{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:42:56Z","timestamp":1782906176826,"version":"3.54.5"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013239","name":"Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro","doi-asserted-by":"publisher","award":["UID\/50006 + LA\/P\/0094\/2020"],"award-info":[{"award-number":["UID\/50006 + LA\/P\/0094\/2020"]}],"id":[{"id":"10.13039\/100013239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013239","name":"Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro","doi-asserted-by":"publisher","award":["LA\/P\/0101\/2020"],"award-info":[{"award-number":["LA\/P\/0101\/2020"]}],"id":[{"id":"10.13039\/100013239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013239","name":"Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro","doi-asserted-by":"publisher","award":["UIDB\/04423\/2020"],"award-info":[{"award-number":["UIDB\/04423\/2020"]}],"id":[{"id":"10.13039\/100013239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013239","name":"Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro","doi-asserted-by":"publisher","award":["UIDP\/04423\/2020"],"award-info":[{"award-number":["UIDP\/04423\/2020"]}],"id":[{"id":"10.13039\/100013239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013239","name":"Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro","doi-asserted-by":"publisher","award":["CEECINST\/00027\/2021\/CP2789\/CT0002"],"award-info":[{"award-number":["CEECINST\/00027\/2021\/CP2789\/CT0002"]}],"id":[{"id":"10.13039\/100013239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["https:\/\/doi.org\/10.54499\/2021.01858.CEECIND\/CP1659\/CT0010"],"award-info":[{"award-number":["https:\/\/doi.org\/10.54499\/2021.01858.CEECIND\/CP1659\/CT0010"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Invertebrate Pathology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jip.2025.108451","type":"journal-article","created":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T22:27:04Z","timestamp":1757284024000},"page":"108451","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Decoding the gene expression response of Cerastoderma edule to chronic trematode infection: A comparison among host tissues"],"prefix":"10.1016","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2877-0317","authenticated-orcid":false,"given":"Sim\u00e3o","family":"Correia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Blanco-Hortas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Garcia-Souto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Poulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Vera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edsa","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Fern\u00e1ndez-Boo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jip.2025.108451_b0005","unstructured":"Andrews, S., 2010. FastQC: A Quality Control Tool for High Throughput Sequence Data. Available online at: http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/."},{"key":"10.1016\/j.jip.2025.108451_b0010","doi-asserted-by":"crossref","first-page":"8691","DOI":"10.1073\/pnas.94.16.8691","article-title":"A family of fibrinogen-related proteins that precipitates parasite-derived molecules is produced by an invertebrate after infection","volume":"94","author":"Adema","year":"1997","journal-title":"PNAS"},{"key":"10.1016\/j.jip.2025.108451_b0015","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jip.2015.05.005","article-title":"Immune responses to infectious diseases in bivalves","volume":"131","author":"Allam","year":"2015","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.jip.2025.108451_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.618726","article-title":"Immunological responses of marine bivalves to contaminant exposure: Contribution of the -omics approach","volume":"12","author":"Balbi","year":"2021","journal-title":"Front. Immunol."},{"issue":"25\u201328","key":"10.1016\/j.jip.2025.108451_b0025","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1080\/00222930701500142","article-title":"Synopsis of the life cycles of Digenea (Platyhelminthes) from lagoons of the northern coast of the western Mediterranean","volume":"41","author":"Bartoli","year":"2007","journal-title":"J. Nat. Hist."