{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:01:01Z","timestamp":1785110461703,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005196","name":"Chinese Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["1610042022005"],"award-info":[{"award-number":["1610042022005"]}],"id":[{"id":"10.13039\/501100005196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010038","name":"Earmarked Fund for China Agriculture Research System","doi-asserted-by":"publisher","award":["CARS-13"],"award-info":[{"award-number":["CARS-13"]}],"id":[{"id":"10.13039\/501100010038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402465"],"award-info":[{"award-number":["32402465"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Hebei Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["C2024204115"],"award-info":[{"award-number":["C2024204115"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Insect Physiology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jinsphys.2025.104861","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T23:48:09Z","timestamp":1753141689000},"page":"104861","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Rnai-mediated knockdown of nuclear receptors impairs cuticle formation by disrupting chitin metabolic pathway in Holotrichia oblita"],"prefix":"10.1016","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0773-0660","authenticated-orcid":false,"given":"Zhi-long","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Nan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinsphys.2025.104861_b0005","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1093\/molbev\/msh200","article-title":"Evolutionary genomics of nuclear receptors: From twenty-five ancestral genes to derived endocrine systems","volume":"21","author":"Bertrand","year":"2004","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0010","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1534-5807(02)00204-6","article-title":"Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila","volume":"3","author":"Bialecki","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jinsphys.2025.104861_b0015","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1365-2583.2006.00654.x","article-title":"The rapid divergence of the ecdysone receptor is a synapomorphy for Mecopterida that clarifies the Strepsiptera problem","volume":"15","author":"Bonneton","year":"2006","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0020","article-title":"Molecular characterization and functional analysis of the ecdysone receptor isoform (EcR) from the oriental fruit moth Grapholita molesta (Lepidoptera: Tortricidae)","volume":"115","author":"Cao","year":"2024","journal-title":"Arch. Insect Biochem. Physiol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0025","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.ibmb.2008.09.013","article-title":"Nuclear receptors in Bombyx mori: Insights into genomic structure and developmental expression","volume":"38","author":"Cheng","year":"2008","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0030","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1186\/1471-2164-11-703","article-title":"Gene discovery in the horned beetle Onthophagus taurus","volume":"11","author":"Choi","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jinsphys.2025.104861_b0035","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1111\/j.1742-4658.2008.06860.x","article-title":"Nuclear receptors in the mosquito Aedes aegypti: Annotation, hormonal regulation and expression profiling","volume":"276","author":"Cruz","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.jinsphys.2025.104861_b0040","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/1744-7917.12774","article-title":"Chitinase 10 controls chitin amounts and organization in the wing cuticle of Drosophila","volume":"27","author":"Dong","year":"2020","journal-title":"Insect Sci."},{"key":"10.1016\/j.jinsphys.2025.104861_b0045","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev-ento-120710-100607","article-title":"Insect nuclear receptors","volume":"57","author":"Fahrbach","year":"2012","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0050","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.scib.2021.06.019","article-title":"Juvenile hormone membrane signaling phosphorylates USP and thus potentiates 20-hydroxyecdysone action in Drosophila","volume":"67","author":"Gao","year":"2022","journal-title":"Sci. Bull."},{"issue":"11","key":"10.1016\/j.jinsphys.2025.104861_bib231","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.3390\/ijms19113691","article-title":"Insect Transcription Factors: A Landscape of Their Structures and Biological Functions in Drosophila and beyond","volume":"19","author":"Guo","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jinsphys.2025.104861_b0055","first-page":"1443","article-title":"Anti-inflammatory and metabolic actions of FXR: Insights into molecular mechanisms","volume":"1821","author":"Hollman","year":"2012","journal-title":"BBA-Mol. Cell Biol. L."},{"key":"10.1016\/j.jinsphys.2025.104861_b0060","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11248-018-0109-7","article-title":"Transgenic potato lines expressing hairpin RNAi construct of molting-associated EcR gene exhibit enhanced resistance against Colorado potato beetle (Leptinotarsa decemlineata, say)","volume":"28","author":"Hussain","year":"2019","journal-title":"Transgenic Res."