{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:48:44Z","timestamp":1785912524325,"version":"3.56.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22377011"],"award-info":[{"award-number":["22377011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jinorgbio.2026.113398","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T23:48:57Z","timestamp":1782431337000},"page":"113398","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["PIKfyve-specific Pt(II)-based targeted drug conjugate in treatment of ovarian cancer through multi-mode actions"],"prefix":"10.1016","volume":"283","author":[{"given":"Heng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2026.113398_bb0005","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.3390\/ijms25031845","article-title":"Paradigm shift: a comprehensive review of ovarian cancer management in an era of advancements","volume":"25","author":"Tavares","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0010","doi-asserted-by":"crossref","first-page":"47","DOI":"10.21037\/cco-20-34","article-title":"Epidemiology of ovarian Cancer","volume":"9","author":"Gaona-Luviano","year":"2020","journal-title":"Chin. Clin. Oncol."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0015","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3390\/diagnostics15040406","article-title":"Early diagnosis of ovarian cancer: a comprehensive review of the advances, challenges, and future directions","volume":"15","author":"Hong","year":"2025","journal-title":"Diagnostics"},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0020","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.3390\/ijms20061466","article-title":"Therapeutic targeting of collective invasion in ovarian cancer","volume":"20","author":"Moffitt","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0025","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.canlet.2020.02.017","article-title":"Fallopian tube initiation of high grade serous ovarian cancer and ovarian metastasis: mechanisms and therapeutic implications","volume":"476","author":"Bergsten","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0030","first-page":"284","article-title":"Ovarian cancer statistics, 2018","volume":"68","author":"Torre","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0035","doi-asserted-by":"crossref","first-page":"7018","DOI":"10.1002\/cam4.2560","article-title":"Ovarian cancer: current status and strategies for improving therapeutic outcomes","volume":"8","author":"Chandra","year":"2019","journal-title":"Cancer Med."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0040","doi-asserted-by":"crossref","first-page":"191","DOI":"10.6004\/jnccn.2021.0007","article-title":"Ovarian cancer, version 2.2020, NCCN clinical practice guidelines in oncology","volume":"19","author":"Armstrong","year":"2021","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0045","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ejpb.2021.03.008","article-title":"Cisplatin-induced ototoxicity: updates on molecular mechanisms and otoprotective strategies","volume":"163","author":"Tang","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0050","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.semcancer.2020.08.013","article-title":"New approaches for targeting platinum-resistant ovarian cancer","volume":"77","author":"McMullen","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0055","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12943-024-01967-3","article-title":"Drug resistance in ovarian cancer: from mechanism to clinical trial","volume":"23","author":"Wang","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0060","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/bjc.2016.203","article-title":"ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel-and olaparib-resistant ovarian cancer cells","volume":"115","author":"Vaidyanathan","year":"2016","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0065","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1159\/000489418","article-title":"Downregulation of RIF1 enhances sensitivity to platinum-based chemotherapy in epithelial ovarian cancer (EOC) by regulating nucleotide excision repair (NER) pathway","volume":"46","author":"Liu","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0070","doi-asserted-by":"crossref","first-page":"6685","DOI":"10.2147\/CMAR.S179189","article-title":"IL-6 and ovarian cancer: inflammatory cytokines in promotion of metastasis","volume":"10","author":"Browning","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0075","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1200\/JCO.22.01207","article-title":"Identification of patients with ovarian cancer experiencing the highest benefit from bevacizumab in the first-line setting on the basis of their tumor-intrinsic chemosensitivity (KELIM): the GOG-0218 validation study","volume":"40","author":"Benoit","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0080","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.1021\/acs.jmedchem.4c03006","article-title":"Concept of targeted drug conjugate and its application in reversing drug resistance","volume":"68","author":"Wang","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0085","doi-asserted-by":"crossref","first-page":"114771","DOI":"10.1016\/j.taap.2019.114771","article-title":"Small molecule PIKfyve inhibitors as cancer therapeutics: translational promises and limitations","volume":"383","author":"Ikonomov","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0090","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1600-0854.2009.00915.x","article-title":"PIKfyve regulation of endosome-linked pathways","volume":"10","author":"Lartigue","year":"2009","journal-title":"Traffic"},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0095","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.1007\/s00018-016-2309-8","article-title":"PIKfyve inhibition increases exosome release and induces secretory autophagy","volume":"73","author":"Hessvik","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0100","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/tra.12525","article-title":"PIKfyve activity regulates reformation of terminal storage lysosomes from endolysosomes","volume":"18","author":"Bissig","year":"2017","journal-title":"Traffic"},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0105","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cellbi.2008.01.006","article-title":"PIKfyve: partners, significance, debates and paradoxes","volume":"32","author":"Shisheva","year":"2008","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0110","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1073\/pnas.2314416120","article-title":"Targeting the lipid kinase PIKfyve