},{"key":"10.1016\/j.jip.2025.108451_b0030","series-title":"Estuarine Processes","first-page":"432","article-title":"Aspects of reproduction in bivalve molluscs","author":"Bayne","year":"1976"},{"key":"10.1016\/j.jip.2025.108451_b0035","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0305-0491(99)00187-X","article-title":"Storage metabolism in the Pacific oyster (Crassostrea gigas) in relation to summer mortalities and reproductive cycle (West Coast of France)","volume":"125","author":"Berthelin","year":"2000","journal-title":"Comp. Biochem. Physiol. B-Biochem. Mol. Biol."},{"key":"10.1016\/j.jip.2025.108451_b0040","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jip.2025.108451_b0045","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/nbt0816-888d","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jip.2025.108451_b0050","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41577-018-0004-8","article-title":"C-type lectins in immunity and homeostasis","volume":"18","author":"Brown","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jip.2025.108451_b0055","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.dci.2014.10.013","article-title":"Diversity of animal immune receptors and the origins of recognition complexity in the deuterostomes","volume":"49","author":"Buckley","year":"2015","journal-title":"Dev. Comp. Immunol."},{"issue":"4","key":"10.1016\/j.jip.2025.108451_b0060","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2307\/3284227","article-title":"Parasitology meets Ecology on its own terms: Margolis et al. revisited","volume":"83","author":"Bush","year":"1997","journal-title":"J. Parasitol."},{"key":"10.1016\/j.jip.2025.108451_b0065","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev-marine-031920-100429","article-title":"Marine parasites and disease in the era of global climate change","volume":"13","author":"Byers","year":"2021","journal-title":"Ann. Rev. Mar. Sci."},{"key":"10.1016\/j.jip.2025.108451_b0070","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.792589","article-title":"Physiological roles of serotonin in bivalves: possible interference by environmental chemicals resulting in neuroendocrine disruption","volume":"13","author":"Canesi","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jip.2025.108451_b0075","series-title":"Lessons in Immunity: from Single-Cell Organisms to Mammals","article-title":"Specificity of innate immunity in bivalves: a lesson from bacteria","author":"Canesi","year":"2016"},{"issue":"2","key":"10.1016\/j.jip.2025.108451_b0080","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/jipa.2001.5049","article-title":"Parasites and pathologic conditions of the cockle Cerastoderma edule populations of the coast of Galicia (NW Spain)","volume":"78","author":"Carballal","year":"2001","journal-title":"J. Invertebr. Pathol."},{"issue":"46","key":"10.1016\/j.jip.2025.108451_b0085","article-title":"AnnotationForge: Tools for building SQLite-based annotation data packages","volume":"1","author":"Carlson","year":"2024","journal-title":"R Package Version"},{"key":"10.1016\/j.jip.2025.108451_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.marenvres.2020.104931","article-title":"Ecosystem services provided by a non-cultured shellfish species: The common cockle Cerastoderma edule","volume":"158","author":"Carss","year":"2020","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.jip.2025.108451_b0095","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","article-title":"The DNA damage response: Making it safe to play with knives","volume":"40","author":"Ciccia","year":"2010","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.jip.2025.108451_b0100","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.molbiopara.2016.06.003","article-title":"Host parasite communications \u2013 Messages from helminths for the immune system","volume":"208","author":"Coakley","year":"2016","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.jip.2025.108451_b0105","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0300-9629(93)90308-Q","article-title":"The parasitic castration of the mussel Mytilus edulis by the trematode parasite Prosorhynchus sqamatus \u2013 Specificity and partial characterization of endogenous and parasite-induced anti-mitotic","volume":"104","author":"Coustau","year":"1993","journal-title":"Comp. Biochem. Physiol. A-Mol. Integr. Physiol."