{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:51:01Z","timestamp":1790268661305,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jinorgbio.2022.111881","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T21:10:30Z","timestamp":1654204230000},"page":"111881","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Investigating the antiproliferative activities of new CuII complexes with pyridine hydrazone derivatives of nalidixic acid"],"prefix":"10.1016","volume":"234","author":[{"given":"Fernando R.G.","family":"Bergamini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia H.B.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Marrote","family":"Manzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Alberto","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Ant\u00f4nio","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Lucia Tasca Gois","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Ernesto","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilton Rog\u00e9rio","family":"Lustri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael Enoque Ferraz","family":"de Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Cecconi","family":"Portes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"da Costa Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Paulo","family":"Corbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2022.111881_bb0005","doi-asserted-by":"crossref","first-page":"16004","DOI":"10.1039\/D0DT02478C","article-title":"What is holding back the development of antiviral metallodrugs? A literature overview and implications for SARS-CoV-2 therapeutics and future viral outbreaks","volume":"49","author":"de Paiva","year":"2020","journal-title":"Dalt. Trans."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0010","doi-asserted-by":"crossref","first-page":"12888","DOI":"10.1039\/D0SC04082G","article-title":"Metallodrugs are unique: opportunities and challenges of discovery and development","volume":"11","author":"Anthony","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2021.111634","article-title":"Copper in tumors and the use of copper-based compounds in cancer treatment","volume":"226","author":"da Silva","year":"2022","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0020","doi-asserted-by":"crossref","DOI":"10.1039\/D1CS00609F","article-title":"Phototherapeutic anticancer strategies with first-row transition metal complexes: a critical review","author":"Gourdon","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0025","article-title":"Second generation of Casiopeinas\u00ae: a joint experimental and theoretical study","volume":"517","author":"Reina","year":"2020","journal-title":"Inorganica Chim. Acta."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0030","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.poly.2015.10.034","article-title":"DNA-binding mode of antitumoral copper compounds (Casiopeinas\u00ae) and analysis of its biological meaning","volume":"102","author":"Bravo-G\u00f3mez","year":"2015","journal-title":"Polyhedron."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0035","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10534-007-9089-4","article-title":"Casiopeina III-ia induces apoptosis in HCT-15 cells in vitro through caspase-dependent mechanisms and has antitumor effect in vivo","volume":"21","author":"Carvallo-Chaigneau","year":"2008","journal-title":"BioMetals."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0040","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.leukres.2016.11.001","article-title":"Casiopeina III-Ea, a copper-containing small molecule, inhibits the in vitro growth of primitive hematopoietic cells from chronic myeloid leukemia","volume":"52","author":"Chavez-Gonzalez","year":"2017","journal-title":"Leuk. Res."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0045","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ica.2018.09.084","article-title":"Polynuclear copper(II) complexes with nalidixic acid hydrazones: Antiproliferative activity and selectivity assessment over a panel of tumor cells","volume":"484","author":"Bergamini","year":"2019","journal-title":"Inorganica Chim. Acta."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jinorgbio.2017.05.001","article-title":"DNA and protein binding, double-strand DNA cleavage and cytotoxicity of mixed ligand copper(II) complexes of the antibacterial drug nalidixic acid","volume":"174","author":"Loganathan","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0055","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejmech.2014.04.080","article-title":"Synthesis, crystal structure and antiproliferative activity of cu(II) nalidixic acid-DACH conjugate: comparative in vitro DNA\/RNA binding profile, cleavage activity and molecular docking studies","volume":"81","author":"Arjmand","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0060","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ica.2019.03.011","article-title":"Biological evaluation of copper(II) complex with nalidixic acid and 2,2\u2032-bipyridine (bpy)","volume":"490","author":"Kumar","year":"2019","journal-title":"Inorganica Chim. Acta."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0065","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10895-017-2185-0","article-title":"Spectro analytical, computational and in vitro biological studies of novel substituted quinolone Hydrazone and it\u2019s metal complexes","volume":"28","author":"Nagula","year":"2018","journal-title":"J. Fluoresc."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ica.2020.119450","article-title":"Bis- and mixed-ligand copper(II) complexes of nalidixic acid the antibacterial drug: mode of nalidixate coordination determines DNA binding and cleavage and cytotoxicity","volume":"504","author":"Sharma","year":"2020","journal-title":"Inorganica Chim. Acta."