{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T23:01:22Z","timestamp":1768258882065,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-cardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.jjcc.2019.08.017","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:18:18Z","timestamp":1568765898000},"page":"360-367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of hybrid therapy using prior administration of bepridil hydrochloride and cryoballoon ablation in patients with persistent atrial fibrillation"],"prefix":"10.1016","volume":"75","author":[{"given":"Daisuke","family":"Yakabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akemi","family":"Aso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Murasato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jjcc.2019.08.017_bib0005","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1056\/NEJM199809033391003","article-title":"Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins","volume":"339","author":"Ha\u00efssaguerre","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0010","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1111\/j.1540-8167.2009.01560.x","article-title":"Comparison of cryoballoon and radiofrequency ablation of pulmonary veins in 40 patients with paroxysmal atrial fibrillation: a case-control study","volume":"20","author":"Linhart","year":"2009","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0015","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/europace\/euw330","article-title":"Cryoablation vs. Radiofrequency ablation for treatment of paroxysmal atrial fibrillation: a systematic review and meta-analysis","volume":"19","author":"Chen","year":"2017","journal-title":"Europace"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0020","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1056\/NEJMoa1408288","article-title":"Approaches to catheter ablation for persistent atrial fibrillation","volume":"372","author":"Verma","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0025","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/europace\/euu350","article-title":"Circumferential pulmonary vein isolation as index procedure for persistent atrial fibrillation: a comparison between radiofrequency catheter ablation and second-generation cryoballoon ablation","volume":"17","author":"Ciconte","year":"2015","journal-title":"Europace"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0030","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1161\/CIRCEP.115.002776","article-title":"Cryoballoon ablation for pulmonary vein isolation in patients with persistent atrial fibrillation: one-year outcome using second generation cryoballoon","volume":"8","author":"Koektuerk","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0035","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jjcc.2016.02.007","article-title":"Cryoballoon ablation for persistent atrial fibrillation - Large single-center experience","volume":"68","author":"Straube","year":"2016","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0040","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/europace\/euv092","article-title":"One-year clinical outcome after pulmonary vein isolation in persistent atrial fibrillation using the second-generation 28 mm cryoballoon: a retrospective analysis","volume":"18","author":"Lemes","year":"2016","journal-title":"Europace"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0045","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.hrthm.2016.05.022","article-title":"Two years outcome in patients with persistent atrial fibrillation after pulmonary vein isolation using the second-generation 28-mm cryoballoon","volume":"13","author":"Tscholl","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0050","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/jce.12924","article-title":"Efficacy of cryoballoon pulmonary vein isolation in patients with persistent atrial fibrillation","volume":"27","author":"Guhl","year":"2016","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0055","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.hrthm.2017.10.038","article-title":"Pulmonary vein isolation cryoablation for patients with persistent and long-standing persistent atrial fibrillation: clinical outcomes from the real-world multicenter observational project","volume":"15","author":"Tondo","year":"2018","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0060","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.jacep.2018.07.007","article-title":"Single-procedure outcomes and quality-of-life improvement 12 months post-cryoballoon ablation in persistent atrial fibrillation: results from the multicenter CRYO4PERSISTENT AF Trial","volume":"4","author":"Boveda","year":"2018","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0065","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jjcc.2018.02.012","article-title":"Impact of catheter ablation of atrial fibrillation on long-term clinical outcomes in patients with heart failure","volume":"72","author":"Ichijo","year":"2018","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0070","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMoa1707855","article-title":"Catheter ablation for atrial fibrillation with heart failure","volume":"378","author":"Marrouche","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0075","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1093\/europace\/eup363","article-title":"Pharmacological cardioversion preceding left atrial ablation: bepridil predicts the clinical outcome following ablation in patients with persistent atrial fibrillation","volume":"11","author":"Miyazaki","year":"2009","journal-title":"Europace"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0080","first-page":"142","article-title":"Pulmonary vein isolation alone in patients with persistent atrial fibrillation: an ablation strategy facilitated by antiarrhythmic drug induced reverse remodeling","volume":"22","author":"Khan","year":"2011","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0085","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.hrthm.2012.02.016","article-title":"Improved outcome following restoration of sinus rhythm prior to catheter ablation of persistent atrial fibrillation: a comparative multicenter study","volume":"9","author":"Rivard","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0090","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.jjcc.2017.10.021","article-title":"Registry of Japanese patients with atrial fibrillation focused on anticoagulant therapy in the new era: the RAFFINE registry study design and baseline characteristics","volume":"71","author":"Miyazaki","year":"2018","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0095","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1253\/circj.CJ-66-0092","article-title":"Guidelines for pharmacotherapy of atrial fibrillation (JCS 2013)","volume":"78","author":"Japanese Circulation Society Joint Working Group","year":"2014","journal-title":"Circ J"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0100","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.amjcard.2010.10.075","article-title":"P wave duration and risk of longitudinal atrial fibrillation in persons \u226560 years old (from the Framingham Heart Study)","volume":"107","author":"Magnani","year":"2011","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0105","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.hrthm.2015.04.026","article-title":"P-wave duration and the risk of atrial fibrillation: results from the Copenhagen ECG Study","volume":"12","author":"Nielsen","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0110","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10840-013-9851-1","article-title":"Prolonged P-wave duration is associated with atrial fibrillation recurrence after successful pulmonary vein isolation for paroxysmal atrial fibrillation","volume":"39","author":"Caldwell","year":"2014","journal-title":"J Interv Card Electrophysiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0115","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.amjcard.2008.04.065","article-title":"Usefulness of P-wave dispersion in standard twelve-lead electrocardiography to predict transition from paroxysmal to persistent atrial fibrillation","volume":"102","author":"Koide","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0120","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.joa.2017.08.001","article-title":"2017 HRS\/EHRA\/ECAS\/APHRS\/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary","volume":"33","author":"Calkins","year":"2017","journal-title":"J Arrhythmia"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0125","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/pace.13247","article-title":"Outcome in patients with left common pulmonary vein after cryoablation with second-generation cryoballoon","volume":"41","author":"Beiert","year":"2018","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0130","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/jce.13040","article-title":"Interatrial conduction time can predict new-onset atrial fibrillation after radiofrequency ablation of isolated, typical atrial flutter","volume":"27","author":"Henmi","year":"2016","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0135","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0002-9149(03)00672-6","article-title":"Usefulness and safety of bepridil in converting persistent atrial fibrillation to sinus rhythm","volume":"92","author":"Fujiki","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0140","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1253\/circj.69.44","article-title":"Conversion and maintenance of sinus rhythm by bepridil in patients with persistent atrial fibrillation","volume":"69","author":"Nakazato","year":"2005","journal-title":"Circ J"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0145","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1136\/heartjnl-2012-302017","article-title":"Effectiveness of amiodarone versus bepridil in achieving conversion to sinus rhythm in patients with persistent atrial fibrillation: a randomised trial","volume":"98","author":"Yamase","year":"2012","journal-title":"Heart"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0150","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1253\/circj.70.206","article-title":"Bepridil inhibits sub-acute phase of atrial electrical remodeling in canine rapid atrial stimulation model","volume":"70","author":"Sato","year":"2006","journal-title":"Circ J"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0155","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1540-8167.2007.00833.x","article-title":"Bepridil reverses atrial electrical remodeling and L-type calcium channel downregulation in a canine model of persistent atrial tachycardia","volume":"18","author":"Nishida","year":"2007","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0160","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1253\/circj.CJ-08-1061","article-title":"Dose-response effects of bepridil in patients with persistent atrial fibrillation monitored with transtelephonic electrocardiograms: a multicenter, randomized, placebo-controlled, double-blind study (J-BAF Study)","volume":"73","author":"Yamashita","year":"2009","journal-title":"Circ J"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0165","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ipej.2016.10.002","article-title":"P-wave dispersion: an update","volume":"16","author":"P\u00e9rez-Riera","year":"2016","journal-title":"Indian Pacing Electrophysiol J"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0170","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/S0002-9149(03)00405-3","article-title":"Anatomic description of Bachmann\u2019s bundle and its relation to the atrial septum","volume":"91","author":"Lemery","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0175","first-page":"1","article-title":"Coronary sinus signal amplitude predicts left atrial scarring","volume":"22","author":"Attanasio","year":"2017","journal-title":"Acta Cardiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0180","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jjcc.2018.04.010","article-title":"Impact of the extent of low-voltage zone on outcomes after voltage-based catheter ablation for persistent atrial fibrillation","volume":"72","author":"Yamaguchi","year":"2018","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0185","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.amjcard.2006.12.073","article-title":"Circumferential ablation with pulmonary vein isolation in permanent atrial fibrillation","volume":"99","author":"Cheema","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0190","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/europace\/euq434","article-title":"Predictors of recurrence following radiofrequency ablation for persistent atrial fibrillation","volume":"13","author":"McCready","year":"2011","journal-title":"Europace"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0195","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.amjcard.2010.02.016","article-title":"Effect of restoration of sinus rhythm by extensive antiarrhythmic drugs in predicting results of catheter ablation of persistent atrial fibrillation","volume":"106","author":"Igarashi","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0200","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/europace\/eur364","article-title":"Association between left atrial size and atrial fibrillation recurrence after single circumferential pulmonary vein isolation: a systematic review and meta-analysis of observational studies","volume":"14","author":"Zhuang","year":"2012","journal-title":"Europace"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0205","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/0735-1097(93)90593-P","article-title":"Changes in left and right atrial size after cardioversion of atrial fibrillation: role of mitral valve disease","volume":"22","author":"Gosselink","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0210","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.hrthm.2004.09.028","article-title":"Effect of rate and rhythm control on left ventricular function and cardiac dimensions in patients with persistent atrial fibrillation: results from the RAte Control versus Electrical Cardioversion for Persistent Atrial Fibrillation (RACE) study","volume":"2","author":"Hagens","year":"2005","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0215","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1253\/circj.CJ-08-0428","article-title":"Changes in left atrial structure and function after catheter ablation and electrical cardioversion for atrial fibrillation","volume":"72","author":"Choi","year":"2008","journal-title":"Circ J"},{"key":"10.1016\/j.jjcc.2019.08.017_bib0220","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1161\/01.CIR.0000062689.04037.3F","article-title":"Reverse structural and gap-junctional remodeling after prolonged atrial fibrillation in the goat","volume":"107","author":"Ausma","year":"2003","journal-title":"Circulation"}],"container-title":["Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508719302783?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508719302783?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:02:20Z","timestamp":1760274140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0914508719302783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0914508719302783"],"URL":"https:\/\/doi.org\/10.1016\/j.jjcc.2019.08.017","relation":{},"ISSN":["0914-5087"],"issn-type":[{"value":"0914-5087","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of hybrid therapy using prior administration of bepridil hydrochloride and cryoballoon ablation in patients with persistent atrial fibrillation","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jjcc.2019.08.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"name":"copyright","label":"Copyright"}]}}