{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T08:59:56Z","timestamp":1780822796163,"version":"3.54.1"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"am","delay-in-days":273,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["1R15GM132990-01A1"],"award-info":[{"award-number":["1R15GM132990-01A1"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008093","name":"DePaul University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jinorgbio.2025.113133","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:10:03Z","timestamp":1761783003000},"page":"113133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Investigations of gold(I) complexes as inhibitors of caspase-1"],"prefix":"10.1016","volume":"275","author":[{"given":"Srirajkumar","family":"Ranganathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella D.","family":"Reda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen A.","family":"Gustafson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Callista G.","family":"Polasek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehxciquiel Jaeroume M.","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger D.","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle A.","family":"Grice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin E.","family":"Karver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2025.113133_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2022.101085","article-title":"Caspase mechanisms in the regulation of inflammation","volume":"88","author":"Bibo-Verdugo","year":"2022","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0010","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202000664","article-title":"Caspase-1 interdomain linker cleavage is required for pyroptosis","volume":"3","author":"Ball","year":"2020","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0015","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev-immunol-101220-030653","article-title":"Inflammatory caspases: toward a unified model for caspase activation by Inflammasomes","volume":"40","author":"Ross","year":"2022","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0020","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.4103\/1673-5374.313031","article-title":"Caspase-1: an important player and possible target for repair of the blood-brain barrier underlying neurodegeneration","volume":"16","author":"Rand","year":"2021","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0025","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1038\/s41467-020-18405-9","article-title":"Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging","volume":"11","author":"Flores","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0030","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.imlet.2022.03.003","article-title":"A small molecule inhibitor of caspase-1 inhibits NLRP3 inflammasome activation and pyroptosis to alleviate gouty inflammation","volume":"244","author":"Cao","year":"2022","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111822","article-title":"Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases","volume":"185","author":"Zhang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0040","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2018.4552","article-title":"P2Y2R-mediated inflammasome activation is involved in tumor progression in breast cancer cells and in radiotherapy-resistant breast cancer","author":"Jin","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0045","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1021\/acscatal.3c00037","article-title":"Unveiling the mechanistic singularities of caspases: a computational analysis of the reaction mechanism in human Caspase-1","volume":"13","author":"Ramos-Guzm\u00e1n","year":"2023","journal-title":"ACS Catal."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0050","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ejmech.2019.02.064","article-title":"Modeling caspase-1 inhibition: implications for catalytic mechanism and drug design","volume":"169","author":"Ramos-Guzm\u00e1n","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0055","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1021\/acs.jmedchem.5b01091","article-title":"Inhibiting the Inflammasome: a chemical perspective","volume":"59","author":"Baldwin","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0060","doi-asserted-by":"crossref","first-page":"12546","DOI":"10.1021\/acs.chemrev.5b00434","article-title":"Small molecule active site directed tools for studying human caspases","volume":"115","author":"Poreba","year":"2015","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0065","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.sbi.2013.10.002","article-title":"Modulating caspase activity: beyond the active site","volume":"23","author":"Murray","year":"2013","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0070","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008680","article-title":"Caspase substrates and inhibitors","volume":"5","author":"Poreba","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0075","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/BF03214618","article-title":"Gold in medicine","volume":"15","author":"Higby","year":"1982","journal-title":"Gold Bull."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0080","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF03214805","article-title":"China\u2019s ancient gold drugs","volume":"34","author":"Huaizhi","year":"2001","journal-title":"Gold Bull."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0085","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S0140-6736(00)82169-8","article-title":"Rheumatoid ARTHRITIS and its treatment by gold salts","volume":"224","author":"Forestier","year":"1934","journal-title":"Lancet"},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0090","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0049-0172(84)90029-5","article-title":"Auranofin: a unique oral chrysotherapeutic agent","volume":"13","author":"Blodgett","year":"1984","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0095","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF03214639","article-title":"Gold compounds for rheumatoid arthritis","volume":"19","author":"Sutton","year":"1986","journal-title":"Gold Bull."