{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:37:29Z","timestamp":1792618649612,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-cardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.jjcc.2019.07.011","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:38:50Z","timestamp":1566347930000},"page":"140-147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Effects of carvedilol vs bisoprolol on inflammation and oxidative stress in patients with chronic heart failure"],"prefix":"10.1016","volume":"75","author":[{"given":"Shigeru","family":"Toyoda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Haruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Inami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuo","family":"Arikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiya","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Sakuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichiro","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Node","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruo","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jjcc.2019.07.011_bib0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0140-6736(98)11181-9","article-title":"The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II); a randomized trial","volume":"353","author":"CIBIS-II Investigators","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0010","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJM199605233342101","article-title":"The effect of carvedilol on morbidity and mortality in patients with chronic heart failure","volume":"334","author":"Packer","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0015","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJM200105313442201","article-title":"Effect of carvedilol on survival in severe chronic heart failure","volume":"344","author":"Packer","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0020","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jjcc.2019.02.005","article-title":"Improvement of the outcome in patients with infantile dilated cardiomyopathy over three decades \u2014 the usefulness of long-term gradually medical supportive care","volume":"74","author":"Tsuda","year":"2019","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0025","unstructured":"The Joint Study Group in 2009 of the Japanese Circulation Society. Guidelines for diagnosis and treatment of cardiovascular diseases; guidelines for treatment of chronic heart failure (JCS 2010). http:\/\/www.j-circ.or.jp\/guideline\/pdf\/JCS2010 _matsuzaki_h.pdf (in Japanese)."},{"key":"10.1016\/j.jjcc.2019.07.011_bib0030","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/00005344-200010000-00008","article-title":"Binding properties of beta-blockers at recombinant beta1, beta2 and beta3-adrenoreceptors","volume":"36","author":"Schnabel","year":"2000","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0035","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijcard.2016.10.046","article-title":"Protective effects of bisoprolol against myocardial injury and pulmonary dysfunction in patients with chronic heart failure","volume":"226","author":"Toyoda","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0040","doi-asserted-by":"crossref","first-page":"682","DOI":"10.2174\/1573406410666140318113325","article-title":"Inflammation and chronic heart failure: from biomarkers to novel anti-inflammatory therapeutic strategies","volume":"10","author":"Bouras","year":"2014","journal-title":"Med Chem"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0045","doi-asserted-by":"crossref","first-page":"H2181","DOI":"10.1152\/ajpheart.00554.2011","article-title":"Oxidative stress and heart failure","volume":"301","author":"Tsutsui","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0050","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1475-2840-8-5","article-title":"Long-term effects of peroxisome proliferator-activated receptor ligand bezafibrate on N-terminal pro-B type natriuretic peptide in patients with advanced functional capacity impairment","volume":"8","author":"Node","year":"2009","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0055","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0735-1097(00)00804-4","volume":"36","author":"Antman","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0060","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.jacc.2013.12.032","article-title":"Age- and sex-dependent upper reference limits for the high-sensitivity cardiac troponin T assay","volume":"63","author":"Gore","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0065","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1161\/CIRCULATIONAHA.110.005264","article-title":"Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study","volume":"123","author":"Saunders","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0070","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1093\/clinchem\/45.12.2136","article-title":"Clinical efficacy of an automated high-sensitivity C-reactive protein assay","volume":"45","author":"Rifai","year":"1999","journal-title":"Clin Chem"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0075","first-page":"127","article-title":"A simple test to monitor oxidative stress","volume":"18","author":"Cearone","year":"1999","journal-title":"Int Angiol"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0080","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1093\/jn\/131.12.3208","article-title":"Bioavailability and antioxidant activity of some food supplements in men and women using the D-Roms test as a marker of oxidative stress","volume":"131","author":"Cornelli","year":"2001","journal-title":"J Nutr"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0085","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1177\/172460080401900312","article-title":"Evaluation of reactive oxygen metabolites in frozen serum samples. Effect of storage and repeated thawing","volume":"19","author":"Cavalleri","year":"2004","journal-title":"Int J Biol Markers"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0090","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0300-483X(00)00231-6","article-title":"The Haber-Weiss reaction and mechanisms of toxity","volume":"149","author":"Kehrer","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0095","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1056\/NEJM199007263230405","article-title":"Elevated circulating levels of tumor necrosis factor in severe chronic heart