},{"key":"10.1016\/j.jip.2025.108451_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecss.2019.106546","article-title":"Large scale patterns of trematode parasite communities infecting Cerastoderma edule along the Atlantic coast from Portugal to Morocco","volume":"233","author":"Correia","year":"2020","journal-title":"Estuar. Coast. Shelf Sci."},{"key":"10.1016\/j.jip.2025.108451_b0115","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/0014-4894(89)90114-8","article-title":"Schistosoma mansoni \u2013 Effect of Infection on reproduction and gonadal growth in Biomphalaria glabrata","volume":"68","author":"Crews","year":"1989","journal-title":"Exp. Parasitol."},{"issue":"5","key":"10.1016\/j.jip.2025.108451_b0120","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1017\/S0025315400002782","article-title":"Longevity of oversized individuals: growth, parasitism, and history in an estuarine snail population","volume":"80","author":"Curtis","year":"2000","journal-title":"J. Mar. Biol. Assoc. U. K."},{"key":"10.1016\/j.jip.2025.108451_b0125","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.it.2014.08.006","article-title":"Infection-avoidance behaviour in humans and other animals","volume":"35","author":"Curtis","year":"2014","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jip.2025.108451_b0130","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1126\/science.1213775","article-title":"Hemoglobins S and C interfere with actin Remodeling in Plasmodium falciparum-infected erythrocytes","volume":"334","author":"Cyrklaff","year":"2011","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jip.2025.108451_b0135","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.clinbiochem.2010.07.006","article-title":"Current status and future developments of LC-MS\/MS in clinical chemistry for quantification of biogenic amines","volume":"44","author":"de Jong","year":"2011","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.jip.2025.108451_b0140","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.826255","article-title":"Bivalve haemocyte subpopulations: A review","volume":"13","author":"de la Ballina","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jip.2025.108451_b0145","article-title":"Catalogue of parasites and diseases of the common cockle Cerastoderma edule","author":"de Montaudouin","year":"2021","journal-title":"UA Editora"},{"key":"10.1016\/j.jip.2025.108451_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2010.03.011","article-title":"Bivalve population health: multistress to identify hot spots","volume":"60","author":"de Montaudouin","year":"2010","journal-title":"Marine Pollut. Bull."},{"issue":"3","key":"10.1016\/j.jip.2025.108451_b0155","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1017\/S0025315409003130","article-title":"Digenean trematode species in the cockle Cerastoderma edule: identification key and distribution along the north-eastern Atlantic shoreline","volume":"89","author":"de Montaudouin","year":"2009","journal-title":"J. Marine Biol. Assoc. UK"},{"issue":"1","key":"10.1016\/j.jip.2025.108451_b0160","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3354\/dao02022","article-title":"Digenean trematodes-marine mollusc relationships: a stable isotope study","volume":"84","author":"Dubois","year":"2009","journal-title":"Diseases Aquat. Org."},{"issue":"7","key":"10.1016\/j.jip.2025.108451_b0165","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1017\/S0031182001007697","article-title":"A perspective on the ecology of trematode communities in snails","volume":"123","author":"Esch","year":"2001","journal-title":"Parasitology"},{"key":"10.1016\/j.jip.2025.108451_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.exppara.2023.108624","article-title":"Prevalence and effects of a parasitic trematode on the blue mussel, Mytilus edulis, in the Boston Harbor","volume":"254","author":"Evensen","year":"2023","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jip.2025.108451_b0175","doi-asserted-by":"crossref","unstructured":"FAO. 2024. In Brief to The State of World Fisheries and Aquaculture 2024. Blue Transformation in action. Rome. https:\/\/doi.org\/10.4060\/cd0683en.","DOI":"10.4060\/cd0683en"},{"issue":"4","key":"10.1016\/j.jip.2025.108451_b0180","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1017\/S0025315410000299","article-title":"Manupulation of Cerastoderma edule burrowing ability by Meiogymnophallus minutus metacercariae?","volume":"91","author":"Fermer","year":"2011","journal-title":"J. Marine