{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:29:19Z","timestamp":1780586959718,"version":"3.54.1"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Invertebrate Pathology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jip.2024.108182","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T11:03:30Z","timestamp":1724324610000},"page":"108182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Under the radar: Transcriptomic responses of bed bugs to an entomopathogen, environmental bacteria, and a human pathogen"],"prefix":"10.1016","volume":"206","author":[{"given":"Hunter K.","family":"Walt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Bronzato-Badial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie E.","family":"Maedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Hinton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas G.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose E.","family":"Pietri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico G.","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jip.2024.108182_b0005","unstructured":"Alexa, A., Rahnenfuhrer, J., 2020. topGO: Enrichment Analysis for Gene Ontology."},{"key":"10.1016\/j.jip.2024.108182_b0010","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.4049\/jimmunol.181.4.2705","article-title":"Host-derived extracellular nucleic acids enhance innate immune responses, induce coagulation, and prolong survival upon infection in insects","volume":"181","author":"Altincicek","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.jip.2024.108182_b0015","unstructured":"Andrews, S., 2010. FASTQC. A quality control tool for high throughput sequence data."},{"key":"10.1016\/j.jip.2024.108182_b0020","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/sysbio\/syr041","article-title":"Survey of branch support methods demonstrates accuracy, power, and robustness of fast likelihood-based approximation schemes","volume":"60","author":"Anisimova","year":"2011","journal-title":"Syst. Biol."},{"key":"10.1016\/j.jip.2024.108182_b0025","doi-asserted-by":"crossref","first-page":"11337","DOI":"10.1073\/pnas.0504982102","article-title":"Laccase 2 is the phenoloxidase gene required for beetle cuticle tanning","volume":"102","author":"Arakane","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1926","key":"10.1016\/j.jip.2024.108182_b0030","doi-asserted-by":"crossref","first-page":"20200302","DOI":"10.1098\/rspb.2020.0302","article-title":"Mating changes the genital microbiome in both sexes of the common bedbug Cimex lectularius across populations","volume":"287","author":"Bellinvia","year":"2020","journal-title":"Proceedings of the Royal Society B"},{"key":"10.1016\/j.jip.2024.108182_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms10165","article-title":"Unique features of a global human ectoparasite identified through sequencing of the bed bug genome","volume":"7","author":"Benoit","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jip.2024.108182_b0040","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/jme\/tjx252","article-title":"Survival and Transstadial Persistence of Trypanosoma cruzi in the bed bug (Hemiptera: Cimicidae)","volume":"55","author":"Blakely","year":"2018","journal-title":"J. Med. Entomol."},{"key":"10.1016\/j.jip.2024.108182_b0045","first-page":"411","article-title":"The Behaviour of Certain Spirochaetes In Cimex lectularius","volume":"4","author":"Blanc","year":"1953","journal-title":"Arch. Inst. Pasteur Maroc"},{"key":"10.1016\/j.jip.2024.108182_b0050","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: A flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jip.2024.108182_b0055","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jip.2024.108182_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ibmb.2021.103620","article-title":"Reactive oxygen species-mediated immunity against bacterial infection in the gut of cat fleas (Ctenocephalides felis)","volume":"136","author":"Brown","year":"2021","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.jip.2024.108182_b0065","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nmeth.3176","article-title":"Fast and sensitive protein alignment using DIAMOND","volume":"12","author":"Buchfink","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jip.2024.108182_b0070","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41592-021-01101-x","article-title":"Sensitive protein alignments at tree-of-life scale using DIAMOND","volume":"18","author":"Buchfink","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jip.2024.108182_b0075","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.1093\/molbev\/msab293","article-title":"eggNOG-mapper v2: functional annotation, orthology assignments, and domain prediction at the metagenomic scale","volume":"38","author":"Cantalapiedra","year":"2021","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.jip.2024.108182_b0080","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/jisesa\/ieab092","article-title":"Galleria mellonella (Lepidoptera: Pyralidae) hemocytes release extracellular traps that confer protection against bacterial infection in the hemocoel","volume":"21","author":"Chen","year":"2021","journal-title":"J. Insect Sci."