{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:06:57Z","timestamp":1791979617621,"version":"4.4.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006013","name":"United Arab Emirates University","doi-asserted-by":"publisher","award":["G00004321"],"award-info":[{"award-number":["G00004321"]}],"id":[{"id":"10.13039\/501100006013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Public Health"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jiph.2025.102761","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T13:35:55Z","timestamp":1742304955000},"page":"102761","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genomic approach to evaluate the intrinsic antibacterial activity of novel diazabicyclooctanes (zidebactam and nacubactam) against clinical Escherichia coli isolates from diverse clonal lineages in the United Arab Emirates"],"prefix":"10.1016","volume":"18","author":[{"given":"Farah","family":"Al-Marzooq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2552-4807","authenticated-orcid":false,"given":"Akela","family":"Ghazawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maitha","family":"Alshamsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Alzaabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6761-2695","authenticated-orcid":false,"given":"Omar","family":"Aleissaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamad","family":"Almansoori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Alsaadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rauda","family":"Aldhaheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafsa","family":"Ahli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9501-6678","authenticated-orcid":false,"given":"Lana","family":"Daoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amna","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Collyns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0728-7783","authenticated-orcid":false,"given":"Seema","family":"Oommen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jiph.2025.102761_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5419874","article-title":"Multidrug-resistant bacteria: their mechanism of action and prophylaxis","volume":"2022","author":"Bharadwaj","year":"2022","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.jiph.2025.102761_bib2","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/j.drudis.2019.08.004","article-title":"Superbugs but no drugs: steps in averting a post-antibiotic era","volume":"24","author":"Hamad","year":"2019","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.jiph.2025.102761_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002184","article-title":"Will 10 million people die a year due to antimicrobial resistance by 2050?","volume":"13","author":"de Kraker","year":"2016","journal-title":"PLOS Med"},{"key":"10.1016\/j.jiph.2025.102761_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abo7793","article-title":"The past, present, and future of antibiotics","volume":"14","author":"Cook","year":"2022","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jiph.2025.102761_bib5","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3390\/antibiotics13030260","article-title":"Role of \u03b2-lactamase inhibitors as potentiators in antimicrobial chemotherapy targeting Gram-negative bacteria","volume":"13","author":"Zhang","year":"2024","journal-title":"Antibiotics"},{"key":"10.1016\/j.jiph.2025.102761_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2024.107228","article-title":"Metallo-\u03b2-lactamase inhibitors: a continuing challenge for combating antibiotic resistance","volume":"309","author":"Kang","year":"2024","journal-title":"Biophys Chem"},{"key":"10.1016\/j.jiph.2025.102761_bib7","first-page":"713","article-title":"Review of novel \u03b2-lactams and \u03b2-lactam\/\u03b2-lactamase inhibitor combinations with implications for pediatric use","volume":"43","author":"Olney","year":"2023","journal-title":"Pharm: J Hum Pharmacol Drug Ther"},{"key":"10.1016\/j.jiph.2025.102761_bib8","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1080\/14656566.2019.1660772","article-title":"The latest advances in \u03b2-lactam\/\u03b2-lactamase inhibitor combinations for the treatment of Gram-negative bacterial infections","volume":"20","author":"Papp-Wallace","year":"2019","journal-title":"Expert Opin Pharm"},{"key":"10.1016\/j.jiph.2025.102761_bib9","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1021\/acs.jmedchem.8b00091","article-title":"Strategic approaches to overcome resistance against gram-negative pathogens using \u03b2-lactamase inhibitors and \u03b2-lactam enhancers: activity of three novel diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234","volume":"61","author":"Papp-Wallace","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.jiph.2025.102761_bib10","article-title":"Bicyclic Boronate \u03b2-lactamase inhibitors: the present hope against deadly bacterial pathogens","volume":"4","author":"Lence","year":"2021","journal-title":"Adv Ther"},{"key":"10.1016\/j.jiph.2025.102761_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2022.127249","article-title":"Global spread of carbapenem-resistant Enterobacteriaceae: epidemiological features, resistance mechanisms, detection and therapy","volume":"266","author":"Ma","year":"2023","journal-title":"Microbiol Res"},{"key":"10.1016\/j.jiph.2025.102761_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01676-21","article-title":"Assessment of activity and resistance mechanisms to cefepime in combination with the novel \u03b2-lactamase inhibitors Zidebactam, Taniborbactam, and Enmetazobactam against a multicenter collection of carbapenemase-producing enterobacterales","volume":"66","author":"V\u00e1zquez-Ucha","year":"2022","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiph.2025.102761_bib13","doi-asserted-by":"crossref","DOI":"10.1093\/trstmh\/trae049","article-title":"Difficult