Biol. Assoc. UK"},{"key":"10.1016\/j.jip.2025.108451_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109431","article-title":"Unravelling the main immune repertoire of Paracentrotus lividus following Vibrio anguillarum bath challenge","volume":"147","author":"Fern\u00e1ndez-Boo","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jip.2025.108451_b0190","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.chom.2009.05.013","article-title":"Role of the parasite and host cytoskeleton in apicomplexa parasitism","volume":"5","author":"Fr\u00e9nal","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jip.2025.108451_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2022.107849","article-title":"Evaluation of the Ruditapes decussatus immune response after differential injected doses of Perkinsus olseni","volume":"195","author":"Garcia","year":"2022","journal-title":"J. Invertebr. Pathol."},{"issue":"6","key":"10.1016\/j.jip.2025.108451_b0200","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s12551-018-0479-3","article-title":"Molecular mechanisms of contractile-ring constriction and membrane trafficking in cytokinesis","volume":"10","author":"Gerien","year":"2018","journal-title":"Biophys. Rev."},{"issue":"3","key":"10.1016\/j.jip.2025.108451_b0205","first-page":"337","article-title":"The status of zinc in malaria (Plasmodium falciparum) infected human red blood cells: stage dependent accumulation, compartmentation and effect of dipicolinate. Biochimica et Biophysica Acta (BBA) \u2013 Molecular","volume":"886","author":"Ginsburg","year":"1986","journal-title":"Cell Res.."},{"issue":"1","key":"10.1016\/j.jip.2025.108451_b0210","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1017\/S0025315400032707","article-title":"Population biology of Meiogymnophallus minutus (Trematoda: Gymnophallidae) in cockles from the Exe Estuary","volume":"73","author":"Goater","year":"1993","journal-title":"J. Mar. Biol. Assoc. U. K."},{"key":"10.1016\/j.jip.2025.108451_b0215","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.03006","article-title":"Parasite recognition and signaling mechanisms in innate immune responses to malaria","volume":"9","author":"Gowda","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jip.2025.108451_b0220","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1017\/S0031182015000918","article-title":"Impacts of a newly identified behaviour-altering trematode on its host amphipod: from the level of gene expression to population","volume":"142","author":"Guler","year":"2015","journal-title":"Parasitology"},{"key":"10.1016\/j.jip.2025.108451_b0225","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2019.00397","article-title":"Who needs a contractile actomyosin Ring?The plethora of alternative ways to divide a protozoan parasite","volume":"9","author":"Hammarton","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"5576","key":"10.1016\/j.jip.2025.108451_b0230","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1126\/science.1063699","article-title":"Ecology - Climate warming and disease risks for terrestrial and marine biota","volume":"296","author":"Harvell","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jip.2025.108451_b0235","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/jipa.1994.1068","article-title":"Biomphalaria glabrata Hemolymph lectins \u2013 Binding to bacteria, mammalian erythrocytes, and to sprococysts and rediae of Echinostoma paraensei","volume":"64","author":"Hertel","year":"1994","journal-title":"J. Invertebr. Pathol."},{"issue":"4","key":"10.1016\/j.jip.2025.108451_b0240","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3390\/cells8040362","article-title":"The Cytoskeleton - A complex interacting meshwork","volume":"8","author":"Hohmann","year":"2019","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.jip.2025.108451_b0245","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.seares.2008.07.005","article-title":"Molluscan assemblages of seagrass-covered and bare intertidal flats on the Banc d'Arguin, Mauritania, in relation to characteristics of sediment and organic matter","volume":"60","author":"Honkoop","year":"2008","journal-title":"J. Sea Res."