{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:23:07Z","timestamp":1785475387415,"version":"3.56.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EMR\/2017\/001374"],"award-info":[{"award-number":["EMR\/2017\/001374"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Public Health"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jiph.2021.10.002","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:25:21Z","timestamp":1633652721000},"page":"1701-1707","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["High viral load positively correlates with thrombocytopenia and elevated haematocrit in dengue infected paediatric patients"],"prefix":"10.1016","volume":"14","author":[{"given":"Bharti","family":"Pathak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Chakravarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuja","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Apr (7446)","key":"10.1016\/j.jiph.2021.10.002_bib0005","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"issue":"Jan (10169)","key":"10.1016\/j.jiph.2021.10.002_bib0010","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0140-6736(18)32560-1","article-title":"Dengue","volume":"393","author":"Wilder-Smith","year":"2019","journal-title":"Lancet"},{"issue":"Oct (10)","key":"10.1016\/j.jiph.2021.10.002_bib0015","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S2352-4642(19)30205-6","article-title":"Dengue infection and advances in dengue vaccines for children","volume":"3","author":"Halstead","year":"2019","journal-title":"Lancet Child Adolesc Health"},{"key":"10.1016\/j.jiph.2021.10.002_bib0020","series-title":"Flaviviridae: the viruses and their replication, field\u2019s virology","author":"Lindenbach","year":"2007"},{"issue":"Jan (1)","key":"10.1016\/j.jiph.2021.10.002_bib0025","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/molbev\/msg010","article-title":"Inferring the rate and time-scale of dengue virus evolution","volume":"20","author":"Twiddy","year":"2003","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.jiph.2021.10.002_bib0030","series-title":"Dengue haemorrhagic fever: diagnosis, treatment, prevention and control","author":"World Health Organization","year":"1997"},{"issue":"Oct (10)","key":"10.1016\/j.jiph.2021.10.002_bib0035","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S1473-3099(10)70166-3","article-title":"Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes","volume":"10","author":"Halstead","year":"2010","journal-title":"Lancet Infect Dis"},{"issue":"Nov (6365)","key":"10.1016\/j.jiph.2021.10.002_bib0040","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1126\/science.aan6836","article-title":"Antibody-dependent enhancement of severe dengue disease in humans","volume":"358","author":"Katzelnick","year":"2017","journal-title":"Science"},{"issue":"58","key":"10.1016\/j.jiph.2021.10.002_bib0045","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jcv.2013.08.001","article-title":"Apropos \u201cviral load in patients infected with dengue is modulated by the presence of anti-dengue IgM antibodies\u201d","volume":"2","author":"Arya","year":"2013","journal-title":"J Clin Virol"},{"issue":"3","key":"10.1016\/j.jiph.2021.10.002_bib0050","doi-asserted-by":"crossref","first-page":"446","DOI":"10.4269\/ajtmh.12-0023","article-title":"Determination of viremia and concentration of circulating nonstructural protein 1 in patients infected with dengue virus in Mexico","volume":"88","author":"Sergio","year":"2013","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"10.1016\/j.jiph.2021.10.002_bib0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004497","article-title":"Immune response to dengue virus infection in pediatric patients in New Delhi, India\u2014association of viremia, inflammatory mediators and monocytes with disease severity","volume":"10","author":"Singla","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"Oct (10)","key":"10.1016\/j.jiph.2021.10.002_bib0060","article-title":"A prospective nested case-control study of Dengue in infants: rethinking and refining the antibody-dependent enhancement dengue hemorrhagic fever model","volume":"6","author":"Libraty","year":"2009","journal-title":"PLoS Med"},{"issue":"Sep (304)","key":"10.1016\/j.jiph.2021.10.002_bib0065","article-title":"Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination","volume":"7","author":"Beatty","year":"2015","journal-title":"Sci