{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:06:21Z","timestamp":1792850781266,"version":"4.5.0"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["IF170457"],"award-info":[{"award-number":["IF170457"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["IF160641"],"award-info":[{"award-number":["IF160641"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jinorgbio.2024.112759","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T10:58:33Z","timestamp":1728730713000},"page":"112759","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Copper(II) complexes containing hydrazone and bipyridine\/phenanthroline ligands for anticancer application against breast cancer cells"],"prefix":"10.1016","volume":"262","author":[{"given":"Dorothy Priyanka","family":"Dorairaj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haritha","family":"Rajasekaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattamai","family":"Bhuvanesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sodio C.N.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramasamy","family":"Karvembu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2024.112759_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-2-37","article-title":"Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000","volume":"2","author":"Shibuya","year":"2002","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0010","doi-asserted-by":"crossref","first-page":"5258","DOI":"10.1073\/pnas.92.12.5258","article-title":"The causes and prevention of cancer","volume":"92","author":"Ames","year":"1995","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0015","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2174\/1871520616666160502122724","article-title":"Breast cancer: Current molecular therapeutic targets and new players","volume":"17","author":"Nagini","year":"2017","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0020","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1517\/14656566.2016.1122757","article-title":"Pharmacotherapeutic options for treating adverse effects of cisplatin chemotherapy","volume":"17","author":"Santabarbara","year":"2016","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0025","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/cancers3011351","article-title":"Cisplatin as an anti-tumor drug: Cellular mechanisms of activity, drug resistance and induced side effects","volume":"3","author":"Florea","year":"2011","journal-title":"Cancers"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0030","doi-asserted-by":"crossref","first-page":"11761","DOI":"10.1021\/acs.inorgchem.3c00757","article-title":"Ru(II)-p-cymene complexes of furoylthiourea ligands for anticancer applications against breast cancer cells","volume":"62","author":"Dorairaj","year":"2023","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1476-5829.2007.00142.x","article-title":"Cisplatin: A review of toxicities and therapeutic applications","volume":"6","author":"Barabas","year":"2008","journal-title":"Vet. Comp. Oncol."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0040","doi-asserted-by":"crossref","first-page":"12888","DOI":"10.1039\/D0SC04082G","article-title":"Metallodrugs are unique: Opportunities and challenges of discovery and development","volume":"11","author":"Anthony","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0045","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/2211-5463.13381","article-title":"Metallodrugs: An approach against invasion and metastasis in cancer treatment","volume":"12","author":"Gonz\u00e1lez-Ballesteros","year":"2022","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0050","doi-asserted-by":"crossref","first-page":"510","DOI":"10.2174\/0929867328666211117094550","article-title":"Copper complexes as antitumor agents: in vitro and in vivo evidence","volume":"30","author":"Balsa","year":"2023","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0055","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00432-024-05641-5","article-title":"Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review","volume":"150","author":"Abdolmaleki","year":"2024","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0060","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1093\/ajcn\/63.5.836","article-title":"Genetic and molecular basis for copper toxicity","volume":"63","author":"Harris","year":"1996","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0065","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.pneurobio.2014.01.002","article-title":"Metabolism and functions of copper in brain","volume":"116","author":"Scheiber","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0070","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejphar.2012.06.004","article-title":"Anticancer activity and mutagenic potential of novel copper(II) quinolinone Schiff base complexes in hepatocarcinoma cells","volume":"3","author":"Duff","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0075","doi-asserted-by":"crossref","first-page":"17731","DOI":"10.1039\/D3DT02597G","article-title":"Copper(II) complexes of a furan-containing aroylhydrazonic ligand: syntheses, structural studies, solution chemistry and interaction with HSA","volume":"52","author":"da Silva Moura","year":"2023","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0080","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0022-3093(02)01853-7","article-title":"Copper redox behavior, structure and properties of copper lead borate glasses","volume":"317","author":"Metwalli","year":"2003","journal-title":"J. Non-Cryst. Solids"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4236\/ajac.2018.91002","article-title":"Copper (cu) an essential redox-active transition metal in living system-a review article","volume":"9","author":"Mustafa","year":"2018","journal-title":"Am. J. Anal. