{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:52:23Z","timestamp":1786992743067,"version":"build-2736575974"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Public Health"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jiph.2022.05.008","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T18:58:37Z","timestamp":1652727517000},"page":"670-676","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Characteristics and outcomes of sepsis patients with and without COVID-19"],"prefix":"10.1016","volume":"15","author":[{"given":"Lars","family":"Heubner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Hattenhauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"G\u00fcldner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Leon","family":"Petrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"R\u00f6\u00dfler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns Christoph","family":"Held","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Mehrholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Bodechtel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Ragaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thea","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Markus","family":"Spieth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jiph.2022.05.008_bib1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"Jama"},{"issue":"10219","key":"10.1016\/j.jiph.2022.05.008_bib2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"issue":"46","key":"10.1016\/j.jiph.2022.05.008_bib3","first-page":"775","article-title":"Long-term survival following sepsis","volume":"117","author":"Schmidt","year":"2020","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.jiph.2022.05.008_bib4","doi-asserted-by":"crossref","first-page":"i2375","DOI":"10.1136\/bmj.i2375","article-title":"Late mortality after sepsis: propensity matched cohort study","volume":"353","author":"Prescott","year":"2016","journal-title":"Bmj"},{"issue":"9","key":"10.1016\/j.jiph.2022.05.008_bib5","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S2213-2600(20)30316-7","article-title":"Case characteristics, resource use, and outcomes of 10\u2008021 patients with COVID-19 admitted to 920 German hospitals: an observational study","volume":"8","author":"Karagiannidis","year":"2020","journal-title":"Lancet Respir Med"},{"issue":"1","key":"10.1016\/j.jiph.2022.05.008_bib6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s15010-020-01509-1","article-title":"Risk factors for Covid-19 severity and fatality: a structured literature review","volume":"49","author":"Wolff","year":"2021","journal-title":"Infection"},{"issue":"10229","key":"10.1016\/j.jiph.2022.05.008_bib7","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet."},{"issue":"32","key":"10.1016\/j.jiph.2022.05.008_bib8","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000026900","article-title":"The prognostic value of the SOFA score in patients with COVID-19: A retrospective, observational study","volume":"100","author":"Yang","year":"2021","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"10.1016\/j.jiph.2022.05.008_bib9","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.kint.2020.03.005","article-title":"Kidney disease is associated with in-hospital death of patients with COVID-19","volume":"97","author":"Cheng","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.jiph.2022.05.008_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105107","article-title":"Acute kidney injury is associated with severe infection and fatality in patients with COVID-19: A systematic review and meta-analysis of 40 studies and 24,527 patients","volume":"161","author":"Shao","year":"2020","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1016\/j.jiph.2022.05.008_bib11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jaci.2020.04.006","article-title":"Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan","volume":"146","author":"Li","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jiph.2022.05.008_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40364-020-00217-0","article-title":"A meta-analysis of potential biomarkers associated with severity of coronavirus disease 2019 (COVID-19)","volume":"8","author":"Danwang","year":"2020","journal-title":"Biomark Res"},{"key":"10.1016\/j.jiph.2022.05.008_bib13","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cca.2020.03.004","article-title":"Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis","volume":"505","author":"Lippi","year":"2020","journal-title":"Clin Chim Acta"},{"issue":"1","key":"10.1016\/j.jiph.2022.05.008_bib14","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1186\/s13054-020-03255-0","article-title":"Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China","volume":"24","author":"Zeng","year":"2020","journal-title":"Crit Care"},{"issue":"10","key":"10.1016\/j.jiph.2022.05.008_bib15","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1111\/all.14462","article-title":"Immunology