{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:59:04Z","timestamp":1792821544057,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jinorgbio.2024.112700","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T16:23:38Z","timestamp":1723652618000},"page":"112700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Phenanthroline and phenyl carboxylate mixed ligand copper complexes in developing drugs to treat cancer"],"prefix":"10.1016","volume":"260","author":[{"given":"Carlos Y.","family":"Fern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Analu","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Felipe S.","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J.","family":"Costa-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Ellena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alzir A.","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianella","family":"Facchin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2024.112700_bb0005","series-title":"Metal-based Anticancer Agents","volume":"vol. 14","author":"Casini","year":"2019"},{"issue":"5","key":"10.1016\/j.jinorgbio.2024.112700_bb0010","doi-asserted-by":"crossref","first-page":"510","DOI":"10.2174\/0929867328666211117094550","article-title":"Copper complexes as antitumor agents: in vitro and in vivo evidence","volume":"30","author":"Balsa","year":"2023","journal-title":"Curr. Med. Chem."},{"issue":"10","key":"10.1016\/j.jinorgbio.2024.112700_bb0015","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3390\/inorganics11100394","article-title":"The importance of being casiopeina as polypharmacologycal profile (mixed chelate\u2013copper (II) complexes and their in vitro and in vivo activities)","volume":"11","author":"Aguilar-Jim\u00e9nez","year":"2023","journal-title":"Inorganics"},{"issue":"1","key":"10.1016\/j.jinorgbio.2024.112700_bb0020","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1021\/cr400135x","article-title":"Advances in copper complexes as anticancer agents","volume":"114","author":"Santini","year":"2014","journal-title":"Chem. Rev."},{"issue":"4","key":"10.1016\/j.jinorgbio.2024.112700_bb0025","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.drudis.2021.01.015","article-title":"Biochemical pathways of copper complexes: progress over the past 5 years","volume":"26","author":"Zehra","year":"2021","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2021.111634","article-title":"Copper in tumors and the use of copper-based compounds in cancer treatment","volume":"226","author":"da Silva","year":"2022","journal-title":"J. Inorg. Biochem."},{"issue":"1","key":"10.1016\/j.jinorgbio.2024.112700_bb0035","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13698-1","article-title":"Therapeutic potential of the phosphino cu(I) complex (HydroCuP) in the treatment of solid tumors","volume":"7","author":"Gandin","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.jinorgbio.2024.112700_bb0040","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1021\/acs.inorgchem.1c03658","article-title":"Cu(I) and Cu(II) complexes based on lonidamine-conjugated ligands designed to promote synergistic antitumor effects","volume":"61","author":"Del Bello","year":"2022","journal-title":"Inorg. Chem."},{"issue":"9","key":"10.1016\/j.jinorgbio.2024.112700_bb0045","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3390\/inorganics11090367","article-title":"Copper(I)\/triphenylphosphine complexes containing naphthoquinone ligands as potential anticancer agents","volume":"11","author":"Leite","year":"2023","journal-title":"Inorganics"},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0050","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jinorgbio.2016.09.012","article-title":"Copper (II) complexes possessing alkyl-substituted polypyridyl ligands: structural characterization and in vitro antitumor activity","volume":"166","author":"Angel","year":"2017","journal-title":"J. Inorg. Biochem."},{"issue":"1","key":"10.1016\/j.jinorgbio.2024.112700_bb0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3390\/molecules27010049","article-title":"Copper(II) phenanthroline-based complexes as potential AntiCancer drugs: a walkthrough on the mechanisms of action","volume":"27","author":"Masuri","year":"2022","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.jinorgbio.2024.112700_bb0060","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s10895-018-2283-7","article-title":"Recent advances in copper Intercalators as anticancer agents","volume":"28","author":"Shobha Devi","year":"2018","journal-title":"J. Fluoresc."