to treat Pseudomonas: successful salvage therapy with cefepime-zidebactam","author":"Sebastian","year":"2024","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.jiph.2025.102761_bib14","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00500-23","article-title":"Successful use of cefepime-zidebactam (WCK 5222) as a salvage therapy for the treatment of disseminated extensively drug-resistant New Delhi metallo-\u03b2-lactamase-producing Pseudomonas aeruginosa infection in an adult patient with acute T-cell leukemia","volume":"67","author":"Tirlangi","year":"2023","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiph.2025.102761_bib15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrmicro818","article-title":"Pathogenic Escherichia coli.","volume":"2","author":"Kaper","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jiph.2025.102761_bib16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jiph.2023.11.003","article-title":"High efficacy and enhanced synergistic activity of the novel siderophore-cephalosporin cefiderocol against multidrug-resistant and extensively drug-resistant Klebsiella pneumoniae from inpatients attending a single hospital in the United Arab Emirates","volume":"16","author":"Daoud","year":"2023","journal-title":"J Infect Public Health"},{"key":"10.1016\/j.jiph.2025.102761_bib17","unstructured":"CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 34rd ed. 2024."},{"key":"10.1016\/j.jiph.2025.102761_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0277946","article-title":"Elucidating the effect of iron acquisition systems in Klebsiella pneumoniae on susceptibility to the novel siderophore-cephalosporin cefiderocol","volume":"17","author":"Daoud","year":"2022","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jiph.2025.102761_bib19","unstructured":"EUCAST: Clinical breakpoints and dosing of antibiotics n.d. \u3008https:\/\/www.eucast.org\/clinical_breakpoints\u3009 (accessed July 8, 2024)."},{"key":"10.1016\/j.jiph.2025.102761_bib20","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/CMR.18.4.657-686.2005","article-title":"Extended-spectrum \u03b2-lactamases: a clinical update","volume":"18","author":"Paterson","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jiph.2025.102761_bib21","doi-asserted-by":"crossref","DOI":"10.1177\/1178633720909798","article-title":"Extended-spectrum \u03b2-lactamase-producing Escherichia coli and Klebsiella species in pediatric patients visiting international friendship children\u2019s hospital, Kathmandu, Nepal","volume":"13","author":"Kayastha","year":"2020","journal-title":"Infect Dis (Auckl)"},{"key":"10.1016\/j.jiph.2025.102761_bib22","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jiph.2025.102761_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.998671","article-title":"Discerning the role of polymyxin B nonapeptide in restoring the antibacterial activity of azithromycin against antibiotic-resistant Escherichia coli.","volume":"13","author":"Al-Marzooq","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jiph.2025.102761_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133654","article-title":"Molecular analysis of antibiotic resistance determinants and plasmids in malaysian isolates of multidrug resistant Klebsiella pneumoniae.","volume":"10","author":"Al-Marzooq","year":"2015","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jiph.2025.102761_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1336856","article-title":"Antimicrobial activity of nature-inspired molecules against multidrug-resistant bacteria","volume":"14","author":"Hamad","year":"2024","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jiph.2025.102761_bib26","doi-asserted-by":"crossref","first-page":"8662","DOI":"10.3390\/ijms24108662","article-title":"Boosting the antibacterial activity of azithromycin on multidrug-resistant Escherichia coli by efflux pump inhibition coupled with outer membrane permeabilization induced by Phenylalanine-Arginine \u03b2-Naphthylamide","volume":"24","author":"Al-Marzooq","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jiph.2025.102761_bib27","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s13404-014-0144-y","article-title":"In vitro antibacterial and time-kill evaluation of phosphanegold(I) dithiocarbamates, R3PAu[S2CN(iPr)CH2CH2OH] for R =\u2009Ph, Cy and Et, against a broad range of Gram-positive and Gram-negative bacteria","volume":"47","author":"Sim","year":"2014","journal-title":"Gold Bull"},{"key":"10.1016\/j.jiph.2025.102761_bib28","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1101\/gr.232397.117","article-title":"GrapeTree: visualization of core genomic relationships among 100,000 bacterial pathogens","volume":"28","author":"Zhou","year":"2018","journal-title":"Genome Res"},{"key":"10.1016\/j.jiph.2025.102761_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1377993","article-title":"Genomic insights into the diversity, virulence, and antimicrobial resistance of group B Streptococcus clinical isolates from Saudi Arabia","volume":"14","author":"Alzayer","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jiph.2025.102761_bib30","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1099\/mic.0.055459-0","article-title":"Ribosomal multilocus sequence typing: universal characterization of bacteria from domain to strain","volume":"158","author":"Jolley","year":"2012","journal-title":"Microbiol (Read)"},{"key":"10.1016\/j.jiph.2025.102761_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.01729","article-title":"Comparison of whole genome (wg-) and Core Genome (cg-) MLST (BioNumericsTM) versus snp variant calling for epidemiological investigation of Pseudomonas aeruginosa.","volume":"11","author":"Blanc","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jiph.2025.102761_bib32","article-title":"ClermonTyping: an easy-to-use and accurate in silico method for Escherichia genus strain phylotyping","volume":"4","author":"Beghain","year":"2018","journal-title":"Micro Genom"},{"key":"10.1016\/j.jiph.2025.102761_bib33","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/1758-2229.12019","article-title":"Escherichia coli phylo-typing method revisited: improvement of specificity and detection of new phylo-groups","volume":"5","author":"Clermont","year":"2013","journal-title":"Environ Microbiol Rep"},{"key":"10.1016\/j.jiph.2025.102761_bib34","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.3201\/eid2909.230390","article-title":"Population analysis of Escherichia coli sequence type 361 and reduced cefiderocol susceptibility, France","volume":"29","author":"Jousset","year":"2023","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jiph.2025.102761_bib35","doi-asserted-by":"crossref","first-page":"52","DOI":"10.5395\/rde.2013.38.1.52","article-title":"Statistical notes for clinical researchers: assessing normal distribution (2) using skewness and kurtosis","volume":"38","author":"Kim","year":"2013","journal-title":"Restor Dent Endod"},{"key":"10.1016\/j.jiph.2025.102761_bib36","series-title":"From data to insights: a beginner\u2019s guide to cross-tabulation analysis","author":"Alberti","year":"2024"},{"key":"10.1016\/j.jiph.2025.102761_bib37","first-page":"4","article-title":"Dry antibiotic pipeline: Regulatory bottlenecks and regulatory reforms","volume":"5","author":"Gupta","year":"2014","journal-title":"J Pharmacol Pharm"},{"key":"10.1016\/j.jiph.2025.102761_bib38","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/jac\/dkab067","article-title":"Activity of cefepime\/zidebactam (WCK 5222) against \u201cproblem\u201d antibiotic-resistant Gram-negative bacteria sent to a national reference laboratory","volume":"76","author":"Mushtaq","year":"2021","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jiph.2025.102761_bib39","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000319912","article-title":"Molecular characterization and epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates in the United Arab Emirates","volume":"20","author":"Alfaresi","year":"2011","journal-title":"Med Princ Pr"},{"key":"10.1016\/j.jiph.2025.102761_bib40","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1007\/s11033-021-06814-y","article-title":"Identification of metallo-\u03b2-lactamases and AmpC production among Escherichia coli strains isolated from hemodialysis patients with urinary tract infection","volume":"48","author":"Bahramian","year":"2021","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.jiph.2025.102761_bib41","article-title":"Relative inhibitory activities of newly developed diazabicyclooctanes, boronic acid derivatives, and penicillin-based sulfone \u03b2-lactamase inhibitors against broad-spectrum AmpC \u03b2-lactamases","volume":"68","author":"Le Terrier","year":"2024","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiph.2025.102761_bib42","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1574-6976.2006.00024.x","article-title":"Penicillin binding proteins: key players in bacterial cell cycle and drug resistance processes","volume":"30","author":"Macheboeuf","year":"2006","journal-title":"FEMS Microbiol Rev"},{"issue":"3","key":"10.1016\/j.jiph.2025.102761_bib43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1469-0691.2000.tb02038.x","article-title":"The final goal: penicillin-binding proteins and the target of cephalosporins","volume":"6","author":"Fontana","year":"2000","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jiph.2025.102761_bib44","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00074-19","article-title":"Identification of mutations in the Mrda gene encoding PBP2 that reduce carbapenem and diazabicyclooctane susceptibility of Escherichia coli clinical isolates with mutations in ftsI (PBP3) and which carry blaNDM-1","volume":"4","author":"Ranjitkar","year":"2019","journal-title":"mSphere"},{"key":"10.1016\/j.jiph.2025.102761_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2024.107150","article-title":"Activity of cefiderocol and innovative \u03b2-lactam\/\u03b2-lactamase inhibitor combinations against isogenic strains of Escherichia coli expressing single and double \u03b2-lactamases under high and low permeability conditions","volume":"63","author":"Blanco-Mart\u00edn","year":"2024","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiph.2025.102761_bib46","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1093\/jac\/dku568","article-title":"Characterization of Escherichia coli NDM isolates with decreased susceptibility to aztreonam\/avibactam: role of a novel insertion in PBP3","volume":"70","author":"Alm","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jiph.2025.102761_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2024.107256","article-title":"Resistance to aztreonam-avibactam among clinical isolates of Escherichia coli is primarily mediated by altered penicillin-binding protein 3 and impermeability","volume":"64","author":"Tellapragada","year":"2024","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiph.2025.102761_bib48","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.3390\/antibiotics13121158","article-title":"Novel variant of New Delhi metallo-beta-lactamase (blaNDM-60) discovered in a clinical strain of Escherichia coli from the United Arab Emirates: an emerging challenge in antimicrobial resistance","volume":"13","author":"Al-Marzooq","year":"2024","journal-title":"Antibiotics"},{"key":"10.1016\/j.jiph.2025.102761_bib49","doi-asserted-by":"crossref","DOI":"10.1007\/s10096-025-05082-z","article-title":"Deciphering the genetic context of the emerging OXA-484-producing carbapenem-resistant Escherichia coli from ST167 