{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:10:28Z","timestamp":1790737828745,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015694","name":"Fondazione Cassa di Risparmio di Firenze","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Fondazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jinorgbio.2024.112479","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T22:01:25Z","timestamp":1704492085000},"page":"112479","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Mercury binding to proteins disclosed by ESI MS experiments: The case of three organomercurials"],"prefix":"10.1016","volume":"252","author":[{"given":"Andrea","family":"Geri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Zineddu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Massai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Ronga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryszard","family":"Lobinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Gailer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Messori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2024.112479_bb0005","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1080\/15287394.2011.590097","article-title":"Ancestry of pink disease (infantile acrodynia) identified as a risk factor for autism Spectrum disorders","volume":"74","author":"Shandley","year":"2011","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0010","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ijbiomac.2020.03.156","article-title":"Toxicity of thimerosal in biological systems: conformational changes in human hemoglobin, decrease of oxygen binding capacity, increase of protein glycation and amyloid\u2019s formation","volume":"154","author":"De Magalh\u00e3es Silva","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0015","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.aogh.2016.12.005","article-title":"Global burden of disease of mercury used in artisanal small-scale gold mining","volume":"83","author":"Steckling","year":"2017","journal-title":"Ann. Glob. Health"},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0020","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neuro.2020.09.018","article-title":"Methyl mercury: loaves versus fishes","volume":"81","author":"Clarkson","year":"2020","journal-title":"NeuroToxicology."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0025","first-page":"370","article-title":"Minamata disease. The outbreak of a neurologic disorder in Minamata, Japan, and its relationship to the ingestion of seafood contaminated by mercuric compounds","volume":"1","author":"Kurland","year":"1960","journal-title":"World Neurol."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0030","series-title":"Metal Sustainability","first-page":"221","article-title":"Effects of non-essential metal releases on the environment and human health","author":"Campbell","year":"2016"},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0035","doi-asserted-by":"crossref","first-page":"mfac010","DOI":"10.1093\/mtomcs\/mfac010","article-title":"Physiologically relevant hCys concentrations mobilize MeHg from rabbit serum albumin to form MeHg\u2013hCys complexes","volume":"14","author":"Bridle","year":"2022","journal-title":"Metallomics."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0040","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3390\/toxics11070599","article-title":"More effective mobilization of Hg2+ from human serum albumin compared to Cd2+ by L-cysteine at near-physiological conditions","volume":"11","author":"Gautam","year":"2023","journal-title":"Toxics."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2020.213343","article-title":"Sulfhydryl groups as targets of mercury toxicity","volume":"417","author":"Ajsuvakova","year":"2020","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2022.214836","article-title":"Selenol (-SeH) as a target for mercury and gold in biological systems: contributions of mass spectrometry and atomic spectroscopy","volume":"474","author":"Bernabeu De Maria","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0055","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.3390\/nu12041067","article-title":"Selenoprotein P as biomarker of selenium status in clinical trials with therapeutic dosages of selenite","volume":"12","author":"Brodin","year":"2020","journal-title":"Nutrients."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0060","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1016\/j.bbagen.2012.11.020","article-title":"Glutathione peroxidases","volume":"1830","author":"Brigelius-Floh\u00e9","year":"2013","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2018.11.007","article-title":"The thioredoxin system as a target for mercury compounds","volume":"1863","author":"Branco","year":"2019","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0070","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1096\/fj.10-157594","article-title":"Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning","volume":"25","author":"Carvalho","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0075","doi-asserted-by":"crossref","first-page":"mfad014","DOI":"10.1093\/mtomcs\/mfad014","article-title":"Roles of glutathione peroxidase 4 on the mercury-triggered ferroptosis in renal cells: implications for the antagonism between selenium and mercury","volume":"15","author":"Chen","year":"2023","journal-title":"Metallomics."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0080","series-title":"Reviews of Environmental Contamination and Toxicology","first-page":"105","article-title":"Alkyl mercury-induced toxicity: multiple mechanisms of action","volume":"Vol. 240","author":"Risher","year":"2016"},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0085","doi-asserted-by":"crossref","first-page":"6942","DOI":"10.1002\/chem.201605801","article-title":"Protein metalation by anticancer metallodrugs: a joint ESI MS and XRD investigative strategy","volume":"23","author":"Merlino","year":"2017","journal-title":"Chem. A Eur. J."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0090","doi-asserted-by":"crossref","first-page":"26680","DOI":"10.1039\/D2RA05332B","article-title":"Reactions of proteins with a few organopalladium compounds of medicinal interest","volume":"12","author":"Massai","year":"2022","journal-title":"RSC Adv."