},{"key":"10.1016\/j.jip.2025.108451_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.145300","article-title":"The functional roles of the non-coding RNAs in molluscs","volume":"768","author":"Hongkuan","year":"2021","journal-title":"Gene"},{"key":"10.1016\/j.jip.2025.108451_b0255","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ijpara.2005.03.002","article-title":"Parasites, ecosystems and sustainability: An ecological and complex systems perspective","volume":"35","author":"Horwitz","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.jip.2025.108451_b0260","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jip.2025.108451_b0265","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.fsi.2016.10.030","article-title":"Comparative study of two single CRD C-type lectins, CgCLec-4 and CgCLec-5, from pacific oyster Crassostrea gigas","volume":"59","author":"Jia","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jip.2025.108451_b0270","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/nature06536","article-title":"Global trends in emerging infectious diseases","volume":"451","author":"Jones","year":"2008","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jip.2025.108451_b0275","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1152\/physrev.00035.2014","article-title":"The Physiological, biochemical, and molecular roles of zinc transporters in zinc homeostasis and metabolism","volume":"95","author":"Kambe","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jip.2025.108451_b0280","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1080\/15476286.2020.1729594","article-title":"LncRNAs in molluscan and mammalian stages of parasitic schistosomes are developmentally-regulated and coordinately expressed with protein-coding genes","volume":"17","author":"Kim","year":"2020","journal-title":"RNA Biol."},{"key":"10.1016\/j.jip.2025.108451_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.144759","article-title":"The involvement of zinc transporters in the zinc accumulation in the Pacific oyster Crassostrea gigas","volume":"750","author":"Kong","year":"2020","journal-title":"Gene"},{"key":"10.1016\/j.jip.2025.108451_b0290","unstructured":"Krakau, M., 2008. Biogeographic patterns of the marine bivalve Cerastoderma edule along the European Atlantic coast Christian-Albrechts-Universit\u00e4t]. Kiel."},{"key":"10.1016\/j.jip.2025.108451_b0295","first-page":"477","article-title":"Diseases of Mollusca: Bivalvia","volume":"Vol. 2","author":"Lauckner","year":"1983","journal-title":"Diseases of Marine Animals"},{"issue":"3","key":"10.1016\/j.jip.2025.108451_b0300","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.fsi.2005.01.003","article-title":"Dopamine depresses the immune ability and increases susceptibility to Lactococcus garvieae in the freshwater giant prawn Macrobranchium Rosenbergii","volume":"19","author":"Li","year":"2005","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.jip.2025.108451_b0305","doi-asserted-by":"crossref","unstructured":"Li, M., Peng, D., Cao, H., Yang, X., Li, S., Qiu, H., Li, L., 2023. The Host Cytoskeleton Functions as a Pleiotropic Scaffold: Orchestrating Regulation of the Viral Life Cycle and Mediating Host Antiviral Innate Immune Responses. Viruses-Basel, 15, Article 1354. https:\/\/doi.org\/10.3390\/v15061354.","DOI":"10.3390\/v15061354"},{"key":"10.1016\/j.jip.2025.108451_b0310","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0020-7519(83)90041-3","article-title":"Acquired-resistance in snails - Induction of resistance to Schistosoma mansoni in Biomphalaria glabrata","volume":"13","author":"Lie","year":"1983","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.jip.2025.108451_b0315","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.01456","article-title":"The Neuroendocrine-immune regulation in response to environmental stress in marine bivalves","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.jip.2025.108451_b0320","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1017\/S0025315412000537","article-title":"A review of the infectious agents, parasites, pathogens and commensals of European cockles (Cerastoderma edule and C. glaucum)","volume":"93","author":"Longshaw","year":"2013","journal-title":"J. Mar. Biol. Assoc. U. K."