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0100","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1039\/c1mt00062d","article-title":"Gold compounds as therapeutic agents for human diseases","volume":"3","author":"Berners-Price","year":"2011","journal-title":"Metallomics"},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0105","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1039\/C8CS00570B","article-title":"Recent advances in gold\u2013NHC complexes with biological properties","volume":"48","author":"Mora","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.665244","article-title":"Editorial: the Golden future in medicinal chemistry: perspectives and resources from old and new gold-based drug candidates","volume":"9","author":"Massai","year":"2021","journal-title":"Front. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0115","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.ccr.2009.02.019","article-title":"On the medicinal chemistry of gold complexes as anticancer drugs","volume":"253","author":"Ott","year":"2009","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202218000","article-title":"Gold complexes in anticancer therapy: from new design principles to particle-based delivery systems","volume":"62","author":"Moreno-Alc\u00e1ntar","year":"2023","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0125","article-title":"\u201cGold compounds and the anticancer immune response\u201d front","volume":"12","author":"Zhou","year":"2021","journal-title":"Pharmacol"},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0130","doi-asserted-by":"crossref","first-page":"17413","DOI":"10.1039\/D1DT02783B","article-title":"Cancer molecular biology and strategies for the design of cytotoxic gold (i ) and gold (iii ) complexes: a tutorial review","volume":"50","author":"Van Der Westhuizen","year":"2021","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0135","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.ccr.2008.12.003","article-title":"Gold complexes as potential anti-parasitic agents","volume":"253","author":"Navarro","year":"2009","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0140","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02968-23","article-title":"Gold(I) ion and the phosphine ligand are necessary for the anti- toxoplasma gondii activity of auranofin","volume":"12","author":"Ma","year":"2024","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0145","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3390\/biochem2020010","article-title":"Biological activity of gold compounds against viruses and Parasitosis: a systematic review","volume":"2","author":"Fonseca","year":"2022","journal-title":"BioChem"},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0150","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1080\/21505594.2016.1196301","article-title":"Repurposing auranofin as an antifungal: in vitro activity against a variety of medically important fungi","volume":"8","author":"Wiederhold","year":"2017","journal-title":"Virulence"},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0155","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/nm.2758","article-title":"A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target","volume":"18","author":"Debnath","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0160","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3390\/pharmaceutics15020466","article-title":"New insights into the behavior of NHC-gold complexes in Cancer cells","volume":"15","author":"Augello","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0165","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1002\/cmdc.202100381","article-title":"Gold(I) and gold(III) N-heterocyclic Carbene complexes asAntibacterial agents and inhibitors of bacterial ThioredoxinReductase","volume":"16","author":"B\u00fcssing","year":"2021","journal-title":"ChemMedChem"},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0170","doi-asserted-by":"crossref","first-page":"16615","DOI":"10.1039\/C9DT03183A","article-title":"Synthesis, characterization, and biological studies of multidentate gold(I) and gold(III) NHC complexes","volume":"48","author":"Bauer","year":"2019","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0175","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1039\/D1DT03528B","article-title":"Investigations of the reactivity, stability and biological activity of halido (NHC)gold (i) complexes","volume":"51","author":"Goetzfried","year":"2022","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0180","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/chem.201604512","article-title":"Gold(I) NHC complexes: Antiproliferative activity, cellular uptake, inhibition of mammalian and bacterial Thioredoxin reductases, and gram-positive directed antibacterial effects","volume":"23","author":"Schmidt","year":"2017","journal-title":"Chem. A Eur. J."