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0095","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1021\/acs.inorgchem.1c03732","article-title":"Reactions of arsenoplatin-1 with protein targets: a combined experimental and theoretical study","volume":"61","author":"Tolbatov","year":"2022","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0100","doi-asserted-by":"crossref","first-page":"16464","DOI":"10.1039\/D1DT03106F","article-title":"Direct detection of iron clusters in L ferritins through ESI-MS experiments","volume":"50","author":"Massai","year":"2021","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2024.112479_bib191","doi-asserted-by":"crossref","first-page":"112236","DOI":"10.1016\/j.jinorgbio.2023.112236","article-title":"19F: A small probe for a giant protein","volume":"244","author":"Cosottini","year":"2023","journal-title":"J Inorg Biochem"},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0105","doi-asserted-by":"crossref","first-page":"11622","DOI":"10.1039\/C7CC06442J","article-title":"Protein metalation by metal-based drugs: X-ray crystallography and mass spectrometry studies","volume":"53","author":"Messori","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0110","doi-asserted-by":"crossref","first-page":"10616","DOI":"10.1021\/acs.inorgchem.9b01900","article-title":"Structural characterization of a gold\/serum albumin complex","volume":"58","author":"Pratesi","year":"2019","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408449509089885","article-title":"Minamata disease: methylmercury poisoning in Japan caused by environmental pollution","volume":"25","author":"Harada","year":"1995","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2019.01.006","article-title":"Methylmercury\u2019s chemistry: From the environment to the mammalian brain","volume":"1863","author":"Nogara","year":"2019","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"59\u201364","key":"10.1016\/j.jinorgbio.2024.112479_bb0125","first-page":"157","article-title":"Thiomersal-containing vaccines - a review of the current state of knowledge","volume":"69","author":"Go\u0142o\u015b","year":"2015","journal-title":"Przegl. Epidemiol."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0130","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s10534-019-00210-7","article-title":"The leading established metal-based drugs: a revisitation of their relevant physico-chemical data","volume":"32","author":"Cirri","year":"2019","journal-title":"Biometals."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0135","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jinorgbio.2014.01.009","article-title":"Insights on the mechanism of thioredoxin reductase inhibition by Gold N-heterocyclic carbene compounds using the synthetic linear Selenocysteine containing C-terminal peptide hTrxR(488-499): an ESI-MS investigation","volume":"136","author":"Pratesi","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0140","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1039\/C7MT00069C","article-title":"Remarkable differences in the biochemical fate of Cd 2+, Hg 2+, CH 3 Hg + and thimerosal in red blood cell lysate","volume":"9","author":"Gibson","year":"2017","journal-title":"Metallomics."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0145","doi-asserted-by":"crossref","first-page":"23116","DOI":"10.1074\/jbc.M109.003459","article-title":"Structure, properties, and engineering of the major zinc binding site on human albumin","volume":"284","author":"Blindauer","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0150","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1021\/pr0700403","article-title":"Human serum albumin\u2212mercurial species interactions","volume":"6","author":"Li","year":"2007","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125158","article-title":"Interaction of mercury ion (Hg2+) with blood and cytotoxicity attenuation by serum albumin binding","volume":"412","author":"Song","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2020.581648","article-title":"Reactions of medicinal gold(III) compounds with proteins and peptides explored by electrospray ionization mass spectrometry and complementary biophysical methods","volume":"8","author":"Massai","year":"2020","journal-title":"Front. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0165","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1002\/rcm.2154","article-title":"Characterization of cysteinylation of pharmaceutical-grade human serum albumin by electrospray ionization mass spectrometry and low-energy collision-induced dissociation tandem mass spectrometry","volume":"19","author":"Kleinova","year":"2005","journal-title":"Rapid Comm Mass Spectrom."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0170","doi-asserted-by":"crossref","first-page":"9268","DOI":"10.1021\/ja015953r","article-title":"Extensive investigations on oxidized amino acid residues in H 2 O 2 -treated Cu,Zn-SOD protein with LC-ESI-Q-TOF-MS, MS\/MS for the determination of the copper-binding site","volume":"123","author":"Kurahashi","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0175","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.3390\/molecules28135196","article-title":"Protein metalation by medicinal gold compounds: identification of the main features of the metalation process through ESI MS experiments","volume":"28","author":"Geri","year":"2023","journal-title":"Molecules."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0180","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.889971","article-title":"Thioredoxin reductase inhibitors as potential antitumors: mercury compounds efficacy in glioma cells","volume":"9","author":"Pires","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0185","doi-asserted-by":"crossref","first-page":"14980","DOI":"10.1021\/acs.inorgchem.3c01708","article-title":"Disclosing the preferential mercury chelation by SeCys containing peptides over their Cys analogues","volume":"62","author":"Bernabeu De Maria","year":"2023","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112479_bb0190","doi-asserted-by":"crossref","first-page":"5906","DOI":"10.1039\/D0DT00283F","article-title":"ESI MS studies highlight the selective interaction of Auranofin with protein free thiols","volume":"49","author":"Zoppi","year":"2020","journal-title":"Dalton Trans."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013424000023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013424000023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:14:09Z","timestamp":1758986049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013424000023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":39,"alternative-id":["S0162013424000023"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2024.112479","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mercury binding to proteins disclosed by ESI MS experiments: The case of three organomercurials","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2024.112479","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112479"}}