{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:40:08Z","timestamp":1758987608722,"version":"3.44.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"am","delay-in-days":279,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jinorgbio.2023.112288","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T19:22:04Z","timestamp":1686165724000},"page":"112288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Physical structure of constitutional isomers influences antiproliferation activity of thiosemicarbazone-alkylthiocarbamate copper complexes"],"prefix":"10.1016","volume":"246","author":[{"given":"Kritika","family":"Bajaj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Andres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dillon T.","family":"Hofsommer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aidan F.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleksandr","family":"Hietsoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Mashuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Weis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levi J.","family":"Beverly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula J.","family":"Bates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig A.","family":"Grapperhaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jinorgbio.2023.112288_bb0005","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.3390\/ijms21113965","article-title":"Copper coordination compounds as biologically active agents","volume":"21","author":"Krasnovskaya","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.jinorgbio.2023.112288_bb0010","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1021\/cr078203u","article-title":"Metals in neurobiology: probing their chemistry and biology with molecular imaging","volume":"108","author":"Que","year":"2008","journal-title":"Chem. Rev."},{"issue":"7","key":"10.1016\/j.jinorgbio.2023.112288_bb0015","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1021\/cr950046o","article-title":"Multicopper oxidases and Oxygenases","volume":"96","author":"Solomon","year":"1996","journal-title":"Chem. Rev."},{"issue":"2","key":"10.1016\/j.jinorgbio.2023.112288_bb0020","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41568-021-00417-2","article-title":"Connecting copper and cancer: from transition metal signalling to metalloplasia","volume":"22","author":"Ge","year":"2022","journal-title":"Nat. Rev. Cancer"},{"issue":"7501","key":"10.1016\/j.jinorgbio.2023.112288_bb0025","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature13180","article-title":"Copper is required for oncogenic BRAF signalling and tumorigenesis","volume":"509","author":"Brady","year":"2014","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.jinorgbio.2023.112288_bb0030","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nchembio.1913","article-title":"Searching for harmony in transition-metal signaling","volume":"11","author":"Chang","year":"2015","journal-title":"Nat. Chem. Biol."},{"issue":"27","key":"10.1016\/j.jinorgbio.2023.112288_bb0035","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.2174\/1568026616666160216155746","article-title":"Bis(thiosemicarbazone) metal complexes as therapeutics for neurodegenerative diseases","volume":"16","author":"McKenzie-Nickson","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"issue":"11","key":"10.1016\/j.jinorgbio.2023.112288_bb0040","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3390\/life10110271","article-title":"Copper-ATSM as a treatment for ALS: support from mutant SOD1 models and beyond","volume":"10","author":"Nikseresht","year":"2020","journal-title":"Life"},{"issue":"7","key":"10.1016\/j.jinorgbio.2023.112288_bb0045","first-page":"1155","article-title":"Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential","volume":"38","author":"Fujibayashi","year":"1997","journal-title":"J. Nucl. Med."},{"issue":"20","key":"10.1016\/j.jinorgbio.2023.112288_bb0050","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1212\/WNL.0000000000001588","article-title":"Increased oxidative stress is related to disease severity in the ALS motor cortex: a PET study","volume":"84","author":"Ikawa","year":"2015","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.jinorgbio.2023.112288_bb0055","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3390\/antiox9090861","article-title":"PET imaging for oxidative stress in neurodegenerative disorders associated with mitochondrial dysfunction","volume":"9","author":"Ikawa","year":"2020","journal-title":"Antioxidants"},{"issue":"3","key":"10.1016\/j.jinorgbio.2023.112288_bb0060","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1021\/jm300938r","article-title":"In vitro and in vivo anticancer activity of copper bis(thiosemicarbazone) complexes","volume":"56","author":"Palanimuthu","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2023.112288_bb0065","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2174\/1874846501003020016","article-title":"Thiosemicarbazone metal complexes: from structure to activity","volume":"3","author":"Pelosi","year":"2010","journal-title":"Open Cryst. J."