{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:13:18Z","timestamp":1784297598907,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-cardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jjcc.2021.08.018","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T07:58:29Z","timestamp":1630655909000},"page":"586-597","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["LncRNA MIAT knockdown alleviates oxygen-glucose deprivation\u2011induced cardiomyocyte injury by regulating JAK2\/STAT3 pathway via miR-181a-5p"],"prefix":"10.1016","volume":"78","author":[{"given":"Jian-Kai","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Feng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Neng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Rong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Qin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4361-614X","authenticated-orcid":false,"given":"Huan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jjcc.2021.08.018_bib0001","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/MCA.0000000000000598","article-title":"Anemia and coronary artery disease\u2013Pathophysiology, prognosis, and treatment","volume":"29","author":"Rymer","year":"2018","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0002","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrg.2016.160","article-title":"Genetics of coronary artery disease\u2013Discovery, biology and clinical translation","volume":"18","author":"Khera","year":"2017","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0003","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1161\/CIRCULATIONAHA.105.537878","article-title":"Pathophysiology of coronary artery disease","volume":"111","author":"Libby","year":"2005","journal-title":"Circ"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijcard.2019.03.059","article-title":"Left ventricular hypertrophy contributes to myocardial ischemia in non-obstructive coronary artery disease (the MicroCAD study)","volume":"286","author":"Eskerud","year":"2019","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0005","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1007\/s12350-017-0923-y","article-title":"Myocardial ischemia without obstructive CAD\u2013There is more than meets the eye!","volume":"25","author":"Neglia","year":"2018","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0006","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.brainres.2018.11.003","article-title":"LncRNA SNHG1 alleviates OGD induced injury in BMEC via miR-338\/HIF-1alpha axis","volume":"1714","author":"Yang","year":"2019","journal-title":"Brain Res"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0007","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/2472630318780639","article-title":"Platforms for investigating LncRNA functions","volume":"23","author":"Richard","year":"2018","journal-title":"SLAS Technol"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0008","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1158\/0008-5472.CAN-16-2634","article-title":"Long noncoding RNA and cancer\u2013A new paradigm","volume":"77","author":"Bhan","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0009","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1139\/bcb-2017-0188","article-title":"LncRNA SNHG1 enhances cell proliferation, migration, and invasion in cervical cancer","volume":"96","author":"Liu","year":"2018","journal-title":"Biochem Cell Biol"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0010","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/jcmm.13338","article-title":"LncRNA PLAC2 down-regulates RPL36 expression and blocks cell cycle progression in glioma through a mechanism involving STAT1","volume":"22","author":"Hu","year":"2018","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0011","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10863-019-09812-9","article-title":"The lncRNA ROR\/miR-124-3p\/TRAF6 axis regulated the ischaemia reperfusion injury-induced inflammatory response in human cardiac myocytes","volume":"51","author":"Liang","year":"2019","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0012","doi-asserted-by":"crossref","first-page":"6779","DOI":"10.1038\/ncomms7779","article-title":"APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p","volume":"6","author":"Wang","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109208","article-title":"Long non-coding RNAs H19, MALAT1 and MIAT as potential novel biomarkers for diagnosis of acute myocardial infarction","volume":"118","author":"Wang","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0014","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6280194","article-title":"LncRNA-MIAT increased in patients with coronary atherosclerotic heart disease","volume":"2019","author":"Tan","year":"2019","journal-title":"Cardiol Res Pract"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0015","article-title":"LncRNA-MIAT regulates fibrosis in hypertrophic cardiomyopathy (HCM) by mediating the expression of miR-29a-3p","author":"Zhou","year":"2018","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0016","first-page":"1864","article-title":"The role of omega-3 fatty acids in the setting of coronary artery disease and COPD\u2013A review","volume":"10","author":"Pizzini","year":"2018","journal-title":"Nutr"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0017","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/MCA.0000000000000625","article-title":"Inflammation