{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:55:39Z","timestamp":1789419339050,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-cardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.jjcc.2021.10.017","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T08:17:25Z","timestamp":1636532245000},"page":"530-536","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reduction of tethering distance by papillary muscle tugging approximation with mitral valve replacement for non-ischemic functional mitral regurgitation induces left ventricular reverse remodeling"],"prefix":"10.1016","volume":"79","author":[{"given":"Takahiro","family":"Ishigaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Wakasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushige","family":"Shingu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Ohkawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8262-6872","authenticated-orcid":false,"given":"Akira","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Anzai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiro","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jjcc.2021.10.017_bib0001","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.jacc.2015.02.009","article-title":"Secondary mitral regurgitation in heart failure: pathophysiology, prognosis, and therapeutic considerations","volume":"65","author":"Asgar","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0002","article-title":"Transcatheter mitral valve repair for functional mitral regurgitation: evaluating the evidence","author":"Gelijns","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0003","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jtcvs.2018.12.102","article-title":"A pathoanatomic approach to secondary functional mitral regurgitation: evaluating the evidence","volume":"158","author":"Badhwar","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0004","article-title":"Treatment options for ischemic mitral regurgitation: a meta-analysis","author":"Nappi","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0005","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jtcvs.2017.03.039","article-title":"Mitral valve surgery and coronary artery bypass grafting for moderate-to-severe ischemic mitral regurgitation: meta-analysis of clinical and echocardiographic outcomes","volume":"154","author":"Virk","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0006","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/ejcts\/ezz238","article-title":"The optimal treatment strategy for secondary mitral regurgitation: a subject of ongoing debate","volume":"56","author":"Petrus","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0007","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/icvts\/ivx187","article-title":"A technical review of subvalvular techniques for repair of ischaemic mitral regurgitation and their associated echocardiographic and survival outcomes","volume":"25","author":"Athanasopoulos","year":"2017","journal-title":"Interac Cardiovasc Thorac Surg"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0008","doi-asserted-by":"crossref","first-page":"S582","DOI":"10.21037\/jtd.2017.05.56","article-title":"Mitral valve repair and subvalvular intervention for secondary mitral regurgitation: a systematic review and meta-analysis of randomized controlled and propensity matched studies","volume":"9","author":"Mihos","year":"2017","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0009","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/jocs.14490","article-title":"Meta-analysis of results of subvalvular repair for severe ischemic mitral regurgitation","volume":"35","author":"Meco","year":"2020","journal-title":"J Card Surg"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0010","doi-asserted-by":"crossref","first-page":"e427","DOI":"10.1016\/j.athoracsur.2018.11.072","article-title":"Papillary muscle tugging approximation for functional mitral regurgitation","volume":"107","author":"Matsui","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0011","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s11748-019-01164-w","article-title":"Perioperative changes of the slope in the preload recruitable stroke work relationship by a single-beat technique after mitral valve surgery in functional mitral regurgitation with non-ischemic dilated cardiomyopathy","volume":"68","author":"Ishigaki","year":"2020","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0012","first-page":"390","article-title":"Failure of reduction annuloplasty for functional ischemic mitral regurgitation","volume":"13","author":"Matsunaga","year":"2004","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0013","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American society of echocardiography developed in collaboration with the society for cardiovascular magnetic resonance","volume":"30","author":"Zoghbi","year":"2017","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0014","doi-asserted-by":"crossref","first-page":"H573","DOI":"10.1152\/ajpheart.2001.281.2.H573","article-title":"Assessment of LV systolic function in atrial fibrillation using an index of preceding cardiac cycles","volume":"281","author":"Tabata","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0015","doi-asserted-by":"crossref","first-page":"07HF16","DOI":"10.7567\/JJAP.52.07HF16","article-title":"Intraventricular flow velocity vector visualization based on the continuity equation and measurements of vorticity and wall shear stress","volume":"52","author":"Itatani","year":"2013","journal-title":"Jpn J Appl Phys"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0016","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00380-017-1093-1","article-title":"The relationship between systolic vector flow mapping parameters and left ventricular cardiac function in healthy dogs","volume":"33","author":"Goya","year":"2018","journal-title":"Heart