},{"key":"10.1016\/j.jip.2024.108182_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2019.103582","article-title":"A novel Laccase gene from Litopenaeus vannamei is involved in the immune responses to pathogen infection and oxidative stress","volume":"105","author":"Chen","year":"2020","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jip.2024.108182_b0090","doi-asserted-by":"crossref","first-page":"18066","DOI":"10.1038\/s41598-019-54484-5","article-title":"Hemocyte-hemocyte adhesion by granulocytes is associated with cellular immunity in the cricket Gryllus bimaculatus","volume":"9","author":"Cho","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jip.2024.108182_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2020.104591","article-title":"The role of extracellular nucleic acids in the immune system modulation of Rhodnius prolixus (Hemiptera: Reduviidae)","volume":"167","author":"Coste Grahl","year":"2020","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.jip.2024.108182_b0100","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/cid\/ciq102","article-title":"Bedbugs and infectious diseases","volume":"52","author":"Delaunay","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jip.2024.108182_b0105","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s13071-017-2118-4","article-title":"Suppression of Laccase 2 severely impairs cuticle tanning and pathogen resistance during the pupal metamorphosis of Anopheles sinensis (Diptera: Culicidae)","volume":"10","author":"Du","year":"2017","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.jip.2024.108182_b0110","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.4269\/ajtmh.18-0804","article-title":"Testing the competence of Cimex lectularius bed bugs for the transmission of Borrelia recurrentis, the agent of relapsing fever","volume":"100","author":"El Hamzaoui","year":"2019","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jip.2024.108182_b0115","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/imm.13390","article-title":"Haemocyte-mediated immunity in insects: Cells, processes and associated components in the fight against pathogens and parasites","volume":"164","author":"Eleftherianos","year":"2021","journal-title":"Immunology"},{"key":"10.1016\/j.jip.2024.108182_b0120","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1186\/s13071-019-3694-2","article-title":"Lack of influence by endosymbiont Wolbachia on virus titer in the common bed bug Cimex lectularius","volume":"12","author":"Fisher","year":"2019","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.jip.2024.108182_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ibmb.2024.104112","article-title":"Dynamics of cuticle-associated transcript profiles during moulting of the bed bug Cimex lectularius","volume":"168","author":"Flaven-Pouchon","year":"2024","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.jip.2024.108182_b0130","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.amjmed.2011.08.010","article-title":"Psychological effects of bed bug attacks (Cimex lectularius L.)","volume":"125","author":"Goddard","year":"2012","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jip.2024.108182_b0135","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1001\/jama.2009.405","article-title":"Bed Bugs (Cimex lectularius) and clinical consequences of their bites","volume":"301","author":"Goddard","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.jip.2024.108182_b0140","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jinsphys.2008.04.013","article-title":"Temporal patterns in immune responses to a range of microbial insults (Tenebrio molitor)","volume":"54","author":"Haine","year":"2008","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.jip.2024.108182_b0145","doi-asserted-by":"crossref","first-page":"eadg5725","DOI":"10.1126\/science.adg5725","article-title":"Ecology-relevant bacteria drive the evolution of host antimicrobial peptides in Drosophila","volume":"381","author":"Hanson","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.jip.2024.108182_b0150","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jip.2017.10.010","article-title":"Involvement of laccase2 and yellow-e genes in antifungal host defense of the model beetle, Tribolium castaneum","volume":"151","author":"Hayakawa","year":"2018","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.jip.2024.108182_b0155","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.dci.2015.12.006","article-title":"Insect immunology and hematopoiesis","volume":"58","author":"Hillyer","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jip.2024.108182_b0160","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.jaad.2015.12.007","article-title":"Lack of evidence that bedbugs transmit pathogens to