and coronary artery disease: from pathophysiology to Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS)","volume":"29","author":"Ali","year":"2018","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0018","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000495161","article-title":"MicroRNA-24-3p attenuates myocardial ischemia\/reperfusion injury by suppressing RIPK1 expression in mice","volume":"51","author":"Tan","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0019","first-page":"784","article-title":"[Role of miRNA-340 in modulating gastric cancer cell proliferation and bioinformatic analysis]","volume":"39","author":"Wang","year":"2019","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0020","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev-pathol-012513-104715","article-title":"MicroRNAs in cancer","volume":"9","author":"Di Leva","year":"2014","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0021","first-page":"96","article-title":"Mirna biogenesis pathway is differentially regulated during adipose derived stromal\/stem cell differentiation","volume":"7","author":"Martin","year":"2018","journal-title":"Adipocyte"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116619","article-title":"MicroRNA-374a protects against myocardial ischemia-reperfusion injury in mice by targeting the MAPK6 pathway","volume":"232","author":"Huang","year":"2019","journal-title":"Life Sci"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0023","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41419-019-1599-9","article-title":"MicroRNA-181a-5p and microRNA-181a-3p cooperatively restrict vascular inflammation and atherosclerosis","volume":"10","author":"Su","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0024","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3892\/ijo.2014.2259","article-title":"The IL-6\/JAK\/STAT3 pathway\u2013Potential therapeutic strategies in treating colorectal cancer (Review)","volume":"44","author":"Wang","year":"2014","journal-title":"Int J Oncol"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0025","first-page":"819","article-title":"IL-6 mediated JAK\/STAT3 signaling pathway in cancer patients with cachexia","volume":"66","author":"Eskiler","year":"2019","journal-title":"Bratisl Lek Listy"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0026","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jdiacomp.2017.12.001","article-title":"The role of lnc-DC long non-coding RNA and SOCS1 in the regulation of STAT3 in coronary artery disease and type 2 diabetes mellitus","volume":"32","author":"Alikhah","year":"2018","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0027","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1159\/000481755","article-title":"Remote limb ischaemic postconditioning protects against myocardial ischaemia\/reperfusion injury in mice\u2013Activation of JAK\/STAT3-mediated Nrf2-antioxidant signalling","volume":"43","author":"Gao","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0028","first-page":"520","article-title":"The effect of hydroxy safflower yellow A on coronary heart disease through Bcl-2\/Bax and PPAR-gamma","volume":"15","author":"Zhou","year":"2018","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0029","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1080\/13880209.2016.1214741","article-title":"Protective effect of curcumin against myocardium injury in ischemia reperfusion rats","volume":"55","author":"Liu","year":"2017","journal-title":"Pharm Biol"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0030","first-page":"55353","article-title":"Murine left anterior descending (LAD) coronary artery ligation: an improved and simplified model for myocardial infarction","volume":"122","author":"Reichert","year":"2017","journal-title":"J Vis Exp"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0031","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1007\/s12350-017-1050-5","article-title":"Invasive assessment of coronary artery disease","volume":"25","author":"Pyxaras","year":"2018","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0032","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1253\/circj.CJ-16-0266","article-title":"Future of the prevention and treatment of coronary artery disease","volume":"80","author":"Steg","year":"2016","journal-title":"Circ J"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0033","first-page":"2422","article-title":"LncRNA TUG1 serves an important role in hypoxia-induced myocardial cell injury by regulating the miR1455pBinp3 axis","volume":"17","author":"Wu","year":"2018","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0034","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/21655979.2019.1605812","article-title":"Targeting MIAT reduces apoptosis of cardiomyocytes after ischemia\/reperfusion injury","volume":"10","author":"Chen","year":"2019","journal-title":"Bioengineered"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0035","doi-asserted-by":"crossref","first-page":"448","DOI":"10.18632\/aging.101751","article-title":"miRNA-mRNA crosstalk in myocardial ischemia induced by calcified aortic valve stenosis","volume":"11","author":"Duan","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0036","doi-asserted-by":"crossref","first-page":"187","DOI":"10.31083\/j.rcm.2019.03.545","article-title":"Inhibition