of COVID-19: Mechanisms, clinical outcome, diagnostics, and perspectives-A report of the European Academy of Allergy and Clinical Immunology (EAACI)","volume":"75","author":"Sokolowska","year":"2020","journal-title":"Allergy"},{"issue":"3","key":"10.1016\/j.jiph.2022.05.008_bib16","doi-asserted-by":"crossref","first-page":"e219","DOI":"10.1097\/CCM.0000000000004899","article-title":"Surviving sepsis campaign guidelines on the management of adults with coronavirus disease 2019 (COVID-19) in the ICU: first update","volume":"49","author":"Alhazzani","year":"2021","journal-title":"Critical Care Medicine"},{"key":"10.1016\/j.jiph.2022.05.008_bib17","first-page":"1","article-title":"Recommendations for treatment of critically ill patients with COVID-19: Version 3 S1 guideline. Der","author":"Kluge","year":"2020","journal-title":"Anaesthesist"},{"key":"10.1016\/j.jiph.2022.05.008_bib18","unstructured":"Koch-Institut SAdK-uBfKdhEaR. Hinweise zu Erkennung, Diagnostik und Therapie von Patienten mit COVID-19. Online Ressource, 13082021: \u3008https:\/\/wwwrkide\/DE\/Content\/Kommissionen\/Stakob\/Stellungnahmen\/Stellungnahme-Covid-19_Therapie_Diagnosehtml\u3009. 2021."},{"issue":"8","key":"10.1016\/j.jiph.2022.05.008_bib19","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1056\/NEJMoa2021436","article-title":"Dexamethasone in Hospitalized Patients with Covid-19. The","volume":"384","author":"Horby","year":"2021","journal-title":"New England journal of medicine"},{"issue":"7","key":"10.1016\/j.jiph.2022.05.008_bib20","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","article-title":"The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine","volume":"22","author":"Vincent","year":"1996","journal-title":"Intensive Care Med"},{"issue":"5","key":"10.1016\/j.jiph.2022.05.008_bib21","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"issue":"6","key":"10.1016\/j.jiph.2022.05.008_bib22","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/aje\/kwq433","article-title":"Updating and validating the charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries","volume":"173","author":"Quan","year":"2011","journal-title":"Am J Epidemiol"},{"issue":"7","key":"10.1016\/j.jiph.2022.05.008_bib23","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/aje\/kwh090","article-title":"A Modified Poisson Regression Approach to Prospective Studies with Binary Data","volume":"159","author":"Zou","year":"2004","journal-title":"Am J Epidemiol"},{"issue":"8","key":"10.1016\/j.jiph.2022.05.008_bib24","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1007\/s00134-020-06151-x","article-title":"Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis","volume":"46","author":"Fleischmann-Struzek","year":"2020","journal-title":"Intensive Care Med"},{"issue":"2746","key":"10.1016\/j.jiph.2022.05.008_bib25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/bmj.2.2746.353","article-title":"Address in Pathology, ON CHEMIOTHERAPY: delivered before the Seventeenth International Congress of Medicine","volume":"2","author":"Ehrlich","year":"1913","journal-title":"Br Med J"},{"key":"10.1016\/j.jiph.2022.05.008_bib26","unstructured":"Leinlinie. AdWMFA-SK. S3-Leitlinie Sepsis - Pr\u00e4vention, Diagnose, Therapie und Nachsorge. Online Ressource Verf\u00fcgbar: \u3008https:\/\/wwwawmforg\/uploads\/tx_szleitlinien\/079\u2013001k_S3_Sepsis-Praevention-Diagnose-Therapie-Nachsorge_2020\u201302pdf\u3009 (Zugriff am 150621). 2018."},{"issue":"2","key":"10.1016\/j.jiph.2022.05.008_bib27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1001\/jamainternmed.2018.5849","article-title":"Association of corticosteroid treatment with outcomes in adult patients with sepsis: a systematic review and meta-analysis","volume":"179","author":"Fang","year":"2019","journal-title":"JAMA internal medicine"},{"issue":"11","key":"10.1016\/j.jiph.2022.05.008_bib28","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1007\/s00134-018-5377-4","article-title":"Challenges in assessing the burden of sepsis and understanding the inequalities of sepsis outcomes between National Health Systems: secular trends in sepsis and infection incidence and mortality in Germany","volume":"44","author":"Fleischmann-Struzek","year":"2018","journal-title":"Intensive Care Med"},{"issue":"4","key":"10.1016\/j.jiph.2022.05.008_bib29","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/1742-6723.13469","article-title":"The Australasian Resuscitation In Sepsis Evaluation: Fluids or vasopressors in emergency department sepsis (ARISE FLUIDS), a multi-centre observational study describing current practice in Australia and New Zealand","volume":"32","author":"Keijzers","year":"2020","journal-title":"Emerg Med Australas"},{"issue":"6","key":"10.1016\/j.jiph.2022.05.008_bib30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jcrc.2012.04.018","article-title":"Cross-validation of a Sequential Organ Failure Assessment score-based model to predict mortality in patients with cancer admitted to the intensive care unit","volume":"27","author":"C\u00e1rdenas-Turanzas","year":"2012","journal-title":"J Crit Care"},{"issue":"14","key":"10.1016\/j.jiph.2022.05.008_bib31","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1001\/jama.286.14.1754","article-title":"Serial evaluation of the SOFA score to predict outcome in critically ill patients","volume":"286","author":"Ferreira","year":"2001","journal-title":"Jama."