{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T13:13:09Z","timestamp":1784207589313,"version":"3.55.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017170","name":"Thailand Science Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["FOOD_FF_68_016_2300_004"],"award-info":[{"award-number":["FOOD_FF_68_016_2300_004"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["_FF_68_016_2300_004"],"award-info":[{"award-number":["_FF_68_016_2300_004"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Invertebrate Pathology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jip.2026.108642","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:56:47Z","timestamp":1777931807000},"page":"108642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Lysozyme i1-type, a crucial antimicrobial enzyme, reduces Ecytonucleospora hepatopenaei infection in Litopenaeus vannamei with potential for feed supplementation"],"prefix":"10.1016","volume":"218","author":[{"given":"Natthanan","family":"Rakchaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nutthapon","family":"Sangklai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pattana","family":"Jaroenlak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anchalee","family":"Tassanakajon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jip.2026.108642_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2021.112271","article-title":"Aquaculture industry: Supply and demand, best practices, effluent and its current issues and treatment technology","volume":"287","author":"Ahmad","year":"2021","journal-title":"J. Environ. Manage."},{"key":"10.1016\/j.jip.2026.108642_b0010","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.scitotenv.2018.10.163","article-title":"The blue dimensions of aquaculture: a global synthesis","volume":"652","author":"Ahmed","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jip.2026.108642_b0015","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.aquaculture.2018.02.039","article-title":"Bioassay for spore polar tube extrusion of shrimp Enterocytozoon hepatopenaei (EHP)","volume":"490","author":"Aldama-Cano","year":"2018","journal-title":"Aquaculture"},{"key":"10.1016\/j.jip.2026.108642_b0020","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/s00239-001-0061-6","article-title":"Phylogenetic analysis of invertebrate lysozymes and the evolution of lysozyme function","volume":"54","author":"Bachali","year":"2002","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.jip.2026.108642_b0025","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1134\/S1068162008030096","article-title":"Polyfunctionality of lysozyme destabilase from the medicinal leech","volume":"34","author":"Baskova","year":"2008","journal-title":"Russ. J. Bioorganic Chem."},{"key":"10.1016\/j.jip.2026.108642_b0030","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1111\/1462-2920.13734","article-title":"Decay of the glycolytic pathway and adaptation to intranuclear parasitism within Enterocytozoonidae microsporidia","volume":"19","author":"Boakye","year":"2017","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.jip.2026.108642_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.667787","article-title":"A comprehensive review on crustaceans\u2019 immune system with a focus on freshwater crayfish in relation to crayfish plague disease","volume":"12","author":"Bouallegui","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jip.2026.108642_b0040","unstructured":"Briggs, M., 2005. Food and Agriculture Organization of the United Nations, Introductions and Movement of Two Penaeid Shrimp Species in Asia and the Pacific, Food & Agriculture Org."},{"key":"10.1016\/j.jip.2026.108642_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2020.107458","article-title":"The shrimp microsporidian Enterocytozoon hepatopenaei (EHP): Biology, pathology, diagnostics and control","volume":"186","author":"Chaijarasphong","year":"2021","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.jip.2026.108642_b0050","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1186\/s13071-023-05908-9","article-title":"The microsporidian polar tube: origin, structure, composition, function, and application","volume":"16","author":"Chen","year":"2023","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.jip.2026.108642_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2019.02.008","article-title":"The fungal cell wall as a target for the development of new antifungal therapies","volume":"37","author":"Cort\u00e9s","year":"2019","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.jip.2026.108642_b0060","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.dci.2007.06.009","article-title":"Diversity in penaeidin antimicrobial peptide form and function","volume":"32","author":"Cuthbertson","year":"2008","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jip.2026.108642_b0065","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2015.0300","article-title":"Antimicrobial