{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T20:25:11Z","timestamp":1776198311805,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["2024-NI-018-01"],"award-info":[{"award-number":["2024-NI-018-01"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection and Public Health"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jiph.2026.103215","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T15:14:00Z","timestamp":1774883640000},"page":"103215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive analysis of antimicrobial resistance and virulence determinants in clinical methicillin-resistant Staphylococcus aureus isolates collected in South Korea"],"prefix":"10.1016","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3424-9210","authenticated-orcid":false,"given":"Du-Gyeong","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Sik","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0825-9057","authenticated-orcid":false,"given":"Se-Mi","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jiph.2026.103215_bib1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3390\/antibiotics14050470","article-title":"Staphylococcus aureus: a review of the pathogenesis and virulence mechanisms","volume":"14","author":"Touaitia","year":"2025","journal-title":"Antibiotics"},{"issue":"10","key":"10.1016\/j.jiph.2026.103215_bib2","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.3390\/antibiotics12101520","article-title":"Staphylococcus aureus adaptation to the skin in health and persistent\/recurrent infections","volume":"12","author":"Gehrke","year":"2023","journal-title":"Antibiotics"},{"issue":"1","key":"10.1016\/j.jiph.2026.103215_bib3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/21505594.2021.1878688","article-title":"Pathogenicity and virulence of Staphylococcus aureus","volume":"12","author":"Cheung","year":"2021","journal-title":"Virulence"},{"issue":"3","key":"10.1016\/j.jiph.2026.103215_bib4","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management","volume":"28","author":"Tong","year":"2015","journal-title":"Clin Microbiol Rev"},{"issue":"16","key":"10.1016\/j.jiph.2026.103215_bib5","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2021.36.e104","article-title":"A longitudinal study of adult patients with Staphylococcus aureus bacteremia over 11 years in Korea","volume":"36","author":"Choi","year":"2021","journal-title":"J Korean Med Sci"},{"issue":"1","key":"10.1016\/j.jiph.2026.103215_bib6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s12879-023-08914-5","article-title":"The molecular epidemiology and clinical implication of methicillin-resistant Staphylococcus aureus (MRSA) sequence types in pediatric bacteremia: a restrospective observational study, 2016\u20132021","volume":"24","author":"Kim","year":"2024","journal-title":"BMC Infect Dis"},{"issue":"10369","key":"10.1016\/j.jiph.2026.103215_bib7","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1016\/S0140-6736(22)02185-7","article-title":"Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"400","author":"Ikuta","year":"2022","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jiph.2026.103215_bib8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3343\/alm.2024.44.1.47","article-title":"Comparative genomic analysis of staphylococcal cassette chromosome mec type V Staphylococcus aureus strains and estimation of the emergence of SCCmec V clinical isolates in Korea","volume":"44","author":"Takahashi","year":"2024","journal-title":"Ann Lab Med"},{"key":"10.1016\/j.jiph.2026.103215_bib9","unstructured":"Korea Disease Control and Prevention Agency, Annual Report on Infectious Disease Notifications, 2024. Cheongju: KDCA; 2024. Available from: https:\/\/dportal.kdca.go.kr\/pot\/bbs\/BD_selectBbs.do?q_bbsSn=1010&q_bbsDocNo=20250626112241525&q_clsfNo=1. Accessed 15 September 2025."},{"issue":"3","key":"10.1016\/j.jiph.2026.103215_bib10","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1093\/cid\/ciq146","article-title":"Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children","volume":"52","author":"Liu","year":"2011","journal-title":"Clin Infect Dis"},{"issue":"3","key":"10.1016\/j.jiph.2026.103215_bib11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5124\/jkma.2018.61.3.207","article-title":"Antimicrobial therapy for methicillin-resistant Staphylococcus aureus","volume":"61","author":"Choo","year":"2018","journal-title":"J Korean Med Assoc"},{"issue":"8","key":"10.1016\/j.jiph.2026.103215_bib12","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/iub.1289","article-title":"Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus","volume":"66","author":"Fishovitz","year":"2014","journal-title":"IUBMB Life"},{"issue":"1","key":"10.1016\/j.jiph.2026.103215_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-69058-z","article-title":"Global prevalence and distribution of vancomycin resistant, vancomycin intermediate and heterogeneously vancomycin intermediate Staphylococcus aureus clinical isolates: a systematic review and