},{"key":"10.1016\/j.jinsphys.2025.104861_b0065","doi-asserted-by":"crossref","first-page":"11381","DOI":"10.1021\/acs.jafc.4c00084","article-title":"Novel environmentally friendly RNAi biopesticides: Targeting V-ATPase in Holotrichia parallela larvae using layered double hydroxide nanocomplexes","volume":"72","author":"Jiang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jinsphys.2025.104861_b0070","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1002\/ps.7056","article-title":"Nuclear receptor HR3 mediates transcriptional regulation of chitin metabolic genes during molting in Tribolium castaneum","volume":"78","author":"Kim","year":"2022","journal-title":"Pest. Manage. Sci."},{"key":"10.1016\/j.jinsphys.2025.104861_b0075","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nrg1581","article-title":"Nuclear receptors\u2013A perspective from Drosophila","volume":"6","author":"King-Jones","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jinsphys.2025.104861_b0080","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.jinsphys.2010.03.029","article-title":"Developmental expression of mRNAs for epidermal and fat body proteins and hormonally regulated transcription factors in the tobacco hornworm","volume":"56","author":"Kiyoshi","year":"2010","journal-title":"Manduca Sexta. J. Insect Physiol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0085","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1517\/13543776.2012.699042","article-title":"Therapeutic modulators of peroxisome proliferator-activated receptors (PPAR): A patent review (2008-present)","volume":"22","author":"Lamers","year":"2012","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.jinsphys.2025.104861_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132459","article-title":"Functional analysis of nuclear receptor genes in molting and metamorphosis of the cigarette beetle Lasioderma Serricorne","volume":"270","author":"Le","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"13","key":"10.1016\/j.jinsphys.2025.104861_bib233","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1046\/j.1432-1033.2002.03001.x","article-title":"Ligand-induced heterodimerization between the ligand binding domains of the Drosophila ecdysteroid receptor and ultraspiracle","volume":"269","author":"Lezzi","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jinsphys.2025.104861_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocontrol.2020.104469","article-title":"Efficacy of entomopathogenic nematode and bacillus thuringiensis combinations against Holotrichia parallela (Coleoptera: Scarabaeidae) larvae","volume":"152","author":"Li","year":"2021","journal-title":"Biol. Control"},{"key":"10.1016\/j.jinsphys.2025.104861_b0100","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/ps.8484","article-title":"RNAi of nuclear receptor E78 inhibits the cuticle formation in the molting process of spider mite Tetranychus Urticae","volume":"81","author":"Li","year":"2024","journal-title":"Pest Manage. Sci."},{"key":"10.1016\/j.jinsphys.2025.104861_b0105","doi-asserted-by":"crossref","DOI":"10.1002\/arch.21910","article-title":"Functional analysis of nuclear receptor HR96 gene in Bombyx mori exposed to phoxim","volume":"111","author":"Liu","year":"2022","journal-title":"Arch. Insect Biochem. Physiol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0110","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1093\/bioinformatics\/btv362","article-title":"IBS: An illustrator for the presentation and visualization of biological sequences","volume":"31","author":"Liu","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jinsphys.2025.104861_b0115","first-page":"96","article-title":"Histopathological changes of Ceroplastes japonicus infected by Lecanicillium lecanii","volume":"101","author":"Liu","year":"2009","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0120","doi-asserted-by":"crossref","first-page":"27370","DOI":"10.1074\/jbc.M115.687293","article-title":"20-Hydroxyecdysone (20E) primary response gene E93 modulates 20E signaling to promote Bombyx larval-pupal metamorphosis","volume":"290","author":"Liu","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jinsphys.2025.104861_b0125","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jinsphys.2025.104861_b0130","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jinsphys.2006.02.003","article-title":"Ecdysteroid titers and developmental expression of ecdysteroid-regulated genes during metamorphosis of the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae)","volume":"52","author":"Margam","year":"2006","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0135","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1111\/j.1742-4658.2008.06428.x","article-title":"RNAi-mediated knockdown of juvenile hormone acid O-methyltransferase gene causes precocious metamorphosis in the red flour beetle Tribolium castaneum","volume":"275","author":"Minakuchi","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.jinsphys.2025.104861_b0140","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-3-319-40740-1_2","article-title":"Chitin metabolic pathways in insects and their regulation","author":"Muthukrishnan","year":"2016","journal-title":"Extracellular Composite Matrices in Arthropods"},{"key":"10.1016\/j.jinsphys.2025.104861_b0145","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ygcen.2012.06.001","article-title":"How does juvenile hormone control insect metamorphosis and reproduction?","volume":"179","author":"Riddiford","year":"2012","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0150","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jinsphys.2012.01.013","article-title":"Ecdysone signaling in adult Drosophila melanogaster","volume":"58","author":"Schwedes","year":"2012","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0155","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1002\/ps.6822","article-title":"RNA interference targeting Ras GTPase gene Ran causes larval and adult lethality in Leptinotarsa decemlineata","volume":"78","author":"Shen","year":"2022","journal-title":"Pest. Manage. Sci."