{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T18:19:49Z","timestamp":1786904389328,"version":"build-2736575974"},"reference-count":61,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T00:00:00Z","timestamp":1648339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Public Health"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jiph.2022.03.014","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T02:00:39Z","timestamp":1648605639000},"page":"566-572","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Combined therapy with ivermectin and doxycycline can effectively alleviate the cytokine storm of COVID-19 infection amid vaccination drive: A narrative review"],"prefix":"10.1016","volume":"15","author":[{"given":"Satish Kumar","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Mohammed Basheeruddin","family":"Asdaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Kanan","family":"Alshammari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer","family":"Alanazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naif Saleh","family":"Alrasheedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bader Abdullah","family":"Alrashdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad Saleh","family":"Alyami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bshayer Hamdan","family":"Alhazmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perwaiz","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prerna","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Tomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep K.","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd.","family":"Imran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jiph.2022.03.014_bib1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41577-021-00592-1","article-title":"Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape","volume":"21","author":"Tregoning","year":"2021","journal-title":"Nat Rev Immunol"},{"issue":"2 & 3","key":"10.1016\/j.jiph.2022.03.014_bib2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4103\/ijmr.IJMR_585_20","article-title":"Perspectives for repurposing drugs for the coronavirus disease 2019","volume":"151","author":"Cherian","year":"2020","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.jiph.2022.03.014_bib3","first-page":"m1844","article-title":"Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data","volume":"369","author":"Mah\u00e9vas","year":"2020","journal-title":"BMJ (Clin Res Ed )"},{"issue":"3","key":"10.1016\/j.jiph.2022.03.014_bib4","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ijtb.2020.07.031","article-title":"White paper on Ivermectin as a potential therapy for COVID-19","volume":"67","author":"Vora","year":"2020","journal-title":"Indian J Tuberc"},{"issue":"10","key":"10.1016\/j.jiph.2022.03.014_bib5","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1177\/009127002237994","article-title":"Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects","volume":"42","author":"Guzzo","year":"2002","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.jiph.2022.03.014_bib6","doi-asserted-by":"crossref","unstructured":"Chowdhury, A.T. M., Shahbaz, M., Karim, M.R., Islam, J., Dan, G., & He, S. (2020). A comparative study on Ivermectin- Doxycycline and Hydroxychloroquine-Azithromycin therapy on COVID19 patients. Unpublished. https:\/\/doi.org\/10.13140\/RG.2.2.22193.81767\/3.","DOI":"10.21203\/rs.3.rs-38896\/v1"},{"issue":"1","key":"10.1016\/j.jiph.2022.03.014_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12941-020-00368-w","article-title":"Ivermectin, a new candidate therapeutic against SARS-CoV-2\/COVID-19","volume":"19","author":"Sharun","year":"2020","journal-title":"Ann Clin Microbiol Antimicrob"},{"issue":"9","key":"10.1016\/j.jiph.2022.03.014_bib8","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41429-020-0336-z","article-title":"Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen","volume":"73","author":"Heidary","year":"2020","journal-title":"J Antibiot"},{"issue":"104787","key":"10.1016\/j.jiph.2022.03.014_bib9","article-title":"The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro","volume":"178","author":"Caly","year":"2020","journal-title":"Antivir Res"},{"issue":"8","key":"10.1016\/j.jiph.2022.03.014_bib10","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1055\/a-1185-8913","article-title":"The Battle against COVID 19 Pandemic: What we Need to Know Before we \u201cTest Fire\u201d Ivermectin","volume":"70","author":"Banerjee","year":"2020","journal-title":"Drug Res"},{"issue":"3","key":"10.1016\/j.jiph.2022.03.014_bib11","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1042\/BJ20120150","article-title":"Ivermectin is a specific inhibitor of importin \u03b1\/\u03b2-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus","volume":"443","author":"Wagstaff","year":"2012","journal-title":"Biochem J"},{"issue":"104760","key":"10.1016\/j.jiph.2022.03.014_bib12","article-title":"The broad spectrum antiviral ivermectin targets the host nuclear transport importin \u03b1\/\u03b21 heterodimer","volume":"177","author":"Yang","year":"2020","journal-title":"Antivir Res"},{"key":"10.1016\/j.jiph.2022.03.014_bib13","article-title":"Role