{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:49:44Z","timestamp":1793922584044,"version":"4.8.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["451-03-136\/2025-03\/200378"],"award-info":[{"award-number":["451-03-136\/2025-03\/200378"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["451-03-136\/2025-03\/200043"],"award-info":[{"award-number":["451-03-136\/2025-03\/200043"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031402","name":"Institute for Information Technologies Kragujevac, University of Kragujevac","doi-asserted-by":"publisher","award":["J01-34\/2023"],"award-info":[{"award-number":["J01-34\/2023"]}],"id":[{"id":"10.13039\/100031402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jinorgbio.2025.112941","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T18:25:40Z","timestamp":1746123940000},"page":"112941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Novel organoruthenium complexes containing \u03b2-Diketonates: Synthesis, characterization, DNA\/HSA interactions, and the impact of biocompatible ionic liquids on biological activities"],"prefix":"10.1016","volume":"270","author":[{"given":"Nenad","family":"Jankovi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran A.","family":"Bogdanovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevenka","family":"Gligorijevi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazar","family":"Milovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Me\u0111edovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovana","family":"Mati\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijana","family":"Kosani\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Vrane\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Rilak","family":"Simovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2025.112941_bb0005","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.7150\/thno.69424","article-title":"Platinum-based drugs for cancer therapy and anti-tumor strategies","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0010","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.2165\/11316640-000000000-00000","article-title":"Cisplatin overdose: toxicities and management","volume":"32","author":"Tsang","year":"2009","journal-title":"Drug Saf."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0015","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.3390\/molecules24101995","article-title":"NAMI-A and KP1019\/1339, two iconic ruthenium anticancer drug candidates face-to-face: a case story in medicinal inorganic chemistry","volume":"24","author":"Alessio","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0020","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/asia.200800149","article-title":"Medicinal organometallic chemistry: designing metal Arene complexes as anticancer agents","volume":"3","author":"Peacock","year":"2008","journal-title":"Chem. Asian J."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0025","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1002\/ejic.200701291","article-title":"Influence of the Diketonato Ligand on the Cytotoxicities of [Ru(\u03b76-p-cymene)(R2acac)(PTA)]+ Complexes (PTA = 1,3,5-triaza-7-phosphaadamantane)","author":"Vock","year":"2008","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0030","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1021\/jm050015d","article-title":"In vitro and in vivo evaluation of ruthenium(II)-arene PTA complexes","volume":"48","author":"Scolaro","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104343","article-title":"2,4-Diketo esters: crucial intermediates for drug discovery","volume":"105","author":"Joksimovi\u0107","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2023.215169","article-title":"An overview of advancement of organoruthenium(II) complexes as prospective anticancer agents","volume":"487","author":"Bashir","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2022.920379","article-title":"Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line","volume":"13","author":"Kljun","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0050","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.3390\/molecules28062499","article-title":"Exploring pta alternatives in the development of ruthenium\u2013arene anticancer compounds","volume":"28","author":"Kljun","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0055","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1039\/D0EN00949K","article-title":"Towards resolution of antibacterial mechanisms in metal and metal oxide nanomaterials: a meta-analysis of the influence of study design on mechanistic conclusions, environ","volume":"8","author":"Albalghiti","year":"2021","journal-title":"Sci Nano"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0060","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.microc.2009.12.006","article-title":"Antibacterial and luminescent properties of new donor\u2013acceptor ruthenium triphenylphosphine\u2013bipyridinium complexes","volume":"95","author":"Thangadurai","year":"2010","journal-title":"Microchem. J."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0065","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.2174\/092986706776360941","article-title":"Ruthenium complexes as anticancer agents","volume":"13","author":"Kostova","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0070","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3389\/fphar.2018.01323","article-title":"Applications of ruthenium complex in tumor diagnosis and therapy","volume":"9","author":"Lin","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0075","first-page":"2942","article-title":"Antibacterial and cytotoxic activity of ruthenium-p-cymene complexes with 2-Methylquinolin-8-ol derivatives","volume":"6","author":"Nain-Perez","year":"2021","journal-title":"Chem. Select."