{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T01:22:38Z","timestamp":1793928158422,"version":"4.8.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100008696","name":"University of the Punjab","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008696","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jinorgbio.2025.113196","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T15:59:44Z","timestamp":1765814384000},"page":"113196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Synthesis, structural characterization, and biological evaluation of a bioactive strontium (II)\u2013mefenamic acid complex: In-vivo and in-silico insights"],"prefix":"10.1016","volume":"277","author":[{"given":"Ashraf","family":"Komal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Azam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibi","family":"Saman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riaz","family":"Maira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Asim Raza","family":"Basra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2025.113196_bb0005","article-title":"A review of the latest insights into the mechanism of action of strontium in bone","volume":"12","author":"Marx","year":"2020","journal-title":"Bone Rep."},{"issue":"4","key":"10.1016\/j.jinorgbio.2025.113196_bb0010","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.bbrc.2004.08.209","article-title":"In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor","volume":"323","author":"Coulombe","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.jinorgbio.2025.113196_bb0015","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/13543784.2017.1283403","article-title":"Strontium ranelate, a promising disease modifying osteoarthritis drug","volume":"26","author":"Han","year":"2017","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"23","key":"10.1016\/j.jinorgbio.2025.113196_bb0020","doi-asserted-by":"crossref","first-page":"11383","DOI":"10.3390\/app112311383","article-title":"Calcium and strontium coordination polymers as controlled delivery systems of the anti-osteoporosis drug risedronate and the augmenting effect of solubilizers","volume":"11","author":"Vassaki","year":"2021","journal-title":"Appl. Sci."},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.113196_bb0025","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1038\/s41467-019-11323-5","article-title":"Octa-coordinated alkaline earth metal\u2013dinitrogen complexes M (N2) 8 (M= ca, Sr, Ba)","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.jinorgbio.2025.113196_bb0030","doi-asserted-by":"crossref","first-page":"14525","DOI":"10.1039\/C8CP02244E","article-title":"On the relationship between the structural and volumetric properties of solvated metal ions in O-donor solvents using new structural data in amide solvents","volume":"20","author":"Lundberg","year":"2018","journal-title":"Phys. Chem. Chem. Phys."},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.113196_bb0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3329\/dujps.v15i1.29202","article-title":"Analgesic activities of synthesized divalent metal complexes of tolfenamic acid","volume":"15","author":"Mazumder","year":"2016","journal-title":"Dhaka Univ. J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.113196_bb0040","doi-asserted-by":"crossref","first-page":"12","DOI":"10.33640\/2405-609X.3392","article-title":"Chemistry of metalloguanines: an overview of their synthesis routes and their implementations for the period 2000-2024","volume":"11","author":"Jaafar","year":"2025","journal-title":"Karbala Int. J. Modern Sci."},{"issue":"8","key":"10.1016\/j.jinorgbio.2025.113196_bb0045","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/S0959-8049(98)00045-8","article-title":"Enhancement of chemotherapeutic drug toxicity to human tumour cells in vitro by a subset of non-steroidal anti-inflammatory drugs (NSAIDs)","volume":"34","author":"Duffy","year":"1998","journal-title":"Eur. J. Cancer"},{"issue":"Suppl. 3","key":"10.1016\/j.jinorgbio.2025.113196_bb0050","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/ar4174","article-title":"Use of NSAIDs in treating patients with arthritis","volume":"15","author":"Crofford","year":"2013","journal-title":"Arthritis Res. Ther."