{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T20:44:25Z","timestamp":1783197865396,"version":"3.54.6"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010442","name":"Universidad Nacional de C\u00f3rdoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010442","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010253","name":"Secretar\u00eda de Ciencia y T\u00e9cnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012478","name":"Secretaria de Ciencia y Tecnolog\u00eda - Universidad Nacional de C\u00f3rdoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jinorgbio.2025.113153","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T04:59:54Z","timestamp":1763701194000},"page":"113153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A zinc (II) gentamicin metalloantibiotic with outstanding antimicrobial activity and reduced susceptibility to bacterial resistance mechanisms: Experimental and theoretical explorations"],"prefix":"10.1016","volume":"276","author":[{"given":"Ivana R.","family":"Scolari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario A.","family":"Quevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina L.","family":"P\u00e1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys E.","family":"Granero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2025.113153_bb0005","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jfma.2013.10.002","article-title":"Update on new medicinal applications of gentamicin: evidence-based review","volume":"113","author":"Chen","year":"2014","journal-title":"J. Formos. Med. Assoc."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0010","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1021\/acsinfecdis.3c00233","article-title":"Synthesis of Gentamicins C1, C2, and C2a and Antiribosomal and antibacterial activity of Gentamicins B1, C1, C1a, C2, C2a, C2b, and X2","volume":"9","author":"Jana","year":"2023","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0015","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1074\/jbc.M112.434159","article-title":"Gentamicin binds to the Megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats","volume":"288","author":"Dagil","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1071278","article-title":"Glutamine potentiates gentamicin to kill lab-evolved gentamicin-resistant and clinically isolated multidrug-resistant Escherichia coli","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0025","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adk6331","article-title":"Supercharged precision killers: genetically engineered biomimetic drugs of screened metalloantibiotics against Acinetobacter baumanni","volume":"10","author":"Wei","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0030","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41570-023-00463-4","article-title":"Metals to combat antimicrobial resistance","volume":"7","author":"Frei","year":"2023","journal-title":"Nat. Rev. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202100554","article-title":"Bioinorganic chemistry of zinc in relation to the immune system","volume":"23","author":"Planeta Kepp","year":"2022","journal-title":"ChemBioChem"},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0040","doi-asserted-by":"crossref","first-page":"9461","DOI":"10.1039\/c1dt10870k","article-title":"Interaction of Zn(ii) with quinolone drugs: structure and biological evaluation","volume":"40","author":"Tarushi","year":"2011","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0045","doi-asserted-by":"crossref","first-page":"6411","DOI":"10.1021\/ja993704l","article-title":"Hydrolysis of \u03b2-lactam antibiotics catalyzed by Dinuclear zinc(II) complexes: functional mimics of Metallo-\u03b2-lactamases","volume":"122","author":"Kaminskaia","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2023.135141","article-title":"Novel copper (II) and zinc (II) complexes with enrofloxacin and oxolinic acid: synthesis, characterization, Hirshfeld surface and DFT\/CAM-B3LYPD3BJ studies: NBO, QTAIM and RDG analysis","volume":"1282","author":"Boughougal","year":"2023","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0055","doi-asserted-by":"crossref","DOI":"10.21161\/mjm.220103","article-title":"A review of current trends of antibacterial Schiff base complexes: lower and higher transition metal complexes","author":"Sarwar","year":"2023","journal-title":"Malays J. Microbiol."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0060","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/10241220802197469","article-title":"Gentamicin complexes of cobalt(II), nickel(II), cadmium(II) and tin(II)","volume":"7","author":"Mishra","year":"2008","journal-title":"Main Group Chem."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0065","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1134\/S1061934809090135","article-title":"Complexation of aminoglycoside antibiotics with metal cations as a derivatization reaction: determination of gentamicin by equilibrium electrochemical and spectrophotometric methods","volume":"64","author":"Petrukhin","year":"2009","journal-title":"J. Anal. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/aoc.6760","article-title":"Synthesis, characterization, in vitro antimicrobial and cytotoxic studies of co(II), Ni(II), cu(II), and Zn(II) complexes obtained from Schiff base ligands of 1, 2, 3, 4-tetrahydro-naphthalen-1-ylamine","volume":"36","author":"Devi","year":"2022","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0075","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1007\/s11696-023-02917-x","article-title":"Thiosemicarbazones-based co(II), Ni(II), cu(II) and Zn(II) complexes: synthesis, structural elucidation, biological activities and molecular docking","volume":"77","author":"Rani","year":"2023","journal-title":"Chem. Pap."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241813819","article-title":"New copper complexes with antibacterial and cytotoxic activity","volume":"24","author":"Hangan","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0085","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.3390\/molecules28062590","article-title":"Antitumor and antibacterial activity of Ni(II), cu(II), ag(I), and hg(II) complexes with ligand derived from thiosemicarbazones: characterization and theoretical studies","volume":"28","author":"Alshater","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.133677","article-title":"Binding and displacement study of gentamicin, 5-fluorouracil, oxytetracycline and rolitetracycline with (BSA: Drug2) complex using spectroscopic and calorimetric techniques: biophysical approach","volume":"276","author":"Thorve","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0095","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/mrc.1222","article-title":"Assignment of the major and minor components of gentamicin for evaluation of batches","volume":"41","author":"Deubner","year":"2003","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0100","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1074-5521(02)00153-9","article-title":"Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site","volume":"9","author":"Vicens","year":"2002","journal-title":"Chem. Biol."