of ivermectin in the prevention of COVID-19 infection among healthcare workers in India: A matched case-control study","author":"Behera","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.jiph.2022.03.014_bib14","article-title":"What is the roles of the antiparasitic drug niclosamide in the treatment of coronavirus disease 2019 (COVID-19)?","author":"Cennimo David","year":"2021","journal-title":"Medscape Com"},{"issue":"1","key":"10.1016\/j.jiph.2022.03.014_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.chest.2020.10.009","article-title":"Use of ivermectin is associated with lower mortality in hospitalized patients with Coronavirus disease 2019: The ivermectin in COVID nineteen study","volume":"159","author":"Rajter","year":"2021","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.jiph.2022.03.014_bib16","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s10753-020-01188-y","article-title":"Immunomodulatory effect of doxycycline ameliorates systemic and pulmonary inflammation in a Murine polymicrobial sepsis model","volume":"43","author":"Patel","year":"2020","journal-title":"Inflammation"},{"issue":"1\u20132","key":"10.1016\/j.jiph.2022.03.014_bib17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.virusres.2005.05.007","article-title":"Nuclear\/nucleolar localization properties of C-terminal nucleocapsid protein of SARS coronavirus","volume":"114","author":"Timani","year":"2005","journal-title":"Virus Res"},{"issue":"1","key":"10.1016\/j.jiph.2022.03.014_bib18","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1128\/JVI.75.1.506-512.2001","article-title":"The coronavirus infectious bronchitis virus nucleoprotein localizes to the nucleolus","volume":"75","author":"Hiscox","year":"2001","journal-title":"J Virol"},{"key":"10.1016\/j.jiph.2022.03.014_bib19","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3389\/fmicb.2015.00553","article-title":"Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses","volume":"6","author":"Wulan","year":"2015","journal-title":"Front Microbiol"},{"issue":"7","key":"10.1016\/j.jiph.2022.03.014_bib20","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00210-020-01902-5","article-title":"Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action","volume":"393","author":"Rizzo","year":"2020","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"10.1016\/j.jiph.2022.03.014_bib21","article-title":"A combination of Ivermectin and doxycycline possibly blocks the viral entry and modulate the innate immune response in COVID-19 patients","author":"Maurya","year":"2020","journal-title":"ChemRxiv"},{"issue":"6","key":"10.1016\/j.jiph.2022.03.014_bib22","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.dsx.2020.09.027","article-title":"Ivermectin in COVID-19: What do we know?","volume":"14","author":"Pandey","year":"2020","journal-title":"Diabetes Metab Syndr"},{"issue":"4","key":"10.1016\/j.jiph.2022.03.014_bib23","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.bjid.2020.06.002","article-title":"Ivermectin: potential candidate for the treatment of Covid 19","volume":"24","author":"Gupta","year":"2020","journal-title":"Braz J Infect Dis: Publ Braz Soc Infect Dis"},{"key":"10.1016\/j.jiph.2022.03.014_bib24","first-page":"S2035","article-title":"Safety and efficacy review of doxycycline","volume":"1","author":"Holmes","year":"2009","journal-title":"Clin Med Ther"},{"issue":"21","key":"10.1016\/j.jiph.2022.03.014_bib25","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.3390\/molecules25215064","article-title":"In vitro antiviral activity of doxycycline against SARS-CoV-2","volume":"25","author":"Gendrot","year":"2020","journal-title":"Mol (Basel, Switz)"},{"issue":"5","key":"10.1016\/j.jiph.2022.03.014_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126360","article-title":"A combination of doxycycline and ribavirin alleviated Chikungunya infection","volume":"10","author":"Rothan","year":"2015","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.jiph.2022.03.014_bib27","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00705-013-1880-7","article-title":"Inhibitory effect of doxycycline against dengue virus replication in vitro","volume":"159","author":"Rothan","year":"2014","journal-title":"Arch Virol"},{"key":"10.1016\/j.jiph.2022.03.014_bib28","doi-asserted-by":"crossref","DOI":"10.1177\/1753466620951053","article-title":"Doxycycline treatment of high-risk COVID-19-positive patients with comorbid pulmonary disease","volume":"14","author":"Yates","year":"2020","journal-title":"Ther Adv Respir Dis"},{"issue":"3","key":"10.1016\/j.jiph.2022.03.014_bib29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.yexmp.2012.03.003","article-title":"Doxycycline treatment attenuates acute lung injury in mice infected with virulent influenza H3N2 virus: involvement of matrix metalloproteinases","volume":"92","author":"Ng","year":"2012","journal-title":"Exp Mol Pathol"},{"issue":"8","key":"10.1016\/j.jiph.2022.03.014_bib30","article-title":"Clinical outcomes of early treatment with doxycycline for 89 high-risk COVID-19 patients in long-term care facilities in New