{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:49:58Z","timestamp":1790858998661,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Insect Physiology"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.jinsphys.2006.09.009","type":"journal-article","created":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T11:42:19Z","timestamp":1158752539000},"page":"216-229","source":"Crossref","is-referenced-by-count":44,"title":["Stage- and cell-specific expression of ecdysone receptors and ecdysone-induced transcription factors during midgut remodeling in the yellow fever mosquito, Aedes aegypti"],"prefix":"10.1016","volume":"53","author":[{"given":"R.","family":"Parthasarathy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subba R.","family":"Palli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinsphys.2006.09.009_bib56","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/BF00321231","article-title":"Patterns of puffing activity in the salivary gland chromosomes of Drosophila","volume":"31","author":"Ashburner","year":"1970","journal-title":"Chromosoma"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib1","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1073\/pnas.95.6.2761","article-title":"Insect juvenile hormone resistance gene homology with the bHLH-PAS family of transcriptional regulators","volume":"956","author":"Ashok","year":"1998","journal-title":"Proceedings of National Academy of Science USA"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib2","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/sj.cdd.4400753","article-title":"Steroid regulation of programmed cell death during Drosophila development","volume":"7","author":"Baehrecke","year":"2000","journal-title":"Cell Death and Differentiation"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib3","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nrm931","article-title":"How death shapes life during development","volume":"3","author":"Baehrecke","year":"2002","journal-title":"Nature Review of Molecular and Cell Biology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib4","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1186\/gb-2005-6-12-r99","article-title":"The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis","volume":"6","author":"Beckstead","year":"2005","journal-title":"Genome Biology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib5","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0092-8674(00)80466-3","article-title":"Drosophila ecdysone receptor mutations reveal functional differences among receptor isoforms","volume":"91","author":"Bender","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0083-6729(05)73006-5","article-title":"Juvenile hormone molecular actions and interactions during development of Drosophila melanogaster","volume":"73","author":"Berger","year":"2005","journal-title":"Vitamins and Hormones"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1534-5807(02)00204-6","article-title":"Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila","volume":"3","author":"Bialecki","year":"2002","journal-title":"Developmental Cell"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib8","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1083\/jcb.200311057","article-title":"Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc, regulating its expression in specific tissues","volume":"165","author":"Cakouros","year":"2004","journal-title":"Journal of Cell Biology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib9","series-title":"Aedes aegypti (L.). The Yellow Fever Mosquito. Its Life History, Bionomics and Structure","author":"Christophers","year":"1960"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib10","series-title":"The Biology of Mosquitoes: Development, Nutrition and Reproduction","author":"Clements","year":"1992"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1242\/dev.111.1.23","article-title":"Apical cell shape changes during Drosophila imaginal leg disc elongation: a novel morphogenetic mechanism","volume":"111","author":"Condic","year":"1991","journal-title":"Development"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0965-1748(96)00068-9","article-title":"Programmed cell death of the prothoracic glands of Manduca sexta during pupal-adult metamorphosis","volume":"27","author":"Dai","year":"1997","journal-title":"Insect Biochemistry and Molecular Biology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib13","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ydbio.2005.03.019","article-title":"Phenotypic analysis of EcR-A mutants suggests that EcR isoforms have unique functions during Drosophila development","volume":"282","author":"Davis","year":"2005","journal-title":"Developmental biology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.tem.2004.11.003","article-title":"Hormonal cross talk in insect development","volume":"16","author":"Dubrovsky","year":"2005","journal-title":"Trends in Endocrinology Metabolism"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib15","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1242\/dev.121.5.1455","article-title":"The Drosophila E74 gene is required for metamorphosis and plays a role in the polytene chromosome puffing response to ecdysone","volume":"121","author":"Fletcher","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib17","series-title":"The development of Drosophila melanogaster","first-page":"843","article-title":"The meatamorphic development of the adult epidermis","author":"Fristrom","year":"1993"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib16","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/icb\/17.3.671","article-title":"The mechanism of evagination of imaginal discs of Drosophila melanogaster","volume":"17","author":"Fristrom","year":"1977","journal-title":"American Journal of Zoology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib18","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1242\/dev.124.22.4673","article-title":"Steroid regulated programmed cell death during Drosophila metamorphosis","volume":"22","author":"Jiang","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1097-2765(00)80439-6","article-title":"A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis","volume":"5","author":"Jiang","year":"2000","journal-title":"Molecular Cell"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1016-8478(23)13509-6","article-title":"Transcript titers of ecdysteroid receptor components vary between tissues and stages during Drosophila development","volume":"9","author":"Kim","year":"1999","journal-title":"Molecular Cells"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib21","unstructured":"Koelle, M.R., 1992. Molecular analysis of the Drosophila ecdysone receptor complex. Ph.D. Thesis, Stanford University, Stanford, CA."