{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:13:34Z","timestamp":1793924014854,"version":"4.8.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["journal-of-cardiology.com","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.jjcc.2023.08.004","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T22:38:58Z","timestamp":1691879938000},"page":"365-370","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Association of delayed diagnosis of pulmonary arterial hypertension with its prognosis"],"prefix":"10.1016","volume":"83","author":[{"given":"Kayoko","family":"Kubota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunao","family":"Miyanaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsumasa","family":"Akao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kokoro","family":"Mitsuyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Iwatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjuro","family":"Higo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Ohishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jjcc.2023.08.004_bb0005","doi-asserted-by":"crossref","first-page":"D42","DOI":"10.1016\/j.jacc.2013.10.032","article-title":"Definitions and diagnosis of pulmonary hypertension","volume":"62","author":"Hoeper","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0010","first-page":"3618","article-title":"2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0015","doi-asserted-by":"crossref","first-page":"1801889","DOI":"10.1183\/13993003.01889-2018","article-title":"Risk stratification and medical therapy of pulmonary arterial hypertension","volume":"53","author":"Gali\u00e8","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0020","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1164\/rccm.202009-3698OC","article-title":"Association between initial treatment strategy and long-term survival in pulmonary arterial hypertension","volume":"204","author":"Boucly","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0025","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S2213-2600(16)00027-8","article-title":"Combination therapy versus monotherapy for pulmonary arterial hypertension: a meta-analysis","volume":"4","author":"Lajoie","year":"2016","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0030","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1378\/chest.10-0969","article-title":"Long-term treatment with sildenafil citrate in pulmonary arterial hypertension: the SUPER-2 study","volume":"140","author":"Rubin","year":"2011","journal-title":"Chest"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0035","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1378\/chest.10-1166","article-title":"Delay in recognition of pulmonary arterial hypertension: factors identified from the REVEAL Registry","volume":"140","author":"Brown","year":"2011","journal-title":"Chest"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0040","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1253\/circj.CJ-66-0158","article-title":"Guidelines for the treartment of pulmonary hypertension (JCS2017\/JPCPHS 2017)","volume":"83","author":"Fukuda","year":"2019","journal-title":"Circ J"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0045","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1378\/chest.126.4.1330","article-title":"Natriuretic peptides, respiratory disease, and the right heart","volume":"126","author":"Yap","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0050","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1161\/01.CIR.102.8.865","article-title":"Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension","volume":"102","author":"Nagaya","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0055","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1164\/rccm.200410-1411OC","article-title":"Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) study","volume":"171","author":"Wilkins","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0060","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1053\/hj.1998.v136.89729","article-title":"Secretion patterns of brain natriuretic peptide and atrial natriuretic peptide in patients with or without pulmonary hypertension complicating atrial septal defect","volume":"136","author":"Nagaya","year":"1998","journal-title":"Am Heart J"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0065","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0735-1097(97)00452-X","article-title":"Plasma brain natriuretic peptide levels increase in proportion to the extent of right ventricular dysfunction in pulmonary hypertension","volume":"31","author":"Nagaya","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0070","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0894-7317(96)90476-9","article-title":"Doppler echocardiographic index for assessment of global right ventricular function","volume":"9","author":"Tei","year":"1996","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0075","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0002-9149(98)00140-4","article-title":"Value of a Doppler-derived index combining systolic and diastolic time intervals in predicting outcome in primary pulmonary hypertension","volume":"81","author":"Yeo","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0080","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/S0002-9149(01)01995-6","article-title":"Effect of chronic infusion of epoprostenol on echocardiographic right ventricular myocardial performance index and its relation to clinical outcome in patients with primary pulmonary hypertension","volume":"88","author":"Sebbag","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0085","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1007\/s00380-017-0991-6","article-title":"Comparison of echocardiographic parameters to assess right ventricular function in pulmonary hypertension","volume":"32","author":"Amano","year":"2017","journal-title":"Heart Vessels"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0090","article-title":"Validation of the tricuspid annular plane systolic excursion\/systolic pulmonary artery pressure ratio for the assessment of right ventricular-arterial coupling in severe pulmonary hypertension","volume":"12","author":"Tello","year":"2019","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0095","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ijcard.2018.01.053","article-title":"Relevance of the TAPSE\/PASP ratio in pulmonary arterial hypertension","volume":"266","author":"Tello","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0100","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/0002-8703(84)90095-4","article-title":"Assessment of right ventricular function using two-dimensional echocardiography","volume":"107","author":"Kaul","year":"1984","journal-title":"Am Heart J"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0105","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1164\/rccm.200604-547OC","article-title":"Tricuspid annular displacement predicts survival in pulmonary hypertension","volume":"174","author":"Forfia","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0110","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.3899\/jrheum.110512","article-title":"Tricuspid annular plane systolic excursion is a robust outcome measure in systemic sclerosis-associated pulmonary arterial hypertension","volume":"38","author":"Mathai","year":"2011","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0115","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/2045893217694175","article-title":"Follow-up tricuspid annular plane systolic excursion predicts survival in pulmonary arterial hypertension","volume":"7","author":"Mazurek","year":"2017","journal-title":"Pulm Circ"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/pul2.12188","article-title":"Time to diagnosis of pulmonary hypertension and diagnostic burden: a retrospective analysis of nationwide US healthcare data","volume":"13","author":"Didden","year":"2023","journal-title":"Pulm Circ"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0125","doi-asserted-by":"crossref","first-page":"750","DOI":"10.33963\/KP.15344","article-title":"Time from symptom onset to final diagnosis of pulmonary arterial hypertension in Polish patients","volume":"78","author":"Bylica","year":"2020","journal-title":"Kardiol Pol"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0130","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.rmed.2010.01.002","article-title":"Burden of pulmonary arterial hypertension in Germany","volume":"104","author":"Wilkens","year":"2010","journal-title":"Respir Med"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0135","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1164\/rccm.200510-1668OC","article-title":"Pulmonary arterial hypertension in France: results from a national registry","volume":"173","author":"Humbert","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0140","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1183\/09031936.00101211","article-title":"Survival in pulmonary hypertension in Spain: insights from the Spanish registry","volume":"40","author":"Escribano-Subias","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0145","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1164\/rccm.201203-0383OC","article-title":"Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: results from the pulmonary hypertension registry of the United Kingdom and Ireland","volume":"186","author":"Ling","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0150","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.ijcard.2015.11.001","article-title":"Incidence and prevalence of pulmonary arterial hypertension in Germany","volume":"203","author":"Hoeper","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0155","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrcardio.2017.84","article-title":"Epidemiology and treatment of pulmonary arterial hypertension","volume":"14","author":"Lau","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jjcc.2023.08.004_bb0160","doi-asserted-by":"crossref","first-page":"216","DOI":"10.7326\/0003-4819-107-2-216","article-title":"Primary pulmonary hypertension. A national prospective study","volume":"107","author":"Rich","year":"1987","journal-title":"Ann Intern Med"}],"container-title":["Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508723001892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508723001892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T23:40:34Z","timestamp":1712965234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0914508723001892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S0914508723001892"],"URL":"https:\/\/doi.org\/10.1016\/j.jjcc.2023.08.004","relation":{},"ISSN":["0914-5087"],"issn-type":[{"value":"0914-5087","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of delayed diagnosis of pulmonary arterial hypertension with its prognosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jjcc.2023.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Japanese College of Cardiology. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}