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0090","doi-asserted-by":"crossref","first-page":"8800","DOI":"10.1021\/acs.inorgchem.9b01195","article-title":"Binucleating hydrazonic ligands and their \u03bc-hydroxodicopper(II) complexes as promising structural motifs for enhanced antitumor activity","volume":"58","author":"Rada","year":"2019","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202400373","article-title":"Deciphering the effect of a Cu(II)-hydrazone complex on intracellular cell signalling pathways in a human osteosarcoma 2D and 3D models","author":"Balsa","year":"2024","journal-title":"ChemBioChem"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0100","doi-asserted-by":"crossref","first-page":"9812","DOI":"10.1039\/D1DT00869B","article-title":"Anticancer activity of a new copper(II) complex with a hydrazone ligand. Structural and spectroscopic characterization, computational simulations and cell mechanistic studies on 2D and 3D breast cancer cell models","volume":"50","author":"Balsa","year":"2021","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2021.106092","article-title":"Antiproliferative activity of two copper(II) complexes on colorectal cancer cell models: impact on ROS production, apoptosis induction and NF-\u03baB inhibition","volume":"169","author":"Ruiz","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0110","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1039\/D1QI00233C","article-title":"Water-mediated reduction of [Cu(dmp)2(CH3CN)]2+: implications of the structure of a classical complex on its activity as an anticancer drug","volume":"8","author":"Lev\u00edn","year":"2021","journal-title":"Inorg. Chem. Front."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0115","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1021\/acs.inorgchem.3c04085","article-title":"Promising dual anticancer and antimetastatic action by a Cu(II) complex derived from acylhydrazone on human osteosarcoma models","volume":"63","author":"de la Parra","year":"2024","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0120","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1080\/15548627.2023.2200554","article-title":"Copper metabolism in cell death and autophagy","volume":"19","author":"Xue","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0125","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/17460441.2021.1851188","article-title":"Frontiers of metal-coordinating drug design","volume":"16","author":"Palermo","year":"2021","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0130","article-title":"Effect of new Pd(II)-aroylthiourea complex on pancreatic cancer cells","volume":"134","author":"Dorairaj","year":"2021","journal-title":"Inorg. Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0135","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/13543776.2017.1252752","article-title":"Schiff bases in medicinal chemistry: a patent review (2010-2015)","volume":"27","author":"Hameed","year":"2017","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0140","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s11224-009-9455-7","article-title":"Three new coordination complexes of cobalt(III), manganese(II), and copper(II) with N, N, O-donor hydrazone ligands: syntheses and structural characterizations","volume":"20","author":"Shit","year":"2009","journal-title":"Struct. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0145","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.1016\/j.ica.2009.05.062","article-title":"Bis-acyl-\/aroyl-hydrazones as multidentate ligands","volume":"362","author":"Stadler","year":"2009","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0150","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3233\/MGC-140133","article-title":"Metal complexes of hydrazones and their biological, analytical and catalytic applications: a review","volume":"13","author":"Shakdofa","year":"2014","journal-title":"Main Group Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0155","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.3390\/12081910","article-title":"Biological activities of hydrazone derivatives","volume":"12","author":"Rollas","year":"2007","journal-title":"Molecules"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0160","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s11243-007-0228-0","article-title":"Synthesis, spectroscopic investigation and biological activity of metal complexes with ONO trifunctionalalized hydrazone ligand","volume":"32","author":"El-Tabl","year":"2007","journal-title":"Transit. Met. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0165","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jinorgbio.2007.11.002","article-title":"Synthesis and characterization of platinum-sterol hydrazone complexes with biological activity against Leishmania (L.) mexicana","volume":"102","author":"Visbal","year":"2008","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0170","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2174\/092986712798918789","article-title":"A review on biological activities and chemical synthesis of hydrazide derivatives","volume":"19","author":"Narang","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0175","first-page":"5796287","article-title":"The anticancer activities of some nitrogen donor ligands containing bis-pyrazole, bipyridine, and phenanthroline moiety using docking methods","volume":"2018","author":"Adeniyi","year":"2018","journal-title":"Bioinorg. