/BSA binding, nuclease activity, molecular docking, cellular uptake, cytotoxicity and the mode of cell death","volume":"45","author":"Yilmaz","year":"2016","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0310","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jphotobiol.2016.10.027","article-title":"DNA interaction, antimicrobial studies of newly synthesized copper (II) complexes with 2-amino-6-(trifluoromethoxy)benzothiazole Schiff base ligands","volume":"165","author":"Rambabu","year":"2016","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0315","series-title":"Transition Metal Complexes of N\u2032-(2-(Hydroxyimino)Propanoyl)Isonicotinohydrazide: Synthesis, Characterization, DNA Interaction and Anticancer Evaluation","author":"Hegde","year":"2017"},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0320","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jphotobiol.2012.09.015","article-title":"Spectroscopic studies on the binding of holmium-1,10-phenanthroline complex with DNA","volume":"117","author":"Niroomand","year":"2012","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0325","first-page":"48","article-title":"Excited-state modalities for studying the binding of copper phenanthrolines to DNA","volume":"402","author":"Tamilarasan","year":"1989","journal-title":"Met. Chem."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0330","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1021\/bi00292a024","article-title":"Interactions of porphyrins with nucleic acids","volume":"22","author":"Pasternack","year":"1983","journal-title":"Biochemistry"},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0335","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jinorgbio.2012.08.011","article-title":"(Dipyrido[3,2-a:2\u2032,3\u2032-c]phenazine)(glycinato)copper(II) perchlorate: a novel DNA-intercalator with anti-proliferative activity against thyroid cancer cell lines","volume":"117","author":"Terenzi","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0340","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jinorgbio.2012.04.018","article-title":"Efficient DNA cleavage mediated by mononuclear mixed ligand copper(II) phenolate complexes: the role of co-ligand planarity on DNA binding and cleavage and anticancer activity","volume":"114","author":"Jaividhya","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0345","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1039\/c2dt12044e","article-title":"Molecular drug design, synthesis and structure elucidation of a new specific target peptide based metallo drug for cancer chemotherapy as topoisomerase i inhibitor","volume":"41","author":"Tabassum","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0350","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.molstruc.2007.09.010","article-title":"Experimental and theoretical studies on the DNA-binding and spectral properties of water-soluble complex [Ru(MeIm)4(dpq)]2+","volume":"881","author":"Chen","year":"2008","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0355","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1093\/nar\/gkp026","article-title":"Circular dichroism and conformational polymorphism of DNA","volume":"37","author":"Kypr","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0360","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jpha.2013.03.003","article-title":"Copper interactions with DNA of chromatin and its role in neurodegenerative disorders","volume":"3","author":"Govindaraju","year":"2013","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jinorgbio.2022.111772_bb0365","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.1021\/ic101791r","article-title":"Two new ternary complexes of copper(II) with tetracycline or doxycycline and 1,10-phenanthroline and their potential as antitumoral: cytotoxicity and DNA cleavage","volume":"50","author":"Silva","year":"2011","journal-title":"Inorg. Chem."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013422000617?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013422000617?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:06:14Z","timestamp":1758985574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013422000617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":73,"alternative-id":["S0162013422000617"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2022.111772","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA, a target of mixed chelate copper(II) compounds (Casiopeinas\u00ae) studied by electrophoresis, UV\u2013vis and circular dichroism techniques.","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2022.111772","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111772"}}