{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:29:33Z","timestamp":1764224973960,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T00:00:00Z","timestamp":1374278400000},"content-version":"vor","delay-in-days":1237,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-cardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiology"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.jjcc.2009.10.006","type":"journal-article","created":{"date-parts":[[2009,12,2]],"date-time":"2009-12-02T05:08:49Z","timestamp":1259730529000},"page":"174-179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy of N-acetylcysteine and aminophylline in preventing contrast-induced nephropathy"],"prefix":"10.1016","volume":"55","author":[{"given":"Terufumi","family":"Kinbara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Hayano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomu","family":"Ohtani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhji","family":"Furutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohshiro","family":"Moritani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masunori","family":"Matsuzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jjcc.2009.10.006_bib1","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1056\/NEJM199411243312104","article-title":"Effect of saline, mannitol, and furosemide to prevent acute decreases in renal function by radiocontrast agents","volume":"331","author":"Solomon","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2009.10.006_bib2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0002-9343(97)00150-2","article-title":"Acute renal failure after coronary intervention","volume":"103","author":"McCullough","year":"1997","journal-title":"Am J Med"},{"key":"10.1016\/j.jjcc.2009.10.006_bib3","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1001\/jama.1996.03530430033035","article-title":"The effect of acute renal failure on mortality","volume":"275","author":"Levy","year":"1996","journal-title":"JAMA"},{"key":"10.1016\/j.jjcc.2009.10.006_bib4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1053\/snep.2001.18375","article-title":"Renal implications of percutaneous coronary intervention","volume":"21","author":"Korr","year":"2001","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.jjcc.2009.10.006_bib5","first-page":"F115","article-title":"Radiocontrast medium-induced declines in renal function: a role for oxygen radicals","volume":"258","author":"Bakris","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jjcc.2009.10.006_bib6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10157-008-0081-2","article-title":"Serofendic acid protects from iodinated contrast medium and high glucose probably against superoxide production in LLC-PK1 cells","volume":"13","author":"Kitamura","year":"2009","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.jjcc.2009.10.006_bib7","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1056\/NEJM200007203430304","article-title":"Prevention of radiographic-contrast-agent-induced reductions in renal functions by acetylcysteine","volume":"343","author":"Tepel","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2009.10.006_bib8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0002-9149(01)02243-3","article-title":"Acetylcysteine to prevent angiography-related renal tissue injury (the APART trial)","volume":"89","author":"Diaz-Sandoval","year":"2002","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2009.10.006_bib9","first-page":"406","article-title":"Role for intrarenal adenosine in the hemodynamic response to contrast media","volume":"110","author":"Arend","year":"1987","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.jjcc.2009.10.006_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF00501815","article-title":"Renal effects of adenosine and their inhibition by theophylline in dogs","volume":"288","author":"Osswald","year":"1975","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jjcc.2009.10.006_bib11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF00585986","article-title":"Adenosine response of rat kidney after saline loading, sodium restriction and hemorrhagia","volume":"357","author":"Osswald","year":"1975","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jjcc.2009.10.006_bib12","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1161\/01.RES.43.3.465","article-title":"Mechanism of adenosine-mediated decreases in glomerular filtration rate in dogs","volume":"43","author":"Osswald","year":"1978","journal-title":"Circ Res"},{"key":"10.1016\/j.jjcc.2009.10.006_bib13","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/BF00506263","article-title":"Adenosine induced fall in glomerular capillary pressure: effect of ureteral obstruction and aortic constriction in the Munich\u2013Wistar rat kidney","volume":"317","author":"Haas","year":"1981","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"Suppl. 32","key":"10.1016\/j.jjcc.2009.10.006_bib14","first-page":"S128","article-title":"Adenosine mediates tubuloglomerular feed back response: an element of metabolic control of kidney function","author":"Osswald","year":"1991","journal-title":"Kidney Int"},{"key":"10.1016\/j.jjcc.2009.10.006_bib15","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0002-9149(98)00833-9","article-title":"Effect of dopamine and aminophylline on contrast-induced acute renal failure after coronary angioplasty in patients with preexisting renal insufficiency","volume":"83","author":"Abizaid","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2009.10.006_bib16","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/ki.1994.186","article-title":"Adenosine antagonist theophylline prevents the reduction of glomerular filtration rate after contrast media applicaton","volume":"45","author":"Erley","year":"1994","journal-title":"Kidney