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Exp."},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0375","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ceca.2010.07.001","article-title":"Monitoring mitochondrial [Ca2+] dynamics with rhod-2, ratiometric pericam and aequorin","volume":"48","author":"Fonteriz","year":"2010","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0380","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1083\/jcb.200505022","article-title":"Selective role for superoxide in InsP3 receptor\u2013mediated mitochondrial dysfunction and endothelial apoptosis","volume":"170","author":"Madesh","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0385","series-title":"Gaussian 16, Revision C.01","author":"Frisch","year":"2019"},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0390","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","article-title":"Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density","volume":"37","author":"Lee","year":"1988","journal-title":"Phys. Rev. B"},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0395","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1063\/1.464913","article-title":"Density-functional thermochemistry. III. The role of exact exchange","volume":"98","author":"Becke","year":"1993","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0400","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1063\/1.1677527","article-title":"Self\u2014consistent molecular orbital methods. XII. Further extensions of Gaussian\u2014type basis sets for use in molecular orbital studies of organic molecules","volume":"56","author":"Hehre","year":"1972","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0405","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF00533485","article-title":"The influence of polarization functions on molecular orbital hydrogenation energies","volume":"28","author":"Hariharan","year":"1973","journal-title":"Theor. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0410","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1063\/1.448975","article-title":"Ab initio effective core potentials for molecular calculations. Potentials for K to Au including the outermost core orbitals","volume":"82","author":"Hay","year":"1985","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0415","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1006\/jmbi.1996.0897","article-title":"Development and validation of a genetic algorithm for flexible docking","volume":"267","author":"Jones","year":"1997","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0420","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.cell.2019.03.050","article-title":"Structural mechanism of EMRE-dependent gating of the human mitochondrial calcium uniporter","volume":"177","author":"Wang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0425","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1021\/ci800298z","article-title":"Empirical scoring functions for advanced protein\u2212ligand docking with PLANTS","volume":"49","author":"Korb","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0430","doi-asserted-by":"crossref","first-page":"8067","DOI":"10.1002\/anie.201601943","article-title":"Water oxidation by ruthenium complexes incorporating multifunctional bipyridyl diphosphonate ligands","volume":"55","author":"Xie","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0435","doi-asserted-by":"crossref","first-page":"12807","DOI":"10.1039\/C6DT01264G","article-title":"Pyridylphosphinate metal complexes: synthesis, structural characterisation and biological activity","volume":"45","author":"Cross","year":"2016","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0440","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1039\/b003285i","article-title":"Hydrogen bonds and other intermolecular interactions in organometallic crystals","author":"Desiraju","year":"2000","journal-title":"J. Chem. Soc. Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0445","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/S0277-5387(00)84604-5","article-title":"Synthesis and properties of tetra-\u03bc-acetatodiruthenium(II,III) phenylphosphinate and phenylphosphonate complexes: X-ray crystal structures of [Ru2(\u03bc-O2CCH3)4(HPhPO2)2]H and [Ru2(\u03bc-O2CCH3)4(PhPO3H)2]H\u00b7H2O","volume":"12","author":"McCann","year":"1993","journal-title":"Polyhedron"},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0450","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/1521-3773(20020104)41:1<48::AID-ANIE48>3.0.CO;2-U","article-title":"The hydrogen bond in the solid state","volume":"41","author":"Steiner","year":"2002","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0455","series-title":"Int. Union Pure Appl. Chem. Comm. Electrochem. 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Res."},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0470","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1023\/A:1008741731244","article-title":"The influence of lipophilicity on the pharmacokinetic behavior of drugs: concepts and examples","volume":"19","author":"Testa","year":"2000","journal-title":"Perspect. Drug Discov. Des."},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0475","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1475-2867-13-89","article-title":"Acidic extracellular microenvironment and cancer","volume":"13","author":"Kato","year":"2013","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0480","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-physiol-021119-034627","article-title":"The acidic tumor microenvironment as a driver of cancer","volume":"82","author":"Boedtkjer","year":"2020","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jinorgbio.2025.113145_bb0485","doi-asserted-by":"crossref","first-page":"8171","DOI":"10.1016\/S0021-9258(18)83165-9","article-title":"Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores","volume":"264","author":"Minta","year":"1989","journal-title":"J. Biol. 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