York","volume":"12","author":"Alam","year":"2020","journal-title":"Cureus"},{"issue":"3","key":"10.1016\/j.jiph.2022.03.014_bib31","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1128\/AAC.25.3.354","article-title":"Influence of tetracyclines on human polymorphonuclear leukocyte function","volume":"25","author":"Glette","year":"1984","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1016\/j.jiph.2022.03.014_bib32","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s12640-015-9592-2","article-title":"Doxycycline suppresses microglial activation by inhibiting the p38 MAPK and NF-kB signaling pathways","volume":"29","author":"Santa-Cec\u00edlia","year":"2016","journal-title":"Neurotox Res"},{"issue":"1","key":"10.1016\/j.jiph.2022.03.014_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/1574891X10666150410153839","article-title":"Dengue patients treated with doxycycline showed lower mortality associated to a reduction in IL-6 and TNF levels","volume":"10","author":"Fredeking","year":"2015","journal-title":"Recent Pat Anti-Infect Drug Discov"},{"key":"10.1016\/j.jiph.2022.03.014_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/370872","article-title":"Modulation of cytokine and cytokine receptor\/antagonist by treatment with doxycycline and tetracycline in patients with dengue fever","volume":"2011","author":"Castro","year":"2011","journal-title":"Clin Dev Immunol"},{"issue":"11","key":"10.1016\/j.jiph.2022.03.014_bib35","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1128\/AAC.47.11.3630-3633.2003","article-title":"Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines","volume":"47","author":"Krakauer","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiph.2022.03.014_bib36","article-title":"The pharmacology of acute lung injury in sepsis","volume":"2011","author":"Varisco","year":"2011","journal-title":"Adv Pharmacol Sci"},{"issue":"2","key":"10.1016\/j.jiph.2022.03.014_bib37","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaad.2005.10.004","article-title":"Tetracyclines: nonantibiotic properties and their clinical implications","volume":"54","author":"Sapadin","year":"2006","journal-title":"J Am Acad Dermatol"},{"issue":"10","key":"10.1016\/j.jiph.2022.03.014_bib38","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/archderm.1984.01650460048018","article-title":"Neutrophil chemotaxis in patients with acne receiving oral tetracycline therapy","volume":"120","author":"Esterly","year":"1984","journal-title":"Arch Dermatol"},{"issue":"2","key":"10.1016\/j.jiph.2022.03.014_bib39","first-page":"131","article-title":"The influence of divalent cations and doxycycline on iodoacetamide-inhibitable leukocyte adherence","volume":"74","author":"Gabler","year":"1991","journal-title":"Res Commun Chem Pathol Pharmacol"},{"issue":"6","key":"10.1016\/j.jiph.2022.03.014_bib40","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/0006-2952(92)90381-R","article-title":"Inhibition of the enzymatic activity of phospholipases A2 by minocycline and doxycycline","volume":"44","author":"Pruzanski","year":"1992","journal-title":"Biochem Pharmacol"},{"issue":"10","key":"10.1016\/j.jiph.2022.03.014_bib41","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1158\/1541-7786.MCR-13-0239","article-title":"Minocycline targets the NF-\u03baB Nexus through suppression of TGF-\u03b21-TAK1-I\u03baB signaling in ovarian cancer","volume":"11","author":"Ataie-Kachoie","year":"2013","journal-title":"Mol Cancer Res: MCR"},{"issue":"1","key":"10.1016\/j.jiph.2022.03.014_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00705-020-04860-8","article-title":"Tetracycline and viruses: a possible treatment for COVID-19?","volume":"166","author":"Mosquera-Sulbaran","year":"2021","journal-title":"Arch Virol"},{"issue":"3","key":"10.1016\/j.jiph.2022.03.014_bib43","doi-asserted-by":"crossref","first-page":"C539","DOI":"10.1152\/ajpcell.00047.2010","article-title":"Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature","volume":"299","author":"Griffin","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"10.1016\/j.jiph.2022.03.014_bib44","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.jinf.2020.06.061","article-title":"Distinct and early increase in circulating MMP-9 in COVID-19 patients with respiratory failure","volume":"81","author":"Ueland","year":"2020","journal-title":"J Infect"},{"issue":"2","key":"10.1016\/j.jiph.2022.03.014_bib45","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1128\/CMR.00047-08","article-title":"Matrix metalloproteinases as drug targets in infections caused by gram-negative bacteria and in septic shock","volume":"22","author":"Vanlaere","year":"2009","journal-title":"Clin Microbiol Rev"},{"issue":"100052","key":"10.1016\/j.jiph.2022.03.014_bib46","article-title":"Inhibition of metalloproteinases in therapy for severe lung injury due to COVID-19","volume":"7","author":"Solun","year":"2020","journal-title":"Med Drug Discov"},{"issue":"4","key":"10.1016\/j.jiph.2022.03.014_bib47","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00271-13","article-title":"Mechanisms of severe acute respiratory syndrome Coronavirus-induced acute lung