{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:05:31Z","timestamp":1785247531270,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012232","name":"National Key Clinical Specialty Discipline Construction Program of China","doi-asserted-by":"publisher","award":["BYSYDL2019007"],"award-info":[{"award-number":["BYSYDL2019007"]}],"id":[{"id":"10.13039\/501100012232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["BYSYZD2022007"],"award-info":[{"award-number":["BYSYZD2022007"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["BMU2024BSS001"],"award-info":[{"award-number":["BMU2024BSS001"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009399","name":"Peking University Third Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Public Health"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jiph.2026.103161","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T15:51:35Z","timestamp":1769874695000},"page":"103161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk factors, clinical outcomes of patients with Ceftazidime\/Avibactam-resistant carbapenem-Resistant Klebsiella pneumoniae infection and its potential resistant mechanisms"],"prefix":"10.1016","volume":"19","author":[{"given":"Zhenchao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9161-7075","authenticated-orcid":false,"given":"Yanqiu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du","family":"Yipeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jiph.2026.103161_bib1","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41564-024-01612-1","article-title":"Carbapenem-resistant Klebsiella pneumoniae capsular types, antibiotic resistance and virulence factors in China: a longitudinal, multi-centre study","volume":"9","author":"Hu","year":"2024","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jiph.2026.103161_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101083","article-title":"Expansion and transmission dynamics of high risk carbapenem-resistant Klebsiella pneumoniae subclones in China: an epidemiological, spatial, genomic analysis","volume":"74","author":"Wang","year":"2024","journal-title":"Drug Resist Updat"},{"issue":"10","key":"10.1016\/j.jiph.2026.103161_bib3","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/s41579-024-01054-w","article-title":"ESKAPE pathogens: antimicrobial resistance, epidemiology, clinical impact and therapeutics","volume":"22","author":"Miller","year":"2024","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jiph.2026.103161_bib4","article-title":"Relationship between biofilm formation and antibiotic resistance of Klebsiella pneumoniae and updates on antibiofilm therapeutic strategies","volume":"14","author":"Li","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"10.1016\/j.jiph.2026.103161_bib5","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02786-22","article-title":"Emergence and Inter- and Intrahost Evolution of Pandrug-Resistant Klebsiella pneumoniae Coharboring tmexCD1-toprJ1, bla(NDM-1), and bla(KPC-2)","volume":"11","author":"Liu","year":"2023","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jiph.2026.103161_bib6","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.2147\/IDR.S411056","article-title":"Clinical and molecular profile of carbapenem resistant Klebsiella pneumoniae infections in a Tertiary Care Hospital -Mangalore","volume":"16","author":"Pattolath","year":"2023","journal-title":"Infect Drug Resist"},{"key":"10.1016\/j.jiph.2026.103161_bib7","unstructured":"Hu, F.D., L. Guo, Y. et al. CHINET report - Carbapenem Resistant Ratio in Klebsiella pneumoniae Infection (2005-2024); Available from: \u3008https:\/\/www.chinets.com\/Data\/AntibioticDrugFast\u3009 ( accessed 19 Februray 2025)."},{"key":"10.1016\/j.jiph.2026.103161_bib8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2147\/IDR.S494208","article-title":"Molecular characterization and risk factors of carbapenem-resistant hypervirulent Klebsiella pneumoniae isolated from Chinese Tertiary Hospital","volume":"18","author":"Zhu","year":"2025","journal-title":"Infect Drug Resist"},{"issue":"1","key":"10.1016\/j.jiph.2026.103161_bib9","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/s42003-021-02148-4","article-title":"Clinical evolution of ST11 carbapenem resistant and hypervirulent Klebsiella pneumoniae","volume":"4","author":"Xie","year":"2021","journal-title":"Commun Biol"},{"key":"10.1016\/j.jiph.2026.103161_bib10","doi-asserted-by":"crossref","first-page":"i47","DOI":"10.1093\/jac\/dkaa497","article-title":"Role of new antibiotics for KPC-producing Klebsiella pneumoniae","volume":"76","author":"Theuretzbacher","year":"2021","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jiph.2026.103161_bib11","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jgar.2021.04.001","article-title":"Resistance to ceftazidime\/avibactam in infections and colonisations by KPC-producing Enterobacterales: a systematic review of observational clinical studies","volume":"25","author":"Di Bella","year":"2021","journal-title":"J Glob Antimicrob Resist"},{"issue":"2","key":"10.1016\/j.jiph.2026.103161_bib12","article-title":"Carbapenem-Resistant Klebsiella pneumoniae: virulence factors, molecular epidemiology and latest updates in treatment options","volume":"12","author":"Karampatakis","year":"2023","journal-title":"Antibiot (Basel)"},{"issue":"4","key":"10.1016\/j.jiph.2026.103161_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/jfb13040174","article-title":"Meropenem\/vaborbactam and cefiderocol as combination or monotherapy to treat multi-drug resistant gram-negative infections: a regional