Transl Med"},{"issue":"Jul (7)","key":"10.1016\/j.jiph.2021.10.002_bib0070","article-title":"Dengue virus NS1 disrupts the endothelial glycocalyx, leading to hyperpermeability","volume":"12","author":"Puerta-Guardo","year":"2016","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jiph.2021.10.002_bib0075","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.715208","article-title":"Dengue virus dysregulates master transcription factors and PI3K\/AKT\/mTOR signaling pathway in megakaryocytes","volume":"11","author":"Lahon","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"issue":"Mar (3)","key":"10.1016\/j.jiph.2021.10.002_bib0080","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1128\/jcm.30.3.545-551.1992","article-title":"Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction","volume":"30","author":"Lanciotti","year":"1992","journal-title":"J Clin Microbiol"},{"issue":"Mar 14","key":"10.1016\/j.jiph.2021.10.002_bib0085","doi-asserted-by":"crossref","first-page":"e2970","DOI":"10.7717\/peerj.2970","article-title":"Occurrence of concurrent infections with multiple serotypes of dengue viruses during 2013\u20132015 in northern Kerala, India","volume":"5","author":"Reddy","year":"2017","journal-title":"PeerJ"},{"issue":"Jan (2)","key":"10.1016\/j.jiph.2021.10.002_bib0090","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1006\/viro.2002.1704","article-title":"High levels of plasma dengue viral load during defervescence in patients with dengue hemorrhagic fever: implications for pathogenesis","volume":"305","author":"Wang","year":"2003","journal-title":"Virology"},{"issue":"Jun (6)","key":"10.1016\/j.jiph.2021.10.002_bib0095","doi-asserted-by":"crossref","first-page":"990","DOI":"10.4269\/ajtmh.2008.78.990","article-title":"Influence of the dengue serotype, previous dengue infection, and plasma viral load on clinical presentation and outcome during a dengue-2 and dengue-4 co-epidemic","volume":"78","author":"Thomas","year":"2008","journal-title":"Am J Trop Med Hyg"},{"issue":"Jan (1)","key":"10.1016\/j.jiph.2021.10.002_bib0100","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jiph.2018.08.008","article-title":"Circulation of single serotype of Dengue Virus (DENV-3) in New Delhi, India during 2016: a change in the epidemiological trend","volume":"12","author":"Parveen","year":"2019","journal-title":"J Infect Public Health"},{"issue":"Nov","key":"10.1016\/j.jiph.2021.10.002_bib0105","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1016\/j.jinf.2014.07.020","article-title":"Dengue in children","volume":"69","author":"Verhagen","year":"2014","journal-title":"J Infect"},{"key":"10.1016\/j.jiph.2021.10.002_bib0110","series-title":"Dengue haemorrhagic fever: diagnosis, treatment, prevention and control","author":"World Health Organization","year":"1997"},{"issue":"Jun (6)","key":"10.1016\/j.jiph.2021.10.002_bib0115","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3390\/v10060326","article-title":"NS1 antigenemia and viraemia load: potential markers of progression to dengue fatal outcome?","volume":"10","author":"Nunes","year":"2018","journal-title":"Viruses"},{"issue":"Nov (3)","key":"10.1016\/j.jiph.2021.10.002_bib0120","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jcv.2014.09.003","article-title":"Differential clinical symptoms among acute phase Indian patients revealed significant association with dengue viral load and serum IFN-gamma level","volume":"61","author":"Pal","year":"2014","journal-title":"J Clin Virol"},{"issue":"Apr (4)","key":"10.1016\/j.jiph.2021.10.002_bib0125","article-title":"The value of daily platelet counts for predicting dengue shock syndrome: Results from a prospective observational study of 2301 Vietnamese children with dengue","volume":"11","author":"Lam","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"Apr (4)","key":"10.1016\/j.jiph.2021.10.002_bib0130","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/(SICI)1096-9071(200004)60:4<432::AID-JMV11>3.0.CO;2-7","article-title":"Prospective study of the duration and magnitude of viraemia in children hospitalised during the 1996\u20131997 dengue\u20102 outbreak in French Polynesia","volume":"60","author":"Murgue","year":"2000","journal-title":"J Med Virol"},{"issue":"Jan (1)","key":"10.1016\/j.jiph.2021.10.002_bib0135","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/1096-9071(200101)63:1<29::AID-JMV1004>3.0.CO;2-S","article-title":"Analysis of plasma viral RNA levels during acute dengue virus infection using quantitative competitor reverse transcription\u2010polymerase chain reaction","volume":"63","author":"Sudiro","year":"2001","journal-title":"J Med Virol"},{"issue":"Apr (4)","key":"10.1016\/j.jiph.2021.10.002_bib0140","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41577-019-0123-x","article-title":"Adaptive immune responses to primary and secondary dengue virus infections","volume":"19","author":"John","year":"2019","journal-title":"Nat Rev Immunol"},{"issue":"Oct (10)","key":"10.1016\/j.jiph.2021.10.002_bib0145","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S1473-3099(10)70166-3","article-title":"Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes","volume":"10","author":"Halstead","year":"2010","journal-title":"Lancet Infect Dis"},{"issue":"Nov (2)","key":"10.1016\/j.jiph.2021.10.002_bib0150","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2249.2004.02626.x","article-title":"Association of increased platelet\u2010associated immunoglobulins with thrombocytopenia and the severity of disease in secondary dengue virus infections","volume":"138","author":"Saito","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jiph.2021.10.002_bib0155","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.4049\/jimmunol.0800672","article-title":"Deletion of the C-terminal region of dengue virus nonstructural protein 1 (NS1) abolishes anti-NS1-mediated platelet dysfunction and bleeding tendency","volume":"183","author":"Chen","year":"2009","journal-title":"J Immunol"},{"issue":"Jan (1)","key":"10.1016\/j.jiph.2021.10.002_bib0160","article-title":"Platelet activation determines the severity of thrombocytopenia in dengue infection","volume":"7","author":"Ojha","year":"2017","journal-title":"Sci Rep"},{"issue":"Apr (4)","key":"10.1016\/j.jiph.2021.10.002_bib0165","article-title":"Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage","volume":"15","author":"Chao","year":"2019","journal-title":"PLoS Pathog"},{"issue":"May (10)","key":"10.1016\/j.jiph.2021.10.002_bib0170","doi-asserted-by":"crossref","first-page":"5508","DOI":"10.1128\/JVI.07081-11","article-title":"The magnitude of dengue virus NS1 protein secretion is strain dependent and does not correlate with severe pathologies in the mouse infection model","volume":"86","author":"Watanabe","year":"2012","journal-title":"J Virol"},{"issue":"Dec (1)","key":"10.1016\/j.jiph.2021.10.002_bib0175","first-page":"1","article-title":"Role of NS1 antibodies in the pathogenesis of acute secondary dengue infection","volume":"9","author":"Jayathilaka","year":"2018","journal-title":"Nat Commun"},{"issue":"Jun (6)","key":"10.1016\/j.jiph.2021.10.002_bib0180","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/trstmh\/trz128","article-title":"The atypical lymphocyte count: a novel predictive factor for severe thrombocytopenia related to dengue","volume":"114","author":"Abeysuriya","year":"2020","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"Jan (1)","key":"10.1016\/j.jiph.2021.10.002_bib0185","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.thromres.2013.09.028","article-title":"Hemostatic derangement in dengue hemorrhagic fever","volume":"133","author":"Chuansumrit","year":"2014","journal-title":"Thromb Res"}],"container-title":["Journal of Infection and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876034121003221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876034121003221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T15:10:19Z","timestamp":1761750619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1876034121003221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S1876034121003221"],"URL":"https:\/\/doi.org\/10.1016\/j.jiph.2021.10.002","relation":{},"ISSN":["1876-0341"],"issn-type":[{"value":"1876-0341","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High viral load positively correlates with thrombocytopenia and elevated haematocrit in dengue infected paediatric patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Public Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiph.2021.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences.","name":"copyright","label":"Copyright"}]}}