{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T09:33:15Z","timestamp":1762248795044,"version":"build-2065373602"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010253","name":"Secretar\u00eda de Ciencia y T\u00e9cnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020170100197BA"],"award-info":[{"award-number":["20020170100197BA"]}],"id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007351","name":"University of Buenos Aires Secretariat of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007351","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021778","name":"National Agency for Scientific and Technological Promotion","doi-asserted-by":"publisher","award":["PICT-2020-001264"],"award-info":[{"award-number":["PICT-2020-001264"]}],"id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jinorgbio.2025.112905","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T15:03:44Z","timestamp":1742915024000},"page":"112905","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ascorbic acid potentiates the formation of IgG-enriched protein aggregates in plasma in a Cu(II)-mediated manner"],"prefix":"10.1016","volume":"269","author":[{"given":"Christian","family":"Saporito-Magri\u00f1a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lila","family":"Lopez-Monta\u00f1ana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Laura","family":"Facio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guadalupe","family":"Pagano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Topp","family":"Nicole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariana","family":"Danzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Ignacio","family":"Bellida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agust\u00edn","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mat\u00edas","family":"Albizzati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa Gabriela","family":"Repetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2025.112905_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1257665","article-title":"Decreasing hydrophobicity or shielding hydrophobic areas of CH2 attenuates low pH-induced IgG4 aggregation","volume":"11","author":"Wu","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.112905_bb0010","first-page":"30","article-title":"Protein Misfolding and Aggregation in Proteinopathies: Causes, Mechanism and Cellular Response","volume":"vol. 11","author":"Ajmal","year":"2023","journal-title":"Diseases (Basel, Switzerland)"},{"key":"10.1016\/j.jinorgbio.2025.112905_bb0015","first-page":"168","article-title":"The proteome of neurofilament-containing protein aggregates in blood","volume":"14","author":"Adiutori","year":"2018","journal-title":"Biochem. Biophys. Rep."},{"issue":"3","key":"10.1016\/j.jinorgbio.2025.112905_bb0020","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11357-016-9919-9","article-title":"Increased levels of hyper-stable protein aggregates in plasma of older adults","volume":"38","author":"Xia","year":"2016","journal-title":"Age"},{"issue":"2","key":"10.1016\/j.jinorgbio.2025.112905_bb0025","doi-asserted-by":"crossref","first-page":"mfad005","DOI":"10.1093\/mtomcs\/mfad005","article-title":"Copper-induced aggregation of IgG: a potential driving force for the formation of circulating protein aggregates","volume":"15","author":"Saporito-Magri\u00f1a","year":"2023","journal-title":"Metallomics"},{"key":"10.1016\/j.jinorgbio.2025.112905_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2021.111536","article-title":"Structure prediction of neutral physiological copper(II) compounds with l-cysteine and l-histidine","volume":"223","author":"Ramek","year":"2021","journal-title":"J. Inorg. Biochem."},{"issue":"29","key":"10.1016\/j.jinorgbio.2025.112905_bb0035","doi-asserted-by":"crossref","first-page":"27402","DOI":"10.1074\/jbc.M504241200","article-title":"Copper-catalyzed protein oxidation and its modulation by carbon dioxide: enhancement of protein radicals in cells","volume":"280","author":"Ramirez","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.jinorgbio.2025.112905_bb0040","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1039\/C8MT00182K","article-title":"Copper-induced cell death and the protective role of glutathione: the implication of impaired protein folding rather than oxidative stress","volume":"10","author":"Saporito-Magri\u00f1\u00e1","year":"2018","journal-title":"Metallomics"},{"issue":"16","key":"10.1016\/j.jinorgbio.2025.112905_bb0045","doi-asserted-by":"crossref","first-page":"5832","DOI":"10.1039\/c3dt32836h","article-title":"Oxidation of copper nanoparticles in water: mechanistic insights revealed by oxygen uptake and spectroscopic methods","volume":"42","author":"Pacioni","year":"2003","journal-title":"Dalton Trans."