cross-sectional survey from Piedmont Infectious Disease Unit Network (PIDUN)","volume":"13","author":"Lupia","year":"2022","journal-title":"J Funct Biomater"},{"issue":"1","key":"10.1016\/j.jiph.2026.103161_bib14","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2024.2426481","article-title":"Overexpression of bla(SHV-12) caused by tandem amplification contributed to ceftazidime\/avibactam resistance in hypervirulent and carbapenem-resistant Klebsiella pneumoniae","volume":"13","author":"Liu","year":"2024","journal-title":"Emerg Microbes Infect"},{"issue":"5","key":"10.1016\/j.jiph.2026.103161_bib15","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02497-17","article-title":"Pneumonia and renal replacement therapy are risk factors for Ceftazidime-Avibactam TReatment Failures and Resistance among Patients With Carbapenem-Resistant enterobacteriaceae infections","volume":"62","author":"Shields","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"issue":"11","key":"10.1016\/j.jiph.2026.103161_bib16","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1016\/j.jfma.2021.04.014","article-title":"Healthcare-associated carbapenem-resistant Klebsiella pneumoniae bloodstream infections: Risk factors, mortality, and antimicrobial susceptibility, 2017-2019","volume":"120","author":"Hsu","year":"2021","journal-title":"J Formos Med Assoc"},{"issue":"2","key":"10.1016\/j.jiph.2026.103161_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2024.107244","article-title":"Mechanisms and fitness of Ceftazidime\/avibactam-resistant Klebsiella pneumoniae clinical strains in Taiwan","volume":"64","author":"Chou","year":"2024","journal-title":"Int J Antimicrob Agents"},{"issue":"5","key":"10.1016\/j.jiph.2026.103161_bib18","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s15010-022-01781-3","article-title":"Risk factors for and clinical outcomes of ceftazidime-avibactam-resistant carbapenem-resistant Klebsiella pneumoniae nosocomial infections: a single-center retrospective study","volume":"50","author":"Liu","year":"2022","journal-title":"Infection"},{"key":"10.1016\/j.jiph.2026.103161_bib19","unstructured":"CaLS, I. Performance Standards for Antimicrobial Susceptibility Testing, 30th ed. 2020; Available from: \u3008https:\/\/clsi.org\/standards\/products\/microbiology\/documents\/m100\/\u3009 (accessed 19 Februray 2025)."},{"issue":"1","key":"10.1016\/j.jiph.2026.103161_bib20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10096-023-04712-8","article-title":"Prevalence and mortality of Ceftazidime\/avibactam-resistant KPC-producing Klebsiella pneumoniae bloodstream infections (2018-2022)","volume":"43","author":"Boattini","year":"2024","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jiph.2026.103161_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2025.128049","article-title":"Rapid emergence, transmission, and evolution of KPC and NDM coproducing carbapenem-resistant Klebsiella pneumoniae","volume":"293","author":"Li","year":"2025","journal-title":"Microbiol Res"},{"issue":"12","key":"10.1016\/j.jiph.2026.103161_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms12122548","article-title":"A decade-long review of the virulence, resistance, and epidemiological risks of Klebsiella pneumoniae in ICUs","volume":"12","author":"Chen","year":"2024","journal-title":"Microorganisms"},{"issue":"3","key":"10.1016\/j.jiph.2026.103161_bib23","article-title":"Risk factors and outcomes of community-acquired Carbapenem-Resistant Klebsiella pneumoniae Infection in Elderly Patients","volume":"13","author":"Chen","year":"2024","journal-title":"Antibiot (Basel)"},{"key":"10.1016\/j.jiph.2026.103161_bib24","unstructured":"Organization, W.H. WHO publishes list of bacteria for which new antibiotics are urgently needed. 2017; Available from: \u3008https:\/\/www.who.int\/news\/item\/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed\u3009 (accessed 25 Februray 2025)."},{"issue":"5","key":"10.1016\/j.jiph.2026.103161_bib25","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s40121-022-00682-0","article-title":"Ceftazidime\/Avibactam-based versus polymyxin B-based therapeutic regimens for the treatment of Carbapenem-Resistant Klebsiella pneumoniae infection in critically Ill patients: a retrospective cohort study","volume":"11","author":"Zheng","year":"2022","journal-title":"Infect Dis Ther"},{"key":"10.1016\/j.jiph.2026.103161_bib26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jgar.2021.04.022","article-title":"Ceftazidime-avibactam in the treatment of infections from carbapenem-resistant Klebsiella pneumoniae: Ceftazidime-avibactam against CR-KP infections","volume":"26","author":"Gu","year":"2021","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.jiph.2026.103161_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106090","article-title":"Efficacy and safety of ceftazidime-avibactam compared to other antimicrobials for the treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae strains, a systematic review and meta-analysis","volume":"179","author":"Karampatakis","year":"2023","journal-title":"Micro Pathog"},{"issue":"6","key":"10.1016\/j.jiph.2026.103161_bib28","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s15010-022-01876-x","article-title":"Update of clinical application in ceftazidime-avibactam for multidrug-resistant Gram-negative bacteria infections","volume":"50","author":"Zhen","year":"2022","journal-title":"Infection"},{"issue":"9","key":"10.1016\/j.jiph.2026.103161_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00447-22","article-title":"Klebsiella pneumoniae Carbapenemase variants resistant