{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:54:33Z","timestamp":1791017673054,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32060834"],"award-info":[{"award-number":["32060834"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2024MS03051"],"award-info":[{"award-number":["2024MS03051"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Invertebrate Pathology"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.jip.2026.108752","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:08:01Z","timestamp":1790035681000},"page":"108752","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pc-JNK plays a crucial role in the comprehensive regulation of crayfish antibacterial innate immune responses"],"prefix":"10.1016","volume":"220","author":[{"given":"Mingyue","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jip.2026.108752_bb0005","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.dci.2012.07.002","article-title":"JNK\/FOXO mediated Peroxiredoxin V expression regulates redox homeostasis during Drosophila melanogaster gut infection","volume":"38","author":"Ahn","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jip.2026.108752_bb0010","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/415977a","article-title":"MAP kinase signalling cascade in Arabidopsis innate immunity","volume":"415","author":"Asai","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jip.2026.108752_bb0015","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.exger.2010.11.003","article-title":"Regulation of Drosophila lifespan by JNK signaling","volume":"46","author":"Biteau","year":"2011","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.jip.2026.108752_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122750","article-title":"JNK signaling and its impact on neural cell maturation and differentiation","volume":"350","author":"Castro-Torres","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.jip.2026.108752_bb0025","doi-asserted-by":"crossref","first-page":"20774","DOI":"10.1073\/pnas.1009223107","article-title":"Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi","volume":"107","author":"Chen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jip.2026.108752_bb0030","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.3390\/biomedicines9101431","article-title":"A perspective on the development of c-Jun N-terminal kinase inhibitors as therapeutics for Alzheimer's disease: investigating structure through docking studies","volume":"9","author":"Cho","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.jip.2026.108752_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003622","article-title":"The JNK pathway is a key mediator of Anopheles gambiae antiplasmodial immunity","volume":"9","author":"Garver","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jip.2026.108752_bb0040","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jare.2024.09.029","article-title":"The role of JNK signaling pathway in organ fibrosis","volume":"74","author":"Hao","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.jip.2026.108752_bb0045","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.dci.2015.12.006","article-title":"Insect immunology and hematopoiesis","volume":"58","author":"Hillyer","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jip.2026.108752_bb0050","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nature02021","article-title":"The immune response of Drosophila","volume":"426","author":"Hoffmann","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jip.2026.108752_bb0055","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.molimm.2021.07.011","article-title":"A novel JNK induces innate immune response by activating the expression of antimicrobial peptides in Chinese mitten crab Eriocheir sinensis","volume":"138","author":"Huang","year":"2021","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jip.2026.108752_bb0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.dci.2013.08.018","article-title":"Overview of Drosophila immunity: a historical perspective","volume":"42","author":"Imler","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jip.2026.108752_bb0065","doi-asserted-by":"crossref","first-page":"31307","DOI":"10.1038\/s41598-025-16579-0","article-title":"Antibiofilm from phyllosphere improves survival and gut health of juvenile pearl gentian hybrid grouper challenged with Vibrio harveyi","volume":"15","author":"Julyantoro","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jip.2026.108752_bb0070","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1474-9726.2009.00476.x","article-title":"JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila","volume":"8","author":"Karpac","year":"2009","journal-title":"Aging Cell"},{"key":"10.1016\/j.jip.2026.108752_bb0075","doi-asserted-by":"crossref","first-page":"17355","DOI":"10.1016\/S0021-9258(17)44910-6","article-title":"pp54 microtubule-associated protein 2 kinase: a novel serine\/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine","volume":"265","author":"Kyriakis","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jip.2026.108752_bb0080","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/369156a0","article-title":"The stress-activated protein kinase subfamily of c-Jun kinases","volume":"369","author":"Kyriakis","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jip.2026.108752_bb0085","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13008-020-00062-5","article-title":"Toll signaling promotes JNK-dependent apoptosis in Drosophila","volume":"15","author":"Li","year":"2020","journal-title":"Cell Div"},{"key":"10.1016\/j.jip.2026.108752_bb0090","first-page":"451","article-title":"Progress in innate immunity-related genes in insects","volume":"40","author":"Liu","year":"2018","journal-title":"Yi Chuan"},{"key":"10.1016\/j.jip.2026.108752_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112905","article-title":"Responses of JNK signaling pathway to the toxic dinoflagellate Prorocentrum lima in the mussel Perna viridis","volume":"227","author":"Lv","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jip.2026.108752_bb0100","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0959-437X(97)80015-9","article-title":"Regulation of cell differentiation by the Drosophila Jun kinase cascade","volume":"7","author":"Mart\u00edn-Blanco","year":"1997","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.jip.2026.108752_bb0105","doi-asserted-by":"crossref","unstructured":"Dev. 7, 666\u2013671. McMenamin, A.J., Daughenbaugh, K.F., Parekh, F., Pizzorno, M.C., Flenniken, M.L., 2018. Honey bee and bumble bee antiviral defense. Viruses 10, 395. Doi:https:\/\/doi.org\/10.3390\/v10080395.","DOI":"10.3390\/v10080395"},{"key":"10.1016\/j.jip.2026.108752_bb0110","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s12031-010-9454-6","article-title":"JNK: a stress-activated protein kinase therapeutic strategies and involvement in Alzheimer\u2019s and various neurodegenerative abnormalities","volume":"43","author":"Mehan","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.jip.2026.108752_bb0115","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00173-25","article-title":"Isolation, identification, and