{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:53:47Z","timestamp":1792464827333,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003384","name":"Chinese Academy of Fishery Sciences East China Sea Fishery Research Institute","doi-asserted-by":"publisher","award":["2019 M03"],"award-info":[{"award-number":["2019 M03"]}],"id":[{"id":"10.13039\/501100003384","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012428","name":"Chinese Academy of Fishery Sciences Central Public-interest Scientific Institution Basal Research Fund","doi-asserted-by":"publisher","award":["2023TD43"],"award-info":[{"award-number":["2023TD43"]}],"id":[{"id":"10.13039\/501100012428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFD2401200"],"award-info":[{"award-number":["2024YFD2401200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005906","name":"Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005906","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Invertebrate Pathology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jip.2025.108344","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T14:30:53Z","timestamp":1745677853000},"page":"108344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Tissue and cell types infected by Ecytonucleospora hepatopenaei (EHP)"],"prefix":"10.1016","volume":"211","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5155-712X","authenticated-orcid":false,"given":"Yuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-ting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-fang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shou-hu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-qing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-cang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-hong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jip.2025.108344_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.742103","article-title":"Susceptibility of five penaeid shrimp species to experimental infection with Ecytonucleospora hepatopenaei","volume":"599","author":"Areekkal","year":"2025","journal-title":"Aquaculture"},{"key":"10.1016\/j.jip.2025.108344_b0010","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1152\/advan.00092.2007","article-title":"New ways of thinking about (and teaching about) intestinal epithelial function","volume":"32","author":"Barrett","year":"2008","journal-title":"Adv. Physiol. Educ."},{"key":"10.1016\/j.jip.2025.108344_b0015","series-title":"A handbook of normal penaeid shrimp histology","author":"Bell","year":"1988"},{"key":"10.1016\/j.jip.2025.108344_b0020","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3354\/dao03036","article-title":"High prevalence of Enterocytozoon hepatopenaei in shrimps Penaeus monodon and Litopenaeus vannamei sampled from slow growth ponds in India","volume":"120","author":"Biju","year":"2016","journal-title":"Dis. Aquat. Organ."},{"key":"10.1016\/j.jip.2025.108344_b0025","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.3390\/ani13233661","article-title":"Enterocytozoon hepatopenaei (EHP) Infection Alters the Metabolic Processes and Induces Oxidative Stress in Penaeus vannamei","volume":"13","author":"Cao","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.jip.2025.108344_b0030","first-page":"91","article-title":"Comparison of 8 different special staining techniques of Enterocytozoon hepatopenaei in histologic section","volume":"41","author":"Chang","year":"2019","journal-title":"Marine Fisheries"},{"key":"10.1016\/j.jip.2025.108344_b0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3354\/dao060089","article-title":"Multiple pathogens found in growth-retarded black tiger shrimp Penaeus monodon cultivated in Thailand","volume":"60","author":"Chayaburakul","year":"2004","journal-title":"Dis. Aquat. Organ."},{"key":"10.1016\/j.jip.2025.108344_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.739642","article-title":"Host and transmission route of Enterocytozoon hepatopenaei (EHP) between dragonfly and shrimp","volume":"574","author":"Dewangan","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.jip.2025.108344_b0045","first-page":"1","article-title":"Reestablishing histopathology as an essential component of health assessment for farmed shrimp in the era of molecular diagnostics","author":"Dhar","year":"2024","journal-title":"Rev. Fish. Sci. Aquac."},{"key":"10.1016\/j.jip.2025.108344_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.736885","article-title":"Response signatures of Litopenaeus vannamei to natural Enterocytozoon hepatopenaei infection revealed by the integration of the microbiome and transcriptome","volume":"542","author":"Duan","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.jip.2025.108344_b0055","first-page":"45","article-title":"Internal anatomy of the Decapoda: an overview","volume":"10","author":"Felgenhauer","year":"1992","journal-title":"Microscopic Anatomy of Invertebrates"},{"key":"10.1016\/j.jip.2025.108344_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.741014","article-title":"Is Artemia susceptible to the microsporidium Ecytonucleospora hepatopenaei (EHP) infection?","volume":"590","author":"Guo","year":"2024","journal-title":"Aquaculture"},{"issue":"11","key":"10.1016\/j.jip.2025.108344_b0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166320","article-title":"A nested PCR assay to avoid false positive detection of the microsporidian Enterocytozoon hepatopenaei (EHP) in environmental samples in shrimp farms","volume":"11","author":"Jaroenlak","year":"2016","journal-title":"Plos One"},{"key":"10.1016\/j.jip.2025.108344_b0070","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/jfd.12945","article-title":"Experimental horizontal transmission of Enterocytozoon hepatopenaei in post-larvae of whiteleg shrimp, Litopenaeus vannamei","volume":"42","author":"Karthikeyan","year":"2019","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.jip.2025.108344_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737525","article-title":"First report on Enterocytozoon hepatopenaei (EHP) infection in Pacific white shrimp (Penaeus vannamei) cultured in Korea","volume":"547","author":"Kim","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.jip.2025.108344_b0080","article-title":"Characterization of Enterocytozoon hepatopenaei causing hepatopancreatic microsporidiosis in L. vannamei and a new molecular method for its detection in shrimps, and other environmental samples","volume":"199","author":"Mithun","year":"2023","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.jip.2025.108344_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2022.107784","article-title":"Propionigenium and Vibrio species identified as possible component causes of shrimp white feces syndrome (WFS) associated with the microsporidian Enterocytozoon hepatopenaei","volume":"192","author":"Munkongwongsiri","year":"2022","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.jip.2025.108344_b0090","first-page":"97","article-title":"Types of cells in the hepatopancreas of the Pacific whiteleg shrimp Litopenaeus vannamei being infected by Enterocytozoon hepatopenaei","volume":"44","author":"Nima","year":"2022","journal-title":"Songklanakarin J. Sci. Technol."