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0080","doi-asserted-by":"crossref","first-page":"38629","DOI":"10.1039\/C9RA08736B","article-title":"Anticancer and antimicrobial properties of novel \u03b76-p-cymene ruthenium(II) complexes containing a N S-type ligand, their structural and theoretical characterization","volume":"9","author":"Namieci\u0144ska","year":"2019","journal-title":"RSC Adv."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.poly.2021.115244","article-title":"Half-sandwich ruthenium (II) p-cymene complexes based on organophosphorus ligands: structure determination, computational investigation, in vitro antiproliferative effect in breast cancer cells and antimicrobial activity","volume":"204","author":"Klaimanee","year":"2021","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0090","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3390\/antibiotics12020365","article-title":"Biological activities of ruthenium NHC complexes: an update","volume":"12","author":"Catalano","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0095","doi-asserted-by":"crossref","first-page":"15067","DOI":"10.1039\/C6DT02257J","article-title":"Synthesis, characterization, biological activity, DNA and BSA binding study: novel copper(II) complexes with 2-hydroxy-4-aryl-4-oxo-2-butenoate","volume":"45","author":"Joksimovi\u0107","year":"2016","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0100","series-title":"Rigaku Oxford Diffraction","author":"CrysAlisPro","year":"2021"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","article-title":"Crystal structure refinement with SHELXL","volume":"C71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst. C"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0110","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1107\/S1600576719014092","article-title":"Mercury 4.0: from visualization to analysis, design and prediction","volume":"53","author":"Macrae","year":"2020","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0115","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1107\/S0021889899006020","article-title":"WinGX suite for small-molecule single-crystal crystallography","volume":"32","author":"Farrugia","year":"1999","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0120","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1107\/S0021889802022112","article-title":"Single-crystal structure validation with the program PLATON","volume":"36","author":"Spek","year":"2003","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0125","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1107\/S0021889895007138","article-title":"PARST95 - an update to PARST: a system of Fortran routines for calculating molecular structure parameters from the results of crystal structure analyses","volume":"28","author":"Nardelli","year":"1995","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0130","series-title":"In Vitro Toxicity Testing Protocols","first-page":"137","article-title":"MTT Assays","author":"Supino","year":"1995"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0135","series-title":"Flow Cytometry, a Practical Approach","author":"Ormerod","year":"1994"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0140","author":"BD Biosciences"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0320(19980101)31:1<1::AID-CYTO1>3.0.CO;2-R","article-title":"Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure","volume":"31","author":"van Engeland","year":"1998","journal-title":"Cytometry"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0150","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ymeth.2007.01.006","article-title":"Microtitre plate-based antibacterial assay incorporating resazurin as an indicator of cell growth, and its application in the in vitro antibacterial screening of phytochemicals","volume":"42","author":"Sarker","year":"2007","journal-title":"Methods"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0155","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1002\/cbdv.200890195","article-title":"KP1019, a new redox-active anticancer agent-preclinical development and results of a clinical phase I study in tumor patients","volume":"5","author":"Hartinger","year":"2008","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0160","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.jinorgbio.2006.02.013","article-title":"From bench to bedside\u2014preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)","volume":"100","author":"Hartinger","year":"2006","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0165","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1158\/1078-0432.CCR-03-0746","article-title":"A phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent","volume":"10","author":"Rademaker-Lakhai","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0170","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jorganchem.2010.11.009","article-title":"Organometallic ruthenium-based antitumor compounds with novel modes of action","volume":"696","author":"Ang","year":"2011","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0175","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.1021\/jm301376a","article-title":"Structure\u2013Activity relationships of targeted