},{"issue":"2","key":"10.1016\/j.jinorgbio.2025.112905_bb0050","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3390\/nu13020615","article-title":"Vitamin C-sources, physiological role, kinetics, deficiency, use, toxicity, and determination","volume":"13","author":"Dosed\u011bl","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jinorgbio.2025.112905_bb0055","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jcat.2013.01.025","article-title":"Fenton-like copper redox chemistry revisited: hydrogen peroxide and superoxide mediation of copper-catalyzed oxidant production","volume":"301","author":"Ninh","year":"2013","journal-title":"J. Catal."},{"key":"10.1016\/j.jinorgbio.2025.112905_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101722","article-title":"Production of superoxide and hydrogen peroxide in the mitochondrial matrix is dominated by site IQ of complex I in diverse cell lines","volume":"37","author":"Fang","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.jinorgbio.2025.112905_bb0065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-030-11488-6_1","article-title":"Diffusion and transport of reactive species across cell membranes","volume":"1127","author":"M\u00f6ller","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"issue":"7","key":"10.1016\/j.jinorgbio.2025.112905_bb0070","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1089\/ars.2018.7583","article-title":"Vascular biology of superoxide-generating NADPH oxidase 5-implications in hypertension and cardiovascular disease","volume":"30","author":"Touyz","year":"2019","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.112905_bb0075","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/cmi.2014.89","article-title":"NADPH oxidases: an overview from structure to innate immunity-associated pathologies","volume":"12","author":"Panday","year":"2015","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.112905_bb0080","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.microc.2010.03.002","article-title":"Metal-induced oxidative burst in isolated human neutrophils","volume":"96","author":"Freitas","year":"2010","journal-title":"Microchem. J."},{"key":"10.1016\/j.jinorgbio.2025.112905_bb0085","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-61779-527-5_8","article-title":"Measurement of oxidative burst in neutrophils","volume":"844","author":"Chen","year":"2012","journal-title":"Meth. Mol. Biol. (Clifton, N.J.)"},{"issue":"4","key":"10.1016\/j.jinorgbio.2025.112905_bb0090","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jlb.51.4.373","article-title":"A monoclonal antibody specific for immunoglobulin a receptor triggers polymorphonuclear neutrophil superoxide release","volume":"51","author":"Shen","year":"1992","journal-title":"J. Leukoc. Biol."},{"issue":"11","key":"10.1016\/j.jinorgbio.2025.112905_bb0095","doi-asserted-by":"crossref","first-page":"15208","DOI":"10.1096\/fj.202001085R","article-title":"IgG-aggregates rapidly upregulate FcgRI expression at the surface of human neutrophils in a FcgRII-dependent fashion: a crucial role for FcgRI in the generation of reactive oxygen species","volume":"34","author":"Huot","year":"2020","journal-title":"FASEB J: Offi. Publicat. Federati. American Soci. Experiment. Biol."},{"issue":"3","key":"10.1016\/j.jinorgbio.2025.112905_bb0100","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3390\/nu13030735","article-title":"High-dose vitamin C in advanced-stage Cancer patients","volume":"13","author":"Zasowska-Nowak","year":"2021","journal-title":"Nutrients"},{"issue":"16","key":"10.1016\/j.jinorgbio.2025.112905_bb0105","doi-asserted-by":"crossref","first-page":"6377","DOI":"10.1073\/pnas.86.16.6377","article-title":"Ascorbate is an outstanding antioxidant in human blood plasma","volume":"86","author":"Frei","year":"1989","journal-title":"PNAS"},{"issue":"3","key":"10.1016\/j.jinorgbio.2025.112905_bb0110","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/1559827616629092","article-title":"Vitamin C in the prevention and treatment of the common cold","volume":"10","author":"Bucher","year":"2016","journal-title":"Am. J. Lifestyle Med."