{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T01:00:00Z","timestamp":1768784400697,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-cardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.jjcc.2017.02.005","type":"journal-article","created":{"date-parts":[[2017,3,18]],"date-time":"2017-03-18T21:49:34Z","timestamp":1489873774000},"page":"303-309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Myocardial contractile reserve predicts left ventricular reverse remodeling and cardiac events in dilated cardiomyopathy"],"prefix":"10.1016","volume":"70","author":[{"given":"Ryota","family":"Morimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Hirashiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Ichii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Furusawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Hiraiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoaki","family":"Kano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Fukaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinori","family":"Sawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyosuke","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko K.","family":"Bando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyoaki","family":"Murohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jjcc.2017.02.005_bib0180","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/01.CIR.93.5.841","article-title":"Report of the 1995 World Health Organization\/International Society and Federation of Cardiology Task Force on the Definition and Classification of Cardiomyopathies","volume":"93","author":"Richardson","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0185","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1056\/NEJMoa052256","article-title":"Trends in prevalence and outcome of heart failure with preserved ejection fraction","volume":"355","author":"Owan","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0190","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2459\/JCM.0b013e32832bba35","article-title":"Natural history of dilated cardiomyopathy: from asymptomatic left ventricular dysfunction to heart failure \u2013 a subgroup analysis from the Trieste Cardiomyopathy Registry","volume":"10","author":"Aleksova","year":"2009","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0195","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1056\/NEJMoa043399","article-title":"Amiodarone or an implantable cardioverter\u2013defibrillator for congestive heart failure","volume":"352","author":"Bardy","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0200","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1161\/01.CIR.94.9.2285","article-title":"Medical therapy can improve the biological properties of the chronically failing heart. A new era in the treatment of heart failure","volume":"94","author":"Eichhorn","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0205","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jjcc.2015.02.004","article-title":"\u03b2-Blocker therapy in heart failure with preserved ejection fraction: importance of dose and duration","volume":"66","author":"Yamamoto","year":"2015","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0210","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jcmg.2010.10.008","article-title":"Left ventricular remodeling in heart failure: current concepts in clinical significance and assessment","volume":"4","author":"Konstam","year":"2011","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0215","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0002-9149(99)00414-2","article-title":"Prevalence, predictors, and prognosis of reversal of maladaptive remodeling with intensive medical therapy in idiopathic dilated cardiomyopathy","volume":"84","author":"Kawai","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0220","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.jacc.2010.11.030","article-title":"Prevalence and prognostic significance of left ventricular reverse remodeling in dilated cardiomyopathy receiving tailored medical treatment","volume":"57","author":"Merlo","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0225","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1253\/circj.CJ-12-0507","article-title":"Predictors of left ventricular reverse remodeling and subsequent outcome in nonischemic dilated cardiomyopathy","volume":"77","author":"Choi","year":"2013","journal-title":"Circ J"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0230","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jacc.2012.07.072","article-title":"Novel predictors of left ventricular reverse remodeling in individuals with recent-onset dilated cardiomyopathy","volume":"61","author":"Kubanek","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0235","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jjcc.2015.02.015","article-title":"B-type natriuretic peptide response and reserve left ventricular remodeling after surgical correction of functional mitral regurgitation in patients with advanced cardiomyopathy","volume":"66","author":"Kainuma","year":"2015","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0240","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/S0735-1097(99)00371-X","article-title":"Myocardial contractile reserve on dobutamine echocardiography predicts late spontaneous improvement in cardiac function in patients with recent onset idiopathic dilated cardiomyopathy","volume":"34","author":"Naqvi","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0245","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1053\/euhj.1999.1937","article-title":"Low-dose dobutamine responsiveness in idiopathic dilated cardiomyopathy: relation to exercise capacity and clinical outcome","volume":"21","author":"Scrutinio","year":"2000","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0250","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/S0002-9149(01)02116-6","article-title":"Prognostic significance of the dobutamine echocardiography test in idiopathic dilated cardiomyopathy","volume":"88","author":"Pratali","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0255","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1161\/01.CIR.0000097111.00170.7B","article-title":"Myocardial contractile reserve by dobutamine stress echocardiography predicts improvement in ejection fraction with beta-blockade in patients with heart failure: the Beta-Blocker Evaluation of Survival Trial (BEST)","volume":"108","author":"Eichhorn","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0260","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/ehjci\/jev069","article-title":"Bi-ventricular