{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:27:08Z","timestamp":1790774828317,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T00:00:00Z","timestamp":1374278400000},"content-version":"vor","delay-in-days":688,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-cardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiology"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.jjcc.2011.07.004","type":"journal-article","created":{"date-parts":[[2011,8,15]],"date-time":"2011-08-15T02:16:30Z","timestamp":1313374590000},"page":"84-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Stent thrombosis of drug eluting stent: Pathological perspective"],"prefix":"10.1016","volume":"58","author":[{"given":"Gaku","family":"Nakazawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jjcc.2011.07.004_bib0005","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1056\/NEJMoa012843","volume":"346","author":"Morice","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0010","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJMoa035071","article-title":"SIRIUS Investigators. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery","volume":"349","author":"Moses","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0015","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1056\/NEJMoa032441","article-title":"TAXUS-IV Investigators. A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease","volume":"350","author":"Stone","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0020","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1016\/j.jacc.2006.10.026","article-title":"BASKET-LATE Investigators. Late clinical events after clopidogrel discontinuation may limit the benefit of drug-eluting stents: an observational study of drug-eluting versus bare-metal stents","volume":"48","author":"Pfisterer","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0025","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1161\/CIRCULATIONAHA.106.687186","article-title":"Offsetting impact of thrombosis and restenosis on the occurrence of death and myocardial infarction after paclitaxel-eluting and bare metal stent implantation","volume":"115","author":"Stone","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0030","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.106.685313","article-title":"Clinical end points in coronary stent trials: a case for standardized definitions","volume":"115","author":"Cutlip","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0035","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.jcin.2011.01.011","article-title":"Autopsy validation study of the academic research consortium stent thrombosis definition","volume":"4","author":"Cutlip","year":"2011","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0040","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1161\/CIRCULATIONAHA.106.666800","article-title":"Stent thrombosis late after implantation of first-generation drug-eluting stents: a cause for concern","volume":"115","author":"Camenzind","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0045","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/01.CIR.0000062700.42060.6F","article-title":"Images in cardiovascular medicine. Sirolimus-eluting stent implanted in human coronary artery for 16 months: pathological findings","volume":"107","author":"Guagliumi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0050","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jacc.2006.03.042","article-title":"Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk","volume":"48","author":"Joner","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0055","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1161\/CIRCULATIONAHA.107.693739","article-title":"Pathological correlates of late drug-eluting stent thrombosis: strut coverage as a marker of endothelialization","volume":"115","author":"Finn","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0060","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jacc.2010.05.066","article-title":"Coronary responses and differential mechanisms of late stent thrombosis attributed to first-generation sirolimus- and paclitaxel-eluting stents","volume":"57","author":"Nakazawa","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0065","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1161\/CIRCULATIONAHA.107.762047","article-title":"Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients: an autopsy study","volume":"118","author":"Nakazawa","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0070","doi-asserted-by":"crossref","first-page":"9463","DOI":"10.1073\/pnas.0400918101","article-title":"Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel","volume":"101","author":"Levin","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0075","first-page":"251","article-title":"Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme","volume":"147","author":"Geng","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0080","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1161\/01.CIR.0000160363.30639.37","article-title":"Thrombosis modulates arterial drug distribution for drug-eluting stents","volume":"111","author":"Hwang","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0085","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jjcc.2010.09.005","article-title":"Retrospective comparison of clinical and angiographic outcomes after primary stenting using sirolimus-eluting and bare-metal stents in nonrandomized consecutive 568 patients with first ST-segment elevated myocardial infarctions","volume":"57","author":"Ishikawa","year":"2011","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0090","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jcin.2010.10.007","article-title":"Four-year follow-up of TYPHOON (trial to assess the use of the CYPHer sirolimus-eluting coronary stent in acute myocardial infarction treated with Balloon angioplasty)","volume":"4","author":"Spaulding","year":"2011","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0195","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jcin.2010.11.003","volume":"4","author":"Vink","year":"2011","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0100","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jcmg.2008.03.012","article-title":"Comparison