{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:14:03Z","timestamp":1788869643638,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T00:00:00Z","timestamp":1483056000000},"content-version":"vor","delay-in-days":548,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Central India Institute of Medical Sciences, Nagpur"}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Public Health"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.jiph.2015.02.003","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T01:57:17Z","timestamp":1428285437000},"page":"329-340","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["The assessment of cytokines in Quantiferon supernatants for the diagnosis of latent TB infection in a tribal population of Melghat, India"],"prefix":"10.1016","volume":"8","author":[{"given":"Prachi R.","family":"Bapat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliabbas A.","family":"Husain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatim F.","family":"Daginawala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha P.","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milind S.","family":"Panchbhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish R.","family":"Satav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girdhar M.","family":"Taori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajpal S.","family":"Kashyap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiph.2015.02.003_bib0190","unstructured":"http:\/\/www.tbfacts.org\/tb-statistics-india.html."},{"key":"10.1016\/j.jiph.2015.02.003_bib0195","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1378\/chest.12-0142","article-title":"Relevance of latent TB infection in areas of high TB prevalence","volume":"142","author":"Sharma","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.jiph.2015.02.003_bib0200","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1128\/IAI.69.7.4195-4201.2001","article-title":"Tuberculosis: latency and reactivation","volume":"69","author":"Flynn","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.jiph.2015.02.003_bib0205","doi-asserted-by":"crossref","first-page":"348","DOI":"10.4065\/mcp.2010.0820","article-title":"Current concepts in the management of tuberculosis","volume":"86","author":"Sia","year":"2011","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jiph.2015.02.003_bib0210","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1128\/CMR.00034-13","article-title":"Gamma interferon release assays for detection of Mycobacterium tuberculosis infection","volume":"27","author":"Pai","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jiph.2015.02.003_bib0215","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1586\/14737159.8.3.247","article-title":"QuantiFERON-TB Gold assay for the diagnosis of latent tuberculosis infection","volume":"8","author":"Manuel","year":"2008","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1016\/j.jiph.2015.02.003_bib0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2466-9-21","article-title":"Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report","volume":"9","author":"Chegou","year":"2009","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.jiph.2015.02.003_bib0225","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1128\/MMBR.00010-14","article-title":"Latent tuberculosis infection: myths, models, and molecular mechanisms","volume":"78","author":"Dutta","year":"2014","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.jiph.2015.02.003_bib0230","doi-asserted-by":"crossref","first-page":"177","DOI":"10.7326\/0003-4819-149-3-200808050-00241","article-title":"Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update","volume":"149","author":"Pai","year":"2008","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jiph.2015.02.003_bib0235","first-page":"213","article-title":"Immunology of tuberculosis","volume":"120","author":"Raja","year":"2004","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.jiph.2015.02.003_bib0240","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1348-0421.2011.00348.x","article-title":"Decreased plasma granulysin and increased interferon-gamma concentrations in patients with newly diagnosed and relapsed tuberculosis","volume":"55","author":"Pitabut","year":"2011","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.jiph.2015.02.003_bib0245","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1348-0421.2011.00307.x","article-title":"Cytokines in response to proteins predicted in genomic regions of difference of Mycobacterium tuberculosis","volume":"55","author":"Mustafa","year":"2011","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.jiph.2015.02.003_bib0250","first-page":"479","article-title":"Increased Th1 and Th2 type cytokine production in patients with active tuberculosis","volume":"9","author":"Handzel","year":"2007","journal-title":"Isr Med Assoc J"},{"key":"10.1016\/j.jiph.2015.02.003_bib0255","first-page":"171","article-title":"Th1\/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens","volume":"81","author":"Surcel","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/j.jiph.2015.02.003_bib0260","doi-asserted-by":"crossref","first-page":"e74652","DOI":"10.1371\/journal.pone.0074652","article-title":"Laboratory investigations on the diagnosis of tuberculosis in the malnourished tribal population of Melghat, India","volume":"8","author":"Kashyap","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jiph.2015.02.003_bib0265","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/0972639X.2008.11886573","article-title":"Study on High Mortality of Children in Melghat Region of Amravati (Maharashtra)","volume":"6","author":"Singh","year":"2008","journal-title":"Stud Tribes Tribals"},{"key":"10.1016\/j.jiph.2015.02.003_bib0270","first-page":"286","article-title":"The relationship between malnutrition and tuberculosis: evidence from studies in humans and experimental animals","volume":"8","author":"Cegielski","year":"2004","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.jiph.2015.02.003_bib0275","first-page":"49","article-title":"Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection, United States","volume":"54","author":"Mazurek","year":"2005","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.jiph.2015.02.003_bib0280","first-page":"1","article-title":"Different patterns of cytokines and chemokines combined with IFN-\u03b3 production reflect Mycobacterium tuberculosis infection and disease","volume":"7","author":"Yu","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jiph.2015.02.003_bib0285","first-page":"153","article-title":"Epidemiology