},{"issue":"6","key":"10.1016\/j.jinorgbio.2024.112700_bb0065","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1021\/bi00406a004","article-title":"Sequence specificity of DNA cleavage by bis (1, 10-phenanthroline) copper (I)","volume":"27","author":"Veal","year":"1988","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.jinorgbio.2024.112700_bb0070","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2174\/187152009787313837","article-title":"Copper complexes as anticancer agents","volume":"9","author":"Marzano","year":"2009","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0075","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cbpa.2021.01.016","article-title":"Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes","volume":"61","author":"Hachey","year":"2021","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0080","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ccr.2018.01.008","article-title":"Interactions of copper complexes with nucleic acids","volume":"360","author":"Erxleben","year":"2018","journal-title":"Coord. Chem. Rev."},{"issue":"10","key":"10.1016\/j.jinorgbio.2024.112700_bb0085","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3390\/inorganics11100396","article-title":"Anti-proliferation and DNA cleavage activities of copper(II) complexes of N3O tripodal polyamine ligands","volume":"11","author":"Serre","year":"2023","journal-title":"Inorganics"},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2024.112481","article-title":"Dinuclear copper(II) complexes with a bridging bis(chalcone) ligand reveal considerable in vitro cytotoxicity on human cancer cells and enhanced selectivity","volume":"252","author":"Tr\u00e1vn\u00ed\u010dek","year":"2024","journal-title":"J. Inorg. Biochem."},{"issue":"3","key":"10.1016\/j.jinorgbio.2024.112700_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2019.126905","article-title":"From coins to cancer therapy: gold, silver and copper complexes targeting human topoisomerases","volume":"30","author":"Ceramella","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0100","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jinorgbio.2018.10.003","article-title":"Anticancer copper complex with nucleus, mitochondrion and cyclooxygenase-2 as multiple targets","volume":"190","author":"Shi","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.101018","article-title":"Cuproptosis: a novel therapeutic target for overcoming cancer drug resistance","volume":"72","author":"Wang","year":"2024","journal-title":"Drug Resist. Updat."},{"issue":"6586","key":"10.1016\/j.jinorgbio.2024.112700_bb0110","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"issue":"21","key":"10.1016\/j.jinorgbio.2024.112700_bb0115","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1002\/cbic.201800358","article-title":"The next generation of anticancer metallopharmaceuticals: cancer stem cell-active inorganics","volume":"19","author":"Laws","year":"2018","journal-title":"Chembiochem"},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2022.102237","article-title":"Targeting chemotherapy-resistant tumour sub-populations using inorganic chemistry: anti-cancer stem cell metal complexes","volume":"72","author":"Northcote-Smith","year":"2023","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0125","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jinorgbio.2014.06.007","article-title":"Synthesis, structural characterization and cytotoxic activity of ternary copper (II)\u2013dipeptide\u2013phenanthroline complexes. A step towards the development of new copper compounds for the treatment of cancer","volume":"139","author":"Iglesias","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0130","first-page":"1","article-title":"Structural characterization and cytotoxic activity of heteroleptic copper (II) complexes with L-dipeptides and 5-NO2-phenanthroline. crystal structure of [Cu (Phe-Ala)(5-NO2-Phen)]. 4H2O","volume":"1","author":"Iglesias","year":"2015","journal-title":"Struct. Chem. Crystallogr. Commun."