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0105","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0022-2836(02)01435-3","article-title":"Crystal structure of geneticin bound to a bacterial 16S ribosomal RNA a site oligonucleotide","volume":"326","author":"Vicens","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0110","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1093\/nar\/gki862","article-title":"Crystal structures of complexes between aminoglycosides and decoding a site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding","volume":"33","author":"Francois","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e25604","article-title":"Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: a promising strategy for repositioning this first-line antibiotic","volume":"10","author":"Scolari","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0120","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3343\/alm.2016.36.2.138","article-title":"In vitro synergistic effects of antimicrobial combinations on extensively drug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii isolates","volume":"36","author":"Lee","year":"2016","journal-title":"Ann. Lab. Med."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0125","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature14098","article-title":"A new antibiotic kills pathogens without detectable resistance","volume":"517","author":"Ling","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0130","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/pro.3934","article-title":"The <scp>AutoDock<\/scp> suite at 30","volume":"30","author":"Goodsell","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0135","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1021\/ci500209e","article-title":"AutoDock4Zn: an improved AutoDock force field for small-molecule docking to zinc metalloproteins","volume":"54","author":"Santos-Martins","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0140","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1021\/ct1002626","article-title":"Structural survey of zinc-containing proteins and development of the zinc AMBER force field (ZAFF)","volume":"6","author":"Peters","year":"2010","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0145","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1021\/acs.chemrev.6b00440","article-title":"Metal ion Modeling using classical mechanics","volume":"117","author":"Li","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0150","author":"Landrum"},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.parco.2021.102861","article-title":"Benchmarking the performance of irregular computations in AutoDock-GPU molecular docking","volume":"109","author":"Solis-Vasquez","year":"2022","journal-title":"Parallel Comput."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0160","first-page":"198","article-title":"An overview of the Amber biomolecular simulation package, WIREs computational molecular","volume":"3","author":"Salomon-Ferrer","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0165","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1021\/acs.jcim.3c01153","article-title":"AmberTools","volume":"63","author":"Case","year":"2023","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0170","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00894-018-3911-5","article-title":"Improved GAFF2 parameters for fluorinated alkanes and mixed hydro- and fluorocarbons","volume":"25","author":"Tr\u00e4g","year":"2019","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0175","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1021\/acs.chemrev.6b00440","article-title":"Metal ion Modeling using classical mechanics","volume":"117","author":"Li","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0180","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1021\/acs.jctc.5b00444","article-title":"Improved force field parameters Lead to a better description of RNA structure","volume":"11","author":"Bergonzo","year":"2015","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0185","series-title":"MDAnalysis: A Python Package for the Rapid Analysis of Molecular Dynamics Simulations","first-page":"98","author":"Gowers","year":"2016"},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0190","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.msec.2016.09.031","article-title":"Characterisation, in vitro release study, and antibacterial activity of montmorillonite-gentamicin complex material","volume":"70","author":"Rapacz-Kmita","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.1053532","article-title":"Synthesis, characterization, and biological activities of zinc(II), copper(II) and nickel(II) complexes of an aminoquinoline derivative","volume":"10","author":"Damena","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0200","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00533-20","article-title":"Unraveling the gentamicin drug product complexity reveals variation in microbiological activities and nephrotoxicity","volume":"64","author":"Bulman","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0205","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1016\/j.carres.2003.08.005","article-title":"An isocratic separation of underivatized gentamicin components, 1H NMR assignment and protonation pattern","volume":"338","author":"Lesniak","year":"2003","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.jinorgbio.2025.113153_bb0210","first-page":"601","article-title":"Determination of the composition of gentamicin sulfates by 1H and 13C nuclear magnetic spectroscopy","volume":"69","author":"Busson","year":"1986","journal-title":"J. Assoc. Off. Anal. Chem."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013425003344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013425003344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:20:45Z","timestamp":1781511645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013425003344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":42,"alternative-id":["S0162013425003344"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2025.113153","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A zinc (II) gentamicin metalloantibiotic with outstanding antimicrobial activity and reduced susceptibility to bacterial resistance mechanisms: Experimental and theoretical explorations","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2025.113153","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113153"}}