},{"key":"10.1016\/j.jip.2025.108344_b0095","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3354\/dao02346","article-title":"Luna stain, an improved selective stain for detection of microsporidian spores in histologic sections","volume":"95","author":"Peterson","year":"2011","journal-title":"Dis. Aquat. Organ."},{"key":"10.1016\/j.jip.2025.108344_b0100","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.aquaculture.2015.12.034","article-title":"Emergence of Enterocytozoon hepatopenaei (EHP) in farmed Penaeus (Litopenaeus) vannamei in India","volume":"454","author":"Rajendran","year":"2016","journal-title":"Aquaculture"},{"key":"10.1016\/j.jip.2025.108344_b0105","doi-asserted-by":"crossref","first-page":"9393","DOI":"10.1007\/s10499-024-01620-2","article-title":"Prevalence of Enterocytozoon hepatopenaei (EHP) in Penaeus monodon farms in India","volume":"32","author":"Rajeshwar","year":"2024","journal-title":"Aquac. Int."},{"key":"10.1016\/j.jip.2025.108344_b0110","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12917-016-0923-1","article-title":"Laboratory cohabitation challenge model for shrimp hepatopancreatic microsporidiosis (HPM) caused by Enterocytozoon hepatopenaei (EHP)","volume":"13","author":"Salachan","year":"2017","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.jip.2025.108344_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737482","article-title":"The lymphoid organ (LO) is an additional, prime target for decapod iridescent virus 1 (DIV1) in Penaeus vannamei","volume":"547","author":"Sanguanrut","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.jip.2025.108344_b0120","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/jfd.12530","article-title":"Biochemical changes and tissue distribution of Enterocytozoon hepatopenaei (EHP) in naturally and experimentally EHP-infected whiteleg shrimp, Litopenaeus vannamei (Boone, 1931), in India","volume":"40","author":"Santhoshkumar","year":"2017","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.jip.2025.108344_b0125","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.dci.2017.10.005","article-title":"An immune-related gene expression atlas of the shrimp digestive system in response to two major pathogens brings insights into the involvement of hemocytes in gut immunity","volume":"79","author":"Silveira","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jip.2025.108344_b0130","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.dci.2016.01.014","article-title":"Immunity to gastrointestinal microparasites of fish","volume":"64","author":"Sitj\u00e0-Bobadilla","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jip.2025.108344_b0135","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/jmor.21281","article-title":"Postembryonic development and differentiation of the midgut in the freshwater shrimp Neocaridina davidi (Crustacea, Malacostraca, Decapoda) larvae","volume":"282","author":"Sonakowska-Czajka","year":"2021","journal-title":"J. Morphol."},{"key":"10.1016\/j.jip.2025.108344_b0140","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jip.2015.06.009","article-title":"Development of in situ hybridization and PCR assays for the detection of Enterocytozoon hepatopenaei (EHP), a microsporidian parasite infecting penaeid shrimp","volume":"130","author":"Tang","year":"2015","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.jip.2025.108344_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jip.2016.08.004","article-title":"Dense populations of the microsporidian Enterocytozoon hepatopenaei (EHP) in feces of Penaeus vannamei exhibiting white feces syndrome and pathways of their transmission to healthy shrimp","volume":"140","author":"Tang","year":"2016","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.jip.2025.108344_b0150","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jip.2009.06.004","article-title":"Enterocytozoon hepatopenaei sp. nov. (Microsporida: Enterocytozoonidae), a parasite of the black tiger shrimp Penaeus monodon (Decapoda: Penaeidae): fine structure and phylogenetic relationships","volume":"102","author":"Tourtip","year":"2009","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.jip.2025.108344_b0155","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/jmor.21040","article-title":"Functional cytology of the hepatopancreas of decapod crustaceans","volume":"280","author":"Vogt","year":"2019","journal-title":"J. Morphol."},{"key":"10.1016\/j.jip.2025.108344_b0160","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3390\/microorganisms8091366","article-title":"Integrated qPCR and staining methods for detection and quantification of Enterocytozoon hepatopenaei in shrimp Litopenaeus vannamei","volume":"8","author":"Wang","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.jip.2025.108344_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2023.107988","article-title":"Ecytonucleospora hepatopenaei n. gen. et comb. (Microsporidia: Enterocytozoonidae): A redescription of the Enterocytozoon hepatopenaei (Tourtip et al., 2009), a microsporidian infecting the widely cultivated shrimp Penaeus vannamei","volume":"201","author":"Wang","year":"2023","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.jip.2025.108344_b0170","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.1038\/s41598-024-55400-2","article-title":"Shrimp injection with dsRNA targeting the microsporidian EHP polar tube protein reduces internal and external parasite amplification","volume":"14","author":"Yuanlae","year":"2024","journal-title":"Sci. Rep."}],"container-title":["Journal of Invertebrate Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022201125000783?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022201125000783?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:39:12Z","timestamp":1762205952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022201125000783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":34,"alternative-id":["S0022201125000783"],"URL":"https:\/\/doi.org\/10.1016\/j.jip.2025.108344","relation":{},"ISSN":["0022-2011"],"issn-type":[{"value":"0022-2011","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tissue and cell types infected by Ecytonucleospora hepatopenaei (EHP)","name":"articletitle","label":"Article Title"},{"value":"Journal of Invertebrate Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jip.2025.108344","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108344"}}