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0180","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jorganchem.2010.01.020","article-title":"Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl) thiazole N, N-chelating ligand","volume":"695","author":"Gras","year":"2010","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0185","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1021\/ja00243a060","article-title":"Nuclease activity of 1,10-phenanthroline-copper ion. Chemistry of deoxyribose oxidation","volume":"109","author":"Goyne","year":"1987","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0190","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1080\/00958972.2013.767449","article-title":"Diorganotin(IV) complexes with furan-2-carbohydrazone derivatives: synthesis, characterization, crystal structure and antibacterial activity","volume":"66","author":"Sedaghat","year":"2013","journal-title":"J. Coord. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0195","doi-asserted-by":"crossref","first-page":"12124","DOI":"10.1039\/c3ra41573b","article-title":"A highly sensitive and selective fluorescent sensor for Al3+ ions based on thiophene-2-carboxylic acid hydrazide Schiff base","volume":"3","author":"Tiwari","year":"2013","journal-title":"RSC Adv."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0200","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jorganchem.2012.08.002","article-title":"Synthesis, structural characterization, electrochemistry and catalytic transfer hydrogenation of ruthenium(II) carbonyl complexes containing tridentate benzoylhydrazone ligands","volume":"718","author":"Prabhu","year":"2012","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0205","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ica.2015.03.029","article-title":"Recognition of Al3+ based on a naphthalene-based \u201coff\u2013on\u201d chemosensor in near 100% aqueous media","volume":"432","author":"Qin","year":"2015","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0210","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.5012\/bkcs.2012.33.10.3361","article-title":"Synthesis, antioxidant activity and fluorescence properties of novel europium complexes with (E)-2-or 4-hydroxy-N'-[(2-hydroxynaphthalen-1-yl) methylene]benzohydrazide Schiff base","volume":"33","author":"Liu","year":"2012","journal-title":"Bull. Korean Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0215","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.cellbi.2006.06.016","article-title":"Analysis of cycloheximide-induced apoptosis in human leukocytes: fluorescence microscopy using Annexin V\/propidium iodide versus acridin orange\/ethidium bromide","volume":"30","author":"Baski\u0107","year":"2006","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0220","first-page":"323","article-title":"Flow cytometric methods for detection and quantification of apoptosis","volume":"85","author":"Steensma","year":"2003","journal-title":"Methods Mol. Med."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0225","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jinorgbio.2018.01.016","article-title":"Synthesis, characterization and cytotoxic activity of novel copper(II) complexes with aroylhydrazone derivatives of 2-oxo-1,2-dihydrobenzo[h]quinoline-3-carbaldehyde","volume":"182","author":"Ramachandran","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0230","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.saa.2005.04.015","article-title":"Synthesis and spectroscopic studies of copper(II) and nickel(II) complexes containing hydrazonic ligands and heterocyclic coligand","volume":"62","author":"Gup","year":"2005","journal-title":"Spectrochim. Acta A"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0235","doi-asserted-by":"crossref","DOI":"10.1002\/aoc.6481","article-title":"New mixed ligand copper(II) hydrazone-based complexes: synthesis, characterization, crystal structure, DNA\/RNA\/BSA binding, in vitro anticancer, apoptotic activity, and cell cycle analysis","volume":"36","author":"Elsayed","year":"2022","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0240","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1021\/acs.organomet.0c00092","article-title":"Synthesis and structure of arene Ru(II) N\u2227 O-chelating complexes: in vitro cytotoxicity and cancer cell death mechanism","volume":"39","author":"Balaji","year":"2020","journal-title":"Organometallics"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.poly.2020.114624","article-title":"Copper(II) hydrazone complexes with different nuclearities and geometries: synthesis, structural characterization, antioxidant, SOD activity and antiproliferative properties","volume":"186","author":"Patel","year":"2020","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0250","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.saa.2014.02.014","article-title":"Mono- and binuclear-copper(II) complexes of new hydrazone ligands derived from 4,6-diacetylresorcinol: synthesis, spectral studies and antimicrobial activity","volume":"126","author":"Shebl","year":"2014","journal-title":"Spectrochim. Acta A"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0255","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/00958979209409214","article-title":"In situ synthesis and spectroscopic studies of copper(II) and nickel(II) complexes of 1-hydroxy-2-naphthylstyrylketoneimines","volume":"26","author":"Natarajan","year":"1992","journal-title":"J. Coord. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.ica.2020.119434","article-title":"Easy coordinate geometry indexes, \u03c44 and \u03c45 and HSA study for unsymmetrical Pd(II), Fe(II), Zn(II), Mn(II), Cu(II) and VO(IV) complexes of a tetradentate ligand: synthesis, characterization, properties, and antioxidant activities","volume":"505","author":"Said","year":"2020","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0265","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1039\/DT9840001349","article-title":"Synthesis, structure, and spectroscopic properties of copper(II) compounds containing nitrogen-sulphur donor ligands; The crystal and molecular structure of aqua[1, 7-bis(N-methylbenzimidazol-2\u2032-yl)-2, 6-dithiaheptane]copper(II)perchlorate","volume":"7","author":"Addison","year":"1984","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0270","doi-asserted-by":"crossref","first-page":"14798","DOI":"10.1039\/D0DT02985H","article-title":"Five-coordinate transition metal complexes and the value of \u03c45: observations and caveats","volume":"49","author":"Blackman","year":"2020","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0275","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/07391102.2008.10507229","article-title":"Intercalation of daunomycin into stacked DNA base pairs. DFT study of an anticancer drug","volume":"26","author":"Barone","year":"2008","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0280","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1021\/ar00177a001","article-title":"On demonstrating DNA intercalation","volume":"23","author":"Long","year":"1990","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0285","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.abb.2015.03.024","article-title":"Studying non-covalent drug\u2013DNA interactions","volume":"576","author":"Rehman","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0290","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/15257770.2021.1880011","article-title":"Studies to explore the UVA photosensitizing action of 9-phenylacridine in cells by interaction with DNA","volume":"40","author":"Hansda","year":"2021","journal-title":"Nucleos. Nucleot. Nucl."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0295","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1016\/j.poly.2009.05.071","article-title":"Syntheses, X-ray crystal structures, DNA binding, oxidative cleavage activities and antimicrobial studies of two Cu(II) hydrazone complexes","volume":"28","author":"Banerjee","year":"2009","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0300","doi-asserted-by":"crossref","first-page":"7210","DOI":"10.1039\/c3dt50371b","article-title":"Potentially cytotoxic new copper(II) hydrazone complexes: synthesis, crystal structure and biological properties","volume":"42","author":"Alagesan","year":"2013","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0305","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1002\/cbdv.200790177","article-title":"Copper(II) complexes of salicylaldehyde hydrazones: synthesis, structure, and DNA interaction","volume":"4","author":"Wu","year":"2007","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0310","doi-asserted-by":"crossref","DOI":"10.1002\/aoc.3680","article-title":"Synthesis, characterization and biological applications of new copper(II) complexes of aryl hydrazones","volume":"31","author":"Tummalapalli","year":"2017","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0315","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1016\/j.ejmech.2011.05.001","article-title":"Evaluation of DNA binding, DNA cleavage, protein binding and in vitro cytotoxic activities of bivalent transition metal hydrazone complexes","volume":"46","author":"Krishnamoorthy","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0320","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/jmbi.2000.3869","article-title":"A thermodynamic and structural analysis of DNA minor-groove complex formation","volume":"300","author":"Mazur","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0325","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1080\/07391102.2018.1503564","article-title":"Example of two novel thiocyanato bridged copper(II) complexes derived from substituted thiosemicarbazone ligand: structural elucidation, DNA\/albumin binding, biological profile analysis, and molecular docking study","volume":"37","author":"Biswas","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0330","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1021\/bi00067a011","article-title":"GC base sequence recognition by oligoimidazolecarboxamide and C-terminus-modified analogs of distamycin deduced from circular dichroism, proton nuclear magnetic resonance, and methidiumpropylethylenediaminetetraacetate-iron(II) footprinting studies","volume":"32","author":"Lee","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112422","article-title":"Targeted delivery of albumin nanoparticles for breast cancer: a review","volume":"213","author":"Kunde","year":"2022","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0340","doi-asserted-by":"crossref","first-page":"S240","DOI":"10.1016\/j.jscs.2014.02.009","article-title":"Fluorescent copper(II) complexes: the electron transfer mechanism, interaction with bovine serum albumin (BSA) and antibacterial activity","volume":"21","author":"Hazra","year":"2017","journal-title":"J. Saudi Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0345","doi-asserted-by":"crossref","unstructured":"J. Liu, J.