meta-analysis","volume":"10","author":"Shariati","year":"2020","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.jiph.2026.103215_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s40495-021-00264-7","article-title":"Molecular typing and global epidemiology of Staphylococcus aureus","volume":"7","author":"Kumar","year":"2021","journal-title":"Curr Pharm Rep"},{"issue":"3","key":"10.1016\/j.jiph.2026.103215_bib15","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1128\/AAC.01260-12","article-title":"Accessory gene regulator (agr) dysfunction in Staphylococcus aureus bloodstream isolates from South Korean patients","volume":"57","author":"Chong","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"10.1016\/j.jiph.2026.103215_bib16","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.3390\/antibiotics12091397","article-title":"Comparing the Phylogenetic Distribution of Multilocus Sequence Typing, Staphylococcal Protein A, and Staphylococcal Cassette Chromosome Mec Types in Methicillin-Resistant Staphylococcus aureus (MRSA) in Korea from 1994 to 2020","volume":"12","author":"Hwang","year":"2023","journal-title":"Antibiotics"},{"issue":"2","key":"10.1016\/j.jiph.2026.103215_bib17","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3349\/ymj.2007.48.2.176","article-title":"Accessory gene regulator group polymorphisms in methicillin-resistant Staphylococcus aureus: an association with clinical significance","volume":"48","author":"Yoon","year":"2007","journal-title":"Yonsei Med J"},{"issue":"3","key":"10.1016\/j.jiph.2026.103215_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.5145\/ACM.2025.28.3.4","article-title":"Complete genome analysis of representative methicillin-resistant Staphylococcus aureus clinical strains prevalent in Korea during 2014-2017","volume":"28","author":"Lade","year":"2025","journal-title":"Ann Clin Microbiol"},{"issue":"7","key":"10.1016\/j.jiph.2026.103215_bib19","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1128\/jcm.32.7.1768-1772.1994","article-title":"Multiplex PCR for identification of methicillin-resistant staphylococci in the clinical laboratory","volume":"32","author":"Geha","year":"1994","journal-title":"J Clin Microbiol"},{"issue":"3","key":"10.1016\/j.jiph.2026.103215_bib20","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1128\/JCM.38.3.1008-1015.2000","article-title":"Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus","volume":"38","author":"Enright","year":"2000","journal-title":"J Clin Microbiol"},{"issue":"2","key":"10.1016\/j.jiph.2026.103215_bib21","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1128\/JCM.01599-07","article-title":"spa typing of Staphylococcus aureus as a frontline tool in epidemiological typing","volume":"46","author":"Strommenger","year":"2008","journal-title":"J Clin Microbiol"},{"issue":"7","key":"10.1016\/j.jiph.2026.103215_bib22","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1128\/AAC.46.7.2155-2161.2002","article-title":"Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus","volume":"46","author":"Oliveira","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"10.1016\/j.jiph.2026.103215_bib23","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s13213-019-01484-5","article-title":"Methicillin resistance and clonal diversity of Staphylococcus aureus isolated from nasal samples of healthy horses in Iran","volume":"69","author":"Dastmalchi Saei","year":"2019","journal-title":"Ann Microbiol"},{"issue":"4","key":"10.1016\/j.jiph.2026.103215_bib24","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1128\/AAC.48.4.1124-1127.2004","article-title":"vitro activities of 28 antimicrobial agents against Staphylococcus aureus isolates from tertiary-care hospitals in Korea: a nationwide survey","volume":"48","author":"Kim","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"10.1016\/j.jiph.2026.103215_bib25","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1128\/AAC.42.5.1249","article-title":"Characterization of grlA, grlB, gyrA, and gyrB mutations in 116 unrelated isolates of Staphylococcus aureus and effects of mutations on ciprofloxacin MIC","volume":"42","author":"Schmitz","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"issue":"18","key":"10.1016\/j.jiph.2026.103215_bib26","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1007\/s00018-010-0389-4","article-title":"Mobile genetic elements of Staphylococcus aureus","volume":"67","author":"Malachowa","year":"2010","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"10.1016\/j.jiph.2026.103215_bib27","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijmm.2013.11.010","article-title":"Staphylococcus aureus genomics and the impact of horizontal gene transfer","volume":"304","author":"Lindsay","year":"2014","journal-title":"Int J Med Microbiol"},{"issue":"1","key":"10.1016\/j.jiph.2026.103215_bib28","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1471-2180-12-104","article-title":"The distribution of plasmids that carry virulence and resistance genes in Staphylococcus aureus is lineage associated","volume":"12","author":"McCarthy","year":"2012","journal-title":"BMC