},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0135","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ica.2017.06.050","article-title":"Synthesis, structural characterization and cytotoxic activity against tumor cells of heteroleptic copper (I) complexes with aromatic diimines and phosphines","volume":"466","author":"Alvarez","year":"2017","journal-title":"Inorg. Chim. Acta"},{"issue":"2","key":"10.1016\/j.jinorgbio.2024.112700_bb0140","doi-asserted-by":"crossref","first-page":"896","DOI":"10.3390\/molecules28020896","article-title":"New copper(II)-L-dipeptide-bathophenanthroline complexes as potential anticancer agents\u2014synthesis, characterization and cytotoxicity studies\u2014and comparative DNA-binding study of related phen complexes","volume":"28","author":"Fern\u00e1ndez","year":"2023","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.jinorgbio.2024.112700_bb0145","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.3390\/pharmaceutics15051345","article-title":"Development of copper complexes with diimines and dipicolinate as anticancer cytotoxic agents","volume":"15","author":"Alvarez","year":"2023","journal-title":"Pharmaceutics"},{"issue":"4\u20135","key":"10.1016\/j.jinorgbio.2024.112700_bb0150","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00775-022-01938-3","article-title":"Tetramethyl-phenanthroline copper complexes in the development of drugs to treat cancer: synthesis, characterization and cytotoxicity studies of a series of copper(II)-L-dipeptide-3,4,7,8-tetramethyl-phenanthroline complexes","volume":"27","author":"Alvarez","year":"2022","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2019.110930","article-title":"Synthesis and structural characterization of a series of ternary copper (II)-L-dipeptide-neocuproine complexes. Study of their cytotoxicity against cancer cells including MDA-MB-231, triple negative breast cancer cells","volume":"203","author":"Alvarez","year":"2020","journal-title":"J. Inorg. Biochem."},{"issue":"23","key":"10.1016\/j.jinorgbio.2024.112700_bb0160","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1021\/ic00191a024","volume":"23","author":"Dubler","year":"1984","journal-title":"Inorg. Chem."},{"issue":"8","key":"10.1016\/j.jinorgbio.2024.112700_bb0165","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1007\/s11064-023-03916-w","article-title":"Active clinical trials in hepatic encephalopathy: something old, something new and something borrowed","volume":"48","author":"Balzano","year":"2023","journal-title":"Neurochem. Res."},{"issue":"10","key":"10.1016\/j.jinorgbio.2024.112700_bb0170","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3390\/inorganics11100398","article-title":"Synthesis, characterization, DNA binding and cytotoxicity of copper(II) Phenylcarboxylate complexes","volume":"11","author":"Fern\u00e1ndez","year":"2023","journal-title":"Inorganics"},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0175","doi-asserted-by":"crossref","DOI":"10.1107\/S2053273314085623","article-title":"SHELXT: integrating space group determination and structure solution","volume":"70","author":"Sheldrick","year":"2014","journal-title":"Acta Crystallogr. Sect. A Found. Adv."},{"issue":"1","key":"10.1016\/j.jinorgbio.2024.112700_bb0180","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","article-title":"Crystal structure refinement with SHELXL","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr. Sect. C Struct. Chem."},{"issue":"6","key":"10.1016\/j.jinorgbio.2024.112700_bb0185","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1107\/S0021889811043202","article-title":"ShelXle: a Qt graphical user interface for SHELXL","volume":"44","author":"H\u00fcbschle","year":"2011","journal-title":"J. Appl. Crystallogr."},{"issue":"1","key":"10.1016\/j.jinorgbio.2024.112700_bb0190","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1107\/S1600576719014092","article-title":"Mercury 4.0: from visualization to analysis, design and prediction","volume":"53","author":"Macrae","year":"2020","journal-title":"J. Appl. Crystallogr."},{"issue":"2","key":"10.1016\/j.jinorgbio.2024.112700_bb0195","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1107\/S0021889804003528","article-title":"CIF applications. XV. enCIFer: a program for viewing, editing and visualizing CIFs","volume":"37","author":"Allen","year":"2004","journal-title":"J. Appl. Crystallogr."