},{"key":"10.1016\/j.jip.2025.108451_b0325","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.jip.2025.108451_b0330","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.envres.2018.02.018","article-title":"Spatio-temporal variation of trematode parasites community in Cerastoderma edule cockles from Ria de Aveiro (Portugal)","volume":"164","author":"Magalh\u00e3es","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.jip.2025.108451_b0335","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ecss.2019.02.012","article-title":"Seasonal variation of transcriptomic and biochemical parameters of Donax trunculus related to its infection by Bacciger bacciger (trematode parasite)","volume":"219","author":"Magalh\u00e3es","year":"2019","journal-title":"Estuar. Coast. Shelf Sci."},{"issue":"4","key":"10.1016\/j.jip.2025.108451_b0340","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s00436-015-4374-6","article-title":"Review: Bucephalus minimus, a deleterious trematode parasite of cockles Cerastoderma spp","volume":"114","author":"Magalh\u00e3es","year":"2015","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.jip.2025.108451_b0345","doi-asserted-by":"crossref","first-page":"7029","DOI":"10.1002\/ece3.7551","article-title":"Latitudinal influence on gametogenesis and host-parasite ecology in a marine bivalve model","volume":"11","author":"Mahony","year":"2021","journal-title":"Ecol. Evol."},{"issue":"2","key":"10.1016\/j.jip.2025.108451_b0350","doi-asserted-by":"crossref","first-page":"467","DOI":"10.20506\/rst.27.2.1820","article-title":"The impact of climate change on the parasites and infectious diseases of aquatic animals","volume":"27","author":"Marcogliese","year":"2008","journal-title":"Rev. Sci. Tech."},{"issue":"6","key":"10.1016\/j.jip.2025.108451_b0355","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.chembiol.2012.04.013","article-title":"Fluxes in \u201cFree\u201d and total zinc are essential for progression of intraerythrocytic stages of Plasmodium falciparum","volume":"19","author":"Marvin","year":"2012","journal-title":"Chem. Biol."},{"issue":"3","key":"10.1016\/j.jip.2025.108451_b0360","doi-asserted-by":"crossref","first-page":"e4781","DOI":"10.1002\/ecs2.4781","article-title":"Meta-analysis suggests that, for marine mammals, the risk of parasitism by anisakids changed between 1978 and 2015","volume":"15","author":"Mastick","year":"2024","journal-title":"Ecosphere"},{"key":"10.1016\/j.jip.2025.108451_b0365","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s11481-019-09851-4","article-title":"Where is dopamine and how do immune cells see it?: Dopamine-mediated immune cell function in health and disease","volume":"15","author":"Matt","year":"2020","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.jip.2025.108451_b0370","doi-asserted-by":"crossref","unstructured":"McLaughlin, J. P., Morton, D. N., Lafferty, K. D., 2020. Parasites in marine food websMarine disease ecology, 45.","DOI":"10.1093\/oso\/9780198821632.003.0002"},{"issue":"4","key":"10.1016\/j.jip.2025.108451_b0375","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1111\/raq.12906","article-title":"Trained immunity: Perspectives for disease control strategy in marine mollusc aquaculture","volume":"16","author":"Montagnani","year":"2024","journal-title":"Rev. Aquac."},{"key":"10.1016\/j.jip.2025.108451_b0380","doi-asserted-by":"crossref","DOI":"10.1007\/s00227-018-3308-0","article-title":"Bivalve transcriptomics reveal pathogen sequences and a powerful immune response of the Mediterranean mussel (Mytilus galloprovincialis)","volume":"165","author":"Moreira","year":"2018","journal-title":"Mar. Biol."},{"issue":"3","key":"10.1016\/j.jip.2025.108451_b0385","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/ece3.419","article-title":"Climate change impacts on potential recruitment in an ecosystem engineer","volume":"3","author":"Morgan","year":"2013","journal-title":"Ecol. Evol."},{"key":"10.1016\/j.jip.2025.108451_b0390","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1017\/S0031182002001476","article-title":"Parasitism, community structure and biodiversity in intertidal ecosystems","volume":"124","author":"Mouritsen","year":"2002","journal-title":"Parasitology"},{"key":"10.1016\/j.jip.2025.108451_b0395","doi-asserted-by":"crossref","first-page":"R619","DOI":"10.1016\/j.cub.2021.01.036","article-title":"The cytoskeleton in phagocytosis and macropinocytosis","volume":"31","author":"Mylvaganam","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jip.2025.108451_b0400","first-page":"190","article-title":"Innate immune memory in mussel (Mytilus galloprovincialis): tolerance of hemocytes after a repeated contact with Vibrio splendidus","volume":"16","author":"Novoa","year":"2019","journal-title":"Invertebr. Surviv. J."