},{"issue":"7","key":"10.1016\/j.jinorgbio.2025.113196_bb0055","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s00198-018-4476-y","article-title":"Understanding osteoporotic pain and its pharmacological treatment","volume":"29","author":"Vellucci","year":"2018","journal-title":"Osteoporos. Int."},{"issue":"6","key":"10.1016\/j.jinorgbio.2025.113196_bb0060","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1152\/japplphysiol.00053.2013","article-title":"NSAID therapy effects on healing of bone, tendon, and the enthesis","volume":"115","author":"Su","year":"2013","journal-title":"J. Appl. Physiol."},{"issue":"3","key":"10.1016\/j.jinorgbio.2025.113196_bb0065","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.contraception.2009.09.014","article-title":"Nonsteroidal anti-inflammatory drugs and hormonal contraceptives for pain relief from dysmenorrhea: a review","volume":"81","author":"Zahradnik","year":"2010","journal-title":"Contraception"},{"issue":"10","key":"10.1016\/j.jinorgbio.2025.113196_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jics.2025.102036","article-title":"Strategic design and bioactive potential of some novel thiazole-based bi-dentate metal complexes: integrated spectroscopic, DFT, and molecular docking investigations","volume":"102","author":"Abu-Dief","year":"2025","journal-title":"J. Indian Chem. Soc."},{"issue":"4","key":"10.1016\/j.jinorgbio.2025.113196_bb0075","doi-asserted-by":"crossref","first-page":"409","DOI":"10.4103\/0250-474X.27809","article-title":"Adverse effects associated with the use of nonsteroidal antiinflammatory drugs: an overview","volume":"68","author":"Derle","year":"2006","journal-title":"Indian J. Pharm. Sci."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0080","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ccr.2017.07.004","article-title":"Complexes of aminobenzoic acids: a comprehensive review concerning synthesis, physical chemistry, structure and application","volume":"348","author":"Kalembkiewicz","year":"2017","journal-title":"Coord. Chem. Rev."},{"issue":"6","key":"10.1016\/j.jinorgbio.2025.113196_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/qua.70021","article-title":"Theoretical exploration of co and ln piroxicam complexes (ln= La and pr), a quest for efficient and safe therapeutic agents","volume":"125","author":"Maira","year":"2025","journal-title":"Int. J. Quantum Chem."},{"issue":"9","key":"10.1016\/j.jinorgbio.2025.113196_bb0090","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202405194","article-title":"Theoretical exploration of ternary tenoxicam-alanine-metal complexes: an innovative avenue toward potential drug design","volume":"10","author":"Maira","year":"2025","journal-title":"ChemistrySelect"},{"issue":"32","key":"10.1016\/j.jinorgbio.2025.113196_bb0095","doi-asserted-by":"crossref","first-page":"10104","DOI":"10.1021\/jacs.6b06185","article-title":"Soluble metal-nanoparticle-decorated porous coordination polymers for the homogenization of heterogeneous catalysis","volume":"138","author":"Huang","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0100","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.poly.2016.06.003","article-title":"New zinc (II) complexes of the non-steroidal anti-inflammatory drug (indomethacin) and various nitrogen donor ligands. Synthesis, characterization and biological activity","volume":"117","author":"Jabali","year":"2016","journal-title":"Polyhedron"},{"issue":"3","key":"10.1016\/j.jinorgbio.2025.113196_bb0105","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0731-7085(96)01873-0","article-title":"Complexes of Fe (III) ions with mefenamic acid","volume":"15","author":"Bojarowicz","year":"1996","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"11","key":"10.1016\/j.jinorgbio.2025.113196_bb0110","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1080\/15257770.2019.1625379","article-title":"Intercalation of manganese-mefenamic acid complex into double stranded of calf thymus DNA","volume":"38","author":"Shahabadi","year":"2019","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0115","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ejmech.2013.12.019","article-title":"Antioxidant activity and interaction with DNA and albumins of zinc\u2013tolfenamato complexes. Crystal structure of [Zn (tolfenamato) 2 (2, 2\u2032-dipyridylketoneoxime) 