RuII(\u03b76-p-Cymene) anticancer complexes with flavonol-derived ligands","volume":"55","author":"Kurzwernhart","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0180","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1021\/jm200912j","article-title":"Ruthenium\u2212Arene complexes of curcumin: X-ray and Density functional theory structure, synthesis, and spectroscopic characterization, in vitro antitumor activity, and DNA docking studies of (p-cymene)Ru(curcuminato)chloro","volume":"55","author":"Caruso","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0185","doi-asserted-by":"crossref","first-page":"5173","DOI":"10.1002\/chem.200400640","article-title":"Use of chelating ligands to tune the reactive site of half-Sandwich ruthenium(II)\u2013Arene anticancer complexes","volume":"10","author":"Fernndez","year":"2004","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0190","doi-asserted-by":"crossref","first-page":"12283","DOI":"10.1002\/chem.200901939","article-title":"Maltol-derived ruthenium\u2212cymene complexes with tumor inhibiting properties: the impact of ligand\u2212metal bond stability on anticancer activity in vitro","volume":"15","author":"Kandioller","year":"2009","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0195","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/jm100020w","article-title":"Organometallic anticancer compounds","volume":"54","author":"Gasser","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0200","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3390\/molecules26010076","article-title":"DNA-binding capabilities and anticancer activities of ruthenium(II) cymene complexes with (poly)cyclic aromatic diamine ligands","volume":"26","author":"Alsaeedi","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2019.07.008","article-title":"Chemistry and reactivity of ruthenium(II) complexes: DNA\/protein binding mode and anticancer activity are related to the complex structure","volume":"398","author":"Rilak Simovi\u0107","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0210","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1038\/ncomms4462","article-title":"Ligand substitutions between ruthenium-cymene compounds can control protein versus DNA targeting and anticancer activity","volume":"5","author":"Adhireksan","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0215","doi-asserted-by":"crossref","first-page":"9461","DOI":"10.1039\/c1dt10870k","article-title":"Interaction of Zn(II) with quinolone drugs: structure and biological evaluation","volume":"40","author":"Tarushi","year":"2011","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0220","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jinorgbio.2012.12.009","article-title":"First- and second-generation quinolone antibacterial drugs interacting with zinc(II): structure and biological perspectives","volume":"121","author":"Tarushi","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.poly.2020.114864","article-title":"Comparable investigation of binding interactions between three arene ruthenium(II) thiosemicarbazone complexes and calf thymus DNA","volume":"192","author":"Huang","year":"2020","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0230","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1039\/D2DT02993F","article-title":"New ruthenium(II) complexes with quinone diimine and substituted bipyridine as inert ligands: synthesis, characterization, mechanism of action, DNA\/HSA binding affinity and cytotoxic activity","volume":"52","author":"Me\u0111edovi\u0107","year":"2023","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0235","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1039\/C7CS00195A","article-title":"The development of anticancer ruthenium(II) complexes: from single molecule compounds to nanomaterials","volume":"46","author":"Zeng","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2021.130326","article-title":"Low DNA and high BSA binding affinity of cationic ruthenium(II) organometallic featuring pyridine and 2\u2032-hydroxychalcone ligands","volume":"1236","author":"Zahirovi\u0107","year":"2021","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0245","doi-asserted-by":"crossref","DOI":"10.1002\/aoc.7623","article-title":"Oxorhenium(V) complexes with pyridinedicarboxylic ligands: synthesis, density functional theory calculations, and drug combination study","volume":"38","author":"Petrovi\u0107","year":"2024","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0250","article-title":"Applications of choline-based ionic liquids in drug delivery","volume":"612","author":"Xiaodan","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0255","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s12551-020-00754-w","article-title":"Mechanisms of action of ionic liquids on living cells: the state of the art","volume":"12","author":"Kumari","year":"2020","journal-title":"Biophys. Rev."