},{"issue":"3","key":"10.1016\/j.jip.2025.108451_b0405","doi-asserted-by":"crossref","first-page":"911","DOI":"10.2983\/035.032.0334","article-title":"Bivalve harvesting and production in Portugal: An overview","volume":"32","author":"Oliveira","year":"2013","journal-title":"J. Shellfish. Res."},{"issue":"2","key":"10.1016\/j.jip.2025.108451_b0410","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1645\/GE-1719.1","article-title":"Identification and description of Bucephalus minimus (Digenea: Bucephalidae) life cycle in Portugal: Morphological, histophathological and molecular data","volume":"95","author":"Pina","year":"2009","journal-title":"J. Parasitol."},{"key":"10.1016\/j.jip.2025.108451_b0415","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1017\/S0031182005008693","article-title":"Global warming and temperature-mediated increases in cercarial emergence in trematode parasites","volume":"132","author":"Poulin","year":"2006","journal-title":"Parasitology"},{"issue":"3","key":"10.1016\/j.jip.2025.108451_b0420","doi-asserted-by":"crossref","DOI":"10.1086\/393500","article-title":"The diversity of parasites","volume":"75","author":"Poulin","year":"2000","journal-title":"Q. Rev. Biol."},{"key":"10.1016\/j.jip.2025.108451_b0425","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2119\/2008-00033.Prasad","article-title":"Zinc in human health: effect of zinc on immune cells","volume":"14","author":"Prasad","year":"2008","journal-title":"Mol. Med."},{"key":"10.1016\/j.jip.2025.108451_b0430","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01894","article-title":"Immune tolerance in Mytilus galloprovincialis hemocytes after repeated contact with Vibrio splendidus","volume":"10","author":"Rey-Campos","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jip.2025.108451_b0435","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.615580","article-title":"Transcriptomic response of mussel gills after a Vibrio splendidus infection demonstrates their role in the immune response","volume":"11","author":"Saco","year":"2020","journal-title":"Front. Immunol."},{"issue":"1513","key":"10.1016\/j.jip.2025.108451_b0440","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1098\/rstb.2008.0157","article-title":"Immune defence, parasite evasion strategies and their relevance for \u2018macroscopic phenomena\u2019 such as virulence","volume":"364","author":"Schmid-Hempel","year":"2008","journal-title":"Philos. Trans. R. Soc. B"},{"issue":"2","key":"10.1016\/j.jip.2025.108451_b0445","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s002270050090","article-title":"Imposex and reproductive failure in Hydrobia ulvae (Gastropoda: Prosobranchia)","volume":"128","author":"SchulteOehlmann","year":"1997","journal-title":"Mar. Biol."},{"key":"10.1016\/j.jip.2025.108451_b0450","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1645\/19-36","article-title":"RNA-Seq: The early response of the snail Physella acuta to the digenetic trematode Echinostoma paraensei","volume":"106","author":"Schultz","year":"2020","journal-title":"J. Parasitol."},{"issue":"2","key":"10.1016\/j.jip.2025.108451_b0455","doi-asserted-by":"crossref","first-page":"447S","DOI":"10.1093\/ajcn\/68.2.447S","article-title":"Zinc and immune function: The biological basis of altered resistance to infection","volume":"68","author":"Shankar","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jip.2025.108451_b0460","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.12688\/f1000research.7563.2","article-title":"Differential analyses for RNA-seq: Transcript-level estimates improve gene-level inferences","volume":"4","author":"Soneson","year":"2016","journal-title":"F1000Research"},{"key":"10.1016\/j.jip.2025.108451_b0465","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.exppara.2017.03.011","article-title":"Parasites as drivers of key processes in aquatic ecosystems: Facts and future directions","volume":"180","author":"Sures","year":"2017","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jip.2025.108451_b0470","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ijppaw.2023.09.009","article-title":"Subtle transcriptomic response of Eurasian perch (Perca fluviatilis) associated with Triaenophorus nodulosus plerocercoid infection","volume":"22","author":"Taube","year":"2023","journal-title":"Int. J. Parasitol. \u2013 