},{"issue":"8","key":"10.1016\/j.jinorgbio.2024.112700_bb0200","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1021\/ja01176a030","article-title":"A spectrophotometric investigation of the interaction of iodine with aromatic hydrocarbons","volume":"71","author":"Benesi","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2013.03.013","article-title":"DRUG-DNA interactions and their study by UV-visible, fluorescence spectroscopies and cyclic voltametry","volume":"124","author":"Sirajuddin","year":"2013","journal-title":"J. Photochem. Photobiol. B Biol."},{"issue":"6","key":"10.1016\/j.jinorgbio.2024.112700_bb0210","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/bip.360020608","article-title":"Viscosity study of DNA","volume":"2","author":"Scruggs","year":"1964","journal-title":"Biopolymers"},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0215","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1039\/DT9840001349","article-title":"Synthesis, structure, and spectroscopic properties of copper(II) compounds containing nitrogen\u2013sulphur donor ligands; the crystal and molecular structure of aqua[1,7-bis(N-methylbenzimidazol-2\u2032-yl)-2,6-dithiaheptane]copper(II) perchlorate","volume":"7","author":"Addison","year":"1984","journal-title":"J. Chem. Soc. Dalton Trans."},{"issue":"2","key":"10.1016\/j.jinorgbio.2024.112700_bb0220","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1107\/S2052520616003954","article-title":"The Cambridge structural database","volume":"72","author":"Groom","year":"2016","journal-title":"Acta Crystallogr. B"},{"issue":"1","key":"10.1016\/j.jinorgbio.2024.112700_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15533174.2015.1137050","article-title":"Syntheses, Hirshfeld surface analyses and magnetism of two complexes with flexible carboxylates","volume":"47","author":"Lu","year":"2017","journal-title":"Inorg. Nano-Metal Chem."},{"issue":"11","key":"10.1016\/j.jinorgbio.2024.112700_bb0230","doi-asserted-by":"crossref","DOI":"10.1107\/S1600536808032480","article-title":"Bis(1,10-phenanthroline-[kappa]2N,N')(phenylacetato-[kappa]O)copper(II) phenylacetate hexahydrate","volume":"64","author":"Tu","year":"2008","journal-title":"Acta Crystallogr. Sect. E"},{"issue":"7","key":"10.1016\/j.jinorgbio.2024.112700_bb0235","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1080\/00958972.2018.1456655","article-title":"Octahedral copper(II) carboxylate complex: synthesis, structural description, DNA-binding and anti-bacterial studies","volume":"71","author":"Iqbal","year":"2018","journal-title":"J. Coord. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.ica.2019.119177","article-title":"Mono- and poly-nuclear copper(II) carboxylates with flourous ligands: synthesis, structure and improved properties","volume":"498","author":"Iqbal","year":"2019","journal-title":"Inorg. Chim. Acta"},{"issue":"28","key":"10.1016\/j.jinorgbio.2024.112700_bb0245","doi-asserted-by":"crossref","first-page":"4456","DOI":"10.1039\/D2CC00570K","article-title":"Copper(ii)-photocatalyzed decarboxylative oxygenation of carboxylic acids","volume":"58","author":"Reichle","year":"2022","journal-title":"Chem. Commun."},{"issue":"2","key":"10.1016\/j.jinorgbio.2024.112700_bb0250","doi-asserted-by":"crossref","DOI":"10.17344\/acsi.2017.3250","article-title":"New bioactive Heteroleptic copper (II) carboxylates: structure, enzymatic and DNA-binding studies","volume":"64","author":"Mushtaq","year":"2017","journal-title":"Acta Chim. Slov."},{"issue":"11","key":"10.1016\/j.jinorgbio.2024.112700_bb0255","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1134\/S0036023619110147","article-title":"Mixed-ligand cu(II) carboxylates: synthesis, crystal structure, FTIR, DNA binding, antidiabetic, and anti-Alzheimer\u2019s studies","volume":"64","author":"Afifa","year":"2019","journal-title":"Russ. J. Inorg. Chem."},{"issue":"11","key":"10.1016\/j.jinorgbio.2024.112700_bb0260","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1080\/15533174.2015.1137043","article-title":"Synthesis and magnetism of a dimeric complex","volume":"46","author":"Lu","year":"2016","journal-title":"Synth. React. Inorg., Met. Org., Nano-Met. Chem."