failure","volume":"323","author":"Levine","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0100","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1161\/01.CIR.92.6.1479","article-title":"Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure","volume":"92","author":"Ferrari","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0105","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0735-1097(97)00494-4","article-title":"Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure","volume":"31","author":"Tsutamoto","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0110","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1161\/CIRCULATIONAHA.104.508465","article-title":"C-reactive protein in heart failure: prognostic value and the effect of valsartan","volume":"112","author":"Anand","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0115","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0008-6363(95)00121-2","article-title":"Mechanical and neuroendocrine regulation of the endocrine heart","volume":"31","author":"de Bold","year":"1996","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0120","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2174\/1568026611313020002","article-title":"NTproBNP: an important biomarker in cardiac diseases","volume":"13","author":"Panagopoulou","year":"2013","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0125","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jjcc.2012.06.007","article-title":"Cardiac troponin and heart failure in the era of high-sensitivity assays","volume":"60","author":"Sato","year":"2012","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0130","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1253\/circj.CJ-13-1372","article-title":"High-sensitivity cardiac troponin T predicts non-cardiac mortality in heart failure","volume":"78","author":"Nakamura","year":"2014","journal-title":"Circ J"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0135","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1016\/j.jacc.2011.01.029","article-title":"Pathobiology of troponin elevations: do elevations occur with myocardial ischemia as well as necrosis?","volume":"57","author":"White","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0140","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ejheart.2008.03.002","article-title":"Beneficial effects of bisoprolol on the survival of hypertensive diastolic heart failure model rats","volume":"10","author":"Nishio","year":"2008","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0145","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1136\/hrt.65.5.245","article-title":"Oxygen free radicals and congestive heart failure","volume":"65","author":"Belch","year":"1991","journal-title":"Br Heart J"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0150","first-page":"291","article-title":"Antioxidant and oxidative stress changes during heart failure subsequent to myocardial infarction in rats","volume":"148","author":"Hill","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0155","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1161\/01.CIR.97.16.1536","article-title":"Elevated levels of 8-iso-prostaglandin F2\u03b1 in pericardial fluid of patients with heart failure","volume":"97","author":"Mallat","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0160","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1161\/01.HYP.0000254415.31362.a7","article-title":"Role of oxidative stress in cardiac hypertrophy and remodeling","volume":"49","author":"Takimoto","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0165","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1161\/01.CIR.0000018605.14470.DD","article-title":"Carvedilol decreases elevated oxidative stress in human failing myocardium","volume":"105","author":"Nakamura","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0170","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1161\/01.CIR.0000139857.85424.45","article-title":"Should angiotensin II receptor blockers and statins be combined?","volume":"110","author":"Nickenig","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0175","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1161\/01.CIR.99.20.2645","article-title":"Prospective, randomized comparison of e\ufb00ect of long-term treatment with metoprolol or carvedilol on symptoms, exercise, ejection fraction, and oxidative stress in heart failure","volume":"99","author":"Kukin","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0180","doi-asserted-by":"crossref","first-page":"H1003","DOI":"10.1152\/ajpheart.00797.2003","article-title":"Importance of antioxidant and antiapoptotic effects of beta-receptor blockers in heart failure therapy","volume":"287","author":"Kawai","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0185","doi-asserted-by":"crossref","first-page":"pii:E72","DOI":"10.3390\/antiox8030072","article-title":"Measurement and clinical significance of lipid peroxidation as a biomarker of oxidative stress: oxidative stress in diabetes, atherosclerosis, and chronic inflammation","volume":"8","author":"Ito","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0190","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5698931","article-title":"Does the interdependence between oxidative stress and in\ufb02ammation explain the antioxidant paradox?","volume":"2016","author":"Biswas","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0195","doi-asserted-by":"crossref","first-page":"206","DOI":"10.5551\/jat.E538","article-title":"Derivatives of reactive oxygen metabolites correlates with high-sensitivity C-reactive protein","volume":"15","author":"Kamezaki","year":"2008","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0200","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1055\/s-0043-105390","article-title":"New knowledge about old drugs: the anti-inflammatory properties of cardiac glycosides","volume":"83","author":"F\u00fcrst","year":"2017","journal-title":"Planta Med"},{"key":"10.1016\/j.jjcc.2019.07.011_bib0205","doi-asserted-by":"crossref","first-page":"pii:E2600","DOI":"10.3390\/ijms19092600","article-title":"The Na\/K-ATPase signaling: from specific ligands to general reactive oxygen species","volume":"19","author":"Pratt","year":"2018","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508719302370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508719302370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:02:12Z","timestamp":1760274132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0914508719302370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S0914508719302370"],"URL":"https:\/\/doi.org\/10.1016\/j.jjcc.2019.07.011","relation":{},"ISSN":["0914-5087"],"issn-type":[{"value":"0914-5087","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of carvedilol vs bisoprolol on inflammation and oxidative stress in patients with chronic heart failure","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jjcc.2019.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"name":"copyright","label":"Copyright"}]}}