},{"key":"10.1016\/j.jinsphys.2006.09.009_bib22","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jinsphys.2004.04.012","article-title":"Critical period for pupal commitment in the yellow fever mosquito, Aedes aegypti","volume":"50","author":"Lan","year":"2004","journal-title":"Journal of Insect Physiology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/dbio.2002.0784","article-title":"Steroid regulation of midgut cell death during Drosophila development","volume":"250","author":"Lee","year":"2002","journal-title":"Developmental Biology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib24","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1242\/dev.128.8.1443","article-title":"Steroid regulation of autophagic programmed cell death during development","volume":"128","author":"Lee","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib25","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/0022-1910(65)90142-3","article-title":"Programmed cell death. 3. Neural control of the breakdown of the intersegmental muscles of silkmoths","volume":"11","author":"Lockshin","year":"1965","journal-title":"Journal of Insect Physiology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0022-1910(65)90099-5","article-title":"Programmed cell death\u2014I. Cytology of degeneration in the intersegmental muscles of the pernyi silkmoth","volume":"11","author":"Lockshin","year":"1965","journal-title":"Journal of Insect Physiology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib27","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0022-1910(65)90159-9","article-title":"Programmed cell death. IV. The influence of drugs on the breakdown of the intersegmental muscles of silkmoths","volume":"11","author":"Lockshin","year":"1965","journal-title":"Journal of Insect Physiology"},{"issue":"7","key":"10.1016\/j.jinsphys.2006.09.009_bib28","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0022-1910(65)90186-1","article-title":"Programmed cell death. V. Cytolytic enzymes in relation to the breakdown of the intersegmental muscles of silkmoths","volume":"11","author":"Lockshin","year":"1965","journal-title":"Journal of Insect Physiology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib29","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF00848459","article-title":"Histological analysis of the dynamics of growth of imaginal discs and histoblast nests during the larval development of Drosophila melanogaster","volume":"183","author":"Madhavan","year":"1977","journal-title":"Roux's Archives of Developmental Biology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib30","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jinsphys.2006.02.003","article-title":"Ecdysteroid titers and developmental expression of ecdysteroid-regulated genes during metamorphosis of the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae)","volume":"52","author":"Margam","year":"2006","journal-title":"Journal of Insect Physiology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib31","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1603\/0013-8746(2002)095[0498:CMCIMI]2.0.CO;2","article-title":"Coordinated morphological changes in midgut, imaginal discs, and respiratory trumpets during metamorphosis of Aedes aegypti (Diptera: Culicidae)","volume":"95","author":"Nishiura","year":"2002","journal-title":"Annals of Entomogical Society of America"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib32","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1603\/0022-2585-40.4.498","article-title":"Methoprene interferes with mosquito midgut remodeling during metamorphosis","volume":"40","author":"Nishiura","year":"2003","journal-title":"Journal of Medical Entomology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib33","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.ibmb.2005.01.019","article-title":"Expression of nuclear receptor-transcription factor genes during Aedes aegypti midgut metamorphosis and the effect of methoprene on expression","volume":"35","author":"Nishiura","year":"2005","journal-title":"Insect Biochemistry and Molecular Biology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib34","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1603\/0013-8746(2000)093[0282:NACCIT]2.0.CO;2","article-title":"Nuclear and cytoplasmic changes in the Culex pipens (Diptera: Culicidae) alimentary canal during metamorphosis and their relationship to programmed cell death","volume":"93","author":"Nishiura","year":"2000","journal-title":"Annals of Entomological Society of America"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib35","first-page":"203","article-title":"Hormone receptors and the regulation of insect metamorphosis","volume":"3","author":"Riddiford","year":"1993","journal-title":"Receptor"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib36","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/(SICI)1520-6327(1996)32:3\/4<271::AID-ARCH2>3.0.CO;2-W","article-title":"Juvenile hormone: the status of its \u201cstatus quo\u201d action","volume":"32","author":"Riddiford","year":"1996","journal-title":"Archives of Insect Biochemistry and Physiology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib37","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0016-6480(91)90181-5","article-title":"Effects of juvenile hormone mimics on larval development and metamorphosis of Drosophila melanogaster","volume":"82","author":"Riddiford","year":"1991","journal-title":"General and Comparative