Parasites Wildlife"},{"key":"10.1016\/j.jip.2025.108451_b0475","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s10750-005-1345-4","article-title":"Parasite induced summer mortality in the cockle Cerastoderma edule by the trematode Gymnophallus choledochus","volume":"559","author":"Thieltges","year":"2006","journal-title":"Hydrobiologia"},{"key":"10.1016\/j.jip.2025.108451_b0480","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3354\/dao059151","article-title":"Parasitic castration of Eurhomalea lenticularis (Bivalvia: Veneridae) by a digenetic trematode: Quantitative histological analysis","volume":"59","author":"Valderrama","year":"2004","journal-title":"Dis. Aquat. Organ."},{"key":"10.1016\/j.jip.2025.108451_b0485","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-12-69","article-title":"Insights into the innate immunity of the Mediterranean mussel Mytilus galloprovincialis","volume":"12","author":"Venier","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jip.2025.108451_b0490","article-title":"Clam focal and systemic immune responses to QPX infection revealed by RNA-seq technology","volume":"17","author":"Wang","year":"2016","journal-title":"BMC Genomics"},{"issue":"1","key":"10.1016\/j.jip.2025.108451_b0495","first-page":"1","article-title":"Package 'ggplot2'. Create elegant data visualisations using the grammar of graphics","volume":"2","author":"Wickham","year":"2016","journal-title":"Version"},{"key":"10.1016\/j.jip.2025.108451_b0500","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-016-2950-5","article-title":"The influence of trematode parasite burden on gene expression in a mammalian host","volume":"17","author":"Wijayawardena","year":"2016","journal-title":"BMC Genom."},{"key":"10.1016\/j.jip.2025.108451_b0505","series-title":"Goods and Services of Marine Bivalves","first-page":"7","article-title":"Global production of marine bivalves. Trends and challenges","author":"Wijsman","year":"2019"},{"key":"10.1016\/j.jip.2025.108451_b0510","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.pt.2009.02.004","article-title":"Environment can alter selection in host-parasite interactions","volume":"25","author":"Wolinska","year":"2009","journal-title":"Trends Parasitol."},{"issue":"1","key":"10.1016\/j.jip.2025.108451_b0515","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00034983.1960.11685951","article-title":"Relationships between Trematodes and Molluscs","volume":"54","author":"Wright","year":"1959","journal-title":"Annals of Tropical Medicine & Parasitology"},{"key":"10.1016\/j.jip.2025.108451_b0520","unstructured":"Yan, L., 2023. Package 'ggvenn'. Draw Venn Diagram by \u2018ggplot2\u2019. Version 0.1.10, Available at https:\/\/CRAN.R-project.org\/package=ggvenn."},{"issue":"24","key":"10.1016\/j.jip.2025.108451_b0525","first-page":"4","article-title":"enrichplot: Visualization of functional enrichment result","volume":"1","author":"Yu","year":"2024","journal-title":"R Package Version"},{"key":"10.1016\/j.jip.2025.108451_b0530","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics-A J. Integr. Biol."},{"key":"10.1016\/j.jip.2025.108451_b0535","article-title":"Insights into mechanism of DNA damage and repair-apoptosis in digestive gland of female scallop Chlamys farreri under benzo[a]pyrene exposure during reproductive stage","volume":"273","author":"Zhou","year":"2023","journal-title":"Compar. Biochem. Physiol. C-Toxicol. Pharmacol."}],"container-title":["Journal of Invertebrate Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022201125001855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022201125001855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:06:19Z","timestamp":1772841979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022201125001855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":107,"alternative-id":["S0022201125001855"],"URL":"https:\/\/doi.org\/10.1016\/j.jip.2025.108451","relation":{},"ISSN":["0022-2011"],"issn-type":[{"value":"0022-2011","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decoding the gene expression response of Cerastoderma edule to chronic trematode infection: A comparison among host tissues","name":"articletitle","label":"Article Title"},{"value":"Journal of Invertebrate Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jip.2025.108451","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108451"}}