},{"issue":"3","key":"10.1016\/j.jinsphys.2025.104861_b0160","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/dgd.12125","article-title":"Function of the nuclear receptor FTZ-F1 during the pupal stage in Drosophila melanogaster","volume":"56","author":"Sultan","year":"2014","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.jinsphys.2025.104861_b0165","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/ps.5686","article-title":"RNA-based biocontrol compounds: current status and perspectives to reach the market","volume":"76","author":"Taning","year":"2020","journal-title":"Pest. Manage. Sci."},{"key":"10.1016\/j.jinsphys.2025.104861_b0170","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10340-013-0540-8","article-title":"Soil insect pests of cold temperate zones of East Asia, including DPR Korea: A review","volume":"87","author":"Toepfer","year":"2014","journal-title":"J. Pest. Sci."},{"key":"10.1016\/j.jinsphys.2025.104861_b0175","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ijbiomac.2019.06.013","article-title":"Molecular and functional characterization of odorant-binding protein genes in Holotrichia oblita Faldermann","volume":"136","author":"Wang","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0180","article-title":"Effects of double-stranded RNA degrading nucleases on RNAi efficiency in beet moth Spodoptera exigua (Lepidoptera: Noctuidae)","volume":"16","author":"Wang","year":"2025","journal-title":"Insects"},{"key":"10.1016\/j.jinsphys.2025.104861_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.aspen.2025.102413","article-title":"The nuclear receptor gene SfE75 regulates the molting of Sogatella furcifera","volume":"28","author":"Wang","year":"2025","journal-title":"J. Asia Pac. Entomol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0190","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/1744-7917.12777","article-title":"RNA interference targeting ecdysone receptor blocks the larval-pupal transition in Henosepilachna vigintioctopunctata","volume":"28","author":"Wu","year":"2021","journal-title":"Insect Sci."},{"key":"10.1016\/j.jinsphys.2025.104861_b0195","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/imb.12876","article-title":"Knockout of nuclear receptor HR38 gene impairs pupal\u2013adult development in silkworm Bombyx mori","volume":"33","author":"Xu","year":"2023","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2023.105417","article-title":"Nuclear receptors potentially regulate phytochemical detoxification in Spodoptera litura","volume":"192","author":"Yang","year":"2023","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0205","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.tibtech.2017.04.009","article-title":"Next-generation insect-resistant plants: RNAi-mediated crop protection","volume":"35","author":"Zhang","year":"2017","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2022.105257","article-title":"Identification and functional analysis of two potential RNAi targets for chitin degradation in Holotrichia parallela Motschulsky (Insecta Coleoptera)","volume":"188","author":"Zhao","year":"2022","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ibmb.2017.11.001","article-title":"Nuclear receptor HR3 controls locust molt by regulating chitin synthesis and degradation genes of Locusta migratoria","volume":"92","author":"Zhao","year":"2018","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.cj.2025.05.006","article-title":"RNAi technologies for insect control in crop protection","author":"Zhong","year":"2025","journal-title":"Crop J."},{"key":"10.1016\/j.jinsphys.2025.104861_b0225","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev-ento-010715-023933","article-title":"Biosynthesis, turnover, and functions of chitin in insects","volume":"61","author":"Zhu","year":"2016","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.jinsphys.2025.104861_b0230","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev-ento-011019-025224","article-title":"Mechanisms, applications, and challenges of insect RNA interference","volume":"65","author":"Zhu","year":"2020","journal-title":"Annu. Rev. Entomol."}],"container-title":["Journal of Insect Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022191025001155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022191025001155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T09:49:00Z","timestamp":1757324940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022191025001155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":48,"alternative-id":["S0022191025001155"],"URL":"https:\/\/doi.org\/10.1016\/j.jinsphys.2025.104861","relation":{},"ISSN":["0022-1910"],"issn-type":[{"value":"0022-1910","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rnai-mediated knockdown of nuclear receptors impairs cuticle formation by disrupting chitin metabolic pathway in Holotrichia oblita","name":"articletitle","label":"Article Title"},{"value":"Journal of Insect Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinsphys.2025.104861","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104861"}}