peptides in marine invertebrate health and disease","volume":"371","author":"Destoumieux-Garz\u00f3n","year":"2016","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.jip.2026.108642_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109769","article-title":"S\u00f6derh\u00e4ll, an i-type lysozyme from a crustacean, Pacifastacus leniusculus, functions as a clot-destabilising enzyme","volume":"152","author":"Ekblom","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jip.2026.108642_b0075","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/faf.12186","article-title":"Vulnerability of aquaculture-related livelihoods to changing climate at the global scale","volume":"18","author":"Handisyde","year":"2017","journal-title":"Fish Fish (Oxf.)"},{"key":"10.1016\/j.jip.2026.108642_b0080","doi-asserted-by":"crossref","DOI":"10.1088\/1742-6596\/1503\/1\/012043","article-title":"The effect of feed supplement on growth, survival rate and immunity response of Pacific white shrimp Litopenaeus vannamei","volume":"1503","author":"Haryanti","year":"2020","journal-title":"J. Phys. Conf. Ser."},{"key":"10.1016\/j.jip.2026.108642_b0085","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ejps.2017.07.005","article-title":"Novel peptide motifs from lysozyme suppress pro-inflammatory cytokines in macrophages by antagonizing toll-like receptor and LPS-scavenging action","volume":"107","author":"Ibrahim","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jip.2026.108642_b0090","doi-asserted-by":"crossref","first-page":"582","DOI":"10.4049\/jimmunol.2100804","article-title":"Heat shock protein 70 is a damage-associated molecular pattern that by binding to lipopolysaccharide and \u03b2-1,3-glucan-binding protein activates the prophenoloxidase system in shrimp","volume":"209","author":"Junprung","year":"2022","journal-title":"J. Immunol."},{"key":"10.1016\/j.jip.2026.108642_b0095","doi-asserted-by":"crossref","first-page":"44344","DOI":"10.1074\/jbc.M111.292672","article-title":"Functional analysis of C-type lysozyme in penaeid shrimp","volume":"286","author":"Kaizu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jip.2026.108642_b0100","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.3390\/ijms25021072","article-title":"Invertebrate immunity, natural transplantation immunity, somatic and germ cell parasitism, and transposon defense","volume":"25","author":"Kloc","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jip.2026.108642_b0105","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1080\/13657305.2015.994240","article-title":"Fish to 2030: the role and opportunity for aquaculture","volume":"19","author":"Kobayashi","year":"2015","journal-title":"Aquacult. Econ. Manage."},{"key":"10.1016\/j.jip.2026.108642_b0110","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12858-015-0056-3","article-title":"A comparison of the enzymatic properties of three recombinant isoforms of thrombolytic and antibacterial protein\u2013Destabilase-Lysozyme from medicinal leech","volume":"16","author":"Kurdyumov","year":"2015","journal-title":"BMC Biochem."},{"key":"10.1016\/j.jip.2026.108642_b0115","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/j.cub.2008.09.030","article-title":"Microsporidia evolved from ancestral sexual fungi","volume":"18","author":"Lee","year":"2008","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jip.2026.108642_b0120","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.fsi.2012.08.023","article-title":"Signaling pathways regulating innate immune responses in shrimp","volume":"34","author":"Li","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jip.2026.108642_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.146846","article-title":"Immune function of a novel lysozyme in Litopenaeus vannamei and its application as a feed supplement","volume":"322","author":"Li","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jip.2026.108642_b0130","doi-asserted-by":"crossref","first-page":"6305","DOI":"10.3390\/molecules27196305","article-title":"Lysozyme and its application as antibacterial agent in food industry","volume":"27","author":"Nawaz","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jip.2026.108642_b0135","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2583.2008.00797.x","article-title":"Cloning and molecular characterization of two invertebrate-type lysozymes from Anopheles gambiae","volume":"17","author":"Paskewitz","year":"2008","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.jip.2026.108642_b0140","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.fsi.2011.10.026","article-title":"Shrimp invertebrate lysozyme i-lyz: gene structure, molecular model and response of c and i lysozymes to lipopolysaccharide (LPS)","volume":"32","author":"Peregrino-Uriarte","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jip.2026.108642_b0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006512","article-title":"From