to Ceftazidime-Avibactam: an evolutionary overview","volume":"66","author":"Hobson","year":"2022","journal-title":"Antimicrob Agents Chemother"},{"issue":"8","key":"10.1016\/j.jiph.2026.103161_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00883-17","article-title":"Ceftazidime-Avibactam is superior to other treatment regimens against Carbapenem-Resistant Klebsiella pneumoniae Bacteremia","volume":"61","author":"Shields","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"10.1016\/j.jiph.2026.103161_bib31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10096-024-05005-4","article-title":"Ceftazidime-avibactam tolerance and persistence among difficult-to-treat KPC-producing Klebsiella pneumoniae clinical isolates from bloodstream infections","volume":"44","author":"Abichabki","year":"2025","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jiph.2026.103161_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1450530","article-title":"Overexpression of KPC contributes to ceftazidime-avibactam heteroresistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae","volume":"14","author":"Li","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jiph.2026.103161_bib33","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.2147\/IDR.S298530","article-title":"Risk factors for and clinical outcomes of Carbapenem-Resistant Klebsiella pneumoniae nosocomial infections: a retrospective study in a Tertiary Hospital in Beijing, China","volume":"14","author":"Zhang","year":"2021","journal-title":"Infect Drug Resist"},{"issue":"1","key":"10.1016\/j.jiph.2026.103161_bib34","doi-asserted-by":"crossref","first-page":"5102","DOI":"10.1038\/s41598-025-88965-7","article-title":"Synergistic combination of ceftazidime and avibactam with Aztreonam against MDR Klebsiella pneumoniae in ICU patients","volume":"15","author":"Khattab","year":"2025","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jiph.2026.103161_bib35","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/jac\/dkae451","article-title":"A systematic review and individual bacterial species level meta-analysis of in vitro studies on the efficacy of Ceftazidime\/Avibactam combined with other antimicrobials against carbapenem-resistant Gram-negative bacteria","volume":"80","author":"Assefa","year":"2025","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"10.1016\/j.jiph.2026.103161_bib36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13756-020-0686-0","article-title":"Risk factors for carbapenem-resistant Klebsiella pneumoniae infection relative to two types of control patients: a systematic review and meta-analysis","volume":"9","author":"Zhu","year":"2020","journal-title":"Antimicrob Resist Infect Control"},{"issue":"2","key":"10.1016\/j.jiph.2026.103161_bib37","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1179\/2047773215Y.0000000004","article-title":"Risk factors for carbapenem-resistant Klebsiella pneumoniae infection\/colonization and predictors of mortality: a retrospective study","volume":"109","author":"Jiao","year":"2015","journal-title":"Pathog Glob Health"},{"issue":"12","key":"10.1016\/j.jiph.2026.103161_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111471","article-title":"Genomic characterization of ST11-KL25 hypervirulent KPC-2-producing multidrug-resistant Klebsiella pneumoniae from China","volume":"27","author":"Kang","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.jiph.2026.103161_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2024.127839","article-title":"Hypervirulent and carbapenem-resistant Klebsiella pneumoniae: a global public health threat","volume":"288","author":"Lei","year":"2024","journal-title":"Microbiol Res"},{"issue":"3","key":"10.1016\/j.jiph.2026.103161_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2024.107411","article-title":"Characterization of a novel KPC-2 variant, KPC-228, conferring resistance to ceftazidime-avibactam in an ST11-KL64 hypervirulent Klebsiella pneumoniae","volume":"65","author":"Zhou","year":"2025","journal-title":"Int J Antimicrob Agents"},{"issue":"6","key":"10.1016\/j.jiph.2026.103161_bib41","article-title":"Hybrid cell membrane-engineered nanocarrier for triple-action strategy to address pseudomonas aeruginosa infection","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.jiph.2026.103161_bib42","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.jconrel.2025.02.024","article-title":"Activated platelet membrane vesicles for broad-spectrum bacterial pulmonary infections management","volume":"380","author":"Wei","year":"2025","journal-title":"J Control Release"}],"container-title":["Journal of Infection and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187603412600033X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187603412600033X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:21:47Z","timestamp":1782199307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187603412600033X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S187603412600033X"],"URL":"https:\/\/doi.org\/10.1016\/j.jiph.2026.103161","relation":{},"ISSN":["1876-0341"],"issn-type":[{"value":"1876-0341","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk factors, clinical outcomes of patients with Ceftazidime\/Avibactam-resistant carbapenem-Resistant Klebsiella pneumoniae infection and its potential resistant mechanisms","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Public Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiph.2026.103161","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences.","name":"copyright","label":"Copyright"}],"article-number":"103161"}}