humans","volume":"74","author":"Ho","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jip.2024.108182_b0165","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/molbev\/msx281","article-title":"UFBoot2: improving the ultrafast bootstrap approximation","volume":"35","author":"Hoang","year":"2018","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.jip.2024.108182_b0170","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/ni0202-121","article-title":"Drosophila innate immunity: an evolutionary perspective","volume":"3","author":"Hoffmann","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jip.2024.108182_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2020.572340","article-title":"Heme-peroxidase 2, a peroxinectin-like gene, regulates bacterial homeostasis in Anopheles stephensi midgut","volume":"11","author":"Kakani","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jip.2024.108182_b0180","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nmeth.4285","article-title":"ModelFinder: fast model selection for accurate phylogenetic estimates","volume":"14","author":"Kalyaanamoorthy","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jip.2024.108182_b0185","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.bbrc.2016.01.100","article-title":"Characterization of Cimex lectularius (bedbug) defensin peptide and its antimicrobial activity against human skin microflora","volume":"470","author":"Kaushal","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jip.2024.108182_b0190","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.ibmb.2004.09.001","article-title":"A Drosophila salivary gland mucin is also expressed in immune tissues: evidence for a function in coagulation and the entrapment of bacteria","volume":"34","author":"Korayem","year":"2004","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.jip.2024.108182_b0195","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00403-016-1661-8","article-title":"Bed bugs and possible transmission of human pathogens: a systematic review","volume":"308","author":"Lai","year":"2016","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jip.2024.108182_b0200","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.ibmb.2005.08.005","article-title":"Immune challenge differentially affects transcript abundance of three antimicrobial peptides in hemocytes from the moth Pseudoplusia includens","volume":"35","author":"Lavine","year":"2005","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.jip.2024.108182_b0205","first-page":"4","article-title":"Competence of Cimex lectularius bed bugs for the transmission of Bartonella quintana, the agent of trench fever","volume":"9","author":"Leulmi","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jip.2024.108182_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.jip.2024.108182_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fonc.2022.869706","article-title":"Extracellular DNA Traps: origin, function and implications for anti-cancer therapies","volume":"12","author":"Mamtimin","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jip.2024.108182_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinsphys.2021.104322","article-title":"Time- and tissue-specific antimicrobial activity of the common bed bug in response to blood feeding and immune activation by bacterial injection","volume":"135","author":"Meraj","year":"2021","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.jip.2024.108182_b0230","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911505","article-title":"Characterization of new defensin antimicrobial peptides and their expression in bed bugs in response to bacterial ingestion and injection","volume":"23","author":"Meraj","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jip.2024.108182_b0235","doi-asserted-by":"crossref","first-page":"13818","DOI":"10.1038\/s41598-024-64691-4","article-title":"A novel prolixicin identified in common bed bugs with activity against both bacteria and parasites","volume":"14","author":"Meraj","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jip.2024.108182_b0240","doi-asserted-by":"crossref","first-page":"1384193","DOI":"10.3389\/fimmu.2024.1384193","article-title":"Activation of immune pathways in common bed bugs, Cimex lectularius, in response to bacterial immune challenges-a transcriptomics analysis","volume":"15","author":"Meraj","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.jip.2024.108182_b0245","doi-asserted-by":"crossref","first-page":"20141107","DOI":"10.1098\/rsif.2014.1107","article-title":"Reduction of female copulatory damage by resilin represents evidence for tolerance in sexual conflict","volume":"12","author":"Michels","year":"2015","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.jip.2024.108182_b0250","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1093\/molbev\/mst024","article-title":"Ultrafast approximation for phylogenetic bootstrap","volume":"30","author":"Minh","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.jip.2024.108182_b0255","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1093\/molbev\/msaa015","article-title":"IQ-TREE 2: new models and efficient methods for phylogenetic inference in the genomic era","volume":"37","author":"Minh","year":"2020","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.jip.2024.108182_b0260","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1126\/science.1257570","article-title":"Phylogenomics resolves the timing and pattern of insect evolution","volume":"346","author":"Misof","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jip.2024.108182_b0265","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s13355-012-0112-z","article-title":"Comparative transcriptomics of the bacteriome and the spermalege of the bedbug Cimex lectularius (Hemiptera: Cimicidae)","volume":"47","author":"Moriyama","year":"2012","journal-title":"Appl. Entomol. Zool."