{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:11:53Z","timestamp":1793337113771,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journal-of-cardiology.com","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jjcc.2024.07.006","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T06:19:42Z","timestamp":1722233982000},"page":"8-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Left atrium as key player and essential biomarker in heart failure"],"prefix":"10.1016","volume":"85","author":[{"given":"Katsuji","family":"Inoue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto A.","family":"Smiseth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jjcc.2024.07.006_bb0005","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0735-1097(03)00956-2","article-title":"The left atrium: a biomarker of chronic diastolic dysfunction and cardiovascular disease risk","volume":"42","author":"Douglas","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0010","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/01.RES.35.1.39","article-title":"Importance of atrial compliance in cardiac performance","volume":"35","author":"Suga","year":"1974","journal-title":"Circ Res"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0020","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/01.CIR.100.4.427","article-title":"Left atrial relaxation and left ventricular systolic function determine left atrial reservoir function","volume":"100","author":"Barbier","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0025","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1152\/ajplegacy.1922.58.3.439","article-title":"The contours of ventricular volume curves under different conditions","volume":"58","author":"Wiggers","year":"1922","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0030","first-page":"566","article-title":"Studies on Starling\u2019s law of the heart IV. Observations on the hemodynamic functions of the left atrium in man","volume":"3","author":"Braunwald","year":"1961","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0035","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jacc.2013.10.055","article-title":"Left atrial size and function: role in prognosis","volume":"63","author":"Hoit","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0040","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/cvr\/21.4.255","article-title":"Left atrial filling in normal human subjects: relation between left atrial contraction and left atrial early filling","volume":"21","author":"Toma","year":"1987","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0045","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S0735-1097(99)00300-9","article-title":"The pulmonary venous systolic flow pulse\u2014its origin and relationship to left atrial pressure","volume":"34","author":"Smiseth","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0050","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/ehjci\/jeab173","article-title":"Changes in left atrial structure and function over a decade in the general population","volume":"23","author":"Olsen","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0055","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15053","article-title":"Left atrial conduit function: a short review","volume":"9","author":"Marino","year":"2021","journal-title":"Physiol Rep"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0060","first-page":"H498","article-title":"Total mechanical energy of a ventricle model and cardiac oxygen consumption","volume":"236","author":"Suga","year":"1979","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0065","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1161\/01.CIR.89.4.1829","article-title":"In vivo assessment of left atrial contractile performance in normal and pathological conditions using a time-varying elastance model","volume":"89","author":"Hoit","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0070","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/eurheartj\/ehs016","article-title":"A novel clinical method for quantification of regional left ventricular pressure-strain loop area: a non-invasive index of myocardial work","volume":"33","author":"Russell","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0075","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/ehjci\/jeaa301","article-title":"How to measure left ventricular myocardial work by pressure-strain loops","volume":"22","author":"Smiseth","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0080","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.echo.2023.11.010","article-title":"Mental stress reduces left ventricular strain: can it Lead to misinterpretation of cancer therapy-related cardiac dysfunction?","volume":"37","author":"Sletten","year":"2024","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0085","doi-asserted-by":"crossref","first-page":"H904","DOI":"10.1152\/ajpheart.00530.2014","article-title":"Compensatory increase of left atrial external work to left ventricular dysfunction caused by afterload increase","volume":"308","author":"Inoue","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0090","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.ultrasmedbio.2018.11.008","article-title":"Assessment of left atrial work during acute coronary occlusion","volume":"45","author":"Inoue","year":"2019","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0095","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/ehjci\/jey042","article-title":"Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging","volume":"19","author":"Badano","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0100","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/ehjci\/jeaa415","article-title":"Determinants of left atrial reservoir and pump strain and use of atrial strain for evaluation of left ventricular filling pressure","volume":"23","author":"Inoue","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0105","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/ehjci\/jeac036","article-title":"Left atrial reservoir strain improves diagnostic accuracy of the 2016 ASE\/EACVI diastolic algorithm in patients with preserved left ventricular ejection fraction: insights from the KARUM haemodynamic database","volume":"23","author":"Venkateshvaran","year":"2022","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0110","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.jcmg.2023.08.011","article-title":"Echocardiographic reference ranges of global longitudinal strain for all cardiac chambers using guideline-directed dedicated views","volume":"16","author":"Nyberg","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0115","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.echo.2016.09.007","article-title":"Normal ranges of left atrial strain by speckle-tracking echocardiography: a systematic review and mneta-analysis","volume":"30","author":"Pathan","year":"2017","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0120","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/ehjci\/jeab201","article-title":"Normal values and reference ranges for left atrial strain by speckle-tracking echocardiography: the Copenhagen City Heart Study","volume":"23","author":"Nielsen","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0125","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.jacc.2019.07.080","article-title":"Alteration of cardiac performance and serum B-type natriuretic peptide level in healthy aging","volume":"74","author":"Yoshida","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0130","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.echo.2009.04.026","article-title":"Correlation between left ventricular end-diastolic pressure and peak left atrial wall strain during left ventricular systole","volume":"22","author":"Wakami","year":"2009","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0135","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/ejechocard\/jer283","article-title":"Relation of left ventricular end-diastolic pressure and N-terminal pro-brain natriuretic peptide level with left atrial deformation parameters","volume":"13","author":"Kurt","year":"2012","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0140","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jcmg.2016.08.014","article-title":"LA strain for categorization of LV diastolic