bacterial killing to immune modulation: recent insights into the functions of lysozyme","volume":"13","author":"Ragland","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jip.2026.108642_b0150","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12917-016-0923-1","article-title":"Laboratory cohabitation challenge model for shrimp hepatopancreatic microsporidiosis (HPM) caused by Enterocytozoon hepatopenaei (EHP)","volume":"13","author":"Salachan","year":"2017","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.jip.2026.108642_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2025.742884","article-title":"Dietary supplementation with recombinant shrimp c-type lysozyme modulates the gut microbiome and enhances growth performance and resistance to Ecytonucleospora hepatopenaei infection in Pacific white shrimp (Litopenaeus vannamei)","volume":"610","author":"Sangklai","year":"2026","journal-title":"Aquaculture"},{"key":"10.1016\/j.jip.2026.108642_b0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012199","article-title":"Immune signaling of Litopenaeus vannamei c-type lysozyme and its role during microsporidian Enterocytozoon hepatopenaei (EHP) infection","volume":"20","author":"Sangklai","year":"2024","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jip.2026.108642_b0165","unstructured":"Sarker, B., Hossain, M.A., Mahbub Alam, M.M., Mian, S., Iqbal, M.M., 2023. Temperature Influences Masculinity, Sex Reversal after Mono-Sex, and the Hormonal Residue in the Flesh Of Nile Tilapia (Oreochromis niloticus). Doi: 10.5281\/ZENODO.7880018."},{"key":"10.1016\/j.jip.2026.108642_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109925","article-title":"Prophenoloxidase-activating system plays a crucial role in innate immune responses to Enterocytozoon hepatopenaei infection in shrimp Litopenaeus vannamei","volume":"154","author":"Sukonthamarn","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jip.2026.108642_b0180","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.fsi.2010.01.003","article-title":"Molecular characterization and expression analysis of a c-type and two novel muramidase-deficient i-type lysozymes from Penaeus monodon","volume":"28","author":"Supungul","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jip.2026.108642_b0185","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1007\/s00018-003-3082-z","article-title":"A small chimerically bifunctional monomeric protein: Tapes japonica lysozyme","volume":"60","author":"Takeshita","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jip.2026.108642_b0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jip.2016.08.004","article-title":"Dense populations of the microsporidian Enterocytozoon hepatopenaei (EHP) in feces of Penaeus vannamei exhibiting white feces syndrome and pathways of their transmission to healthy shrimp","volume":"140","author":"Tang","year":"2016","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.jip.2026.108642_b0195","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/1746-6148-9-139","article-title":"The microsporidian Enterocytozoon hepatopenaei is not the cause of white feces syndrome in whiteleg shrimp Penaeus (Litopenaeus) vannamei","volume":"9","author":"Tangprasittipap","year":"2013","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.jip.2026.108642_b0200","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.dci.2017.05.009","article-title":"Shrimp humoral responses against pathogens: antimicrobial peptides and melanization","volume":"80","author":"Tassanakajon","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jip.2026.108642_b0205","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.aquaculture.2015.10.028","article-title":"Review of current disease threats for cultivated penaeid shrimp in Asia","volume":"452","author":"Thitamadee","year":"2016","journal-title":"Aquaculture"},{"key":"10.1016\/j.jip.2026.108642_b0210","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jip.2009.06.004","article-title":"Enterocytozoon hepatopenaei sp. nov. (Microsporida: Enterocytozoonidae), a parasite of the black tiger shrimp Penaeus monodon (Decapoda: Penaeidae): Fine structure and phylogenetic relationships","volume":"102","author":"Tourtip","year":"2009","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.jip.2026.108642_b0215","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3390\/v14040743","article-title":"Role of cellular receptors in the innate immune system of crustaceans in response to White Spot syndrome virus","volume":"14","author":"Tran","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.jip.2026.108642_b0220","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s12038-012-9201-y","article-title":"Invertebrate lysozymes: diversity and distribution, molecular mechanism and in vivo function","volume":"37","author":"Van Herreweghe","year":"2012","journal-title":"J. Biosci."