Microbiol"},{"issue":"3","key":"10.1016\/j.jiph.2026.103215_bib29","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/jac\/dkp214","article-title":"Diversity of the tetracycline resistance gene tet (M) and identification of Tn 916-and Tn 5801-like (Tn 6014) transposons in Staphylococcus aureus from humans and animals","volume":"64","author":"De Vries","year":"2009","journal-title":"J Antimicrob Chemother"},{"issue":"6","key":"10.1016\/j.jiph.2026.103215_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/microbiolspec.PLAS-0020-2014","article-title":"Plasmid-mediated antimicrobial resistance in staphylococci and other firmicutes","volume":"2","author":"Schwarz","year":"2014","journal-title":"Microbiol Spectr"},{"issue":"2","key":"10.1016\/j.jiph.2026.103215_bib31","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1128\/jb.150.2.804-814.1982","article-title":"Nucleotide sequence and functional map of pE194, a plasmid that specifies inducible resistance to macrolide, lincosamide, and streptogramin type B antibodies","volume":"150","author":"Horinouchi","year":"1982","journal-title":"J Bacteriol"},{"issue":"4","key":"10.1016\/j.jiph.2026.103215_bib32","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3390\/antibiotics12040733","article-title":"The plasmidomic landscape of clinical methicillin-resistant Staphylococcus aureus isolates from Malaysia","volume":"12","author":"Al-Trad","year":"2023","journal-title":"Antibiotics"},{"issue":"1","key":"10.1016\/j.jiph.2026.103215_bib33","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1186\/s12864-017-4065-z","article-title":"Evolution of mobile genetic element composition in an epidemic methicillin-resistant Staphylococcus aureus: temporal changes correlated with frequent loss and gain events","volume":"18","author":"Jamrozy","year":"2017","journal-title":"BMC Genom"},{"issue":"5","key":"10.1016\/j.jiph.2026.103215_bib34","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3390\/pathogens9050401","article-title":"Simultaneous nasal carriage by methicillin-resistant and methicillin susceptible Staphylococcus aureus of lineage ST398 in a live pig transporter","volume":"9","author":"G\u00f3mez","year":"2020","journal-title":"Pathogens"},{"issue":"4","key":"10.1016\/j.jiph.2026.103215_bib35","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/infdis\/jiaa651","article-title":"An outbreak of USA300 methicillin-resistant Staphylococcus aureus among people with HIV in Japan","volume":"223","author":"Ikeuchi","year":"2021","journal-title":"J Infect Dis"},{"issue":"1","key":"10.1016\/j.jiph.2026.103215_bib36","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02037-21","article-title":"Comparison of genetic features and evolution of global and Chinese strains of community-associated methicillin-resistant Staphylococcus aureus ST22","volume":"10","author":"Zhou","year":"2022","journal-title":"Microbiol Spectr"},{"issue":"3","key":"10.1016\/j.jiph.2026.103215_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.01242-22","article-title":"Phenotypic and genomic analysis of the hypervirulent ST22 methicillin-resistant Staphylococcus aureus in China","volume":"8","author":"Zhao","year":"2023","journal-title":"mSystems"},{"issue":"4","key":"10.1016\/j.jiph.2026.103215_bib38","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41579-018-0147-4","article-title":"Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research","volume":"17","author":"Turner","year":"2019","journal-title":"Nat Rev Microbiol"},{"issue":"5","key":"10.1016\/j.jiph.2026.103215_bib39","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/jac\/dkr024","article-title":"Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study","volume":"66","author":"Song","year":"2011","journal-title":"J Antimicrob Chemother"},{"issue":"7","key":"10.1016\/j.jiph.2026.103215_bib40","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/1469-0691.12705","article-title":"New epidemiology of Staphylococcus aureus infection in Asia","volume":"20","author":"Chen","year":"2014","journal-title":"Clin Microbiol Infect"}],"container-title":["Journal of Infection and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876034126000870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876034126000870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:28:14Z","timestamp":1776194894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1876034126000870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S1876034126000870"],"URL":"https:\/\/doi.org\/10.1016\/j.jiph.2026.103215","relation":{},"ISSN":["1876-0341"],"issn-type":[{"value":"1876-0341","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive analysis of antimicrobial resistance and virulence determinants in clinical methicillin-resistant Staphylococcus aureus isolates collected in South Korea","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection and Public Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jiph.2026.103215","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences.","name":"copyright","label":"Copyright"}],"article-number":"103215"}}