dysfunction","volume":"10","author":"Singh","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0145","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00392-018-1399-8","article-title":"Left atrial strain improves estimation of filling pressures in heart failure: a simultaneous echocardiographic and invasive haemodynamic study","volume":"108","author":"Lundberg","year":"2019","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0150","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/ehjci\/jez272","article-title":"Potential usefulness and clinical relevance of a novel left atrial filling index to estimate left ventricular filling pressures in patients with preserved left ventricular ejection fraction","volume":"21","author":"Braunauer","year":"2020","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0155","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1093\/ehjci\/jeab154","article-title":"Multimodality imaging in patients with heart failure and preserved ejection fraction: an expert consensus document of the European Association of Cardiovascular Imaging","volume":"23","author":"Smiseth","year":"2022","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0160","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s44156-024-00051-2","article-title":"The assessment of left ventricular diastolic function: guidance and recommendations from the British Society of Echocardiography","volume":"11","author":"Robinson","year":"2024","journal-title":"Echo Res Pract"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0165","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s44156-024-00048-x","article-title":"Evaluation of left ventricular filling pressure by echocardiography in patients with atrial fibrillation","volume":"11","author":"Khan","year":"2024","journal-title":"Echo Res Pract"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0170","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jcmg.2019.01.037","article-title":"Diastolic stress test: invasive and noninvasive testing","volume":"13","author":"Ha","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0175","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/ejhf.2862","article-title":"Diagnostic value of reduced left atrial compliance during ergometry exercise in heart failure with preserved ejection fraction","volume":"25","author":"Harada","year":"2023","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0180","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1161\/CIRCULATIONAHA.120.051542","article-title":"Exercise stress real-time cardiac magnetic resonance imaging for noninvasive characterization of heart failure with preserved ejection fraction: the HFpEF-Stress Trial","volume":"143","author":"Backhaus","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0185","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jcmg.2016.09.021","article-title":"Left atrial function dynamics during exercise in heart failure: pathophysiological implications on the right heart and exercise ventilation inefficiency","volume":"10","author":"Sugimoto","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.echo.2014.03.010","article-title":"Left atrial strain provides incremental value for embolism risk stratification over CHA\u2082DS\u2082-VASc score and indicates prognostic impact in patients with atrial fibrillation","volume":"27","author":"Obokata","year":"2014","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0195","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1002\/ehf2.14106","article-title":"Incremental prognostic value of left atrial strain in patients with heart failure","volume":"9","author":"Bo","year":"2022","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0200","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.121.013556","article-title":"Left atrial reservoir strain-based left ventricular diastolic function grading and incident heart failure in hypertrophic cardiomyopathy","volume":"15","author":"Lee","year":"2022","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0205","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.115.002763","article-title":"Prognostic relevance of left atrial dysfunction in heart failure with preserved ejection fraction","volume":"9","author":"Santos","year":"2016","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0210","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0215","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1161\/01.CIR.68.2.302","article-title":"Noninvasive evaluation of pulmonary hypertension by a pulsed Doppler technique","volume":"68","author":"Kitabatake","year":"1983","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0220","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jcmg.2023.12.004","article-title":"Echocardiographic evaluation of left ventricular filling pressure in patients with pulmonary hypertension","volume":"17","author":"Inoue","year":"2024","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0225","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/joa3.12624","article-title":"Persistence of left atrial abnormalities despite left atrial volume normalization after successful ablation of atrial fibrillation","volume":"37","author":"Kawakami","year":"2021","journal-title":"J Arrhythm"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0230","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/01.CIR.67.3.566","article-title":"Importance of left atrial function in patients with myocardial infarction","volume":"67","author":"Matsuda","year":"1983","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0235","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1097\/01.CCM.0000296274.51933.4C","article-title":"Practical recommendations for prehospital and early in-hospital management of patients presenting with acute heart failure syndromes","volume":"36","author":"Mebazaa","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0240","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12574-017-0348-2","article-title":"Prominent v wave as a result of left atrial stiffening","volume":"16","author":"Inoue","year":"2018","journal-title":"J Echocardiogr"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0245","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0002-9149(99)00915-7","article-title":"Is the left atrial v. wave the determinant of peak pulmonary artery pressure in patients with pure mitral stenosis?","volume":"85","author":"Ha","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0250","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1111\/jce.14241","article-title":"Extensive left atrial ablation was associated with exacerbation of left atrial stiffness and dyspnea","volume":"30","author":"Moon","year":"2019","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0255","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.jacc.2020.07.009","article-title":"Atrial dysfunction in patients with heart failure with preserved ejection fraction and atrial fibrillation","volume":"76","author":"Reddy","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0260","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1161\/CIRCULATIONAHA.123.065134","article-title":"Cardiac and metabolic effects of dapagliflozin in heart failure with preserved ejection fraction: the CAMEO-DAPA Trial","volume":"148","author":"Borlaug","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2024.07.006_bb0265","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1002\/ehf2.13442","article-title":"Restricted left atrial dilatation can visually differentiate cardiac amyloidosis from hypertrophic cardiomyopathy","volume":"8","author":"Higashi","year":"2021","journal-title":"ESC Heart Fail"}],"container-title":["Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508724001357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508724001357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T02:05:59Z","timestamp":1736042759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0914508724001357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0914508724001357"],"URL":"https:\/\/doi.org\/10.1016\/j.jjcc.2024.07.006","relation":{},"ISSN":["0914-5087"],"issn-type":[{"value":"0914-5087","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Left atrium as key player and essential biomarker in heart failure","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jjcc.2024.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Japanese College of Cardiology. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}