of miR-34a-5p protected myocardial ischemia reperfusion injury-induced apoptosis and reactive oxygen species accumulation through regulation of Notch Receptor 1 signaling","volume":"20","author":"Wang","year":"2019","journal-title":"Rev Cardiovasc Med"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0037","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000504959","article-title":"MiR-375 mediates chondrocyte metabolism and oxidative stress in osteoarthritis mouse models through the JAK2\/STAT3 signaling pathway","volume":"208","author":"Zou","year":"2019","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0038","first-page":"2453","article-title":"MiR-630 inhibits papillary thyroid carcinoma cell growth, metastasis, and epithelial-mesenchymal transition by suppressing JAK2\/STAT3 signaling pathway","volume":"23","author":"Pan","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0039","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1038\/s41388-020-1322-4","article-title":"Cancer exosome-derived miR-9 and miR-181a promote the development of early-stage MDSCs via interfering with SOCS3 and PIAS3 respectively in breast cancer","volume":"39","author":"Jiang","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0040","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1538\/expanim.19-0058","article-title":"Inhibition of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 attenuates high glucose-induced cardiomyocyte apoptosis via regulation of miR-181a-5p","volume":"69","author":"Cheng","year":"2020","journal-title":"Exp Anim"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0041","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/978-1-4939-3378-5_21","article-title":"Analyzing MiRNA-LncRNA interactions","volume":"1402","author":"Paraskevopoulou","year":"2016","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0042","doi-asserted-by":"crossref","first-page":"9050","DOI":"10.1073\/pnas.161283798","article-title":"An essential role of the JAK-STAT pathway in ischemic preconditioning","volume":"98","author":"Xuan","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0043","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.3390\/ijms21051692","article-title":"Remote ischemic preconditioning induces cardioprotective autophagy and signals through the IL-6-dependent JAK-STAT pathway","volume":"21","author":"Billah","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0044","doi-asserted-by":"crossref","first-page":"854","DOI":"10.3390\/cells8080854","article-title":"Roles of JAK2 in aging, inflammation, hematopoiesis and malignant transformation","volume":"8","author":"Perner","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0045","doi-asserted-by":"crossref","first-page":"G774","DOI":"10.1152\/ajpgi.00053.2019","article-title":"Renin-angiotensin system promotes colonic inflammation by inducing TH17 activation via JAK2\/STAT pathway","volume":"316","author":"He","year":"2019","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0046","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrc2734","article-title":"STATs in cancer inflammation and immunity\u2013A leading role for STAT3","volume":"9","author":"Yu","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0047","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.yjmcc.2012.09.007","article-title":"Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway","volume":"53","author":"Das","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0048","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00395-018-0671-4","article-title":"Cardioprotective effect of ghrelin against myocardial infarction-induced left ventricular injury via inhibition of SOCS3 and activation of JAK2\/STAT3 signaling","volume":"113","author":"Eid","year":"2018","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0049","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ebiom.2018.07.013","article-title":"The long noncoding RNA MEG3 and its target miR-147 regulate JAK\/STAT pathway in advanced chronic myeloid leukemia","volume":"34","author":"Li","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jjcc.2021.08.018_bib0050","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1042\/CS20200039","article-title":"miR-210 transferred by lung cancer cell-derived exosomes may act as proangiogenic factor in cancer-associated fibroblasts by modulating JAK2\/STAT3 pathway","volume":"134","author":"Fan","year":"2020","journal-title":"Clin Sci (Lond)"}],"container-title":["Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508721002215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508721002215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:37:07Z","timestamp":1778701027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0914508721002215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0914508721002215"],"URL":"https:\/\/doi.org\/10.1016\/j.jjcc.2021.08.018","relation":{},"ISSN":["0914-5087"],"issn-type":[{"value":"0914-5087","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LncRNA MIAT knockdown alleviates oxygen-glucose deprivation\u2011induced cardiomyocyte injury by regulating JAK2\/STAT3 pathway via miR-181a-5p","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jjcc.2021.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Japanese College of Cardiology. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}