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0075","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.saa.2018.12.045","article-title":"Structure, DNA\/proteins binding, docking and cytotoxicity studies of copper(II) complexes with the first quinolone drug nalidixic acid and 2,2\u2032-dipyridylamine, Spectrochim. Acta - part a Mol","volume":"212","author":"Kumar","year":"2019","journal-title":"Biomol. Spectrosc."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0080","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.poly.2018.09.046","article-title":"Novel copper(II) coordination polymer containing the drugs nalidixic acid and 8-hydroxyquinoline: evaluation of the structural, magnetic, electronic, and antitumor properties","volume":"156","author":"de Carvalho","year":"2018","journal-title":"Polyhedron."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0085","series-title":"Synthesis, characterization and biological activities of 1, 3, 4-oxadiazole derivatives of nalidixic acid and their copper complexes","first-page":"206","volume":"4","author":"Deeba","year":"2018"},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0090","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.molstruc.2016.05.025","article-title":"Synthesis, spectroscopic characterizations, crystal structures and DFT studies of nalidixic acid carbonyl hydrazones derivatives","volume":"1120","author":"Bergamini","year":"2016","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0095","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1107\/S0021889808042726","article-title":"OLEX2\u202f: a complete structure solution, refinement and analysis program","volume":"42","author":"Dolomanov","year":"2009","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053273314026370","article-title":"SHELXT \u2013 integrated space-group and crystal-structure determination","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr. Sect. A Found. Adv."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0105","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1107\/S0108767307043930","article-title":"A short history of SHELX","volume":"64","author":"Sheldrick","year":"2008","journal-title":"Acta Crystallogr. Sect. A Found. Crystallogr."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0110","series-title":"Munksgaard","author":"Johson","year":"1970"},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0115","first-page":"9","article-title":"PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors, Acta Crystallogr. Sect. C","volume":"71","author":"Spek","year":"2015","journal-title":"Struct. Chem."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0120","author":"T.C.C.D.C. (CCDC)"},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0125","author":"The Cambridge cCrystallographic dData Centre (CCDC)"},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0130","series-title":"Seventeenth Informational Supplement","author":"Performance Standards for Antimicrobial Susceptibility Testing","year":"2007"},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0135","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.foodchem.2015.06.024","article-title":"Antioxidant and antiproliferative activities in different maturation stages of broccoli (Brassica oleracea Italica) biofortified with selenium","volume":"190","author":"Bachiega","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0140","doi-asserted-by":"crossref","first-page":"13023","DOI":"10.3390\/ijms160613023","article-title":"Synthesis, DNA binding, and Antiproliferative activity of novel Acridine-Thiosemicarbazone derivatives","volume":"16","author":"de Almeida","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0145","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/jnci\/83.11.757","article-title":"Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines","volume":"83","author":"Monks","year":"1991","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0155","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nrd3801","article-title":"The determination and interpretation of the therapeutic index in drug development","volume":"11","author":"Muller","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0160","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jinorgbio.2018.04.005","article-title":"Linear gold(I) complex with tris-(2-carboxyethyl)phosphine (TCEP): selective antitumor activity and inertness toward sulfur proteins","volume":"186","author":"Gomes","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0165","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1002\/slct.201703078","article-title":"A silver complex with Cycloserine: synthesis, Spectroscopic Characterization, Crystal Structure and In Vitro Biological Studies","volume":"3","author":"Ciol","year":"2018","journal-title":"ChemistrySelect."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0170","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.molstruc.2019.03.020","article-title":"A new palladium ( II ) complex with ibuprofen : Spectroscopic characterization, DFT studies, antibacterial activities and interaction with biomolecules","volume":"1186","author":"Fiori-duarte","year":"2019","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0175","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jinorgbio.2018.07.011","article-title":"Sulfonamide-containing copper(II) metallonucleases: correlations with in vitro antimycobacterial and antiproliferative activities","volume":"187","author":"Nakahata","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0180","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1039\/DT9840001349","article-title":"Synthesis, structure, and spectroscopic properties of copper( <scp>II<\/scp> ) compounds containing nitrogen\u2013sulphur donor ligands; the crystal and molecular structure of aqua[1,7-bis(N-methylbenzimidazol-2\u2032-yl)-2,6-dithiaheptane]copper( <scp>II<\/scp> ) pe","author":"Addison","year":"1984","journal-title":"J. Chem. Soc., Dalt. Trans."