},{"key":"10.1016\/j.jip.2024.108182_b0270","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1098\/rspb.2003.2514","article-title":"Costly traumatic insemination and a female counter-adaptation in bed bugs","volume":"270","author":"Morrow","year":"2003","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.jip.2024.108182_b0275","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.dci.2018.01.012","article-title":"DNA extracellular traps are part of the immune repertoire of Periplaneta americana","volume":"84","author":"Nascimento","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jip.2024.108182_b0280","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/molbev\/msu300","article-title":"IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies","volume":"32","author":"Nguyen","year":"2015","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.jip.2024.108182_b0285","article-title":"Functional crosstalk across IMD and Toll pathways: insight into the evolution of incomplete immune cascades","volume":"286","author":"Nishide","year":"2019","journal-title":"Proc.. Biol. Sci."},{"key":"10.1016\/j.jip.2024.108182_b0290","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jip.2024.108182_b0295","doi-asserted-by":"crossref","first-page":"619","DOI":"10.4269\/ajtmh.20-0121","article-title":"Case not closed: Arguments for new studies of the interactions between bed bugs and human pathogens","volume":"103","author":"Pietri","year":"2020","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jip.2024.108182_b0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jip.2017.10.004","article-title":"Virulence of entomopathogenic bacteria in the bed bug, Cimex lectularius","volume":"151","author":"Pietri","year":"2018","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.jip.2024.108182_b0305","doi-asserted-by":"crossref","DOI":"10.3390\/insects12040303","article-title":"Effects of NF-kB signaling inhibitors on bed bug resistance to orally provisioned entomopathogenic bacteria","volume":"12","author":"Pietri","year":"2021","journal-title":"Insects"},{"key":"10.1016\/j.jip.2024.108182_b0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2020.107422","article-title":"Ex vivo characterization of the circulating hemocytes of bed bugs and their responses to bacterial exposure","volume":"174","author":"Potts","year":"2020","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.jip.2024.108182_b0315","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s00436-021-07079-x","article-title":"Molecular analysis of the blood meals and bacterial communities of bed bugs (Cimex lectularius L.) to assess interactions with alternative hosts","volume":"120","author":"Potts","year":"2021","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.jip.2024.108182_b0320","doi-asserted-by":"crossref","first-page":"e0068321","DOI":"10.1128\/iai.00683-21","article-title":"A comparative study of body lice and bed bugs reveals factors potentially involved in differential vector competence for the relapsing fever spirochete Borrelia recurrentis","volume":"90","author":"Potts","year":"2022","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jip.2024.108182_b0325","unstructured":"R Core Team, 2020. R: A Language and Environment for Statistical Computing."},{"key":"10.1016\/j.jip.2024.108182_b0330","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1098\/rspb.2003.2515","article-title":"Reducing a cost of traumatic insemination: female bedbugs evolve a unique organ","volume":"270","author":"Reinhardt","year":"2003","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.jip.2024.108182_b0335","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.0307-6946.2005.00730.x","article-title":"Potential sexual transmission of environmental microbes in a traumatically inseminating insect","volume":"30","author":"Reinhardt","year":"2005","journal-title":"Ecol. Entomol."},{"key":"10.1016\/j.jip.2024.108182_b0340","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms5627","article-title":"Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon","volume":"5","author":"Robb","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jip.2024.108182_b0345","article-title":"The evolution of female-biased genital diversity in bedbugs (Cimicidae)","author":"Roth","year":"2023","journal-title":"Evolution."