},{"key":"10.1016\/j.jinorgbio.2025.112905_bb0115","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1475-2891-11-7","article-title":"Intravenous vitamin C administration reduces fatigue in office workers: a double-blind randomized controlled trial","volume":"11","author":"Suh","year":"2012","journal-title":"Nutr. J."},{"issue":"7","key":"10.1016\/j.jinorgbio.2025.112905_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011414","article-title":"Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects","volume":"5","author":"Padayatty","year":"2010","journal-title":"PloSone"},{"key":"10.1016\/j.jinorgbio.2025.112905_bb0125","doi-asserted-by":"crossref","unstructured":"J. Brown, C. Robertson, L. Sevilla, J. Garza, H. Rashid, A.C. Benitez, M., Shipotko, Z. Ali, 2022. A systematic review and Meta-analysis on possible role of vitamin C in Sepsis. Cureus, 14(12), e32886. doi: https:\/\/doi.org\/10.7759\/cureus.32886.","DOI":"10.7759\/cureus.32886"},{"issue":"11","key":"10.1016\/j.jinorgbio.2025.112905_bb0130","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3390\/nu9111211","article-title":"Vitamin C and immune function","volume":"9","author":"Carr","year":"2017","journal-title":"Nutrients"},{"issue":"32","key":"10.1016\/j.jinorgbio.2025.112905_bb0135","doi-asserted-by":"crossref","first-page":"11105","DOI":"10.1073\/pnas.0804226105","article-title":"Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice","volume":"105","author":"Chen","year":"2008","journal-title":"PNAS"},{"issue":"11","key":"10.1016\/j.jinorgbio.2025.112905_bb0140","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/annonc\/mdn377","article-title":"Phase I clinical trial of i.v. ascorbic acid in advanced malignancy","volume":"19","author":"Hoffer","year":"2008","journal-title":"Ann. Oncol."},{"issue":"2","key":"10.1016\/j.jinorgbio.2025.112905_bb0145","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s10787-023-01169-1","article-title":"The effects of vitamin C on respiratory, allergic and immunological diseases: an experimental and clinical-based review","volume":"31","author":"Ghalibaf","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"32","key":"10.1016\/j.jinorgbio.2025.112905_bb0150","doi-asserted-by":"crossref","first-page":"18996","DOI":"10.1016\/S0021-9258(19)47256-6","article-title":"Ascorbic acid transport and accumulation in human neutrophils","volume":"264","author":"Washko","year":"1989","journal-title":"J. Biol. Chem."},{"issue":"21","key":"10.1016\/j.jinorgbio.2025.112905_bb0155","doi-asserted-by":"crossref","first-page":"15531","DOI":"10.1016\/S0021-9258(18)82289-X","article-title":"Ascorbic acid recycling in human neutrophils","volume":"268","author":"Washko","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.jinorgbio.2025.112905_bb0160","first-page":"2743","article-title":"Kinetics of formation of oligomeric species from the aggregation of a model protein","volume":"104","author":"Arosio","year":"2013","journal-title":"Biophys. J."},{"key":"10.1016\/j.jinorgbio.2025.112905_bb0165","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0021-9258(18)84277-6","article-title":"On tyrosine and tryptophane determinations in proteins","volume":"73","author":"Folin","year":"1927","journal-title":"Biol. Chem."},{"issue":"6","key":"10.1016\/j.jinorgbio.2025.112905_bb0170","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/hep.20720","article-title":"Albumin: biochemical properties and therapeutic potential","volume":"41","author":"Quinlan","year":"2005","journal-title":"Hepatol"},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.112905_bb0175","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4161\/pri.2.1.6297","article-title":"Ceruloplasmin fragmentation is implicated in 'free' copper deregulation of Alzheimer's disease","volume":"2","author":"Squitti","year":"2008","journal-title":"Prion"},{"issue":"2","key":"10.1016\/j.jinorgbio.2025.112905_bb0180","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1309\/AJCP7Z9KBFINVGYF","article-title":"Direct measurement of free copper in serum or plasma ultrafiltrate","volume":"131","author":"McMillin","year":"2009","journal-title":"Am. J. Clin. Pathol."