-n. Tian, J. Zhang, Z. Hu, X. Chen, Interaction of magnolol with bovine serum albumin: a fluorescence-quenching study, Anal. Bioanal. Chem. 376 (2003) 864\u2013867.","DOI":"10.1007\/s00216-003-2017-8"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0350","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jinorgbio.2012.05.018","article-title":"Two new dicopper(II) complexes with oxamido-bridged ligand: synthesis, crystal structures, DNA binding\/cleavage and BSA binding activity","volume":"115","author":"Xue","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.ica.2021.120536","article-title":"Investigation of DNA\/BSA binding and cytotoxic properties of new Co(II), Ni(II) and Cu(II) hydrazone complexes","volume":"526","author":"Kanchanadevi","year":"2021","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0360","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00775-011-0844-1","article-title":"Structure\u2013activity relationship study of copper(II) complexes with 2-oxo-1,2-dihydroquinoline-3-carbaldehyde(4\u2032-methylbenzoyl) hydrazone: synthesis, structures, DNA and protein interaction studies, antioxidative and cytotoxic activity","volume":"17","author":"Senthil Raja","year":"2012","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2021.132126","article-title":"Spectroanalytical, computational, DNA\/BSA binding and in vitro cytotoxic activity studies of new transition metal complexes of novel aryl hydrazone","volume":"1252","author":"Chennam","year":"2022","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0370","first-page":"439","article-title":"Understanding intermolecular and intramolecular hydrogen bonds: spectroscopic and computational approaches","volume":"5","author":"Samuel","year":"2023","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0375","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.comptc.2010.09.011","article-title":"Intermolecular hydrogen bonding interactions of furan, isoxazole and oxazole with water","volume":"963","author":"Kaur","year":"2011","journal-title":"Comput. Theor. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0380","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/cbdd.14116","article-title":"DNA intercalators as anticancer agents","volume":"100","author":"Venugopal","year":"2022","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0385","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.3390\/ijms17111818","article-title":"Transition metal intercalators as anticancer agents-recent advances","volume":"17","author":"Deo","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0390","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.2174\/1381612013397113","article-title":"Intercalators as anticancer drugs","volume":"7","author":"Brana","year":"2001","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0395","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/cmdc.200800097","article-title":"Phenanthroline derivatives with improved selectivity as DNA-targeting anticancer or antimicrobial drugs","volume":"3","author":"Roy","year":"2008","journal-title":"ChemMedChem"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0400","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ejmech.2018.07.022","article-title":"Mixed-ligand Cu(II) hydrazone complexes designed to enhance anticancer activity","volume":"156","author":"Mo","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0405","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1080\/00958972.2020.1843160","article-title":"Cu(II) complexes of hydrazones\u2013NSAID conjugates: synthesis, characterization and anticancer activity","volume":"73","author":"Kaur","year":"2020","journal-title":"J. Coord. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0410","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.molliq.2018.08.075","article-title":"Synthesis, characterization, DNA binding and antitumor activities of Cu(II) complexes","volume":"269","author":"Shoair","year":"2018","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2021.130469","article-title":"Aroylhydrazone Cu(II) complexes: syntheses, crystal structures, and anticancer properties","volume":"1239","author":"Hou","year":"2021","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0420","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ica.2018.09.084","article-title":"Polynuclear copper(II) complexes with nalidixic acid hydrazones: Antiproliferative activity and selectivity assessment over a panel of tumor cells","volume":"484","author":"Bergamini","year":"2019","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0430","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1039\/C5RA20157H","article-title":"DNA and BSA binding, anticancer and antimicrobial properties of Co(II), Co(II\/III), Cu(II) and Ag(I) complexes of arylhydrazones of barbituric acid","volume":"6","author":"Palmucci","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0435","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ica.2015.03.016","article-title":"A novel cationic copper(II) Schiff base complex: synthesis, characterization, crystal structure, electrochemical evaluation, anticancer activity, and preparation of its metal oxide nanoparticles","volume":"430","author":"Ebrahimipour","year":"2015","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0440","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202100520","article-title":"Anticancer