},{"key":"10.1016\/j.jip.2024.108182_b0350","doi-asserted-by":"crossref","first-page":"331","DOI":"10.4269\/ajtmh.14-0483","article-title":"Bed bugs (Cimex lectularius) as vectors of Trypanosoma cruzi","volume":"92","author":"Salazar","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jip.2024.108182_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.cris.2020.100006","article-title":"Rhodnius prolixus uses the peptidoglycan recognition receptor rpPGRP-LC\/LA to detect Gram-negative bacteria and activate the IMD pathway","volume":"1","author":"Salcedo-Porras","year":"2021","journal-title":"Curr. Res. Insect Sci."},{"key":"10.1016\/j.jip.2024.108182_b0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2017.04.026","article-title":"Identification and characterization of a laccase from Litopenaeus vannamei involved in anti-bacterial host defense","volume":"66","author":"Shi","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jip.2024.108182_b0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2806(05)32001-7","article-title":"Insect immunity: an evolutionary ecology perspective","volume":"32","author":"Siva-Jothy","year":"2005","journal-title":"Advances in insect physiology"},{"key":"10.1016\/j.jip.2024.108182_b0370","doi-asserted-by":"crossref","first-page":"14682","DOI":"10.1073\/pnas.1904539116","article-title":"Female bed bugs (Cimex lectularius L) anticipate the immunological consequences of traumatic insemination via feeding cues","volume":"116","author":"Siva-Jothy","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jip.2024.108182_b0375","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.12688\/f1000research.7563.1","article-title":"Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences","volume":"4","author":"Soneson","year":"2015","journal-title":"F1000Research"},{"key":"10.1016\/j.jip.2024.108182_b0380","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1073\/pnas.101440698","article-title":"Traumatic insemination and sexual conflict in the bed bug Cimex lectularius","volume":"98","author":"Stutt","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jip.2024.108182_b0385","doi-asserted-by":"crossref","first-page":"W609","DOI":"10.1093\/nar\/gkl315","article-title":"PAL2NAL: robust conversion of protein sequence alignments into the corresponding codon alignments","volume":"34","author":"Suyama","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jip.2024.108182_b0390","doi-asserted-by":"crossref","first-page":"e3041","DOI":"10.1371\/journal.pone.0003041","article-title":"A potential role for Drosophila mucins in development and physiology","volume":"3","author":"Syed","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jip.2024.108182_b0395","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev-ento-011613-162111","article-title":"Traumatic Insemination in Terrestrial Arthropods","volume":"59","author":"Tatarnic","year":"2014","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.jip.2024.108182_b0400","series-title":"Monograph of Cimicidae (Hemiptera, Heteroptera)","author":"Usinger","year":"1966"},{"key":"10.1016\/j.jip.2024.108182_b0405","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jinsphys.2018.04.001","article-title":"Laccase 1 gene from Plutella xylostella (PxLac1) and its functions in humoral immune response","volume":"107","author":"Wang","year":"2018","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.jip.2024.108182_b0410","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315132","article-title":"The intestinal immune defense system in insects","volume":"23","author":"Zeng","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jip.2024.108182_b0415","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13071-017-2561-2","article-title":"Comparative genomics analysis of triatomines reveals common first line and inducible immunity-related genes and the absence of Imd canonical components among hemimetabolous arthropods","volume":"11","author":"Zumaya-Estrada","year":"2018","journal-title":"Parasit. Vectors"}],"container-title":["Journal of Invertebrate Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022201124001253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022201124001253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T05:00:32Z","timestamp":1725771632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022201124001253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":82,"alternative-id":["S0022201124001253"],"URL":"https:\/\/doi.org\/10.1016\/j.jip.2024.108182","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.02.28.582586","asserted-by":"object"}]},"ISSN":["0022-2011"],"issn-type":[{"value":"0022-2011","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Under the radar: Transcriptomic responses of bed bugs to an entomopathogen, environmental bacteria, and a human pathogen","name":"articletitle","label":"Article Title"},{"value":"Journal of Invertebrate Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jip.2024.108182","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108182"}}