{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:23:25Z","timestamp":1773163405035,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Public Health"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.jiph.2017.05.006","type":"journal-article","created":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T18:17:39Z","timestamp":1497291459000},"page":"661-666","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Kolaviron shows anti-proliferative effect and down regulation of vascular endothelial growth factor-C and toll like receptor-2 in Wuchereria bancrofti infected blood lymphocytes"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4167-7793","authenticated-orcid":false,"given":"Aliyu","family":"Muhammad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audu","family":"Funmilola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idowu A.","family":"Aimola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iliya S.","family":"Ndams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mairo H.","family":"Inuwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Nok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jiph.2017.05.006_bib0005","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1371\/journal.ppat.0020092","article-title":"Doxycycline reduces plasma VEGF-C\/sVEGFR-3 and improves pathology in lymphatic filariasis","volume":"2","author":"Debrah","year":"2006","journal-title":"PLoS Pathog."},{"issue":"6","key":"10.1016\/j.jiph.2017.05.006_bib0010","doi-asserted-by":"crossref","first-page":"e1002749","DOI":"10.1371\/journal.ppat.1002749","article-title":"Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease","volume":"8","author":"Anuradha","year":"2012","journal-title":"PLoS Pathog."},{"issue":"389","key":"10.1016\/j.jiph.2017.05.006_bib0015","first-page":"400","article-title":"Global programme to eliminate lymphatic filariasis: progress report","volume":"88","author":"WHO","year":"2012","journal-title":"Wkly Epidemiol Rec"},{"key":"10.1016\/j.jiph.2017.05.006_bib0020","first-page":"1","article-title":"Global programme to eliminate lymphatic filariasis lymphatic filariasis managing morbidity and preventing disability lymphatic filariasis: preventing disability global programme to eliminate preventing disability","author":"WHO","year":"2013","journal-title":"An Aide-memoire Natl Programmes Manag"},{"issue":"3","key":"10.1016\/j.jiph.2017.05.006_bib0025","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1089\/lrb.2013.0021","article-title":"Insights into the pathogenesis of disease in human lymphatic filariasis","volume":"11","author":"Nutman","year":"2013","journal-title":"Lymphat Res Biol"},{"issue":"April","key":"10.1016\/j.jiph.2017.05.006_bib0030","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1365-3024.2009.01133.x","article-title":"Filariasis and lymphoedema","author":"Pfarr","year":"2009","journal-title":"Parasite Immunol"},{"issue":"4","key":"10.1016\/j.jiph.2017.05.006_bib0035","doi-asserted-by":"crossref","first-page":"884","DOI":"10.4269\/ajtmh.2010.10-0039","article-title":"Elevated levels of plasma angiogenic factors are associated with human lymphatic filarial infections","volume":"83","author":"Bennuru","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.jiph.2017.05.006_bib0040","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"K","year":"2010","journal-title":"Nat Immunol"},{"issue":"July","key":"10.1016\/j.jiph.2017.05.006_bib0045","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.4049\/jimmunol.178.2.1068","article-title":"Innate immune reponses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, and Mal but not TLR4, TRIF, or TRAM","volume":"178","author":"Hise","year":"2007","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.jiph.2017.05.006_bib0050","doi-asserted-by":"crossref","first-page":"234","DOI":"10.4269\/ajtmh.2005.73.234","article-title":"Detection Of benzimidazole resistance\u2014associated mutations in the filarial nematode wuchereria bancrofti and evidence for selection by albendazole and ivermectin combination treatment","volume":"73","author":"Schwab","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.jiph.2017.05.006_bib0055","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/QCO.0b013e328315cde7","article-title":"Filariasis: new drugs and new opportunity for lymphatic filariasis and onchocerciasis","volume":"21","author":"Hoerauf","year":"2008","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.jiph.2017.05.006_bib0060","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.3390\/ijerph8062533","article-title":"Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid","author":"Farombi","year":"2011","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jiph.2017.05.006_bib0065","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/921080","article-title":"Kolaviron improved resistance to oxidative stress and inflammation in the blood (Erythrocyte, Serum, and Plasma) of streptozotocin-induced diabetic rats","volume":"2014","author":"Ayepola","year":"2014","journal-title":"Sci World J"},{"key":"10.1016\/j.jiph.2017.05.006_bib0070","first-page":"1","article-title":"Helminthic infections, filariasis","author":"Simonsen","year":"2008","journal-title":"Elevier"},{"key":"10.1016\/j.jiph.2017.05.006_bib0075","first-page":"171","article-title":"Analgesic and anti-inflammatory effects of kolaviron (A Garcinia Kola seed extract)","volume":"3","author":"Olaleye","year":"2000","journal-title":"Afr J Biomed Res"},{"issue":"2","key":"10.1016\/j.jiph.2017.05.006_bib0080","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1023\/B:CBTO.0000027916.61347.bc","article-title":"Ex-vivo and in vitro protective effects of kolaviron against oxygen- derived radical- induced DNA damage and oxidative stress in human lymphocytes and rat liver cells","volume":"20","author":"Farombi","year":"2004","journal-title":"Cell Biol Toxicol"},{"issue":"1","key":"10.1016\/j.jiph.2017.05.006_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-3305-5-292","article-title":"Effect of combinations of marketed human anthelmintic drugs against Trichuris muris in vitro and in vivo","volume":"5","author":"Keiser","year":"2012","journal-title":"Parasit