2]","volume":"74","author":"Tarushi","year":"2014","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.113196_bb0120","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1080\/10408398.2017.1357534","article-title":"How important is tryptophan in human health?","volume":"59","author":"Ka\u0142u\u017cna-Czapli\u0144ska","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"34","key":"10.1016\/j.jinorgbio.2025.113196_bb0125","doi-asserted-by":"crossref","first-page":"8555","DOI":"10.1039\/c1dt10714c","article-title":"Non-steroidal antiinflammatory drug\u2013copper (II) complexes: structure and biological perspectives","volume":"40","author":"Dimiza","year":"2011","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2020.111046","article-title":"Synthesis, chemical characterization and DNA interaction study of new diclofenac and ibuprofen zinc (II)-nicotinamide ternary complexes as cyclooxygenase inhibitor prototypes","volume":"206","author":"Dos Santos","year":"2020","journal-title":"J. Inorg. Biochem."},{"issue":"5","key":"10.1016\/j.jinorgbio.2025.113196_bb0135","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0223-5234(00)00145-8","article-title":"Palladium (II) complexes of NS donor ligandsderived from S-methyl-dithiocarbazate, S-benzyldithiocarbazateand thiosemicarbazide as antiamoebic agents","volume":"35","author":"Neelam","year":"2000","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0140","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00280-009-1220-5","article-title":"Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper\u2013indomethacin in rats","volume":"66","author":"Bonin","year":"2010","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2021.111507","article-title":"Nickel (II)\u2013meclofenamate complexes: structure, in vitro and in silico DNA\u2013and albumin\u2013binding studies, antioxidant and anticholinergic activity","volume":"222","author":"Barmpa","year":"2021","journal-title":"J. Inorg. Biochem."},{"issue":"12","key":"10.1016\/j.jinorgbio.2025.113196_bb0150","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1016\/j.xphs.2018.08.003","article-title":"Salts of mefenamic acid with amines: structure, thermal stability, desolvation, and solubility","volume":"107","author":"Boudiombo","year":"2018","journal-title":"J. Pharm. Sci."},{"issue":"6","key":"10.1016\/j.jinorgbio.2025.113196_bb0155","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3390\/cryst11060703","article-title":"Improvement of drug-loading properties of hydroxyapatite particles using triethylamine as a capping agent: a novel approach","volume":"11","author":"Wen","year":"2021","journal-title":"Crystals"},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.ica.2020.119878","article-title":"Manganese (II)-imidazole complexes of the non-steroidal anti-inflammatory drug mefenamic acid: synthesis, and structural studies","volume":"512","author":"Borkar","year":"2020","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0165","doi-asserted-by":"crossref","unstructured":"Dokorou, V., et al., Synthesis, crystal structures and spectroscopic studies of diorganotin derivatives with mefenamic acid. Crystal and molecular structures of 1, 2: 3, 4-di-\u03bc2\u20132-[(2, 3-dimethylphenyl) amino]-benzoato-O, O-1, 3-bis-2-[(-[(2, 3-dimethylphenyl) amino] benzoato-O-1, 2, 4: 2, 3, 4-di-\u03bc3-oxo-tetrakis [di-methyltin (IV)] and 1, 2: 3, 4-di-\u03bc2-2-[(-[(-[(2, 3-dimethylphenyl) amino]-benzoato-O, O-1, 3-bis-2-[(-[(-[(2, 3-dimethylphenyl) amino] benzoato-O-1, 2, 4: 2, 3, 4-di-\u03bc3-oxo-tetrakis [di-n-butyltin (IV)]. J. Organometal. Chem., 2001. 630(2): p. 205\u2013214.","DOI":"10.1016\/S0022-328X(01)01026-9"},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0170","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ica.2019.05.008","article-title":"Novel silver (I) complexes bearing mefenamic acid and pyridine derivatives: synthesis, chemical characterization and in vitro anticancer evaluation","volume":"493","author":"Altay","year":"2019","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.ica.2020.119942","article-title":"Synthesis, characterization, antioxidant and antidiabetic studies of Cu (II) and Zn (II) complexes of tolfenamic acid\/mefenamic acid with 1-methylimidazole","volume":"513","author":"Shamle","year":"2020","journal-title":"Inorg. Chim. Acta"},{"issue":"9","key":"10.1016\/j.jinorgbio.2025.113196_bb0180","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.jinorgbio.2011.05.025","article-title":"Synthesis, crystal structures and spectroscopy of meclofenamic acid and its metal complexes with manganese (II), copper (II), zinc (II) and cadmium (II). Antiproliferative and superoxide dismutase activity","volume":"105","author":"Kovala-Demertzi","year":"2011","journal-title":"J. Inorg. Biochem."