Vessel"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0017","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jacc.2007.07.093","article-title":"Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation","volume":"51","author":"Beeri","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0018","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.athoracsur.2007.08.040","article-title":"Restrictive mitral annuloplasty cures ischemic mitral regurgitation and heart failure","volume":"85","author":"Braun","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0019","first-page":"390","article-title":"Failure of reduction annuloplasty for functional ischemic mitral regurgitation","volume":"13","author":"Matsunaga","year":"2004","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0020","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1016\/j.jtcvs.2018.06.090","article-title":"Estimating postoperative left ventricular volume: identification of responders to surgical ventricular reconstruction","volume":"156","author":"Wakasa","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0021","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/j.jtcvs.2013.06.036","article-title":"Risk scores for predicting mortality after surgical ventricular reconstruction for ischemic cardiomyopathy: results of a Japanese multicenter study","volume":"147","author":"Wakasa","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0022","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jjcc.2014.04.010","article-title":"Slope in preload recruitable stroke work relationship predicts survival after left ventriculoplasty and mitral repair in patients with idiopathic cardiomyopathy","volume":"65","author":"Shingu","year":"2015","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0023","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s11748-020-01512-1","article-title":"Non-heart transplant surgical approaches with mitral valve operation and surgical ventricular reconstruction for non-ischaemic dilated cardiomyopathy: a Japanese multicenter study","volume":"69","author":"Cho","year":"2021","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0024","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0008-6363(97)00215-0","article-title":"Shortening versus isometric contractions in isolated human failing and non-failing left ventricular myocardium: dependency of external work and force on muscle length, heart rate and inotropic stimulation","volume":"37","author":"Holubarsch","year":"1998","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0025","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11897-006-0016-8","article-title":"Neurohormonal modulation in heart failure of ischemic etiology: correlates with left ventricular remodeling","volume":"3","author":"Latini","year":"2006","journal-title":"Curr Heart Fail Rep"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0026","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10047-018-1086-6","article-title":"Re-do mitral valve replacement for a bioprosthetic valve with central transvalvular leakage in a patient with ischemic cardiomyopathy: a case report","volume":"22","author":"Seki","year":"2019","journal-title":"J Artif Organs"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0027","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004056","article-title":"Exercise hemodynamic and functional capacity after mitral valve replacement in patients with ischemic mitral regurgitation: a comparison of mechanical versus biological prostheses","volume":"11","author":"Fino","year":"2018","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0028","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jchf.2018.10.007","article-title":"Heart failure and liver disease: cardiohepatic interactions","volume":"7","author":"Xanthopoulos","year":"2019","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0029","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/jocs.12457","article-title":"Aortic valve repair versus replacement for aortic regurgitation: effects on left ventricular remodeling","volume":"30","author":"Regeer","year":"2015","journal-title":"J Card Surg"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0030","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1016\/j.jacc.2016.03.478","article-title":"Papillary muscle approximation versus restrictive annuloplasty alone for severe ischemic mitral regurgitation","volume":"67","author":"Nappi","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0031","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJMoa1312808","article-title":"Mitral-valve repair versus replacement for severe ischemic mitral regurgitation","volume":"370","author":"Acker","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jjcc.2021.10.017_bib0032","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJMoa1512913","article-title":"Two-year outcomes of surgical treatment of severe ischemic mitral regurgitation","volume":"374","author":"Goldstein","year":"2016","journal-title":"N Engl J Med"}],"container-title":["Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508721002847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508721002847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:05:24Z","timestamp":1760274324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0914508721002847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0914508721002847"],"URL":"https:\/\/doi.org\/10.1016\/j.jjcc.2021.10.017","relation":{},"ISSN":["0914-5087"],"issn-type":[{"value":"0914-5087","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduction of tethering distance by papillary muscle tugging approximation with mitral valve replacement for non-ischemic functional mitral regurgitation induces left ventricular reverse remodeling","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jjcc.2021.10.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Japanese College of Cardiology. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}