Int"},{"key":"10.1016\/j.jjcc.2009.10.006_bib17","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1093\/ndt\/14.5.1146","article-title":"Prevention of radiocontrast-media-induced nephropathy in patients with pre-existing renal insufficiency by hydration in combination with the adenosine antagonist theophylline","volume":"14","author":"Erley","year":"1999","journal-title":"Nephrol Dial Transpl"},{"key":"10.1016\/j.jjcc.2009.10.006_bib18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1148\/radiology.195.1.7892462","article-title":"Nephrotoxicity from contrast media: attenuation with theophylline","volume":"195","author":"Katholi","year":"1995","journal-title":"Radiology"},{"key":"10.1016\/j.jjcc.2009.10.006_bib19","first-page":"151","article-title":"The nonselective adenosine antagonist theophylline does prevent renal dysfunction induced by radiographic contrast agents","volume":"11","author":"Kolonko","year":"1998","journal-title":"J Nephrol"},{"key":"10.1016\/j.jjcc.2009.10.006_bib20","first-page":"738","article-title":"Aminophylline does not protect against radiocontrast nephropathy in pateients undergoing percutaneous angiographic procedures","volume":"13","author":"Shammas","year":"2001","journal-title":"J Invasive Cardiol"},{"key":"10.1016\/j.jjcc.2009.10.006_bib21","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1148\/radiol.2233010609","article-title":"Effect of theophylline on contrast material-induced nephropathy in patients with chronic renal insufficiency: controlled, randomaized, double-blinded study","volume":"223","author":"Huber","year":"2002","journal-title":"Radiology"},{"key":"10.1016\/j.jjcc.2009.10.006_bib22","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0002-9149(03)00259-5","article-title":"Effectiveness of theophylline prophylaxis of renal impairment after coronary angiography in patients with chronic renal insufficiency","volume":"91","author":"Huber","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2009.10.006_bib23","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0735-1097(02)02308-2","article-title":"Acetylcysteine protects against acute renal damage in patients with abnormal renal function undergoing a coronary procedure","volume":"40","author":"Shyu","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2009.10.006_bib24","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1001\/jama.289.5.553","article-title":"Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial","volume":"289","author":"Kay","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jjcc.2009.10.006_bib25","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1046\/j.1523-1755.2002.00673.x","article-title":"A randomized controlled trial of N-acetylcysteine to prevent contrast nephropathy in cardiac angiography","volume":"62","author":"Duraham","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.jjcc.2009.10.006_bib26","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0735-1097(02)01958-7","article-title":"Acetylcysteine and contrast agent-associated nephrotoxicity","volume":"40","author":"Buriguori","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2009.10.006_bib27","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1016\/S0735-1097(03)00487-X","article-title":"A rapid protocol for the prevention of contrast-induced renal dysfunction: the RAPPID study","volume":"41","author":"Baker","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2009.10.006_bib28","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ahj.2005.01.055","article-title":"N-Acetylcysteine and contrast-induced nephropathy: a meta-analysis of 13 randomized trials","volume":"151","author":"Zagler","year":"2006","journal-title":"Am Heart J"},{"issue":"2","key":"10.1016\/j.jjcc.2009.10.006_bib29","first-page":"119","article-title":"Prevention of contrast-induced nephropathy using cardiac catheterization combined with hydration, oral N-acetylcysteine, sodium bicarbonate and iso-osmolar contrast agents","volume":"50","author":"Hoshino","year":"2007","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2009.10.006_bib30","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.crad.2003.11.005","article-title":"Prevention of contrast media nephrotoxicity\u2014the story so far","volume":"59","author":"Morocos","year":"2004","journal-title":"Clin Radiol"},{"key":"10.1016\/j.jjcc.2009.10.006_bib31","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/S0140-6736(95)92057-9","article-title":"Acute renal failure","volume":"346","author":"Brady","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.jjcc.2009.10.006_bib32","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0140-6736(05)74933-3","article-title":"Improvement in renal function in hepatorenal syndrome with N-acetylcysteine","volume":"353","author":"Holt","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jjcc.2009.10.006_bib33","first-page":"F246","article-title":"Direct toxic effect of the radiocontrast agent diatriazote on renal proximal tubule cells","volume":"252","author":"Humes","year":"1987","journal-title":"Am J Physiol"}],"container-title":["Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508709002809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508709002809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:46:53Z","timestamp":1760273213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0914508709002809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0914508709002809"],"URL":"https:\/\/doi.org\/10.1016\/j.jjcc.2009.10.006","relation":{},"ISSN":["0914-5087"],"issn-type":[{"type":"print","value":"0914-5087"}],"subject":[],"published":{"date-parts":[[2010,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of N-acetylcysteine and aminophylline in preventing contrast-induced nephropathy","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jjcc.2009.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Japanese College of Cardiology. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}