},{"issue":"29","key":"10.1016\/j.jinorgbio.2025.113196_bb0185","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202301269","article-title":"Comprehensive biological, photodegradation, density functional theory, and docking exploration of Zn (II) and Mn (II) complexes of piroxicam","volume":"8","author":"Maha","year":"2023","journal-title":"ChemistrySelect"},{"issue":"4 (Social)","key":"10.1016\/j.jinorgbio.2025.113196_bb0190","first-page":"130","article-title":"Antioxidation and phytochemical analysis of mint, fennel seeds and cardamom; an approach towards synergistic potential","volume":"3","author":"Tahir","year":"2025","journal-title":"Insights"},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.134234","article-title":"Bi (III) complexes of piroxicam and meloxicam: synthesis, characterization, antioxidant, anti-inflammatory and DNA cleavage studies","volume":"1272","author":"Samra","year":"2023","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0200","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.molstruc.2017.07.042","article-title":"Synthesis, antihyperglycemic activity and computational studies of antioxidant chalcones and flavanones derived from 2, 5 dihydroxyacetophenone","volume":"1148","author":"Tajammal","year":"2017","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2021.132256","article-title":"Synthesis, characterization, docking and biological studies of M (II)(M= Mg, Ca, Sr) piroxicam complexes","volume":"1254","author":"Samra","year":"2022","journal-title":"J. Mol. Struct."},{"issue":"6","key":"10.1016\/j.jinorgbio.2025.113196_bb0210","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1007\/s13369-021-06521-7","article-title":"Synthesis, spectroscopic and biological investigation of a new Ca (II) complex of meloxicam as potential COX-2 inhibitor","volume":"47","author":"Samra","year":"2022","journal-title":"Arab. J. Sci. Eng."},{"issue":"2","key":"10.1016\/j.jinorgbio.2025.113196_bb0215","first-page":"4","article-title":"Anti-inflammatory, antithrombotic and molecular docking studies of 1, 3, 4 oxadiazole derivatives in rats","volume":"8","author":"Basra","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.134814","article-title":"Synthesis, molecular docking, bio-evaluation and quantitative structure activity relationship of new chalcone derivatives as antioxidants","volume":"1277","author":"Siddiqa","year":"2023","journal-title":"J. Mol. Struct."},{"issue":"2\u2013s","key":"10.1016\/j.jinorgbio.2025.113196_bb0225","doi-asserted-by":"crossref","first-page":"276","DOI":"10.22270\/jddt.v9i2-s.2511","article-title":"Analgesic activity of poly herbal formulation in experimental rats by acetic acid induced writhing test model and hot plate model","volume":"9","author":"Sharma","year":"2019","journal-title":"J. Drug Deliv. Ther."},{"issue":"12","key":"10.1016\/j.jinorgbio.2025.113196_bb0230","doi-asserted-by":"crossref","DOI":"10.1002\/aoc.7712","article-title":"Synthesis, structural characterization, anticancer, antimicrobial, antioxidant, and computational assessments of Zinc (II), Iron (II), and Copper (II) chelates derived from selenated schiff base","volume":"38","author":"Shaaban","year":"2024","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0235","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0076-6879(08)03811-1","article-title":"Evaluation and comparison of computational models","volume":"454","author":"Myung","year":"2009","journal-title":"Methods Enzymol."},{"issue":"4","key":"10.1016\/j.jinorgbio.2025.113196_bb0240","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202304429","article-title":"Synthesis, characterization, in silico DFT, molecular docking, ADMET profiling studies and toxicity predictions of Ag (I) complex derived from 4-aminoacetophenone","volume":"9","author":"Kyhoiesh","year":"2024","journal-title":"ChemistrySelect"},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.113196_bb0245","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.139867","volume":"1321","author":"Waheeb","year":"2025","journal-title":"J. Mol. Struct."