of vascular response after sirolimus-eluting stent implantation between patients with unstable and stable angina pectoris a serial optical coherence tomography study","volume":"1","author":"Kubo","year":"2008","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0105","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s12928-009-0005-4","article-title":"Incidence and outcome of surgical procedures after sirolimus eluting stent implantation: a report from the j-Cypher registry","volume":"25","author":"Kimura","year":"2010","journal-title":"Cardiovasc Interv Ther"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0110","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1161\/01.CIR.0000116202.41966.D4","article-title":"Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious?","volume":"109","author":"Virmani","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0115","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00019501-200205000-00008","article-title":"Twenty-eight-day efficacy and phamacokinetics of the sirolimus-eluting stent","volume":"13","author":"Klugherz","year":"2002","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0120","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0142-9612(97)00118-X","article-title":"Review of the biological response to a novel bone cement containing poly(ethyl methacrylate) and n-butyl methacrylate","volume":"19","author":"Revell","year":"1998","journal-title":"Biomaterials"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0125","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1586\/14779072.6.10.1379","article-title":"Drug-eluting stent safety: findings from preclinical studies","volume":"6","author":"Nakazawa","year":"2008","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0130","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jacc.2005.05.068","article-title":"Late incomplete stent apposition after sirolimus-eluting stent implantation: a serial intravascular ultrasound analysis","volume":"46","author":"Ako","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0135","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1161\/CIRCULATIONAHA.110.003459","article-title":"Incidence, risk factors, and clinical sequelae of angiographic peri-stent contrast staining after sirolimus-eluting stent implantation","volume":"123","author":"Imai","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0140","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/hc3001.092037","article-title":"Pathological analysis of local delivery of paclitaxel via a polymer-coated stent","volume":"104","author":"Farb","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0145","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1161\/01.CIR.103.18.2289","article-title":"Paclitaxel stent coating inhibits neointimal hyperplasia at 4 weeks in a porcine model of coronary restenosis","volume":"103","author":"Heldman","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0150","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jcin.2009.03.005","article-title":"Heterogeneous arterial healing in patients following paclitaxel-eluting stent implantation: comparison with sirolimus-eluting stents","volume":"2","author":"Awata","year":"2009","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0155","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.jacc.2011.01.011","article-title":"The pathology of neoatherosclerosis in human coronary implants bare-metal and drug-eluting stents","volume":"57","author":"Nakazawa","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0160","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jacc.2008.04.030","article-title":"Endothelial cell recovery between comparator polymer-based drug-eluting stents","volume":"52","author":"Joner","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0165","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis \u2013 an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0170","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jjcc.2008.10.010","article-title":"A case of a newly developed yellow neointima at stent implanted site 1 year after sirolimus-eluting stent placement: angioscopic findings","volume":"54","author":"Kawakami","year":"2009","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0175","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.jcmg.2008.12.026","article-title":"Atherosclerotic and thrombogenic neointima formed over sirolimus drug-eluting stent: an angioscopic study","volume":"2","author":"Higo","year":"2009","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0180","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0140-6736(07)60314-6","article-title":"Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort study","volume":"369","author":"Daemen","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0185","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/CIRCULATIONAHA.108.808311","article-title":"Antiplatelet therapy and stent thrombosis after sirolimus-eluting stent implantation","volume":"119","author":"Kimura","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2011.07.004_bib0190","unstructured":"Administration FaD. Guidance for Industry \u2013 Coronary Drug-Eluting Stents, http:\/\/www.fda.gov\/cdrh\/ode\/guidance\/6255comp.pdf. 2008."}],"container-title":["Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508711001262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508711001262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:48:33Z","timestamp":1760273313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0914508711001262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0914508711001262"],"URL":"https:\/\/doi.org\/10.1016\/j.jjcc.2011.07.004","relation":{},"ISSN":["0914-5087"],"issn-type":[{"value":"0914-5087","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stent thrombosis of drug eluting stent: Pathological perspective","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jjcc.2011.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}