},{"key":"10.1016\/j.jinorgbio.2023.112288_bb0070","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/bs.ampbs.2017.01.007","article-title":"Copper and antibiotics: discovery, modes of action, and opportunities for medicinal applications","author":"Dalecki","year":"2017","journal-title":"Adv. Microb. Physiol."},{"key":"10.1016\/j.jinorgbio.2023.112288_bb0075","first-page":"225","article-title":"Antifungal activity of thiosemicarbazones, bis(thiosemicarbazones), and their metal complexes","author":"Bajaj","year":"2021","journal-title":"J. Inorg. Biochem."},{"issue":"7","key":"10.1016\/j.jinorgbio.2023.112288_bb0080","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1021\/cb400198p","article-title":"Increasing intracellular bioavailable copper selectively targets prostate cancer cells","volume":"8","author":"Cater","year":"2013","journal-title":"ACS Chem. Biol."},{"issue":"14","key":"10.1016\/j.jinorgbio.2023.112288_bb0085","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/ejic.202100168","article-title":"Anticancer activity and mode of action of copper(II)-bis(thiosemicarbazonato) complexes with pendant nitrogen heterocycles","volume":"2021","author":"Palma","year":"2021","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2023.112288_bb0090","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ica.2017.02.003","article-title":"Syntheses, structures, and electrochemical studies of N, N\u2019-bis (alkylthiocarbamate) butane-2,3-diimine cu(II) complexes as pendent alkoxy derivatives of cu(ATSM)","author":"Vishnosky","year":"2017","journal-title":"Inorg. Chim. Acta"},{"issue":"7","key":"10.1016\/j.jinorgbio.2023.112288_bb0095","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.1021\/acs.inorgchem.0c00182","article-title":"Synthesis, characterization, and biological activity of hybrid thiosemicarbazone\u2013alkylthiocarbamate metal complexes","volume":"59","author":"Andres","year":"2020","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2023.112288_bb0100","first-page":"9","article-title":"Selective targeting of cancer cells by copper ionophores: an overview","author":"Oliveri","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"7","key":"10.1016\/j.jinorgbio.2023.112288_bb0105","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1021\/jm0104217","article-title":"Studies on the mechanism of hypoxic selectivity in copper bis(thiosemicarbazone) radiopharmaceuticals","volume":"45","author":"Maurer","year":"2002","journal-title":"J. Med. Chem."},{"issue":"10","key":"10.1016\/j.jinorgbio.2023.112288_bb0110","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1021\/ic702440e","article-title":"Transfer of copper between bis(thiosemicarbazone) ligands and intracellular copper-binding proteins. Insights into mechanisms of copper uptake and hypoxia selectivity","volume":"47","author":"Xiao","year":"2008","journal-title":"Inorg. Chem."},{"issue":"1","key":"10.1016\/j.jinorgbio.2023.112288_bb0115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1073\/pnas.1116227108","article-title":"An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copper(II)","volume":"109","author":"Donnelly","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.jinorgbio.2023.112288_bb0120","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1021\/jm00168a035","article-title":"Structure-activity relationships for metal-labeled blood flow tracers: comparison of keto aldehyde bis (thiosemicarbazonato) copper (II) derivatives","volume":"33","author":"John","year":"1990","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.jinorgbio.2023.112288_bb0125","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1021\/ja00235a007","article-title":"Orientation and mobility of a copper square-planar complex in a lipid bilayer","volume":"109","author":"Subczynski","year":"1987","journal-title":"J. Am. Chem. Soc."},{"issue":"20","key":"10.1016\/j.jinorgbio.2023.112288_bb0130","doi-asserted-by":"crossref","first-page":"7715","DOI":"10.1021\/acs.inorgchem.2c00371","article-title":"Investigations of bis(alkylthiocarbamato)copper linkage isomers","volume":"61","author":"Bajaj","year":"2022","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2023.112288_bb0135","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/hlca.19720550414","article-title":"Arbetien \u00fcber Phosphos\u00e4ure- und Thiosphosphors\u00e4ureester mit einem Heterocyclischen Substituenten Thiadiazol-Ringschluss und eine Dabei Auftretende Methyl\u00fcbertragung","volume":"55","author":"Re\u00fcfenacht","year":"1972","journal-title":"Helv. Chim. Acta"},{"issue":"9","key":"10.1016\/j.jinorgbio.2023.112288_bb0140","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1021\/jacs.5b13215","article-title":"Exploiting copper redox for F-19 magnetic resonance-based detection of cellular hypoxia","volume":"138","author":"Xie","year":"2016","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.jinorgbio.2023.112288_bb0145","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1107\/S0108767307043930","article-title":"A short history of SHELX","volume":"64","author":"Sheldrick","year":"2008","journal-title":"Acta Crystallogr A"},{"key":"10.1016\/j.jinorgbio.2023.112288_bb0150","first-page":"179","article-title":"Tetrazolium (MTT) assay for cellular viability and activity","volume":"79","author":"Morgan","year":"1998","journal-title":"Methods Mol. Biol."