},{"issue":"5","key":"10.1016\/j.jinorgbio.2025.113196_bb0255","doi-asserted-by":"crossref","DOI":"10.1002\/aoc.70144","article-title":"Ni (II) and Cu (II) complexes with a tridentate (O, N, O) azo dye antipyrine-based ligand: synthesis, spectral characterization, cytotoxicity, and in silico approaches","volume":"39","author":"Waheeb","year":"2025","journal-title":"Appl. Organomet. Chem."},{"issue":"9","key":"10.1016\/j.jinorgbio.2025.113196_bb0260","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1080\/1062936X.2019.1653966","article-title":"Drug-drug interaction prediction using PASS","volume":"30","author":"Dmitriev","year":"2019","journal-title":"SAR QSAR Environ. Res."},{"issue":"3","key":"10.1016\/j.jinorgbio.2025.113196_bb0265","doi-asserted-by":"crossref","DOI":"10.1002\/aoc.7002","article-title":"Synthesis, spectroscopic, in vitro, in vivo biological evaluation, and in silico docking analysis of new meloxicam metal complexes","volume":"37","author":"Samra","year":"2023","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0270","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10973-015-5120-0","article-title":"Synthesis, spectral and thermal study of La (III), Nd (III), Sm (III), Eu (III), Gd (III) and Tb (III) complexes with mefenamic acid","volume":"124","author":"Zapa\u0142a","year":"2016","journal-title":"J. Therm. Anal. Calorim."},{"issue":"80","key":"10.1016\/j.jinorgbio.2025.113196_bb0275","doi-asserted-by":"crossref","first-page":"50858","DOI":"10.1039\/C7RA10451K","article-title":"Electrochromism and electrochemical properties of complexes of transition metal ions with benzimidazole-based ligand","volume":"7","author":"Wa\u0142\u0119sa-Chorab","year":"2017","journal-title":"RSC Adv."},{"issue":"3","key":"10.1016\/j.jinorgbio.2025.113196_bb0280","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1007\/s10973-011-1911-0","article-title":"Synthesis, spectral and thermal studies of Mn (II), Co (II), Ni (II), cu (II) and Zn (II) complex dyes based on hydroxyquinoline moiety","volume":"109","author":"Gaber","year":"2012","journal-title":"J. Therm. Anal. Calorim."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.133263","article-title":"Tailoring of some novel bis-hydrazone metal chelates, spectral based characterization and DFT calculations for pharmaceutical applications and in-silico treatments for verification","volume":"1264","author":"Qasem","year":"2022","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0290","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s11696-019-01003-5","article-title":"Biological activity of two novel zinc (II) complexes with NSAID mefenamic acid","volume":"74","author":"Smolkov\u00e1","year":"2020","journal-title":"Chem. Pap."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2023.136432","article-title":"Zn (II) complexes with mefenamic acid: synthesis, characterization, and anticancer activity","volume":"1294","author":"Nnabuike","year":"2023","journal-title":"J. Mol. Struct."},{"issue":"8","key":"10.1016\/j.jinorgbio.2025.113196_bb0300","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1021\/cg300812v","article-title":"Conformational polymorphism in a non-steroidal anti-inflammatory drug, mefenamic acid","volume":"12","author":"SeethaLekshmi","year":"2012","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0305","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jinorgbio.2013.07.013","article-title":"Antioxidant capacity and DNA-interaction studies of zinc complexes with a non-steroidal anti-inflammatory drug, mefenamic acid","volume":"128","author":"Tarushi","year":"2013","journal-title":"J. Inorg. Biochem."