Vectors"},{"key":"10.1016\/j.jiph.2017.05.006_bib0090","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.phymed.2004.06.015","article-title":"The Anticarcinigenic effect of propolis in human lymphocytes culture","volume":"12","author":"Ozkyul","year":"2005","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.jiph.2017.05.006_bib0095","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.4049\/jimmunol.168.9.4701","article-title":"Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses 1","volume":"168","author":"Sabroe","year":"2002","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.jiph.2017.05.006_bib0100","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/sj.leu.2402880","article-title":"Optimization of quantitative real time RT-PCR parameters for the study of lymphoid malignancies","volume":"17","author":"Lossos","year":"2003","journal-title":"Leukaemia"},{"key":"10.1016\/j.jiph.2017.05.006_bib0105","first-page":"1885","article-title":"VEGFR-3, VEGF-C and VEGF-D mRNA quantification by RT-PCR in different human cell types","volume":"26","author":"Leclers","year":"2006","journal-title":"Anticancer Res."},{"issue":"9","key":"10.1016\/j.jiph.2017.05.006_bib0110","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1371\/journal.ppat.0020092","article-title":"Doxycycline reduces plasma VEGF-C\/sVEGFR-3 and improves pathology in lymphatic filariasis","volume":"2","author":"Debrah","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jiph.2017.05.006_bib0115","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4269\/ajtmh.2011.11-0086","article-title":"Heightened measures of immune complex and complement function and immune complex-mediated granulocyte activation in human lymphatic filariasis","volume":"85","author":"Senbagavalli","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.jiph.2017.05.006_bib0120","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1089\/lrb.2009.0022","article-title":"Lymphatics in human lymphatic filariasis: in vitro models of parasiteinduced lymphatic remodeling","volume":"7","author":"Bennuru","year":"2009","journal-title":"Lymphat Res Biol"},{"issue":"6","key":"10.1016\/j.jiph.2017.05.006_bib0125","doi-asserted-by":"crossref","first-page":"e1002749","DOI":"10.1371\/journal.ppat.1002749","article-title":"Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease","volume":"8","author":"Anuradha","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jiph.2017.05.006_bib0130","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/1091581812436726","article-title":"Aqueous extracts of Lippaturbunata and aloysiacitridora: assessment of antioxidant capacity and DNA damage","volume":"31","author":"Portman","year":"2012","journal-title":"Int J Toxicol"},{"issue":"3","key":"10.1016\/j.jiph.2017.05.006_bib0135","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3109\/01480545.2011.621954","article-title":"Genotoxic and cytotoxic effects of doxycycline in cultured human peripheral blood lymphocytes","volume":"35","author":"Sekeroglu","year":"2012","journal-title":"Drug Chem Toxicol"},{"issue":"1","key":"10.1016\/j.jiph.2017.05.006_bib0140","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00281-012-0346-4","article-title":"Immunopathogenesis of lymphatic filarial pathology","volume":"34","author":"Babu","year":"2012","journal-title":"Semin Immunopathol"},{"issue":"8","key":"10.1016\/j.jiph.2017.05.006_bib0145","doi-asserted-by":"crossref","first-page":"22364","DOI":"10.1074\/jbc.M901528200","article-title":"Wolbachia lipoproteinstimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis","volume":"191","author":"Turner","year":"2009","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.jiph.2017.05.006_bib0150","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1128\/IAI.06179-11","article-title":"Growth factors in filarial lymphatic pathology","volume":"80","author":"Babu","year":"2012","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.jiph.2017.05.006_bib0155","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1042\/CS20040370","article-title":"The vascular endothelial growth factor (VEGF)\/VEGF receptor system and its role under physiological and pathological condition","volume":"109","author":"Takahashi","year":"2005","journal-title":"Clin Sci"},{"issue":"4","key":"10.1016\/j.jiph.2017.05.006_bib0160","doi-asserted-by":"crossref","first-page":"601","DOI":"10.4269\/ajtmh.2007.77.601","article-title":"Plasma vascular endothelial growth Factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis","volume":"77","author":"Debrah","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jiph.2017.05.006_bib0165","first-page":"548","article-title":"Vascular endothelial growth factor and angiogenesis","volume":"56","author":"Hoeben","year":"2004","journal-title":"Phamacol Rev"},{"key":"10.1016\/j.jiph.2017.05.006_bib0170","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jiph.2017.05.006_bib0175","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3347\/kjp.2008.46.3.119","article-title":"Clinical and pathological aspects of filarial lymphedema and its management","volume":"46","author":"Shenoy","year":"2008","journal-title":"Korean J Parasitol"}],"container-title":["Journal of Infection and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876034117301399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876034117301399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T19:38:27Z","timestamp":1569440307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1876034117301399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S1876034117301399"],"URL":"https:\/\/doi.org\/10.1016\/j.jiph.2017.05.006","relation":{},"ISSN":["1876-0341"],"issn-type":[{"value":"1876-0341","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kolaviron shows anti-proliferative effect and down regulation of vascular endothelial growth factor-C and toll like receptor-2 in Wuchereria bancrofti infected blood lymphocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Public Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiph.2017.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Production and hosting by Elsevier Limited on behalf of King Saud Bin Abdulaziz University for Health Sciences.","name":"copyright","label":"Copyright"}]}}