},{"key":"10.1016\/j.jip.2026.108642_b0225","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.fsi.2020.03.010","article-title":"Crystal structure of a C-type lysozyme from Litopenaeus vanamei exhibiting a high binding constant to its chitotriose inhibitor","volume":"100","author":"Vargas-Requena","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jip.2026.108642_b0230","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/B978-0-12-407706-5.00004-6","article-title":"Microsporidia and \u201cthe art of living together.","volume":"82","author":"V\u00e1vra","year":"2013","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.jip.2026.108642_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737062","article-title":"Identification and characterization polar tube protein 2 (PTP2) from Enterocytozoon hepatopenaei and its potential effect on shrimp microsporidian germination activity evaluation","volume":"544","author":"Wang","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.jip.2026.108642_b0240","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/nar\/29.1.281","article-title":"The TRANSFAC system on gene expression regulation","volume":"29","author":"Wingender","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jip.2026.108642_b0245","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.fsi.2021.12.052","article-title":"Dietary recombinant human lysozyme improves the growth, intestinal health, immunity and disease resistance of Pacific white shrimp Litopenaeus vannamei","volume":"121","author":"Wu","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jip.2026.108642_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108871","article-title":"Characterization of a crustin-like peptide involved in shrimp immune response to bacteria and Enterocytozoon hepatopenaei (EHP) infection in Palaemon carinicauda","volume":"139","author":"Xu","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jip.2026.108642_b0255","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.fsi.2022.07.048","article-title":"Immune regulation mediated by JAK\/STAT signaling pathway in hemocytes of Pacific white shrimps, Litopenaeus vannamei stimulated by lipopolysaccharide","volume":"130","author":"Yan","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jip.2026.108642_b0260","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.exppara.2018.03.007","article-title":"The roles of microsporidia spore wall proteins in the spore wall formation and polar tube anchorage to spore wall during development and infection processes","volume":"187","author":"Yang","year":"2018","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jip.2026.108642_b0265","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11705-012-1277-2","article-title":"Antifungal and antibacterial functions of medicinal leech recombinant destabilase-lysozyme and its heated-up derivative","volume":"6","author":"Yudina","year":"2012","journal-title":"Front. Chem. Sci. Eng."},{"key":"10.1016\/j.jip.2026.108642_b0270","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1134\/S0006297910090129","article-title":"Destabilase-lysozyme of medicinal leech","volume":"75","author":"Zavalova","year":"2010","journal-title":"Multifunctionality of Recombinant Protein. Biochemistry (mosc.)"},{"key":"10.1016\/j.jip.2026.108642_b0275","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.fsi.2010.08.023","article-title":"Functional analysis of two invertebrate-type lysozymes from red swamp crayfish","volume":"29","author":"Zhang","year":"2010","journal-title":"Procambarus Clarkii. Fish Shellfish Immunol."},{"key":"10.1016\/j.jip.2026.108642_b0280","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.dci.2017.04.017","article-title":"Newly identified invertebrate-type lysozyme (Splys-i) in mud crab (Scylla paramamosain) exhibiting muramidase-deficient antimicrobial activity","volume":"74","author":"Zhou","year":"2017","journal-title":"Dev. Comp. Immunol."}],"container-title":["Journal of Invertebrate Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022201126001175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022201126001175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:18:46Z","timestamp":1784204326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022201126001175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":55,"alternative-id":["S0022201126001175"],"URL":"https:\/\/doi.org\/10.1016\/j.jip.2026.108642","relation":{},"ISSN":["0022-2011"],"issn-type":[{"value":"0022-2011","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lysozyme i1-type, a crucial antimicrobial enzyme, reduces Ecytonucleospora hepatopenaei infection in Litopenaeus vannamei with potential for feed supplementation","name":"articletitle","label":"Article Title"},{"value":"Journal of Invertebrate Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jip.2026.108642","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108642"}}