{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:57:34Z","timestamp":1787885854030,"version":"build-2784847793"},"reference-count":18,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidsponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology Symposium Proceedings"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.jisp.2017.01.003","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T13:45:43Z","timestamp":1505915143000},"page":"S81-S84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes"],"prefix":"10.1016","volume":"18","author":[{"given":"Alon","family":"Mantel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Tyson","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennedy","family":"Goldsborough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie M.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jisp.2017.01.003_bib1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1468-3083.2010.03799.x","article-title":"Lipid peroxidation\/antioxidant activity in patients with alopecia areata","volume":"25","author":"Abdel Fattah","year":"2011","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jisp.2017.01.003_bib2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s40257-013-0036-6","article-title":"Oxidative stress in alopecia areata: a case-control study","volume":"15","author":"Bakry","year":"2014","journal-title":"Am J Clin Dermatol"},{"issue":"Suppl. 6","key":"10.1016\/j.jisp.2017.01.003_bib3","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/j.1610-0379.2011.07802.x","article-title":"Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men","volume":"9","author":"Blumeyer","year":"2011","journal-title":"J\u00a0Dtsch Dermatol Ges"},{"issue":"126","key":"10.1016\/j.jisp.2017.01.003_bib4","doi-asserted-by":"crossref","first-page":"126ra34","DOI":"10.1126\/scitranslmed.3003122","article-title":"Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia","volume":"4","author":"Garza","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jisp.2017.01.003_bib5","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1080\/09553009214551291","article-title":"Topical or systemic 16, 16 dm prostaglandin E2 or WR-2721 (WR-1065) protects mice from alopecia after fractionated irradiation","volume":"61","author":"Geng","year":"1992","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.jisp.2017.01.003_bib6","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00210-016-1257-z","article-title":"15-deoxy prostaglandin J2, the nonenzymatic metabolite of prostaglandin D2, induces apoptosis in keratinocytes of human hair follicles: a possible explanation for prostaglandin D2-mediated inhibition of hair growth","volume":"389","author":"Joo","year":"2016","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"issue":"7\u20138","key":"10.1016\/j.jisp.2017.01.003_bib7","first-page":"551","article-title":"Human hair growth enhancement in\u00a0vitro by green tea epigallocatechin-3-gallate (EGCG)","volume":"14","author":"Kwon","year":"2007","journal-title":"Int J Phytother Phytopharmacol"},{"key":"10.1016\/j.jisp.2017.01.003_bib8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-4939-2522-3_7","article-title":"Detecting reactive oxygen species by immunohistochemistry","volume":"1292","author":"Liou","year":"2015","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jisp.2017.01.003_bib9","first-page":"725","article-title":"Lipid peroxides induce early onset of catagen phase in murine hair cycles","volume":"22","author":"Naito","year":"2008","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jisp.2017.01.003_bib10","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/jid.2012.398","article-title":"Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44","volume":"133","author":"Nelson","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jisp.2017.01.003_bib11","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.bbrc.2016.02.099","article-title":"Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotestosterone","volume":"472","author":"Sasaki","year":"2016","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1016\/j.jisp.2017.01.003_bib12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.0906-6705.2005.00270.x","article-title":"Influence of prostaglandin F2alpha and its analogues on hair regrowth and follicular melanogenesis in a murine model","volume":"14","author":"Sasaki","year":"2005","journal-title":"Exp Dermatol"},{"issue":"1\u20132","key":"10.1016\/j.jisp.2017.01.003_bib13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000211275","article-title":"Hormonal basis of male and female androgenic alopecia: clinical relevance","volume":"7","author":"Schmidt","year":"1994","journal-title":"Skin Pharmacol"},{"key":"10.1016\/j.jisp.2017.01.003_bib14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bcp.2007.03.023","article-title":"PGD2 metabolism in plasma: kinetics and relationship with bioactivity on DP1 and CRTH2 receptors","volume":"74","author":"Schuligoi","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jisp.2017.01.003_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/09168451.2015.1012149","article-title":"15-deoxy-delta-prostaglandin J as an electrophilic mediator","volume":"79","author":"Shibata","year":"2015","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.jisp.2017.01.003_bib16","doi-asserted-by":"crossref","first-page":"10459","DOI":"10.1074\/jbc.M110314200","article-title":"15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes","volume":"277","author":"Shibata","year":"2002","journal-title":"J\u00a0Biol Chem"},{"issue":"3\u20134","key":"10.1016\/j.jisp.2017.01.003_bib17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.prostaglandins.2011.01.004","article-title":"Induction of apoptosis by 15d-PGJ2 via ROS formation: an alternative pathway without PPARgamma activation in non-small cell lung carcinoma A549 cells","volume":"94","author":"Wang","year":"2011","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.jisp.2017.01.003_bib18","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1095\/biolreprod.103.022079","article-title":"Expression and regulation of lipocalin-type prostaglandin d synthase in rat testis and epididymis","volume":"70","author":"Zhu","year":"2004","journal-title":"Biol Reprod"}],"container-title":["Journal of Investigative Dermatology Symposium Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1087002417300035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1087002417300035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T03:33:50Z","timestamp":1538364830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1087002417300035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S1087002417300035"],"URL":"https:\/\/doi.org\/10.1016\/j.jisp.2017.01.003","relation":{},"ISSN":["1087-0024"],"issn-type":[{"value":"1087-0024","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology Symposium Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jisp.2017.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}