activity and mechanism of action evaluation of an acylhydrazone Cu(II) complex toward breast cancer cells, spheroids, and mammospheres","volume":"17","author":"Balsa","year":"2022","journal-title":"ChemMedChem"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0445","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.1101\/pdb.prot4493","article-title":"Acridine orange\/ethidium bromide (AO\/EB) staining to detect apoptosis","volume":"3","author":"Kasibhatla","year":"2006","journal-title":"Cold Spring Harb Protoc"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2022.111843","article-title":"Bidentate acylthiourea ligand anchored Pd-PPh3 complexes with biomolecular binding, cytotoxic, antioxidant and antihemolytic properties","volume":"233","author":"Dorairaj","year":"2022","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0455","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2007.02.010","article-title":"A fluorescence vital assay for the recognition and quantification of excitotoxic cell death by necrosis and apoptosis using confocal microscopy on neurons in culture","volume":"163","author":"Mironova","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0460","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.brainresprot.2004.04.001","article-title":"Quantification of sPLA2-induced early and late apoptosis changes in neuronal cell cultures using combined TUNEL and DAPI staining","volume":"13","author":"Daniel","year":"2004","journal-title":"Brain Res. Protocol."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0465","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s004180100249","article-title":"Fluorescent dyes for cell viability: an application on prefixed conditions","volume":"115","author":"Foglieni","year":"2001","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0470","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/jmi.12133","article-title":"Cell-death assessment by fluorescent and nonfluorescent cytosolic and nuclear staining techniques","volume":"255","author":"Atale","year":"2014","journal-title":"J. Microsc."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0475","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1042\/BC20090077","article-title":"Plasma membrane and nuclear envelope integrity during the blebbing stage of apoptosis: a time-lapse study","volume":"102","author":"Andrade","year":"2010","journal-title":"Biol. Cell."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0480","doi-asserted-by":"crossref","first-page":"6986","DOI":"10.1016\/S0021-9258(17)37471-9","article-title":"Casein kinase II is required for transition of G0\/G1, early G1, and G1\/S phases of the cell cycle","volume":"269","author":"Pepperkok","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0485","first-page":"143","article-title":"Anticancer effects of copper(II) hydrazone Schiff base complex: a review. Basic","volume":"13","author":"Fekri","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0490","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1039\/C8MD00223A","article-title":"Copper(II) complexes based on quinoline-derived Schiff-base ligands: synthesis, characterization, HSA\/DNA binding ability, and anticancer activity","volume":"9","author":"Hu","year":"2018","journal-title":"Med. Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0495","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s10895-016-1892-2","article-title":"Synthesis of dipyridyl ketone isonicotinoyl hydrazone copper(II) complex: structure, anticancer activity and anticancer mechanism","volume":"26","author":"Deng","year":"2016","journal-title":"J. Fluoresc."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0500","first-page":"191","article-title":"Apoptosis measurement by Annexin-V staining","author":"Miller","year":"2004","journal-title":"Methods Protoc."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0505","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.3748\/wjg.14.2174","article-title":"Detection of apoptosis induced by new type gosling viral enteritis virus in vitro through fluorescein Annexin V-FITC\/PI double labeling","volume":"14","author":"Chen","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0510","first-page":"179","article-title":"Evaluation of anticancer agents using flow cytometry analysis of cancer stem cells","volume":"716","author":"Gupta","year":"2011","journal-title":"Drug Des. Discov."},{"key":"10.1016\/j.jinorgbio.2024.112759_bb0515","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/cyto.a.23873","article-title":"Multiparameter flow cytometry assay for quantification of immune cell subsets, PD-1 expression levels and PD-1 receptor occupancy by nivolumab and pembrolizumab","volume":"95","author":"Pluim","year":"2019","journal-title":"Cytom. Part A"}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013424002848?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013424002848?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T16:11:34Z","timestamp":1732637494000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013424002848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":102,"alternative-id":["S0162013424002848"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2024.112759","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Copper(II) complexes containing hydrazone and bipyridine\/phenanthroline ligands for anticancer application against breast cancer cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2024.112759","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112759"}}