},{"issue":"11","key":"10.1016\/j.jinorgbio.2025.113196_bb0310","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.3390\/pharmaceutics14112276","article-title":"The role of hidden conformers in determination of conformational preferences of mefenamic acid by NOESY spectroscopy","volume":"14","author":"Belov","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.ica.2023.121908","article-title":"Synthesis, characterization, and anticancer activity of Co (II), Cu (II), and Zn (II) complexes containing mefenamic acid and 2-methylimidazole","volume":"563","author":"Nnabuike","year":"2024","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0320","series-title":"The Systematic Identification of Organic Compounds","author":"Shriner","year":"2003"},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.113196_bb0325","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/14756366.2020.1869225","article-title":"Solubility enhancement of mefenamic acid by inclusion complex with \u03b2-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies","volume":"36","author":"Sid","year":"2021","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.113196_bb0330","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s13065-024-01239-7","article-title":"Metal complexes featuring a quinazoline schiff base ligand and glycine: synthesis, characterization, DFT and molecular docking analyses revealing their potent antibacterial, anti-helicobacter pylori, and anti-COVID-19 activities","volume":"18","author":"Mansour","year":"2024","journal-title":"BMC Chem."},{"issue":"5","key":"10.1016\/j.jinorgbio.2025.113196_bb0335","doi-asserted-by":"crossref","first-page":"135","DOI":"10.22159\/ajpcr.2017.v10i5.15863","article-title":"Studies of preparation, characterization, and solubility of mefenamic acid-nicotinamide co-crystal synthesized by using melt crystallization method","volume":"10","author":"Purwantoro","year":"2017","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0340","first-page":"1","article-title":"Mefenamic acid-layered zinc hydroxide nanohybrids: a new platform to elaborate drug delivery systems","author":"Nabipour","year":"2018","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"issue":"3","key":"10.1016\/j.jinorgbio.2025.113196_bb0345","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3390\/molecules28031057","article-title":"Structural features of small molecule antioxidants and strategic modifications to improve potential bioactivity","volume":"28","author":"Charlton","year":"2023","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.jinorgbio.2025.113196_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.tetlet.2020.151607","article-title":"Electronic (donating or withdrawing) effects of ortho-phenolic substituents in dendritic antioxidants","volume":"61","author":"Lee","year":"2020","journal-title":"Tetrahedron Lett."},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.113196_bb0355","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3390\/antiox12010204","article-title":"Antioxidant and anti-inflammatory effects of 6, 3\u2032, 4-and 7, 3, 4-trihydroxyflavone on 2D and 3D RAW264. 7 models","volume":"12","author":"Wang","year":"2023","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.113196_bb0360","doi-asserted-by":"crossref","first-page":"5276130","DOI":"10.1155\/2016\/5276130","article-title":"Role of antioxidants and natural products in inflammation","volume":"2016","author":"Arulselvan","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.113196_bb0365","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13045-023-01512-7","article-title":"Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy","volume":"16","author":"Liu","year":"2023","journal-title":"J. Hematol. Oncol."},{"issue":"6","key":"10.1016\/j.jinorgbio.2025.113196_bb0370","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1002\/cbdv.200800120","article-title":"Anti-inflammatory, antiproliferative, and radical-scavenging activities of tolfenamic acid and its metal complexes","volume":"6","author":"Kovala-Demertzi","year":"2009","journal-title":"Chem. Biodivers."},{"issue":"3","key":"10.1016\/j.jinorgbio.2025.113196_bb0375","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4103\/0253-7613.157127","article-title":"A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats","volume":"47","author":"Mansouri","year":"2015","journal-title":"Ind. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.113196_bb0380","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0014-2999(98)00340-9","article-title":"Induction of cyclooxygenase-2 causes an enhancement of writhing response in mice","volume":"352","author":"Matsumoto","year":"1998","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.jinorgbio.2025.113196_bb0385","doi-asserted-by":"crossref","first-page":"104","DOI":"10.31083\/j.jin2204104","article-title":"Flumazenil pretreatment reduces mefenamic acid-induced central nervous system toxicity in mice","volume":"22","author":"Jarrar","year":"2023","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0390","article-title":"Synthesis, biological evaluation, molecular docking analyses, and ADMET study of azo derivatives containing 1-naphthol against M\u03b2L-producing S. maltophilia","volume":"12","author":"Azeez","year":"2024","journal-title":"Results Chem."},{"issue":"4","key":"10.1016\/j.jinorgbio.2025.113196_bb0395","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.3390\/pharmaceutics15041314","article-title":"Highly cytotoxic copper (II) mixed-ligand quinolinonato complexes: pharmacokinetic properties and interactions with drug metabolizing cytochromes P450","volume":"15","author":"Medved\u00edkov\u00e1","year":"2023","journal-title":"Pharmaceutics"},{"issue":"W1","key":"10.1016\/j.jinorgbio.2025.113196_bb0400","doi-asserted-by":"crossref","first-page":"W257","DOI":"10.1093\/nar\/gky318","article-title":"ProTox-II: a webserver for the prediction of toxicity of chemicals","volume":"46","author":"Banerjee","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.rechem.2024.101916","article-title":"Synthesis, molecular docking, ADMET profiling, and anti-PC3 activity of new Schiff base derivatives","volume":"12","author":"Kamil","year":"2024","journal-title":"Results Chem."},{"issue":"3","key":"10.1016\/j.jinorgbio.2025.113196_bb0410","doi-asserted-by":"crossref","first-page":"164","DOI":"10.5185\/amlett.2019.2096","article-title":"Evaluation of NSAIDs antioxidant activity on lipid peroxidation in splenocyte membranes","volume":"10","author":"Ferreira","year":"2019","journal-title":"Adv. Mater. Lett."},{"issue":"11","key":"10.1016\/j.jinorgbio.2025.113196_bb0415","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.2174\/0929867003374255","article-title":"COX-2 selectivity and inflammatory processes","volume":"7","author":"Ryn","year":"2000","journal-title":"Curr. Med. Chem."},{"issue":"13","key":"10.1016\/j.jinorgbio.2025.113196_bb0420","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.2174\/1389557520666200505124922","article-title":"Anticancer and antimicrobial activities of naproxen and naproxen derivatives","volume":"20","author":"Han","year":"2020","journal-title":"Mini Rev. Med. Chem."},{"issue":"1","key":"10.1016\/j.jinorgbio.2025.113196_bb0425","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1038\/s41598-021-82009-6","article-title":"Discovery of potential inhibitors against New Delhi metallo-\u03b2-lactamase-1 from natural compounds: in silico-based methods","volume":"11","author":"Salari-Jazi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jinorgbio.2025.113196_bb0430","doi-asserted-by":"crossref","first-page":"102219","DOI":"10.1016\/j.rechem.2025.102219","article-title":"DNA gyrase inhibition by Ni (II)-Schiff base complexes via in silico molecular docking studies: spectroscopic, DFT calculations and in vitro pharmacological assessment","volume":"15","author":"Ejidike","year":"2025","journal-title":"Results Chem."},{"issue":"3","key":"10.1016\/j.jinorgbio.2025.113196_bb0435","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3892\/etm.2022.11131","article-title":"The anti-inflammation effect of strontium ranelate on rat chondrocytes with or without IL-1\u03b2 in vitro","volume":"23","author":"Yu","year":"2022","journal-title":"Exp. Ther. Med."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013425003770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013425003770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T08:32:24Z","timestamp":1782117144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013425003770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":87,"alternative-id":["S0162013425003770"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2025.113196","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis, structural characterization, and biological evaluation of a bioactive strontium (II)\u2013mefenamic acid complex: In-vivo and in-silico insights","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2025.113196","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113196"}}