and disease burden of tuberculosis in children: a global perspective","volume":"7","author":"Seddon","year":"2014","journal-title":"Infect Drug Resist"},{"key":"10.1016\/j.jiph.2015.02.003_bib0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2193-1801-2-686","article-title":"Interleukin-6: a potent biomarker of mycobacterial infection","volume":"2","author":"Singh","year":"2013","journal-title":"Springerplus"},{"key":"10.1016\/j.jiph.2015.02.003_bib0295","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/mi.2011.7","article-title":"The role of IL-10 in immune regulation during M. tuberculosis infection","volume":"4","author":"Redford","year":"2001","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jiph.2015.02.003_bib0300","doi-asserted-by":"crossref","first-page":"6938","DOI":"10.4049\/jimmunol.172.11.6938","article-title":"Healthy individuals that control a latent infection with Mycobacterium tuberculosis express high levels of Th1 cytokines and the IL-4 antagonist IL-4\u03b42","volume":"172","author":"Demissie","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jiph.2015.02.003_bib0305","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1128\/IAI.00602-06","article-title":"Dynamic changes in pro- and anti-inflammatory cytokine profiles and gamma interferon receptor signaling integrity correlate with tuberculosis disease activity and response to curative treatment","volume":"75","author":"Sahiratmadja","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.jiph.2015.02.003_bib0310","first-page":"1","article-title":"Increased cytokines response in patients with tuberculosis complicated with chronic obstructive pulmonary disease","volume":"8","author":"Tang","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jiph.2015.02.003_bib0315","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/sj.jidsymp.5650027","article-title":"Tumor necrosis factor and tuberculosis","volume":"12","author":"Lin","year":"2007","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1016\/j.jiph.2015.02.003_bib0320","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1136\/ard.2005.042531","article-title":"Immunological control of tuberculosis: role of tumour necrosis factor and more","volume":"64","author":"Stenger","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jiph.2015.02.003_bib0325","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1086\/590262","article-title":"Discordant QuantiFERON-TB Gold test results among US healthcare workers with increased risk of latent tuberculosis infection: a problem or solution?","volume":"29","author":"Pollock","year":"2008","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.jiph.2015.02.003_bib0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0089524","article-title":"Latent TB infection diagnosis in population exposed to TB subjects in close and poor ventilated high TB endemic zone in India","volume":"9","author":"Kashyap","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jiph.2015.02.003_bib0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0049050","article-title":"Association between smoking and latent tuberculosis in the U.S. population: an analysis of the National Health and Nutrition Examination Survey","volume":"7","author":"Horne","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jiph.2015.02.003_bib0340","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1128\/IAI.74.5.2817-2822.2006","article-title":"The 6-kilodalton early secreted antigenic target-responsive, asymptomatic contacts of tuberculosis patients express elevated levels of interleukin-4 and reduced levels of gamma interferon","volume":"74","author":"Demissie","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.jiph.2015.02.003_bib0345","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jcla.20290","article-title":"Evaluation of memory immune response to mycobacterium extract among household contact of tuberculosis cases","volume":"23","author":"Cavalcanti","year":"2009","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.jiph.2015.02.003_bib0350","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1046\/j.1365-3083.2001.00844.x","article-title":"Circulating TNF-alpha, TGF-beta, and IL-10 in tuberculosis patients and healthy contacts","volume":"53","author":"Olobo","year":"2001","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jiph.2015.02.003_bib0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/745483","article-title":"Role of TNF-alpha, IFN-gamma, and IL-10 in the development of pulmonary tuberculosis","volume":"2012","author":"Cavalcanti","year":"2012","journal-title":"Pulm Med"},{"key":"10.1016\/j.jiph.2015.02.003_bib0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/1354750X.2011.628048","article-title":"Host biomarkers of clinical relevance in tuberculosis: review of gene and protein expression studies","volume":"17","author":"John","year":"2012","journal-title":"Biomarkers"},{"key":"10.1016\/j.jiph.2015.02.003_bib0365","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/gene.2013.26","article-title":"Identification of biomarkers for Mycobacterium tuberculosis infection and disease in BCG-vaccinated young children in Southern India","volume":"14","author":"Dhanasekaran","year":"2013","journal-title":"Genes Immun"},{"key":"10.1016\/j.jiph.2015.02.003_bib0370","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.cyto.2012.12.031","article-title":"Multiplex analysis of cytokines\/chemokines as biomarkers that differentiate healthy contacts from tuberculosis patients in high endemic settings","volume":"61","author":"Anbarasu","year":"2013","journal-title":"Cytokine"}],"container-title":["Journal of Infection and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876034115000404?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876034115000404?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T20:26:14Z","timestamp":1566505574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1876034115000404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1876034115000404"],"URL":"https:\/\/doi.org\/10.1016\/j.jiph.2015.02.003","relation":{},"ISSN":["1876-0341"],"issn-type":[{"value":"1876-0341","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The assessment of cytokines in Quantiferon supernatants for the diagnosis of latent TB infection in a tribal population of Melghat, India","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Public Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiph.2015.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}