},{"issue":"4","key":"10.1016\/j.jinorgbio.2024.112700_bb0265","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/cjoc.20000180435","article-title":"Synthesis, molecular structure and intramolecular aromatic-ring stacking interaction of a novel binuclear cu(II) complex with 1,10-phenanthroline and phenylacetate","volume":"18","author":"Xue-Yi","year":"2000","journal-title":"Chin. J. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0270","series-title":"The Weak Hydrogen Bond: In Structural Chemistry and Biology","volume":"vol. 9","author":"Desiraju","year":"2001"},{"issue":"1","key":"10.1016\/j.jinorgbio.2024.112700_bb0275","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0162-0134(00)00214-2","article-title":"Synthesis and characterization of a binuclear coumarin-3-carboxylate copper(II) complex","volume":"84","author":"Karaliota","year":"2001","journal-title":"J. Inorg. Biochem."},{"issue":"25","key":"10.1016\/j.jinorgbio.2024.112700_bb0280","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1016\/S0277-5387(99)00279-X","article-title":"Spectrum\u2013structure correlation for visible absorption spectra of copper (II) complexes in aqueous solution","volume":"18","author":"Prenesti","year":"1999","journal-title":"Polyhedron"},{"issue":"15","key":"10.1016\/j.jinorgbio.2024.112700_bb0285","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.poly.2006.04.026","article-title":"Spectrum\u2013structure correlation for visible absorption spectra of copper (II) complexes showing axial co-ordination in aqueous solution","volume":"25","author":"Prenesti","year":"2006","journal-title":"Polyhedron"},{"issue":"13","key":"10.1016\/j.jinorgbio.2024.112700_bb0290","doi-asserted-by":"crossref","first-page":"9116","DOI":"10.1021\/acs.inorgchem.0c00925","article-title":"Copper complexes with 1,10-Phenanthroline derivatives: underlying factors affecting their cytotoxicity","volume":"59","author":"Nunes","year":"2020","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2021.111566","article-title":"Interaction of the potent antitumoral compounds Casiopeinas\u00ae with blood serum and cellular bioligands","volume":"224","author":"Ugone","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0300","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.abb.2015.03.024","article-title":"Studying non-covalent drug-DNA interactions","volume":"576","author":"Rehman","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"issue":"6","key":"10.1016\/j.jinorgbio.2024.112700_bb0305","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/0968-0896(95)00053-J","article-title":"Criteria for the mode of binding of DNA binding agents","volume":"3","author":"Suh","year":"1995","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105851","article-title":"1H-imidazo[4,5-f][1,10]phenanthroline carbohydrate conjugates: synthesis, DNA interactions and cytotoxic activity","volume":"125","author":"Gratal","year":"2022","journal-title":"Bioorg. Chem."},{"issue":"9","key":"10.1016\/j.jinorgbio.2024.112700_bb0315","doi-asserted-by":"crossref","first-page":"22754","DOI":"10.3390\/ijms160922754","article-title":"Interaction of DNA with simple and mixed ligand copper (II) complexes of 1, 10-Phenanthrolines as studied by DNA-Fiber EPR spectroscopy","volume":"16","author":"Chikira","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jinorgbio.2024.112700_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2022.111772","article-title":"DNA, a target of mixed chelate copper(II) compounds (Casiopeinas(R)) studied by electrophoresis, UV-vis and circular dichroism techniques","volume":"231","author":"Figueroa-DePaz","year":"2022","journal-title":"J. Inorg. Biochem."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013424002241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013424002241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T08:42:19Z","timestamp":1742028139000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013424002241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":64,"alternative-id":["S0162013424002241"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2024.112700","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenanthroline and phenyl carboxylate mixed ligand copper complexes in developing drugs to treat cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2024.112700","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112700"}}