injury","volume":"4","author":"Gralinski","year":"2013","journal-title":"MBio"},{"issue":"2","key":"10.1016\/j.jiph.2022.03.014_bib48","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1172\/JCI114217","article-title":"Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome","volume":"84","author":"Idell","year":"1989","journal-title":"J Clin Investig"},{"issue":"4693","key":"10.1016\/j.jiph.2022.03.014_bib49","first-page":"1487","volume":"227","author":"Dang","year":"1985","journal-title":"Disorganization Cult Vasc Endothel Cell monolayers fibrinogen Fragm D Sci (N Y, N Y )"},{"issue":"3","key":"10.1016\/j.jiph.2022.03.014_bib50","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3390\/biom11030390","article-title":"Targeting MMP-regulation of inflammation to increase metabolic tolerance to COVID-19 pathologies: A hypothesis","volume":"11","author":"Hardy","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jiph.2022.03.014_bib51","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.thromres.2020.04.013","article-title":"Incidence of thrombotic complications in critically ill ICU patients with COVID-19","volume":"191","author":"Klok","year":"2020","journal-title":"Thromb Res"},{"issue":"1","key":"10.1016\/j.jiph.2022.03.014_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1874091X02115010001","article-title":"Repositioning adequate antibiotics to treat\/cure the Coronavirus Disease 2019 (COVID-19): Current treatments and future directions","volume":"15","author":"Hountondji","year":"2021","journal-title":"Open Biochem J"},{"issue":"11","key":"10.1016\/j.jiph.2022.03.014_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001176","article-title":"Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture","volume":"6","author":"te Velthuis","year":"2010","journal-title":"PLoS Pathog"},{"issue":"45","key":"10.1016\/j.jiph.2022.03.014_bib54","doi-asserted-by":"crossref","first-page":"32433","DOI":"10.1074\/jbc.274.45.32433","article-title":"Zinc inhibits protein synthesis in neurons: Potential role of phosphorylation of translation initiation factor-2\u03b1","volume":"274","author":"Alirezaei","year":"1999","journal-title":"J Biol Chem"},{"issue":"23","key":"10.1016\/j.jiph.2022.03.014_bib55","doi-asserted-by":"crossref","first-page":"11486","DOI":"10.1128\/JVI.01314-08","article-title":"Role of Zn2+ ions in host-virus interactions","volume":"82","author":"Lazarczyk","year":"2008","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.jiph.2022.03.014_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.293","article-title":"Targeting endosomal acidification by chloroquine analogues as a promising strategy for the treatment of emerging viral diseases","volume":"5","author":"Al-Bari","year":"2017","journal-title":"Pharmacol Res Perspect"},{"issue":"22","key":"10.1016\/j.jiph.2022.03.014_bib57","doi-asserted-by":"crossref","DOI":"10.1093\/femsle\/fnv195","article-title":"Antiviral activity of doxycycline against vesicular stomatitis virus in vitro","volume":"362","author":"Wu","year":"2015","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.jiph.2022.03.014_bib58","unstructured":"An Outpatient Clinical Trial Using Ivermectin and Doxycycline in COVID-19 Positive Patients at High Risk to Prevent COVID-19 Related Hospitalization. (n.d.). Clinicaltrials.Gov. Retrieved February 22, 2022, from \u3008https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04729140\u3009."},{"key":"10.1016\/j.jiph.2022.03.014_bib59","unstructured":"Clinical Trial of Ivermectin Plus Doxycycline for the Treatment of Confirmed Covid-19 Infection. (n.d.). Clinicaltrials.Gov. Retrieved February 22, 2022, from \u3008https:\/\/clinicaltrials.gov\/ct2\/show\/results\/NCT04523831\u3009."},{"key":"10.1016\/j.jiph.2022.03.014_bib60","unstructured":"Effectiveness of Ivermectin and Doxycycline on COVID-19 Patients. (n.d.). Clinicaltrials.Gov. Retrieved February 22, 2022, from \u3008https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04591600\u3009."},{"key":"10.1016\/j.jiph.2022.03.014_bib61","unstructured":"Efficacy and Safety of Ivermectin and Doxycycline in Combination or IVE Alone in Patients With COVID-19 Infection. (n.d.). Clinicaltrials.Gov. Retrieved February 22, 2022, from \u3008https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT04407130\u3009."}],"container-title":["Journal of Infection and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876034122000727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876034122000727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T15:14:05Z","timestamp":1761750845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1876034122000727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S1876034122000727"],"URL":"https:\/\/doi.org\/10.1016\/j.jiph.2022.03.014","relation":{},"ISSN":["1876-0341"],"issn-type":[{"value":"1876-0341","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined therapy with ivermectin and doxycycline can effectively alleviate the cytokine storm of COVID-19 infection amid vaccination drive: A narrative review","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Public Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiph.2022.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences.","name":"copyright","label":"Copyright"}]}}