},{"issue":"3","key":"10.1016\/j.jinorgbio.2023.112288_bb0155","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0006-3061(00)80074-5","article-title":"Comparative properties of the antineoplastic agent, 3-ethoxy-2-oxobutyraldehyde bis(thiosemicarbazonato) copper(II) and related chelates: linear free energy correlations","volume":"3","author":"Winkelmann","year":"1974","journal-title":"Bioinorg. Chem."},{"issue":"1","key":"10.1016\/j.jinorgbio.2023.112288_bb0160","first-page":"124","article-title":"Structure-function correlations in the reaction of Bis(thiosemicarbazonato) copper(II) complexes with ehrlich ascites tumor cells1","volume":"38","author":"Minkel","year":"1978","journal-title":"Cancer Res."},{"key":"10.1016\/j.jinorgbio.2023.112288_bb0165","first-page":"303","article-title":"Copper depletion as a therapeutic strategy in cancer","volume":"19","author":"Lopez","year":"2019","journal-title":"Met. Ions Life Sci"},{"key":"10.1016\/j.jinorgbio.2023.112288_bb0170","series-title":"Oxidative stress and biomaterials","first-page":"1","article-title":"A free radical primer","author":"Gupta","year":"2016"},{"key":"10.1016\/j.jinorgbio.2023.112288_bb0175","first-page":"469","article-title":"Copper complexes in cancer therapy","volume":"18","author":"Denoyer","year":"2018","journal-title":"Met. Ions Life Sci"},{"issue":"5","key":"10.1016\/j.jinorgbio.2023.112288_bb0180","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1039\/c0cs00215a","article-title":"Copper complexes of bis(thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals","volume":"40","author":"Paterson","year":"2011","journal-title":"Chem. Soc. Rev."},{"issue":"1","key":"10.1016\/j.jinorgbio.2023.112288_bb0185","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1021\/cr400135x","article-title":"Advances in copper complexes as anticancer agents","volume":"114","author":"Santini","year":"2014","journal-title":"Chem. Rev."},{"issue":"5","key":"10.1016\/j.jinorgbio.2023.112288_bb0190","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1039\/c9mt00061e","article-title":"Reactivity of Cu (II)\u2013, Zn (II)\u2013and Fe (II)\u2013thiosemicarbazone complexes with glutathione and metallothionein: from stability to dissociation to transmetallation","volume":"11","author":"Santoro","year":"2019","journal-title":"Metallomics"},{"key":"10.1016\/j.jinorgbio.2023.112288_bb0195","doi-asserted-by":"crossref","first-page":"10758","DOI":"10.1039\/C7DT01955F","article-title":"A perspective \u2013 can copper complexes be developed as a novel class of therapeutics?","volume":"33","author":"Wehbe","year":"2017","journal-title":"Dalton Trans."},{"issue":"6","key":"10.1016\/j.jinorgbio.2023.112288_bb0200","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1021\/acs.inorgchem.6b03178","article-title":"New iminodiacetate\u2013thiosemicarbazone hybrids and their copper (II) complexes are potential ribonucleotide reductase R2 inhibitors with high antiproliferative activity","volume":"56","author":"Zaltariov","year":"2017","journal-title":"Inorg. Chem."},{"issue":"7684","key":"10.1016\/j.jinorgbio.2023.112288_bb0205","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature25016","article-title":"Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4","volume":"552","author":"Skrott","year":"2017","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.jinorgbio.2023.112288_bb0210","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41589-019-0291-9","article-title":"Mitochondrial metabolism promotes adaptation to proteotoxic stress","volume":"15","author":"Tsvetkov","year":"2019","journal-title":"Nat. Chem. Biol."},{"issue":"6586","key":"10.1016\/j.jinorgbio.2023.112288_bb0215","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.jinorgbio.2023.112288_bb0220","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1200\/JCO.2012.44.5585","article-title":"Final results of phase III SYMMETRY study: randomized, double-blind trial of elesclomol plus paclitaxel versus paclitaxel alone as treatment for chemotherapy-naive patients with advanced melanoma","volume":"31","author":"O\u2019Day","year":"2013","journal-title":"J. Clin. Oncol."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013423001708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013423001708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:10:57Z","timestamp":1758985857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013423001708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":44,"alternative-id":["S0162013423001708"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2023.112288","relation":{},"ISSN":["0162-0134"],"issn-type":[{"type":"print","value":"0162-0134"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physical structure of constitutional isomers influences antiproliferation activity of thiosemicarbazone-alkylthiocarbamate copper complexes","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2023.112288","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112288"}}