},{"issue":"2","key":"10.1016\/j.jinorgbio.2025.112905_bb0185","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.bbrc.2005.12.013","article-title":"Ascorbic acid reduction of microtubule protein disulfides and its relevance to protein S-nitrosylation assays","volume":"340","author":"Landino","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"18","key":"10.1016\/j.jinorgbio.2025.112905_bb0190","doi-asserted-by":"crossref","first-page":"8463","DOI":"10.1073\/pnas.92.18.8463","article-title":"Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments","volume":"92","author":"Schweers","year":"1995","journal-title":"PNAS"},{"key":"10.1016\/j.jinorgbio.2025.112905_bb0195","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1039\/B813398K","article-title":"Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-\u03b2 peptide","volume":"7","author":"Faller","year":"2009","journal-title":"Dalton Trans."},{"issue":"7","key":"10.1016\/j.jinorgbio.2025.112905_bb0200","first-page":"797","article-title":"Similarity of copper and technetium binding sites in human IgG. International journal of radiation applications and instrumentation. Part B, nuclear","volume":"19","author":"Zamora","year":"1992","journal-title":"La Medicina Biologica"},{"issue":"17","key":"10.1016\/j.jinorgbio.2025.112905_bb0205","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1002\/anie.200802808","article-title":"Alzheimer's disease: from pathology to therapeutic approaches","volume":"48","author":"Jakob-Roetne","year":"2009","journal-title":"Angew. Chem. Int. Ed. Eng."},{"issue":"12","key":"10.1016\/j.jinorgbio.2025.112905_bb0210","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1039\/D3CB00145H","article-title":"Copper binding and protein aggregation: a journey from the brain to the human lens","volume":"4","author":"Posadas","year":"2023","journal-title":"RSC Chem. Biol."},{"issue":"5\u20136","key":"10.1016\/j.jinorgbio.2025.112905_bb0215","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.2166\/wst.2018.416","article-title":"Generation of reactive oxygen species by promoting the cu(II)\/cu(I) redox cycle with reducing agents in aerobic aqueous solution. Water science and technology","volume":"78","author":"Li","year":"2018","journal-title":"J. Int. Assoc. Water Pollution Res."},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.112905_bb0220","first-page":"143","article-title":"The combined Administration of Vitamin C and Copper Induces a systemic oxidative stress and kidney injury","volume":"13","author":"Jiang","year":"2023","journal-title":"Biomol"},{"issue":"3","key":"10.1016\/j.jinorgbio.2025.112905_bb0225","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1006\/bbrc.2001.5042","article-title":"An analog of the human albumin N-terminus (asp-ala-his-Lys) prevents formation of copper-induced reactive oxygen species","volume":"284","author":"Bar-Or","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"25","key":"10.1016\/j.jinorgbio.2025.112905_bb0230","doi-asserted-by":"crossref","first-page":"21530","DOI":"10.1074\/jbc.M112.372961","article-title":"Serum albumin prevents protein aggregation and amyloid formation and retains chaperone-like activity in the presence of physiological ligands","volume":"287","author":"Finn","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.jinorgbio.2025.112905_bb0235","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1006\/bbrc.1994.1278","article-title":"The role of individual fc gamma receptors in aggregated IgG-stimulated protein tyrosine phosphorylation in the human neutrophil","volume":"199","author":"Richard","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013425000856?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013425000856?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T09:30:02Z","timestamp":1762248602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013425000856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":47,"alternative-id":["S0162013425000856"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2025.112905","relation":{},"ISSN":["0162-0134"],"issn-type":[{"type":"print","value":"0162-0134"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ascorbic acid potentiates the formation of IgG-enriched protein aggregates in plasma in a Cu(II)-mediated manner","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2025.112905","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112905"}}