upregulates surface expression of MHC class I to augment cancer immunotherapy","volume":"120","author":"Bao","year":"2023","journal-title":"PNAS"},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0115","doi-asserted-by":"crossref","first-page":"5487","DOI":"10.1038\/s41467-024-48931-9","article-title":"PIKfyve, expressed by CD11c-positive cells, controls tumor immunity","volume":"15","author":"Choi","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0120","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1158\/0008-5472.CAN-24-1757","article-title":"Concurrent inhibition of the RAS-MAPK pathway and PIKfyve is a therapeutic strategy for pancreatic cancer","volume":"85","author":"DeLiberty","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0125","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41586-025-08917-z","article-title":"Targeting PIKfyve-driven lipid metabolism in pancreatic cancer","volume":"642","author":"Cheng","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0130","doi-asserted-by":"crossref","first-page":"102086","DOI":"10.1016\/j.ceb.2022.102086","article-title":"Roles of PIKfyve in multiple cellular pathways","volume":"76","author":"Rivero-R\u00edos","year":"2022","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0135","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1182\/blood-2016-09-736892","article-title":"Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma","volume":"129","author":"Gayle","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0140","doi-asserted-by":"crossref","first-page":"e0204532","DOI":"10.1371\/journal.pone.0204532","article-title":"Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P\u2082 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation","volume":"13","author":"Sbrissa","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0145","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1002\/art.34339","article-title":"A phase IIa, randomized, double-blind, placebo-controlled trial of apilimod mesylate, an interleukin-12\/interleukin-23 inhibitor, in patients with rheumatoid arthritis","volume":"64","author":"Krausz","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0150","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3390\/cells10010030","article-title":"The PIKfyve inhibitor apilimod: a double-edged sword against COVID-19","volume":"10","author":"Baranov","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0155","doi-asserted-by":"crossref","first-page":"15216","DOI":"10.1002\/chem.201404090","article-title":"Potent anticancer activity and possible low toxicity of platinum(II) complexes with functionalized 1,1-cyclobutanedicarboxylate as a leaving ligand","volume":"20","author":"Zhao","year":"2014","journal-title":"Chem. A Eur. J."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0160","doi-asserted-by":"crossref","first-page":"12432","DOI":"10.1021\/acs.jmedchem.3c00912","article-title":"Discovery of a first-in-class degrader for the lipid kinase PIKfyve","volume":"66","author":"Li","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0165","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-1-4939-7401-6_8","article-title":"In vitro tumorigenic assay: colony forming assay for cancer stem cells","volume":"1692","author":"Rajendran","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0170","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.3390\/cells13221838","article-title":"Apoptosis: a comprehensive overview of signaling pathways, morphological changes, and physiological significance and therapeutic implications","volume":"13","author":"Mustafa","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0175","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nrm2952","article-title":"Mitochondria and cell death: outer membrane permeabilization and beyond","volume":"11","author":"Tait","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0180","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.4161\/cc.6.14.4480","article-title":"An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells","volume":"6","author":"Krempler","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0185","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/febs.14186","article-title":"Bax, Bak and beyond-mitochondrial performance in apoptosis","volume":"285","author":"Pe\u00f1a-Blanco","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0190","doi-asserted-by":"crossref","first-page":"16254","DOI":"10.1073\/pnas.1418000111","article-title":"Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome","volume":"111","author":"Hu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0195","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.7150\/jca.72601","article-title":"Saponins of Marsdenia Tenacissima promotes apoptosis of hepatocellular carcinoma cells through damaging mitochondria then activating cytochrome C\/Caspase-9\/Caspase-3 pathway","volume":"13","author":"Jiang","year":"2022","journal-title":"J. Cancer"},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0200","doi-asserted-by":"crossref","first-page":"200290","DOI":"10.1016\/j.tvr.2024.200290","article-title":"HBx integration in diffuse large B-cell lymphoma inhibits Caspase-3-PARP related apoptosis","volume":"18","author":"Wang","year":"2024","journal-title":"Tumour Virus Res."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0205","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.3390\/ijms23063238","article-title":"Targeting DNA damage response and immune checkpoint for anticancer therapy","volume":"23","author":"Huang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jinorgbio.2026.113398_bb0210","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bcp.2015.08.112","article-title":"Quantitative evaluation of cellular uptake, DNA incorporation and adduct formation in cisplatin sensitive and resistant cell lines: comparison of different Pt-containing drugs","volume":"98","author":"Corte-Rodr\u00edguez","year":"2015","journal-title":"Biochem. Pharmacol."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016201342600187X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016201342600187X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:10:15Z","timestamp":1785910215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016201342600187X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":42,"alternative-id":["S016201342600187X"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2026.113398","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PIKfyve-specific Pt(II)-based targeted drug conjugate in treatment of ovarian cancer through multi-mode actions","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2026.113398","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113398"}}