pathogenicity of Pseudoalteromonas aliena associated with oyster disease outbreaks in summer","volume":"13","author":"Mu","year":"2025","journal-title":"Microbiol. Spectrum"},{"key":"10.1016\/j.jip.2026.108752_bb0120","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.aquatox.2015.03.023","article-title":"Essential roles of Cdc42 and MAPK in cadmium-induced apoptosis in Litopenaeus vannamei","volume":"163","author":"Peng","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.jip.2026.108752_bb0125","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.dci.2019.01.001","article-title":"Two novel MKKs (MKK4 and MKK7) from Ctenopharyngodon idella are involved in the intestinal immune response to bacterial muramyl dipeptide challenge","volume":"93","author":"Qu","year":"2019","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jip.2026.108752_bb0130","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/dbio.2001.0502","article-title":"JNK signaling pathway is required for efficient wound healing in Drosophila","volume":"241","author":"R\u00e4met","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jip.2026.108752_bb0135","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/B978-0-12-396456-4.00013-4","article-title":"Role of the JNK pathway in human diseases","volume":"106","author":"Sabapathy","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.jip.2026.108752_bb0140","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/1744-7917.12285","article-title":"Oxidation resistance 1 (OXR1) participates in silkworm defense against bacterial infection through the JNK pathway","volume":"24","author":"Su","year":"2017","journal-title":"Insect Sci."},{"key":"10.1016\/j.jip.2026.108752_bb0145","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3109\/10799893.2015.1030412","article-title":"Signaling pathway of MAPK\/ERK in cell proliferation, differentiation, migration, senescence and apoptosis","volume":"35","author":"Sun","year":"2015","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.jip.2026.108752_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167942","article-title":"Antimicrobial resistance in aquaculture: occurrence and strategies in Southeast Asia","volume":"907","author":"Suyamud","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jip.2026.108752_bb0155","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.imlet.2020.06.017","article-title":"JNK signaling in Drosophila immunity and homeostasis","volume":"226","author":"Tafesh-Edwards","year":"2020","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jip.2026.108752_bb0160","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-065X.2012.01146.x","article-title":"PAMPs and DAMPs: signal 0s that spur autophagy and immunity","volume":"249","author":"Tang","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jip.2026.108752_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109804","article-title":"Characterization of c-Jun N-terminal kinase (JNK) gene reveals involvement of immune defense against Vibrio splendidus infection in Apostichopus japonicus","volume":"153","author":"Tao","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jip.2026.108752_bb0170","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/s13071-015-1016-x","article-title":"Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during plasmodium falciparum infection","volume":"8","author":"Wang","year":"2015","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.jip.2026.108752_bb0175","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.fsi.2015.12.014","article-title":"Identification and characterization of MKK7 as an upstream activator of JNK in Litopenaeus vannamei","volume":"48","author":"Wang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jip.2026.108752_bb0180","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202255903","article-title":"PcEiger links the Imd\/relish pathway to ROS production in the intestine of the red swamp crayfish","volume":"24","author":"Wang","year":"2023","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jip.2026.108752_bb0185","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1002\/med.21574","article-title":"JNK signaling in cancer cell survival","volume":"39","author":"Wu","year":"2019","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jip.2026.108752_bb0190","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/s41467-024-45141-1","article-title":"UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors","volume":"15","author":"Yang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jip.2026.108752_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.990297","article-title":"Andrographolide promotes the growth and immunity of Litopenaeus vannamei, and protects shrimps against vibrio alginolyticus by regulating inflammation and apoptosis via a ROS-JNK dependent pathway","volume":"13","author":"Yin","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jip.2026.108752_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104292","article-title":"Vibrio harveyi infections induce production of proinflammatory cytokines in murine peritoneal macrophages via activation of p38 MAPK and NF-\u03baB pathways, but reversed by PI3K\/AKT pathways","volume":"127","author":"Yu","year":"2022","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jip.2026.108752_bb0205","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3390\/cells9030706","article-title":"Role of c-Jun N-terminal kinase (JNK) in obesity and type 2 diabetes","volume":"9","author":"Yung","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jip.2026.108752_bb0210","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.it.2016.12.004","article-title":"Crosstalk between cytoplasmic RIG-I and STING sensing pathways","volume":"38","author":"Zevini","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jip.2026.108752_bb0215","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/lam.13606","article-title":"ToxR modulates biofilm formation in fish pathogen Vibrio harveyi","volume":"74","author":"Zhang","year":"2022","journal-title":"Lett. Appl. Microbiol."}],"container-title":["Journal of Invertebrate Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022201126002284?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022201126002284?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:29:12Z","timestamp":1791016152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022201126002284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":43,"alternative-id":["S0022201126002284"],"URL":"https:\/\/doi.org\/10.1016\/j.jip.2026.108752","relation":{},"ISSN":["0022-2011"],"issn-type":[{"value":"0022-2011","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pc-JNK plays a crucial role in the comprehensive regulation of crayfish antibacterial innate immune responses","name":"articletitle","label":"Article Title"},{"value":"Journal of Invertebrate Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jip.2026.108752","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108752"}}