contractile reserve offers an incremental prognostic value for patients with dilated cardiomyopathy","volume":"16","author":"Matsumoto","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0265","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0002-8703(03)00247-3","article-title":"Ejection fraction by echocardiography: the full monty or just a peep show?","volume":"146","author":"Schiller","year":"2003","journal-title":"Am Heart J"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0270","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.jcmg.2008.04.012","article-title":"Dobutamine stress testing as a diagnostic tool for evaluation of myocardial contractile reserve in asymptomatic or mildly symptomatic patients with dilated cardiomyopathy","volume":"1","author":"Kobayashi","year":"2008","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0275","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ijcard.2011.05.065","article-title":"Association between cardiopulmonary exercise and dobutamine stress testing in ambulatory patients with idiopathic dilated cardiomyopathy: a comparison with peak VO2 and VE\/VCO2 slope","volume":"162","author":"Okumura","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0280","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1016\/j.jacc.2013.01.074","article-title":"Increased (99m)Tc-sestamibi washout reflects impaired myocardial contractile and relaxation reserve during dobutamine stress due to mitochondrial dysfunction in dilated cardiomyopathy patients","volume":"61","author":"Hayashi","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0285","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s00259-012-2256-z","article-title":"Myocardial 123I-MIBG scintigraphy predicts an impairment in myocardial functional reserve during dobutamine stress in patients with idiopathic dilated cardiomyopathy","volume":"40","author":"Ohshima","year":"2013","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0290","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0140-6736(03)13800-7","article-title":"Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol or Metoprolol European Trial (COMET): randomised controlled trial","volume":"362","author":"Poole-Wilson","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0295","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1007\/s00392-008-0681-6","article-title":"Bisoprolol vs. carvedilol in elderly patients with heart failure: rationale and design of the CIBIS-ELD trial","volume":"97","author":"D\u00fcngen","year":"2008","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0300","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0894-7317(89)80014-8","article-title":"Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms","volume":"2","author":"Schiller","year":"1989","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0305","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1161\/hc3101.093869","article-title":"Reduced myocardial sarcoplasmic reticulum Ca(2+)-ATPase mRNA expression and biphasic force\u2013frequency relations in patients with hypertrophic cardiomyopathy","volume":"104","author":"Somura","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0310","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1161\/01.CIR.103.18.2254","article-title":"Controlled trial of intravenous immune globulin in recent-onset dilated cardiomyopathy","volume":"103","author":"McNamara","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0315","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.jacc.2011.05.033","article-title":"Clinical and demographic predictors of outcomes in recent onset dilated cardiomyopathy: results of the IMAC (Intervention in Myocarditis and Acute Cardiomyopathy)-2 study","volume":"58","author":"McNamara","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0320","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1161\/01.RES.59.3.297","article-title":"Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure","volume":"59","author":"Bristow","year":"1986","journal-title":"Circ Res"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0325","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1161\/01.CIR.74.6.1290","article-title":"Assessment of the beta-adrenergic receptor pathway in the intact failing human heart: progressive receptor down-regulation and subsensitivity to agonist response","volume":"74","author":"Fowler","year":"1986","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0330","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0735-1097(95)00483-1","article-title":"Analysis of interinstitutional observer agreement in interpretation of dobutamine stress echocardiograms","volume":"27","author":"Hoffmann","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0335","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/0002-9149(93)90883-E","article-title":"Impact of left ventricular cavity size on survival in advanced heart failure","volume":"72","author":"Lee","year":"1993","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0340","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/CIRCULATIONAHA.105.538272","article-title":"Left ventricular reverse remodeling but not clinical improvement predicts long-term survival after cardiac resynchronization therapy","volume":"112","author":"Yu","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0345","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1056\/NEJM199108013250501","article-title":"Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD Investigators","volume":"325","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2017.02.005_bib0350","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJM199605233342101","article-title":"The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group","volume":"334","author":"Packer","year":"1996","journal-title":"N Engl J Med"}],"container-title":["Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508717300588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508717300588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:57:11Z","timestamp":1760273831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0914508717300588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0914508717300588"],"URL":"https:\/\/doi.org\/10.1016\/j.jjcc.2017.02.005","relation":{},"ISSN":["0914-5087"],"issn-type":[{"value":"0914-5087","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myocardial contractile reserve predicts left ventricular reverse remodeling and cardiac events in dilated cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jjcc.2017.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}