high-risk clone in the United Arab Emirates","author":"Al-Marzooq","year":"2025","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jiph.2025.102761_bib50","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/jac\/dky476","article-title":"Characterization of mutations in Escherichia coli PBP2 leading to increased carbapenem MICs","volume":"74","author":"Lange","year":"2019","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jiph.2025.102761_bib51","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/jac\/dkv318","article-title":"A new mechanism to render clinical isolates of Escherichia coli non-susceptible to imipenem: substitutions in the PBP2 penicillin-binding domain","volume":"71","author":"Aissa","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jiph.2025.102761_bib52","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10822-014-9809-0","article-title":"Proteochemometric model for predicting the inhibition of penicillin-binding proteins","volume":"29","author":"Nabu","year":"2015","journal-title":"J Comput Aided Mol Des"},{"key":"10.1016\/j.jiph.2025.102761_bib53","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1574-6976.2008.00105.x","article-title":"The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis","volume":"32","author":"Sauvage","year":"2008","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.jiph.2025.102761_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2023.106877","article-title":"Mechanisms of ceftazidime\/avibactam resistance in drug-na\u00efve bacteraemic Enterobacterales strains without metallo-beta-lactamase production: Associated with ceftazidime impedance","volume":"62","author":"Xiong","year":"2023","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiph.2025.102761_bib55","doi-asserted-by":"crossref","first-page":"314","DOI":"10.7164\/antibiotics.43.314","article-title":"T. Comparison of two carbapenems, SM-7338 and imipenem: affinities for penicillin-binding proteins and morphological changes","volume":"43","author":"Sumita","year":"1990","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.jiph.2025.102761_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.812544","article-title":"The resistance mechanism governs physiological adaptation of Escherichia coli to growth with sublethal concentrations of carbapenem","volume":"12","author":"Sch\u00e4fer","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jiph.2025.102761_bib57","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00115-18","article-title":"NDM metallo-\u03b2-lactamases and their bacterial producers in health care settings","volume":"32","author":"Wu","year":"2019","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jiph.2025.102761_bib58","doi-asserted-by":"crossref","DOI":"10.1128\/aac.01339-23","article-title":"Escherichia coli sequence type 410 with carbapenemases: a paradigm shift within E. coli toward multidrug resistance","volume":"68","author":"Pitout","year":"2024","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiph.2025.102761_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2022.106649","article-title":"High-risk lineages among extended-spectrum \u03b2-lactamase-producing Escherichia coli from extraintestinal infections in Maputo Central Hospital, Mozambique","volume":"60","author":"Santona","year":"2022","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jiph.2025.102761_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1387497","article-title":"A review of the mechanisms that confer antibiotic resistance in pathotypes of E. coli.","volume":"14","author":"Nasrollahian","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jiph.2025.102761_bib61","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1128\/AAC.02788-15","article-title":"First characterization of CTX-M-15-producing Escherichia coli strains belonging to sequence type (ST) 410, ST224, and ST1284 from commercial swine in South America","volume":"60","author":"Silva","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jiph.2025.102761_bib62","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1093\/jac\/dku218","article-title":"Identification of fluoroquinolone-resistant extended-spectrum \u03b2-lactamase (CTX-M-8)-producing Escherichia coli ST224, ST2179 and ST2308 in buffalo (Bubalus bubalis)","volume":"69","author":"Aizawa","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jiph.2025.102761_bib63","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3390\/genes14040875","article-title":"Occurrence of high-risk clonal lineages ST58, ST69, ST224, and ST410 among extended-spectrum \u03b2-lactamase-producing Escherichia coli isolated from healthy free-range chickens (Gallus gallus domesticus) in a rural region in Tunisia","volume":"14","author":"Benlabidi","year":"2023","journal-title":"Genes"}],"container-title":["Journal of Infection and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876034125001108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876034125001108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:15:37Z","timestamp":1778829337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1876034125001108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1876034125001108"],"URL":"https:\/\/doi.org\/10.1016\/j.jiph.2025.102761","relation":{},"ISSN":["1876-0341"],"issn-type":[{"value":"1876-0341","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic approach to evaluate the intrinsic antibacterial activity of novel diazabicyclooctanes (zidebactam and nacubactam) against clinical Escherichia coli isolates from diverse clonal lineages in the United Arab Emirates","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Public Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiph.2025.102761","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences.","name":"copyright","label":"Copyright"}],"article-number":"102761"}}