{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:15:34Z","timestamp":1791605734126,"version":"4.3.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-cardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.jjcc.2016.04.003","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T17:14:28Z","timestamp":1462382068000},"page":"253-259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Cholesterol crystal as a new feature of coronary vulnerable plaques: An optical coherence tomography study"],"prefix":"10.1016","volume":"69","author":[{"given":"Satoshi","family":"Nishimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Ehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenei","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jjcc.2016.04.003_bib0135","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1161\/01.ATV.20.5.1262","article-title":"Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions","volume":"20","author":"Virmani","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0140","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1161\/ATVBAHA.108.179739","article-title":"Concept of vulnerable\/unstable plaque","volume":"30","author":"Finn","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0145","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.amjcard.2008.12.019","article-title":"Effect of cholesterol crystals on plaques and intima in arteries of patients with acute coronary and cerebrovascular syndromes","volume":"103","author":"Abela","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0150","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jacc.2007.04.082","article-title":"Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy","volume":"50","author":"Kubo","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0155","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.jacc.2011.09.079","article-title":"Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation","volume":"59","author":"Tearney","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0160","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00392-014-0748-5","article-title":"Relationship between cholesterol crystals and culprit lesion characteristics in patients with stable coronary artery disease: an optical coherence tomography study","volume":"103","author":"Nakamura","year":"2014","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0165","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jacc.2014.11.039","article-title":"Cholesterol crystals associate with coronary plaque vulnerability in vivo","volume":"65","author":"Kataoka","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl.","key":"10.1016\/j.jjcc.2016.04.003_bib0170","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/0021-9150(96)05852-2","article-title":"High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport","volume":"124","author":"Assmann","year":"1996","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0175","first-page":"202","article-title":"Advantage of next-generation frequency-domain optical coherence tomography compared with conventional time-domain system in the assessment of coronary lesion","volume":"75","author":"Takarada","year":"2010","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0180","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.4244\/EIJV6I9A182","article-title":"First-in-man evaluation of intravascular optical frequency domain imaging (OFDI) of Terumo: a comparison with intravascular ultrasound and quantitative coronary angiography","volume":"6","author":"Okamura","year":"2011","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0185","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/ehjci\/jer305","article-title":"Hyperintense plaque identified by magnetic resonance imaging relates to intracoronary thrombus as detected by optical coherence tomography in patients with angina pectoris","volume":"13","author":"Ehara","year":"2012","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0190","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/clc.4960280906","article-title":"Cholesterol crystals cause mechanical damage to biological membranes: a proposed mechanism of plaque rupture and erosion leading to arterial thrombosis","volume":"28","author":"Abela","year":"2005","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0195","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.amjcard.2011.02.336","article-title":"Effects of statins on cholesterol crystallization and atherosclerotic plaque stabilization","volume":"107","author":"Abela","year":"2011","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0200","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4049\/jimmunol.1403044","article-title":"Reconstituted high-density lipoprotein attenuates cholesterol crystal-induced inflammatory responses by reducing complement activation","volume":"195","author":"Niyonzima","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0205","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jcmg.2008.10.017","article-title":"Plaque characteristics in culprit lesions and inflammatory status in diabetic acute coronary syndrome patients","volume":"2","author":"Hong","year":"2009","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0210","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.jcin.2012.06.019","article-title":"Comparison of nonculprit coronary plaque characteristics between patients with and without diabetes: a 3-vessel optical coherence tomography study","volume":"5","author":"Kato","year":"2012","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0215","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0014-827X(01)01065-5","article-title":"Low-density lipoprotein (LDL) behavior after in vitro oxidation in three groups of diabetics","volume":"56","author":"Seghrouchni","year":"2001","journal-title":"Farmaco"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0220","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1253\/circj.CJ-10-0086","article-title":"Clinical predictors of culprit plaque rupture assessed on intravascular ultrasound in acute coronary syndrome","volume":"74","author":"Kato","year":"2010","journal-title":"Circ J"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0225","first-page":"33","article-title":"Correlation between high density lipoprotein-cholesterol and remodeling index in patients with coronary artery disease. IDEAS (IVUS diagnostic evaluation of atherosclerosis in Singapore)-HDL study","volume":"28","author":"Lee","year":"2012","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0230","doi-asserted-by":"crossref","first-page":"24511","DOI":"10.1016\/S0021-9258(19)51113-9","article-title":"Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux","volume":"269","author":"Kruth","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0235","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0021-9150(78)90142-9","article-title":"The action of human high density lipoprotein on cholesterol crystals. Part 1. Light-microscopic observations","volume":"31","author":"Adams","year":"1978","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0240","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1161\/01.ATV.19.8.1891","article-title":"Crystallization of free cholesterol in model macrophage foam cells","volume":"19","author":"Kellner-Weibel","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0245","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1056\/NEJMoa035655","article-title":"Intraplaque hemorrhage and progression of coronary atheroma","volume":"349","author":"Kolodgie","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0250","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.yjmcc.2007.05.023","article-title":"Pathological mechanisms and dose dependency of erythrocyte-induced vulnerability of atherosclerotic plaques","volume":"43","author":"Lin","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0255","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/j.bpj.2012.03.016","article-title":"Characterization of cholesterol crystals in atherosclerotic plaques using stimulated Raman scattering and second-harmonic generation microscopy","volume":"102","author":"Suhalim","year":"2012","journal-title":"Biophys J"},{"key":"10.1016\/j.jjcc.2016.04.003_bib0260","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1194\/jlr.M018077","article-title":"Identification of cholesterol crystals in plaques of atherosclerotic mice using hyperspectral CARS imaging","volume":"52","author":"Lim","year":"2011","journal-title":"J Lipid Res"}],"container-title":["Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508716300491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508716300491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:57:35Z","timestamp":1760273855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0914508716300491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0914508716300491"],"URL":"https:\/\/doi.org\/10.1016\/j.jjcc.2016.04.003","relation":{},"ISSN":["0914-5087"],"issn-type":[{"value":"0914-5087","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cholesterol crystal as a new feature of coronary vulnerable plaques: An optical coherence tomography study","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jjcc.2016.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd on behalf of Japanese College of Cardiology.","name":"copyright","label":"Copyright"}]}}