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0185","doi-asserted-by":"crossref","first-page":"14524","DOI":"10.1002\/anie.201805727","article-title":"On the mechanism of gold\/NHC compounds binding to DNA G-Quadruplexes: combined Metadynamics and biophysical methods","volume":"57","author":"Wragg","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0190","doi-asserted-by":"crossref","first-page":"14237","DOI":"10.1021\/acs.inorgchem.7b02345","article-title":"Characterization of hydrophilic gold(I) N-heterocyclic Carbene (NHC) complexes as potent TrxR inhibitors using biochemical and mass spectrometric approaches","volume":"56","author":"Karaca","year":"2017","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0195","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jinorgbio.2007.10.019","article-title":"Tuning the au(I)-mediated inhibition of cathepsin B through ligand substitutions","volume":"102","author":"Gunatilleke","year":"2008","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0200","first-page":"40","article-title":"Bioinorganic and medicinal chemistry: aspects of gold(i)-protein complexes","volume":"2099","author":"Bhabak","year":"2011","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0205","doi-asserted-by":"crossref","first-page":"6912","DOI":"10.1021\/jm901220m","article-title":"Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of au(I) complexes","volume":"52","author":"Karver","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0210","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/chem.201904837","article-title":"Role of gold in inflammation and Tristetraprolin activity","volume":"26","author":"Ok","year":"2020","journal-title":"Chem. A Eur. J."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0215","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1002\/cmdc.202000608","article-title":"Gold drugs with {Au(PPh3 )}+ Moiety: advantages and medicinal applications","volume":"15","author":"Stenger-Smith","year":"2020","journal-title":"ChemMedChem"},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0220","doi-asserted-by":"crossref","first-page":"8786","DOI":"10.1039\/C5CS00132C","article-title":"Chemical biology of anticancer gold(iii) and gold(i) complexes","volume":"44","author":"Zou","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0225","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jinorgbio.2012.08.006","article-title":"A new target for gold(I) compounds: glutathione-S-transferase inhibition by auranofin","volume":"119","author":"De Luca","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0230","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/ijch.201600044","article-title":"Deubiquitinases as anticancer targets of gold complexes","volume":"56","author":"Zou","year":"2016","journal-title":"Isr. J. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0235","doi-asserted-by":"crossref","first-page":"6612","DOI":"10.1021\/acs.chemrev.2c00649","article-title":"Next generation gold drugs and probes: chemistry and biomedical applications","volume":"123","author":"Mertens","year":"2023","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0240","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.3390\/biom12111675","article-title":"Gold-based metal drugs as inhibitors of coronavirus proteins: the inhibition of SARS-CoV-2 Main protease by Auranofin and its analogs","volume":"12","author":"Massai","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0245","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1021\/ic00306a023","article-title":"Bis(triethylphosphine)gold(I) chloride: ionization in aqueous solution, reduction in vitro of the external and internal disulfide bonds of bovine serum albumin and antiarthritic activity","volume":"28","author":"Isab","year":"1989","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0250","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1021\/ic50211a041","article-title":"Phosphorus-31 [proton] nuclear magnetic resonance investigation of gold cluster compounds","volume":"19","author":"Vollenbroek","year":"1980","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0255","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1021\/ic50137a055","article-title":"Gold(I) complexes of 4-ethyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane","volume":"13","author":"Fenske","year":"1974","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0260","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1021\/ic00105a016","volume":"34","author":"Assefa","year":"1995","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0265","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jorganchem.2015.09.031","article-title":"Intramolecular C\u2013H activation by air-stable Pt(II) phosphite complexes","volume":"799\u2013800","author":"Grice","year":"2015","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0270","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1124\/dmd.115.066597","article-title":"The reliability of estimating Ki values for direct, reversible inhibition of cytochrome P450 enzymes from corresponding IC50 values: a retrospective analysis of 343 experiments","volume":"43","author":"Haupt","year":"2015","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0275","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1021\/ed080p214","article-title":"An intuitive look at the relationship of Ki and IC50: W a more general use for the dixon plot","volume":"80","author":"Burlingham","year":"2003","journal-title":"J. Chem. Educ."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0280","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/sj.cdd.4400497","article-title":"Purification and catalytic properties of human caspase family members","volume":"6","author":"Garcia-Calvo","year":"1999","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0285","series-title":"Gaussian","volume":"09","author":"Frisch","year":"2009"},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0290","unstructured":"M. J. Frisch, G. W. Trucks, H. B. Schlegel, G. E. Scuseria, M. A. Robb, J. R. Cheeseman, G. Scalmani, V. Barone, G. A. Petersson, H. Nakatsuji, X. Li, M. Caricato, A. V. Marenich, J. Bloino, B. G. Janesko, R. Gomperts, B. Mennucci, H. P. Hratchian, J. V. Ortiz, A. F. Izmaylov, J. L. Sonnenberg, Williams, F. Ding, F. Lipparini, F. Egidi, J. Goings, B. Peng, A. Petrone, T. Henderson, D. Ranasinghe, V. G. Zakrzewski, J. Gao, N. Rega, G. Zheng, W. Liang, M. Hada, M. Ehara, K. Toyota, R. Fukuda, J. Hasegawa, M. Ishida, T. Nakajima, Y. Honda, O. Kitao, H. Nakai, T. Vreven, K. Throssell, J. A. Montgomery Jr, J. E. Peralta, F. Ogliaro, M. J. Bearpark, J. J. Heyd, E. N. Brothers, K. N. Kudin, V. N. Staroverov, T. A. Keith, R. Kobayashi, J. Normand, K. Raghavachari, A. P. Rendell, J. C. Burant, S. S. Iyengar, J. Tomasi, M. Cossi, J. M. Millam, M. Klene, C. Adamo, R. Cammi, J. W. Ochterski, R. L. Martin, K. Morokuma, O. Farkas, J. B. Foresman, D. J. Fox 2016."