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0185","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1107\/S2053229616008913","article-title":"A novel binuclear copper complex incorporating a nalidixic acid derivative displaying a one-dimensional coordination polymeric structure","volume":"72","author":"Bergamini","year":"2016","journal-title":"Acta Crystallogr. Sect. C Struct. Chem."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0190","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jfluchem.2017.01.016","article-title":"Synthesis, characterization and in vitro biological assays of a silver(I) complex with 5-fluorouracil: a strategy to overcome multidrug resistant tumor cells","volume":"195","author":"Nunes","year":"2017","journal-title":"J. Fluor. Chem."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0195","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jep.2008.07.005","article-title":"In vitro anticancer screening of south African plants","volume":"119","author":"Fouche","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0200","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/carcin\/bgp105","article-title":"The isatin-Schiff base copper(II) complex cu(isaepy)2 acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein kinase-dependent apoptosis","volume":"30","author":"Filomeni","year":"2009","journal-title":"Carcinogenesis."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0205","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-4165(02)00417-8","article-title":"Copper(II) complex of a tridentate ligand: an artificial metalloprotease for bovine serum albumin","volume":"1573","author":"Shrivastava","year":"2002","journal-title":"Biochim. Biophys. Acta - Gen. Subj."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0210","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.saa.2017.11.063","article-title":"Interactions of hemin with bovine serum albumin and human hemoglobin: a fluorescence quenching study, Spectrochim. Acta - part a Mol","volume":"193","author":"Makarska-Bialokoz","year":"2018","journal-title":"Biomol. Spectrosc."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0215","doi-asserted-by":"crossref","DOI":"10.1039\/D0NJ01889A","article-title":"Sulfonamide-containing copper(II) complexes: new insights on biophysical interactions and antibacterial activities","volume":"44","author":"Nakahata","year":"2020","journal-title":"New J. Chem."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0220","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ica.2017.08.043","article-title":"Copper complexes as artificial DNA metallonucleases: from Sigman\u2019s reagent to next generation anti-cancer agent?","volume":"472","author":"McGivern","year":"2017","journal-title":"Inorganica Chim. Acta."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0225","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/ijc.2910060207","article-title":"Inhibitory effects of anti-tumor platinum compounds on DNA, RNA and protein syntheses in mammalian cellsin vitro","volume":"6","author":"Harder","year":"1970","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0230","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/377649a0","article-title":"Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin","volume":"377","author":"Takahara","year":"1995","journal-title":"Nature."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0235","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1039\/c3cc00177f","article-title":"The path for metal complexes to a DNA target","volume":"49","author":"Komor","year":"2013","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0240","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1093\/nar\/gku1255","article-title":"Electrophoretic mobility of supercoiled, catenated and knotted DNA molecules","volume":"43","author":"Cebri\u00e1n","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0245","doi-asserted-by":"crossref","first-page":"10244","DOI":"10.1039\/c3dt50416f","article-title":"Mixed-ligand copper(ii)\u2013sulfonamide complexes: effect of the sulfonamide derivative on DNA binding, DNA cleavage, genotoxicity and anticancer activity","volume":"42","author":"Gonz\u00e1lez-\u00c1lvarez","year":"2013","journal-title":"Dalt. Trans."},{"key":"10.1016\/j.jinorgbio.2022.111881_bb0250","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1039\/C4SC00384E","article-title":"A mitochondrion-targeting copper complex exhibits potent cytotoxicity against cisplatin-resistant tumor cells through multiple mechanisms of action","volume":"5","author":"Zhou","year":"2014","journal-title":"Chem. Sci."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013422001702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013422001702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:08:23Z","timestamp":1758985703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013422001702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":49,"alternative-id":["S0162013422001702"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2022.111881","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the antiproliferative activities of new CuII complexes with pyridine hydrazone derivatives of nalidixic acid","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2022.111881","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111881"}}