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142964","article-title":"Mechanisms of cytotoxicity in six classes of ionic liquids: evaluating cell cycle impact and genotoxic and apoptotic effects","volume":"364","author":"Dzhemileva","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0265","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1039\/b602161a","article-title":"Anion effects on the cytotoxicity of ionic liquids","volume":"8","author":"Stolte","year":"2006","journal-title":"Green Chem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e12567","article-title":"Controversy on the toxic nature of deep eutectic solvents and their potential contribution to environmental pollution","volume":"8","author":"Mart\u00ednez","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0275","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jinorgbio.2016.01.005","article-title":"Synthesis, characterization and biological evaluation of novel Ru(II)\u2013arene complexes containing intercalating ligands","volume":"160","author":"Nikoli\u0107","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2022.119989","article-title":"An update on synthesis, properties, applications and toxicity of the ILs","volume":"364","author":"Himani","year":"2022","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0285","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1002\/cssc.201700261","article-title":"Environmental impact of ionic liquids: recent advances in (eco)toxicology and (bio)degradability","volume":"10","author":"Costa","year":"2017","journal-title":"Chem. Sus. Chem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0290","doi-asserted-by":"crossref","first-page":"6067","DOI":"10.1039\/D3GC00151B","article-title":"Aromatic long chain cations of amphiphilic ionic liquids permeabilise the inner mitochondrial membrane and induce mitochondrial dysfunction at cytotoxic concentration","volume":"25","author":"Duman","year":"2023","journal-title":"Green Chem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0295","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.3390\/ijms22115612","article-title":"Ionic liquids\u2014a review of their toxicity to living organisms","volume":"22","author":"Gon\u00e7alves","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0300","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a000414","article-title":"The bacterial cell envelope","volume":"2","author":"Silhavy","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0305","first-page":"643","article-title":"The antimicrobial activity of mononuclear ruthenium(II) complexes containing the dppz ligand","volume":"83","author":"Liu","year":"2018","journal-title":"Chem. Plus Chem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0310","doi-asserted-by":"crossref","first-page":"16713","DOI":"10.1039\/C4DT02139H","article-title":"Tri- and tetra-nuclear polypyridyl ruthenium(ii) complexes as antimicrobial agents","volume":"43","author":"Gorle","year":"2014","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0315","doi-asserted-by":"crossref","first-page":"3607924","DOI":"10.1155\/2016\/3607924","article-title":"Synthesis and assessment of antibacterial activities of ruthenium(III) mixed ligand complexes containing 1,10-Phenanthroline and Guanide","volume":"2016","author":"Abebe","year":"2016","journal-title":"Bioinorg. Chem. Appl."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0320","doi-asserted-by":"crossref","first-page":"10113","DOI":"10.3390\/ijms221810113","article-title":"Ruthenium complexes with 2-Pyridin-2-yl-1H-benzimidazole as potential antimicrobial agents: correlation between chemical properties and anti-biofilm effects","volume":"22","author":"Jab\u0142o\u0144ska-Wawrzycka","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0325","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/molecules28010040","article-title":"Synthesis, characterization and biological investigations of half-Sandwich ruthenium(II) complexes containing Benzimidazole moiety","volume":"28","author":"Rogala","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0330","doi-asserted-by":"crossref","first-page":"16371","DOI":"10.1039\/D2DT02577A","article-title":"DNA binding, antitubercular, antibacterial and anticancer studies of newly designed piano-stool ruthenium(II) complexes","volume":"51","author":"Navale","year":"2022","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0335","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0022-328X(02)01926-5","article-title":"Synthesis and characterisation of some water soluble ruthenium(II)\u2013arene complexes and an investigation of their antibiotic and antiviral properties","volume":"668","author":"Allardyce","year":"2003","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.msec.2014.08.007","article-title":"Ruthenium (II) complexes of thiosemicarbazone: synthesis, biosensor applications and evaluation as antimicrobial agents","volume":"44","author":"Y\u0131ld\u0131r\u0131m","year":"2014","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.jinorgbio.2025.112941_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2020.111164","article-title":"Synthesis, characterization, antimicrobial and cytotoxic activity of novel half-sandwich Ru(II) arene complexes with benzoylthiourea derivatives","volume":"210","author":"Obradovi\u0107","year":"2020","journal-title":"J. Inorg. Biochem."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013425001217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013425001217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T09:29:48Z","timestamp":1762248588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013425001217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":69,"alternative-id":["S0162013425001217"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2025.112941","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel organoruthenium complexes containing \u03b2-Diketonates: Synthesis, characterization, DNA\/HSA interactions, and the impact of biocompatible ionic liquids on biological activities","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2025.112941","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112941"}}