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0295","series-title":"GaussView 5.0. 8","author":"Dennington","year":"2008"},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0300","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1021\/cr9904009","article-title":"Quantum mechanical continuum solvation models","volume":"105","author":"Tomasi","year":"2005","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0305","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/s41557-019-0319-5","article-title":"Towards the online computer-aided design of catalytic pockets","volume":"11","author":"Falivene","year":"2019","journal-title":"Nat. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0310","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.1021\/jm400268b","article-title":"Design, synthesis, and biological evaluation of Aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse","volume":"56","author":"Vasiljevik","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0315","doi-asserted-by":"crossref","DOI":"10.1111\/cbdd.70031","article-title":"Expansion of the structure\u2013activity relationship profile of triaminopyrimidines as inhibitors of caspase-1","volume":"104","author":"East","year":"2024","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0320","doi-asserted-by":"crossref","first-page":"5476","DOI":"10.1016\/j.bmcl.2016.10.025","article-title":"Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases","volume":"26","author":"Kent","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0325","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1021\/cm0700100","article-title":"Seedless, Surfactantless, high-yield synthesis of branched gold nanocrystals in HEPES buffer solution","volume":"19","author":"Xie","year":"2007","journal-title":"Chem. Mater."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0330","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1021\/ac0702084","article-title":"Determination of size and concentration of gold Nanoparticles from UV\u2212Vis spectra","volume":"79","author":"Haiss","year":"2007","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0335","doi-asserted-by":"crossref","first-page":"4788","DOI":"10.1016\/j.jorganchem.2006.07.034","article-title":"The preparation, properties and X-ray structures of gold(I) trithiophosphite complexes","volume":"691","author":"Strasser","year":"2006","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0340","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00726-011-0997-9","article-title":"A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition","volume":"42","author":"Ilari","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0345","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1016\/j.csbj.2023.03.013","article-title":"Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr","volume":"21","author":"Zhang","year":"2023","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0350","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00775-022-01983-y","article-title":"Gold drugs as colistin adjuvants in the fight against MCR-1 producing bacteria","volume":"28","author":"Zhang","year":"2023","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0355","doi-asserted-by":"crossref","first-page":"14162","DOI":"10.3390\/ijms232214162","article-title":"Evaluation of Auranofin loading within ferritin Nanocages","volume":"23","author":"Lucignano","year":"2022","journal-title":"IJMS"},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0360","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jsb.2016.02.015","article-title":"X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action","volume":"194","author":"Parsonage","year":"2016","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0365","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.1038\/s41467-020-18939-y","article-title":"Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin","volume":"11","author":"Sun","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0370","doi-asserted-by":"crossref","first-page":"28977","DOI":"10.1074\/jbc.M109.020701","article-title":"Inhibition of Schistosoma mansoni Thioredoxin-glutathione reductase by Auranofin","volume":"284","author":"Angelucci","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0375","doi-asserted-by":"crossref","first-page":"12308","DOI":"10.1021\/acs.inorgchem.7b01762","article-title":"Probing the HIV-1 NCp7 Nucleocapsid protein with site-specific gold(I)\u2013phosphine complexes","volume":"56","author":"De Paiva","year":"2017","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0380","doi-asserted-by":"crossref","first-page":"10389","DOI":"10.1021\/acs.inorgchem.3c01280","article-title":"Mechanistic evaluations of the effects of Auranofin Triethylphosphine replacement with a Trimethylphosphite moiety","volume":"62","author":"Ronga","year":"2023","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113133_bb0385","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jbspin.2015.07.006","article-title":"Caspase-1 mediated interleukin-18 activation in neutrophils promotes the activity of rheumatoid arthritis in a NLRP3 inflammasome independent manner","volume":"83","author":"Yang","year":"2016","journal-title":"Joint Bone Spine"}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013425003149?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013425003149?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T08:29:15Z","timestamp":1780820955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013425003149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":77,"alternative-id":["S0162013425003149"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2025.113133","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigations of gold(I) complexes as inhibitors of caspase-1","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2025.113133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113133"}}