Endocrinology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0083-6729(00)60016-X","article-title":"Ecdysone receptors and their biological actions","volume":"60","author":"Riddiford","year":"2000","journal-title":"Vitamins and Hormones"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib39","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1242\/dev.119.4.1251","article-title":"Programmed cell death in the Drosophila CNS is ecdysone-regulated and coupled with a specific ecdysone receptor isoform","volume":"119","author":"Robinow","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib40","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF00848591","article-title":"Regulation and metamorphosis of the abdominal histoblasts of Drosophila melanogaster","volume":"186","author":"Roseland","year":"1979","journal-title":"Roux's Archives of Developmental Biology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib41","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1073\/pnas.0409868102","article-title":"Remodeling of the intestine during metamorphosis of Xenopus laevis","volume":"102","author":"Schreiber","year":"2005","journal-title":"Proceedings of National Academy of Science USA"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib42","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0925-4773(99)00310-X","article-title":"Characterization of the regulatory elements controlling neuronal expression of the A-isoform of the ecdysone receptor gene of Drosophila melanogaster","volume":"91","author":"Sung","year":"2000","journal-title":"Mechanisms of Development"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib43","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/0092-8674(93)90359-X","article-title":"Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms","volume":"73","author":"Talbot","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib44","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s004270000100","article-title":"Programmed cell death triggered by insect steroid hormone, 20-hydroxyecdysone in the anterior silk gland of the silkworm, Bombyx mori","volume":"210","author":"Tereshima","year":"2000","journal-title":"Development Genes and Evolution"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib45","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/362471a0","article-title":"Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle","volume":"362","author":"Thomas","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib46","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0168-9525(96)10032-9","article-title":"Files on steroids\u2014Drosophila metamorphosis and the mechanisms of steroid hormone action","volume":"12","author":"Thummel","year":"1996","journal-title":"Trends in Genetics"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib48","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1146\/annurev.ento.47.091201.145230","article-title":"Endocrine insights into the evolution of metamorphosis in insects","volume":"47","author":"Truman","year":"2002","journal-title":"Annual Review of Entomology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib47","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/0166-2236(82)90169-2","article-title":"Programmed cell death in the nervous system of a moth","volume":"5","author":"Truman","year":"1982","journal-title":"Trends in Neuroscience"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib49","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/neu.480230917","article-title":"Programmed neuronal death in insect development","volume":"23","author":"Truman","year":"1992","journal-title":"Journal of Neurobiology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib50","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00441-002-0515-1","article-title":"Replacement of midgut epithelium in the greater wax moth, Galleria mellonella, during larval\u2013pupal moult","volume":"308","author":"Uwo","year":"2002","journal-title":"Cell and Tissue Research"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib51","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/bies.950170806","article-title":"The making of a fly leg: a model for epithelial morphogenesis","volume":"17","author":"von Kalm","year":"1995","journal-title":"Bioessays"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib52","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.mod.2006.05.005","article-title":"Mechanisms of midgut remodeling: Juvenile hormone analog methoprene blocks midgut metamorphosis by modulating ecdysone action","volume":"123","author":"Wu","year":"2006","journal-title":"Mechanisms of Development"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib53","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/366476a0","article-title":"Functional ecdysone receptor is the product of EcR and ultraspiracle genes","volume":"366","author":"Yao","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib54","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/dbio.1998.9059","article-title":"Juvenile hormone prevents ecdysteroid-induced expression of broad complex RNAs in the epidermis of the tobacco hornworm, Manduca sexta","volume":"203","author":"Zhou","year":"1998","journal-title":"Developmental Biology"},{"key":"10.1016\/j.jinsphys.2006.09.009_bib55","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1242\/dev.129.9.2259","article-title":"Broad specifies pupal development and mediates the \u2018status quo\u2019 action of juvenile hormone on the pupal\u2013adult transformation in Drosophila and Manduca","volume":"129","author":"Zhou","year":"2002","journal-title":"Development"}],"container-title":["Journal of Insect Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022191006001612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022191006001612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T15:30:28Z","timestamp":1707233428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022191006001612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0022191006001612"],"URL":"https:\/\/doi.org\/10.1016\/j.jinsphys.2006.09.009","relation":{},"ISSN":["0022-1910"],"issn-type":[{"value":"0022-1910","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}