},{"issue":"10141","key":"10.1016\/j.jiph.2022.05.008_bib32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"The Lancet"},{"issue":"10","key":"10.1016\/j.jiph.2022.05.008_bib33","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1111\/anae.15201","article-title":"Outcomes from intensive care in patients with COVID-19: a systematic review and meta-analysis of observational studies","volume":"75","author":"Armstrong","year":"2020","journal-title":"Anaesthesia."},{"issue":"10","key":"10.1016\/j.jiph.2022.05.008_bib34","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1001\/jamainternmed.2020.3539","article-title":"Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy","volume":"180","author":"Grasselli","year":"2020","journal-title":"JAMA Intern Med"},{"issue":"3","key":"10.1016\/j.jiph.2022.05.008_bib35","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S2213-2600(20)30527-0","article-title":"Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study","volume":"9","author":"Piroth","year":"2021","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jiph.2022.05.008_bib36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.thromres.2020.11.017","article-title":"Pulmonary embolism in COVID-19 patients: prevalence, predictors and clinical outcome","volume":"198","author":"Scudiero","year":"2021","journal-title":"Thrombosis research"},{"issue":"6","key":"10.1016\/j.jiph.2022.05.008_bib37","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.rce.2017.02.018","article-title":"Update on the risk stratification of acute symptomatic pulmonary thromboembolism","volume":"217","author":"Maestre Peir\u00f3","year":"2017","journal-title":"Rev Clin Esp (Barc)"},{"key":"10.1016\/j.jiph.2022.05.008_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejim.2022.01.035","article-title":"Pulmonary embolism severity and in-hospital mortality: An international comparative study between COVID-19 and non-COVID patients","author":"Mir\u00f3","year":"2022","journal-title":"Eur J Intern Med"},{"issue":"5","key":"10.1016\/j.jiph.2022.05.008_bib39","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/MCC.0000000000000861","article-title":"Sepsis in patients hospitalized with coronavirus disease 2019: how often and how severe?","volume":"27","author":"da Silva Ramos","year":"2021","journal-title":"Current Opinion in Critical Care"},{"key":"10.1016\/j.jiph.2022.05.008_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.chest.2021.04.002","article-title":"Hospital-acquired infections in critically ill patients with COVID-19","author":"Grasselli","year":"2021","journal-title":"Chest."},{"issue":"4","key":"10.1016\/j.jiph.2022.05.008_bib41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S2213-2600(20)30560-9","article-title":"Characterisation of the first 250,000 hospital admissions for COVID-19 in Brazil: a retrospective analysis of nationwide data","volume":"9","author":"Ranzani","year":"2021","journal-title":"Lancet Respir Med"},{"issue":"22","key":"10.1016\/j.jiph.2022.05.008_bib42","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000026131","article-title":"Serum IL-6 and procalcitonin are two promising novel biomarkers for evaluating the severity of COVID-19 patients","volume":"100","author":"Tang","year":"2021","journal-title":"Medicine"},{"issue":"1","key":"10.1016\/j.jiph.2022.05.008_bib43","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s13054-021-03720-4","article-title":"Machine learning identifies ICU outcome predictors in a multicenter COVID-19 cohort","volume":"25","author":"Magunia","year":"2021","journal-title":"Crit Care"}],"container-title":["Journal of Infection and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876034122001289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876034122001289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T15:12:25Z","timestamp":1761750745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1876034122001289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S1876034122001289"],"URL":"https:\/\/doi.org\/10.1016\/j.jiph.2022.05.008","relation":{},"ISSN":["1876-0341"],"issn-type":[{"value":"1876-0341","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characteristics and outcomes of sepsis patients with and without COVID-19","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Public Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiph.2022.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences.","name":"copyright","label":"Copyright"}]}}